42 completed, 13 recruiting, 10 terminated, 10 unknown. 85 Phase 2, 11 Phase 3, 5 Phase 1.
Follow Colchicine: new trials by email Literature Review of Colchicine trials Research Report on Colchicine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Ph2, Colchicine For Inflammatory Carotid Injury And Disease Evolution After Radiotherapy Colchicine, Placebo - Head and Neck Cancer | Phase 2 | Not yet recruiting | M.D. Anderson Cancer Center | 250 | 2027-03-01 | 2026-10-05 |
| Colchicine Effect on Amyotrophic Lateral Sclerosis Patients Colchicine 0.5 MG Oral Tablet, Placebo Oral Tablet - Amyotrophic Lateral Sclerosis | Phase 2 | Not yet recruiting | Azienda Ospedaliero-Universitaria di Modena | 87 | 2026-10-01 | 2026-09-10 |
| Colchicine to Reduce Your SympToms And Lower Levels of Inflammation, Zeroing in on Effective CPPD Disease Treatment Colchicine Pill, Placebo - CPPD - Calcium Pyrophosphate Deposition Disease | Phase 2 | Recruiting | Brigham and Women's Hospital | 150 | 2026-08-12 | 2026-09-21 |
| A Study of SSGJ-613 in Gout Participants Initiating Urate-Lowering Treatment SSGJ-613 100 mg Q12W, SSGJ-613 200 mg Q12W, SSGJ-613 100 mg Q4W - Gout Arthritis | Phase 2 | Not yet recruiting | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 200 | 2026-08-02 | 2026-07-20 |
| Colchicine for the Prevention of Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Single-Center, Strategy-Stratified, Randomized, Double-Blind, Placebo-Controlled Trial Colchicine 0.5 MG oral tablet twice daily, Placebo Oral Tablet - Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) | Phase 2 / Phase 3 | Enrolling by invitation | National Taiwan University Hospital | 400 | 2026-07-06 | 2026-07-10 |
| Colchicine for Autoimmune and Subacute Thyroiditis colchicine, Prednisolone, NSAID - Hashimoto Thyroiditis, Subacute Thyroiditis | Phase 2 / Phase 3 | Recruiting | Mansoura University | 300 | 2026-06-15 | 2026-07-29 |
| Colchicine to Reduce Coronary Artery Inflammation in People With HIV Colchicine 0.5 mg, Placebo - HIV Infection, Cardiovascular Diseases (CVD) | Phase 2 | Recruiting | Instituto de Investigación Hospital Universitario La Paz | 90 | 2026-06-01 | 2026-07-15 |
| Effect of Colchicine in Patients With Myocardial Infarction Colchicine, Placebo oral tablet - Myocardium; Injury, Myocardial Infarction | Phase 2 | Withdrawn | Shifa Tameer-e-Millat University | 2025-12-01 | 2023-04-12 | |
| The Effect of Colchicine, on Insulin Sensitivity in Individuals With Type 1 Diabetes and Systemic Low-grade Inflammation Colchicin 0.5 mg once daily for two weeks, then twice daily for two weeks, Placebo once daily for two weeks, then twice daily for two weeks, Colchicine tablet 0.5 mg once-daily for two weeks, then twice daily for two weeks - Type 1 Diabetes, Chronic Inflammation | Phase 2 | Recruiting | Asger Lund, MD | 26 | 2025-12-01 | 2025-12-23 |
| Safety and Efficacy of ABP-745 in Participants With an Acute Gout Flare ABP-745 Dose A, ABP-745 Dose B, Colchicine - Acute Gouty Arthritis, Gout Flare | Phase 2 | Recruiting | Atom Therapeutics Co., Ltd | 380 | 2025-08-26 | 2025-12-08 |
| Colchicine for Primary Prevention of Cardiovascular Disease in Adults With Type 2 Diabetes Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Type 2 Diabetes Mellitus (T2DM), Atherosclerosis | Phase 2 | Recruiting | Tan Tock Seng Hospital | 300 | 2025-07-24 | 2026-09-24 |
| Colchicine for the Prevention of Recurrence in Cerebral Amyloid Angiopathy RElated IntraCerebral Hemorrhage Colchicine 0.5mg, Matching placebo - Cerebral Amyloid Angiopathy, Intracerebral Hemorrhage Lobar | Phase 2 | Recruiting | Huashan Hospital | 80 | 2025-06-18 | 2025-06-26 |
| Using Tumor Models to Determine Treatments Cobimetinib, Ponatinib, Brigatinib - Pancreatic Ductal Carcinoma, Advanced Cancer | Phase 2 | Recruiting | University Health Network, Toronto | 25 | 2025-04-07 | 2026-06-23 |
| EFFICACY OF COLCHICINE IN IMPROVING CLINICAL OUTCOMES IN PATIENTS WITH MILD TO MODERATE COVID-19 PNEUMONIA IN LAHORE: A RANDOMIZED CONTROL TRIAL Colchicine 0.5 MG Oral Tablet - COVID - 19 | Phase 1 / Phase 2 | Completed | Zaeema Kanwal | 66 | 2025-02-24 | 2025-09-04 |
