51 completed, 7 terminated, 6 unknown, 5 withdrawn. 77 Phase 2, 19 Phase 3, 8 Phase 1.
Follow Gabapentin: new trials by email Literature Review of Gabapentin trials Research Report on Gabapentin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Mechanistic Evaluation of Polypharmacy Effects for Pain Within-subject test of blinded study medications (Placebo, Hydromorphone, Gabapentin) - Chronic Lower Back Pain (CLBP) | Phase 1 / Phase 2 | Not yet recruiting | University of Maryland, Baltimore | 110 | 2027-01-15 | 2026-09-29 |
| Analgesic Efficacy of Pre-operative Dose of Ketorolac and Gabapentin Ketorolac Tromethamine 30 MG/ML Prefilled Syringe, Gabapentin, Empty Medication Capsules - Pain, Postoperative, Osteoarthritis, Knee | Phase 2 / Phase 3 | Not yet recruiting | Assiut University | 86 | 2025-08-15 | 2025-08-01 |
| Gabapentin and Pressor Response to Intubation Gabapentin Group (Group G): Patients will receive 300 mg of oral Gabapentin, Placebo Oral Tablet - Elective Surgical Patients, Blood Pressure | Phase 1 / Phase 2 | Not yet recruiting | Liaquat National Hospital & Medical College | 144 | 2024-12-15 | 2024-11-26 |
| Gabapentin to Reduce Alcohol and Improve Viral Load Suppression Gabapentin, Placebo - HIV, Heavy Drinking | Phase 2 | Active not recruiting | Boston Medical Center | 220 | 2023-11-20 | 2026-07-01 |
| Comparison of the Efficacy and Safety of Duloxetine Augmented With Gabapentin and Duloxetine Augmented With Amitriptyline vs Duloxetine Alone in Chemotherapy -Induced Neuropathy Duloxetine alone, Duloxetine augmented with gabapentin, Duloxetine augmented with amitriptyline (as combined therapy) - Neuropathy in Cacer Patien | Phase 2 | Unknown | Beni-Suef University | 160 | 2023-10-10 | 2024-04-16 |
| To Evaluate Efficacy of Monotherapy of Oxcarbazepine Versus Combination of Gabapentin With Oxcarbazepine in the Management of Trigeminal Neuralgia oxcarbamezapine(300 mg twice daily), combination therapy(oxcarbamezapine 300 mg twice daily and gabapentine) - Effectiveness of Drugs Was Compared for Treating Trigeminal Neuralgia, Pain | Phase 2 / Phase 3 | Completed | Rehman Medical Institute - RMI | 44 | 2023-05-01 | 2026-06-04 |
| Glutamate Inhibitors in Glioblastoma Gabapentin, Sulfasalazine, Memantine - Glioblastoma | Phase 1 / Phase 2 | Recruiting | University of Zurich | 120 | 2023-01-01 | 2024-05-10 |
| Effect of PP-01 on Cannabis Withdrawal Syndrome PP-01 High Dose, PP-01 Low Dose, Placebo - Cannabis Withdrawal | Phase 2 | Completed | PleoPharma, Inc. | 234 | 2022-10-27 | 2024-08-16 |
| Opioid-Free Pain Control Regiment Following Robotic Radical Prostatectomy Tramadol, Gabapentin, Hydrocodone-Acetaminophen - Radical Prostatectomies | Phase 2 / Phase 3 | Withdrawn | Wake Forest University Health Sciences | 2022-08-01 | 2022-09-06 | |
| Gabapentin for Restoring GABA/Glutamate Homeostasis in Co-occurring Bipolar and Cannabis Use Disorders Gabapentin, Placebo - Bipolar Disorder, Cannabis Use | Phase 2 | Completed | Medical University of South Carolina | 51 | 2022-02-24 | 2026-09-09 |
| Gabapentin & Ketamine for Prevention/Treatment of Acute/Chronic Pain in Locally Advanced Head and Neck Cancer Gabapentin, Ketamine - Head and Neck Cancer, Locally Advanced Head and Neck Carcinoma | Phase 1 / Phase 2 | Recruiting | Natalie Lockney | 64 | 2022-01-24 | 2024-10-21 |
| Gabapentin to Reduce Opioid Use Postoperatively (GROUP) in Children Gabapentin, Placebo - Pain, Postoperative | Phase 2 / Phase 3 | Recruiting | University of California, Davis | 60 | 2021-08-23 | 2026-10-26 |
| Efficacy of Gabapentin in Treating Pain in Children With SNI (Gabapentin Trial) Gabapentin, Placebo - Pain, Neuropathic Pain | Phase 2 | Unknown | University of British Columbia | 5 | 2021-05-15 | 2024-05-08 |
