93 completed, 37 unknown, 14 terminated, 12 recruiting. 166 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 166 | Completed 93, Unknown 37, Terminated 14, Recruiting 12, Not yet recruiting 4, Withdrawn 3, Active not recruiting 2, Enrolling by invitation 1 |
Follow control: new trials by email Literature Review of control trials Research Report on control
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Geko™ Device in Prevention of Pain and Swelling Following Knee Arthroscopy Geko, control - Post Operative Swelling | Phase 4 | Not yet recruiting | Cedars-Sinai Medical Center | 46 | 2026-12-01 | 2026-10-27 |
| Effects of Hypoxia or Caffeine on 4km Time-trial Morning Cycling. Caffeine (300mg), Placebo (caffeine, paracetamol, cephalexin, or ibuprofen), Control - Caffeine, Hypoxia | Phase 4 | Recruiting | Liverpool John Moores University | 20 | 2026-11-15 | 2026-11-13 |
| Improving Morning Strength and Cognitive Performance Using Caffeine or Whole-body Vibration. Caffeine (300mg), whole-body vibration, Placebo - Vibration Therapy, Caffeine | Phase 4 | Recruiting | Liverpool John Moores University | 20 | 2026-11-01 | 2026-11-06 |
| Randomized Controlled Clinical Study on the Prophylactic Intraoperative Use of Desmopressin in Complex Sellar Region Tumors Desmopressin (DDAVP), Control - Craniopharyngiomas, Pituitary Macroadenoma | Phase 4 | Enrolling by invitation | Zhaoyun Zhang | 152 | 2026-06-02 | 2026-07-17 |
| Effect of Noninvasive Ventilation on Physical Activity and Inflammation in COPD Patients Control, NIMV group - Chronic Obstructive Pulmonary Disease, Hypercapnic | Phase 4 | Unknown | Hospital Universitario La Paz | 50 | 2025-12-01 | 2023-03-06 |
| Effects of Pre-procedure and Intra-procedure Simethicone and Dicyclomine Administration in Improving Quality of Endoscopic Reterograde Cholangipancreaticography (ERCP) Preprocedural, Intraprocedural, Control - Motility Disorder of Intestine, Mucosal Clarity | Phase 4 | Completed | CMH Lahore Medical College and Institute of Dentistry | 90 | 2025-10-01 | 2026-04-13 |
| Impact of ERAS Protocol on Length of Hospital Stay After Laparoscopic Surgeries Enhanced Recovery After Surgery, Control - ERAS | Phase 4 | Recruiting | Aga Khan University | 98 | 2025-08-20 | 2026-02-17 |
| Post-discharge Malaria Chemoprevention Implementation Trial in Benin Adherence support strategy A, Adherence support strategy B, Control - Severe Malaria, Severe Anaemia | Phase 4 | Recruiting | Institut de Recherche Clinique du Benin | 648 | 2025-07-02 | 2026-08-12 |
| Magnesium-L-Threonate for Sleep Quality Post-Arthroplasty Magnesium Threonate, Control - Sleep, Knee Osteoarthritis | Phase 4 | Recruiting | University of Miami | 64 | 2025-04-21 | 2026-07-09 |
| Coronally Advanced Tunnel Combined With Xenogenic Dermal Matrix and L-PRF Coronally Advanced Tunel + ADM (Novomatrix®), Coronally Advanced Tunel + ADM (Novomatrix®) + L-PRF - Gingival Recession, Gingival Recession, Localized | Phase 4 | Not yet recruiting | Andres Matteo Pascual La Rocca | 44 | 2025-04-01 | 2025-01-28 |
| Histidine Oral Supplementation as a Therapeutic Modality for Alzheimer's Disease l-Histidine, Control - Alzheimer Disease | Phase 4 | Withdrawn | Wake Forest University Health Sciences | 2025-04-01 | 2025-04-27 | |
| A Multicentre, Randomised, Single-blind, Controlled Protocol to Evaluate the Efficacy of Early Administration of Botulinum Toxin for Primary Midline Closure in Patients With Open Abdomen. Botulinum Toxin A, CONTROL - Botulinum Toxin Type A, Open Abdomen | Phase 4 | Not yet recruiting | Instituto de Investigación Hospital Universitario La Paz | 50 | 2025-01-01 | 2024-08-15 |
| Using Glialia for Treating Persistent Perceptual Postural Dizziness Glialia, Placebo, Control - Persistent Postural Perceptual Dizziness | Phase 4 | Recruiting | I.R.C.C.S. Fondazione Santa Lucia | 30 | 2024-12-21 | 2026-10-05 |
| inDividual, Targeted thrombosIS Prophylaxis Versus the Standard 'One Size Fits All' Approach in Patients Undergoing Total hIp or Total kNee replaCemenT Short duration prophylaxis, Higher intensity and longer duration prophylaxis, Control - Venous Thromboembolism, Venous Thromboses | Phase 4 | Recruiting | Leiden University Medical Center | 10078 | 2024-11-11 | 2026-09-08 |