| Baricitinib in CPPD - the BAPTIST Study Baricitinib 4 MG Oral Tablet, Methylprednisolone (Corticosteroid), Colchicine 1 MG Oral Tablet - Calcium Pyrophosphate Deposition Disease, Chondrocalcinosis | Phase 2 | Not yet recruiting | I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio | 32 | 2025-01-01 | 2025-01-10 |
| Inflammation REduction to Prevent cArdiovascular Injury in Renal Disease (REPAIR) Colchicine - Chronic Kidney Diseases, Renal Failure | Phase 2 | Completed | Hamilton Health Sciences Corporation | 96 | 2024-11-15 | 2026-08-13 |
| Efficacy of LoDoCo in Improving Exercise Capacity Among Patients With HFpEF and Inflammation Low Dose Colchicine, Placebo - Heart Failure, Inflammation | Phase 2 | Recruiting | University of Texas Southwestern Medical Center | 60 | 2024-04-24 | 2026-02-27 |
| A Study of SSGJ-613 in Gout Subjects Initiating Urate-Lowering Treatment. Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 100 mg, Recombinant Anti-IL-1β Humanized Monoclonal Antibody Injection 200 mg, Colchicine 0.5 mg - Gout Arthritis | Phase 2 | Unknown | Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. | 157 | 2024-03-30 | 2024-08-05 |
| Reversing Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction Colchicine, Placebo - Heart Failure With Preserved Ejection Fraction, Microvascular Coronary Artery Disease | Phase 2 / Phase 3 | Unknown | Montreal Heart Institute | 60 | 2024-03-01 | 2024-01-25 |
| The COLchicine HEART Failure PRESERVED Trial (COLHEART-PRESERVED) Colchicine, Placebo - Heart Failure With Preserved Ejection Fraction | Phase 2 | Unknown | Tor Biering-Sørensen | 152 | 2024-01-18 | 2024-02-28 |
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Inflammation (14) · COVID-19 (12) · Gout (12) · Cardiovascular Diseases (7) · Atherosclerosis (6) · Coronary Artery Disease (6) · Coronavirus Infections (5) · Hyperuricemia (5) · Acute Coronary Syndrome (4) · Heart Diseases (4) · Arthritis, Gouty (3) · Atrial Fibrillation (3) · Heart Failure (3) · Myocardial Infarction (3) · Amyotrophic Lateral Sclerosis (2)
Gilead Sciences (5) · Montreal Heart Institute (3) · Asger Lund, MD (2) · Azienda Ospedaliero-Universitaria di Modena (2) · Brigham and Women's Hospital (2) · Changchun GeneScience Pharmaceutical Co., Ltd. (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Hamilton Health Sciences Corporation (2) · Johns Hopkins University (2) · Kaohsiung Medical University Chung-Ho Memorial Hospital (2) · St. Vincent Cardiovascular Research Institute (2) · Sunshine Guojian Pharmaceutical (Shanghai) Co., Ltd. (2) · University of Sao Paulo General Hospital (2) · Assaf-Harofeh Medical Center (1) · Atom Therapeutics Co., Ltd (1)
United States (28) · Canada (11) · Italy (6) · China (5) · Denmark (4) · Spain (4) · Taiwan (4) · Iran (3) · Israel (3) · Russia (3) · Singapore (3) · Brazil (2) · Colombia (2) · Egypt (2) · Georgia (2)
Hejian Zou (2) · Jack A Yanovski, M.D. (2) · Parin J. Patel, MD (2) · Robert G Weiss, MD (2) · Alexandra Steinberg, MD, PhD (1) · Ambarish Pandey, MD (1) · Amr A. El Sehrawy, MD, PhD, FRCPE (1) · Anastasia Shchendrygina (1) · Anna Toso, MD (1) · Arash Tehrani Banihashemi, MD, MPH (1) · Aristeidis Katsanos, MD (1) · Aryan MF Jalal (1) · Asger B Lund, MD, PhD (1)
PMID 34658014, PMID 16186437, PMID 23040570, PMID 24508207, PMID 25172965, PMID 26228647, PMID 32081221, PMID 32553209, PMID 32720823, PMID 33270311, PMID 15308692, PMID 15320751, PMID 16134130, PMID 19597921, PMID 20336760, PMID 20704622, PMID 21435708, PMID 22090167, PMID 23208422, PMID 24773578, PMID 25925674, PMID 26576054, PMID 26989892, PMID 27344959, PMID 27378573, PMID 27585965, PMID 27980008, PMID 29426008, PMID 29848361, PMID 30349811, PMID 30869182, PMID 30937899, PMID 30976418, PMID 31152038, PMID 31740368, PMID 31978293, PMID 32020029, PMID 32074550, PMID 32083985, PMID 32109013, PMID 32150618, PMID 32171740, PMID 32187464, PMID 32205204, PMID 32251729, PMID 32345372, PMID 32503620, PMID 32579195, PMID 32863171, PMID 33587443
2025 (1), K23HL150311 (1), R01HL120905 (1), R01HL125059 (1), U54AR057319 (1), ZIAHD000641-23 (1)