| St. PETERsburg Pain and Alcohol Intervention With Naltrexone and Gabapentin Low-dose naltrexone, Gabapentin, Placebo - Chronic Pain, Alcohol Use, Unspecified | Phase 2 | Completed | Boston Medical Center | 45 | 2021-01-25 | 2022-11-10 |
| Gabapentin and Tizanidine for Insomnia in Chronic Pain Gabapentin, Placebo, Tizanidine - Insomnia Due to Medical Condition, Chronic Pain | Phase 2 | Completed | University of California, San Diego | 9 | 2020-07-29 | 2025-01-03 |
| Preemptive Oral Gabapentin 600 mg in Reducing Morphine Requirement After Non Obstetric Lower Abdominal Surgery Gabapentin, Placebo - Non-obstetric Lower Abdominal Surgery | Phase 1 / Phase 2 | Completed | Universitas Indonesia | 72 | 2019-11-11 | 2021-09-13 |
| Gabapentin for Relief of Immediate Postoperative Pain Gabapentin 600mg, Placebo oral capsule - Postoperative Pain | Phase 1 / Phase 2 | Withdrawn | Indiana University | 2019-07-02 | 2020-07-29 | |
| Effectiveness of an Opioid Sparing Pain Regimen in Cardiac Surgery Oral Gabapentin and Intravenous Acetaminophen (IV APAP), Opiate based pain regimen. - Pain, Postoperative | Phase 2 | Completed | Inova Health Care Services | 19 | 2019-04-19 | 2022-11-08 |
| Effectiveness of Ropinirole and Gabapentin for the Treatment of RLS in Patients on Maintenance HD Ropinirole, Gabapentin, Placebos - Restless Legs Syndrome, End Stage Renal Disease | Phase 2 | Terminated | University of Alberta | 3 | 2019-02-19 | 2022-07-12 |
| Nonopioid Analgesia After Labral Surgery Celecoxib, Hydrocodone-Acetaminophen, Ketorolac - Narcotic Use | Phase 2 / Phase 3 | Recruiting | Henry Ford Health System | 100 | 2019-01-22 | 2019-01-31 |
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Alcoholism (7) · Pain (7) · Pain, Postoperative (6) · Neuralgia (5) · Agnosia (4) · Bipolar Disorder (4) · Chronic Pain (4) · Opioid-Related Disorders (4) · Hot Flashes (3) · Sleep Initiation and Maintenance Disorders (3) · Tinnitus (3) · Alcohol Drinking (2) · Anterior Cruciate Ligament Injuries (2) · Anxiety Disorders (2) · Depression (2)
Medical University of South Carolina (5) · New York State Psychiatric Institute (5) · Henry Ford Health System (3) · The Scripps Research Institute (3) · University of Arkansas (3) · Assiut University (2) · Boston Medical Center (2) · National Institute on Alcohol Abuse and Alcoholism (NIAAA) (2) · St. Jude Children's Research Hospital (2) · Washington University School of Medicine (2) · Abramson Cancer Center at Penn Medicine (1) · Aziende Chimiche Riunite Angelini Francesco S.p.A (1) · Beni-Suef University (1) · British Columbia Cancer Agency (1) · Depomed (1)
United States (48) · Egypt (4) · Iran (3) · Canada (2) · France (2) · Czechia (1) · Denmark (1) · India (1) · Indonesia (1) · Pakistan (1) · Philippines (1) · Poland (1) · Russia (1) · Sweden (1) · Switzerland (1)
Toufic R Jildeh, MD (3) · Alison Oliveto, PhD (2) · Doralina Anghelescu, MD (2) · James J Prisciandaro, PhD (2) · Raymond F Anton, MD (2) · Abualauon Elpiplaoy, MD (1) · Adrienne D Bonham, MD (1) · Alison Oliveto, Ph.D. (1) · Amit Sood, MD (1) · Anurag Singh (1) · Badie Mansour, MD (1) · Barbara J Mason, Ph.D. (1) · Barbara J. Mason, Ph.D. (1)
PMID 12933409, PMID 17438255, PMID 17960408, PMID 18040817, PMID 18582931, PMID 19593171, PMID 19672167, PMID 20081039, PMID 21631542, PMID 22373942, PMID 22775354, PMID 23703420, PMID 24190578, PMID 26304905, PMID 26526062, PMID 26962719, PMID 26963844, PMID 27875389, PMID 28150436, PMID 29392234, PMID 30646965, PMID 31169568, PMID 31403587, PMID 32150232, PMID 32217888, PMID 33451591, PMID 34120336, PMID 34256607, PMID 34390300, PMID 38126709, PMID 38408060, PMID 38828963, PMID 38914876, PMID 41282191, PMID 41401348, PMID 42236678, PMID 42237416
2014 (1), 2018 (1), K23DA021209 (1), P30CA015704 (1), P50DA018197 (1), R01AA025365 (1), R01AA030460 (1), R01DA010017 (1), R01DA026758 (1), R01DA039088 (1), R01DA054275 (1), R01DA061796 (1), R01DC006253 (1), R01HD076313 (1), R21DA020766 (1)