11 completed, 8 unknown, 2 terminated, 1 not yet recruiting. 23 Phase 2, 5 Phase 1, 3 Phase 3.
Follow esmolol: new trials by email Literature Review of esmolol trials Research Report on esmolol
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| POCUS-Guided Esmolol in Septic Shock: A Pilot RCT Esmolol - Septic Shock | Phase 1 / Phase 2 | Not yet recruiting | John Basmaji | 100 | 2026-01-15 | 2026-01-06 |
| REMAP ECMO - Beta Receptor Modulation Trial Esmolol - Heart Failure, Cardiogenic Shock | Phase 2 | Unknown | Erasmus Medical Center | 20 | 2024-06-01 | 2024-07-26 |
| Esmolol Versus Lidocaine on the Quality of Postoperative Recovery in Patients Undergoing Functional Endoscopic Sinus Surgery Esmolol Injection, Lidocaine IV - Chronic Rhinosinusitis, Enhanced Recovery After Surgery | Phase 1 / Phase 2 | Unknown | The Second People's Hospital of Huai'an | 60 | 2023-11-21 | 2024-06-13 |
| Efficacy of Esmolol Versus Magnesium Sulphate on Quality of Recovery in Patients Undergoing Laparoscopic Cholecystectomy: Randomized Controlled Study Esmolol, Magnesium sulfate - Esmolol Adverse Reaction | Phase 2 / Phase 3 | Completed | Alexandria University | 60 | 2022-10-05 | 2023-05-09 |
| Esmolol in Sepsis Management:Evaluating Immunomodulatory Effects and Impact on Patient Outcomes esmolol - Sepsis, Lymphocyte Disorder T | Phase 2 | Completed | Lin Chen | 150 | 2021-01-01 | 2024-05-29 |
| Lidocaine, Esmolol, or Placebo to Relieve IV Propofol Pain Lidocaine, Esmolol, Placebo - Injection Site Irritation, Pain | Phase 2 / Phase 3 | Terminated | Wake Forest University Health Sciences | 33 | 2020-09-09 | 2024-09-19 |
| Lidocaine Versus Esmolol for Optimizing Surgical Field Visibility Lidocaine, Esmolol - Lumbar Disc Herniation | Phase 2 | Completed | Zagazig University | 70 | 2020-02-04 | 2020-07-02 |
| Dexmedetomidine and Esmolol Early Post Operative Cognitive Dysfunction Esmolol Hydrochloride, Dexmedetomidine - Cognitive Dysfunction | Phase 1 / Phase 2 | Unknown | Beni-Suef University | 58 | 2019-04-01 | 2019-03-27 |
| Esmolol to Control Adrenergic Storm in Septic Shock- ROLL-IN 2 Esmolol - Septic Shock | Phase 2 | Unknown | Samuel Brown | 10 | 2017-08-07 | 2019-02-26 |
| Esmolol vs. Labetalol in Endoscopic Sinus Surgery Labetalol, Esmolol - Chronic Sinusitis | Phase 2 | Completed | The University of Texas Medical Branch, Galveston | 28 | 2017-03-01 | 2021-02-08 |
| Esmolol Infusion for Patients With Septic Shock and Persistent Tachycardia Esmolol - Septic Shock | Phase 2 | Completed | Intermountain Health Care, Inc. | 7 | 2016-04-01 | 2019-01-09 |
| Concomitant Milrinone and Esmolol Treatment in Patients with Acute Myocardial Infarction Milrinone, Esmolol, Saline Infusion - Myocardial Reperfusion Injury | Phase 2 | Completed | Shantou University Medical College | 25 | 2015-05-01 | 2025-01-09 |
| Pilot Phase II Study: Hemodynamic Tolerance and Anti-inflammatory Effects of Esmolol During the Treatment of Septic Shock Esmolol administration - Septic Shock | Phase 2 | Unknown | Assistance Publique - Hôpitaux de Paris | 45 | 2015-04-01 | 2023-08-31 |
