18 completed, 2 terminated, 1 recruiting. 10 Phase 1, 8 Phase 2, 3 Phase 3, 1 Early Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 10 | Completed 8, Recruiting 1, Terminated 1 |
| Phase 2 | 8 | Completed 7, Terminated 1 |
| Phase 3 | 3 | Completed 3 |
| Early Phase 1 | 1 | Completed 1 |
Follow Flortaucipir F18: new trials by email Literature Review of Flortaucipir F18 trials Research Report on Flortaucipir F18
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A First-In-Human Study of LY3954068 in Participants With Early Symptomatic Alzheimer's Disease LY3954068, Placebo, Flortaucipir F18 - Alzheimer Disease | Phase 1 | Recruiting | Eli Lilly and Company | 56 | 2024-08-15 | 2026-10-29 |
| Evaluation of Flortaucipir PET Signal and Cognitive Change in Early Alzheimer's Disease flortaucipir F18, Brain PET Scan - Alzheimer Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 205 | 2019-03-28 | 2020-08-28 |
| Cognitive Decline and Alzheimer's Disease in the Dallas Lifespan Brain Study [18F]AV-1451, Positron Emission Tomography - Alzheimer Disease, Cognitive Decline | Phase 2 | Completed | Neil M Rofsky, MD, MHA | 125 | 2019-01-15 | 2023-09-28 |
| Tau Screening Study in Subjects With Early Symptomatic AD Flortaucipir F18, Brain PET Scan - Alzheimer Disease | Phase 2 | Completed | Avid Radiopharmaceuticals | 161 | 2018-03-08 | 2020-08-24 |
| Tau Screening Study in Patients With Early Symptomatic AD Flortaucipir F18, Brain PET Scan - Alzheimer Disease | Phase 2 | Completed | Avid Radiopharmaceuticals | 155 | 2017-11-21 | 2020-08-24 |
| Flortaucipir PET Imaging in Subjects With FTD Flortaucipir F18, Brain PET scan - Frontotemporal Dementia | Phase 1 | Completed | Avid Radiopharmaceuticals | 16 | 2017-04-11 | 2020-09-25 |
| Flortaucipir 18F PET Imaging in BIOCARD Study Flortaucipir F18, Brain PET scan - Cognitive Decline | Phase 1 | Terminated | Avid Radiopharmaceuticals | 23 | 2017-03-23 | 2020-09-25 |
| A Study of LY3303560 in Participants With Mild Cognitive Impairment or Alzheimer's Disease LY3303560 - IV, Placebo - IV, Florbetapir F 18 - Alzheimer Disease | Phase 1 | Completed | Eli Lilly and Company | 22 | 2017-01-31 | 2023-10-10 |
| 18F-AV-1451 High Resolution Autopsy Study Flortaucipir F18 - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 3 | 2016-11-26 | 2025-06-10 |
| Follow up 18F-AV-1451 Scan in Confirmatory Cohort Subjects From Study 18F-AV-1451-A05 Flortaucipir F18, PET Scan - Alzheimer's Disease | Phase 2 | Completed | Avid Radiopharmaceuticals | 79 | 2016-08-01 | 2020-08-24 |
| 18F-AV-1451 Autopsy Study Flortaucipir F18, PET Scan - Alzheimer's Disease | Phase 3 | Completed | Avid Radiopharmaceuticals | 156 | 2015-09-01 | 2020-09-07 |
| Tau Imaging in Professional Fighters Flortaucipir F18, Brain PET scan - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 35 | 2015-02-18 | 2020-09-10 |
| Augmenting Flortaucipir Dosimetry Estimates Flortaucipir F18 - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 6 | 2015-01-01 | 2020-08-11 |
| Clinical Evaluation of Flortaucipir F 18 Flortaucipir F18, Brain PET scan - Alzheimer's Disease, Traumatic Brain Injury | Phase 2 | Completed | Avid Radiopharmaceuticals | 179 | 2014-12-01 | 2020-09-10 |
| Flortaucipir PET Imaging in the Preclinical, Prodromal and Dementia Phases of Alzheimer's Disease Flortaucipir F18, Brain PET scan - Alzheimer Disease, Mild Cognitive Impairment | Phase 1 | Completed | Avid Radiopharmaceuticals | 89 | 2014-10-01 | 2020-09-25 |
| Tau Imaging in Subjects With Progressive Supranuclear Palsy, Corticobasal Degeneration and Healthy Volunteers Flortaucipir F18, Brain PET scan - Progressive Supranuclear Palsy, Corticobasal Degeneration | Phase 1 | Completed | Avid Radiopharmaceuticals | 29 | 2014-08-12 | 2020-08-28 |
| 18F-AV-1451 and Florbetapir F 18 PET (Positron Emission Tomography) Imaging in Subjects at Risk for Chronic Traumatic Encephalopathy florbetapir F 18, Flortaucipir F18 - Chronic Traumatic Encephalopathy | Phase 2 | Completed | Avid Radiopharmaceuticals | 41 | 2014-06-01 | 2020-09-07 |
| Imaging Characteristics of a Follow-up 18F-AV-1451 Scan Flortaucipir F18, Florbetapir F 18, Brain PET Scan - Alzheimer's Disease | Phase 2 | Terminated | Avid Radiopharmaceuticals | 44 | 2014-05-01 | 2020-09-07 |
| Analysis of 18F-AV-1451 PET Imaging in Cognitively Healthy, MCI, and AD Subjects florbetapir F 18, Flortaucipir F18, Brain PET Scan - Alzheimer's Disease | Phase 2 / Phase 3 | Completed | Avid Radiopharmaceuticals | 383 | 2013-12-01 | 2020-09-22 |
| A Study of Flortaucipir PET in Healthy Volunteers and Cognitively Impaired Subjects Flortaucipir F18, Brain PET scan - Alzheimer's Disease | Phase 1 | Completed | Avid Radiopharmaceuticals | 24 | 2013-11-13 | 2020-09-07 |
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Alzheimer Disease (17) · Cognitive Dysfunction (4) · Brain Diseases (1) · Brain Injuries, Traumatic (1) · Central Nervous System Diseases (1) · Chronic Traumatic Encephalopathy (1) · Corticobasal Degeneration (1) · Dementia (1) · Depression (1) · Frontotemporal Dementia (1) · Mental Disorders (1) · Nervous System Diseases (1) · Neurocognitive Disorders (1) · Neurodegenerative Diseases (1) · Pick Disease of the Brain (1)
Avid Radiopharmaceuticals (18) · Eli Lilly and Company (2) · Neil M Rofsky, MD, MHA (1)
United States (20) · Japan (2) · United Kingdom (2) · Australia (1) · Canada (1)
Denise Park, PhD (1)
PMID 33587110, PMID 29284675, PMID 30969506, PMID 32338734, PMID 32542468, PMID 33141172, PMID 37849628, PMID 42467182
2016 (1)