| REstoration of VItamin D in Pulmonary Arterial Hypertension Calcifediol Oral Capsule, Placebo - Pulmonary Artery Hypertension, Vitamin d Deficiency | Phase 4 | Not yet recruiting | Parc de Salut Mar | 102 | 2024-07-01 | 2024-02-14 |
| Efficacy of Lavender Essential Oil Chest Wraps in Infants With Bronchiolitis Lavender essential oil 10%, diluted in 90% olive oil, Control - Bronchiolitis | Phase 4 | Recruiting | University Hospital, Geneva | 400 | 2023-12-07 | 2025-03-30 |
| Nasal Steroids, Irrigation, Oral Antibiotics, and Subgroup Targeting for Effective Management of Acute Sinusitis amoxicillin/clavulanate potassium, Placebo, Budesonide nasal spray - Sinus Infection, Acute Sinusitis | Phase 4 | Recruiting | Daniel Merenstein | 3720 | 2023-11-21 | 2026-03-03 |
| Preemptive Ibuprofen Effects on Pain Perception Following Extraction and Bone Graft Ibuprofen 600 mg, Placebo, Acetaminophen - Pain, Post Operative, Quality of Life | Phase 4 | Recruiting | Marquette University | 50 | 2023-10-19 | 2024-09-27 |
| The Effect of Mediclore as an Anti-adhesion Agent and Safety in Full-endoscopic Spine Surgery: a Preliminary Study Mediclore, Normal Saline - Lumbar Disc Disease, Epidural Fibrosis | Phase 4 | Unknown | King Chulalongkorn Memorial Hospital | 78 | 2023-10-01 | 2023-09-14 |
| Diode Laser and Photodynamic Therapy Vs. Ciclopirox. Diode laser combined with photodynamic-red laser therapy by RapidoPodia Laser Diodo®, Ciclopirox Hydroxypropyl Chitosan (HPCH) Nail Lacquer - Onychomycosis | Phase 4 | Unknown | Universidad Complutense de Madrid | 26 | 2023-09-01 | 2023-05-10 |
Showing 20 of 166. Sign in to see all of them.
Diabetes Mellitus (8) · Hemorrhage (6) · Pain, Postoperative (6) · Diabetes Mellitus, Type 2 (4) · Hypertension (4) · Peripheral Arterial Disease (4) · Anemia (3) · Cardiovascular Diseases (3) · Diabetic Foot (3) · Dyslipidemias (3) · Intermittent Claudication (3) · Metabolic Syndrome (3) · Pain (3) · Sinusitis (3) · Acute Kidney Injury (2)
Mahidol University (6) · Seoul National University Hospital (4) · Konkuk University Medical Center (3) · National Cheng-Kung University Hospital (3) · RenJi Hospital (3) · Ain Shams University (2) · Assistance Publique - Hôpitaux de Paris (2) · Centre for Endocrinology and Reproductive Medicine, Italy (2) · Chulalongkorn University (2) · Healthpoint (2) · Huazhong University of Science and Technology (2) · Leonardo Clavijo (2) · Liverpool John Moores University (2) · Mansoura University (2) · Massachusetts General Hospital (2)
United States (50) · China (11) · South Korea (10) · Thailand (9) · Egypt (7) · Spain (7) · Brazil (6) · Canada (6) · Italy (6) · Taiwan (5) · Germany (4) · United Kingdom (4) · Australia (3) · Turkey (Türkiye) (3) · Belgium (2)
Ting-Hsing Chao, MD (3) · Herbert B Slade, MD (2) · Leonardo Clavijo, MD, PhD (2) · Sirilak Suksompong, MD (2) · Talerngsak Kanjanabuch, Assist. Prf. (2) · Ahmed R EL-Nahas, A. Professor (1) · Alessandra Sandrini, MD, PhD (1) · Alshaimaa Mohamed, phd (1) · Amin R Javer, MD, FRCSC, FARS (1) · Amin R Javer, MD, FRCSC,FARS (1) · Ana Ciscar, MD (1) · Andrei C Sposito, MD,Phd (1) · Arianna Di Stadio, PhD (1) · Arkom Nongnuch, MD (1)
PMID 27207972, PMID 10214567, PMID 10389803, PMID 10671850, PMID 11350323, PMID 11812709, PMID 12190806, PMID 12198045, PMID 12768180, PMID 12803269, PMID 13998, PMID 14557435, PMID 14766688, PMID 14980919, PMID 15235946, PMID 16235676, PMID 16363316, PMID 16731324, PMID 17202008, PMID 17241503, PMID 17261216, PMID 17424883, PMID 17513629, PMID 18044291, PMID 18285392, PMID 18343266, PMID 18433676, PMID 18640467, PMID 19344620, PMID 19509014, PMID 19696679, PMID 20304348, PMID 20381077, PMID 20478449, PMID 20542472, PMID 20825986, PMID 21103330, PMID 21396214, PMID 21453656, PMID 2200299, PMID 23145922, PMID 23162393, PMID 23195688, PMID 23429813, PMID 23705925, PMID 23878437, PMID 23959584, PMID 24145042, PMID 24200273, PMID 24295879
2018 (1), 2019 (1), 2023 (1), 2025 (1), K23MH074540 (1), K24MH122514 (1), R01DA030998 (1), R01DK097554 (1), R01MH035182 (1)