| Esmolol to Treat the Hemodynamic Effects of Septic Shock Esmolol, Saline - Septic Shock, Hypotension | Phase 2 | Terminated | Beth Israel Deaconess Medical Center | 40 | 2015-03-01 | 2021-06-28 |
| Pilot Study: Echocardiographic and Hemodynamic Effects of Esmolol in Septic Shock Patients Esmolol - Shock, Septic | Phase 2 / Phase 3 | Unknown | Peking Union Medical College Hospital | 36 | 2014-12-01 | 2016-07-25 |
| Clinical Investigation of Galnobax® for the Treatment of Diabetic Foot Ulcers Esmolol hydrochloride, Placebo gel - Diabetic Foot Ulcer | Phase 1 / Phase 2 | Completed | Novalead Pharma Private Limited | 44 | 2014-02-20 | 2024-05-20 |
| Esmolol Effects on Heart and Inflammation in Septic Shock Esmolol - Septic Shock | Phase 2 | Unknown | Central Hospital, Nancy, France | 25 | 2013-12-01 | 2016-01-28 |
| The Effect of Intraoperative Labetalol on Time to Discharge Esmolol, Labetalol, Fentanyl - Bloodpressure, Heart Rate | Phase 2 | Completed | Dr. Robert Tanzola | 172 | 2012-11-01 | 2020-02-13 |
| Controlling Hyperadrenergic Activity in Neurologic Injury Esmolol, Propranolol - Traumatic Brain Injury, Dysautonomia | Phase 1 / Phase 2 | Withdrawn | Johns Hopkins University | 2011-07-01 | 2017-04-20 | |
| A Short Term Pharmacokinetic, Pharmacodynamic and Tolerability Study to Compare AOP200704 vs. Esmolol AOP200704, Esmolol hydrochloride, infusion - Healthy Volunteers, Pharmacokinetics/Dynamics Study | Phase 2 | Completed | AOP Orphan Pharmaceuticals AG | 16 | 2011-03-01 | 2012-07-19 |
Showing 20 of 23. Sign in to see all of them.
Shock, Septic (8) · Autonomic Nervous System Diseases (2) · Hypotension (2) · Sepsis (2) · Tachycardia (2) · Atrial Fibrillation (1) · Brain Injuries (1) · Brain Injuries, Traumatic (1) · Cardiovascular Diseases (1) · Cognitive Dysfunction (1) · Cytokine Release Syndrome (1) · Diabetic Foot (1) · Heart Failure (1) · Intervertebral Disc Displacement (1) · Multiple Trauma (1)
AOP Orphan Pharmaceuticals AG (1) · Alexandria University (1) · Andrea Morelli (1) · Assistance Publique - Hôpitaux de Paris (1) · Beni-Suef University (1) · Beth Israel Deaconess Medical Center (1) · Central Hospital, Nancy, France (1) · Dr. Robert Tanzola (1) · Erasmus Medical Center (1) · Gilead Sciences (1) · Intermountain Health Care, Inc. (1) · John Basmaji (1) · Johns Hopkins University (1) · Lin Chen (1) · Novalead Pharma Private Limited (1)
United States (9) · China (3) · Egypt (3) · France (2) · Canada (1) · Czechia (1) · India (1) · Italy (1) · Malaysia (1) · Netherlands (1) · Singapore (1)
Andrea Morelli, MD (1) · Antoine Kimmoun, MD (1) · Bruno Levy, MD PhD (1) · Christiaan L. Meuwese (1) · John Basmaji (1) · Lin Chen, doctoral (1) · Michael Norton, MD (1) · Ming-He Huang, MD, PhD (1) · Mohamad Chaaban, MD (1) · Olfat Ibrahem Amin, M.D (1) · Randall Friese, MD (1) · Robert Tanzola, MD, FRCPC (1)
PMID 18404076, PMID 23989533, PMID 24108526, PMID 30123523, PMID 33413583, PMID 35066509, PMID 38240494, PMID 40009025, PMID 40421209, PMID 42402640