28 completed, 20 recruiting, 12 unknown, 8 terminated. 80 Phase 3, 11 Phase 2.
Follow Colchicine: new trials by email Literature Review of Colchicine trials Research Report on Colchicine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Randomized Interventional Clinical Trial on the Prevention of Atrial Fibrillation Using Colchicine, Amiodarone And a Posterior Pericardiotomy. Colchicine, Amiodarone, Posterior pericardiotomy - Atrial Fibrillation (AF) | Phase 3 | Not yet recruiting | Elsan | 636 | 2027-01-01 | 2026-10-21 |
| Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage Colchicine 0.5 MG, Placebo - Colchicine, ICH - Intracerebral Hemorrhage | Phase 3 | Not yet recruiting | Population Health Research Institute | 1125 | 2026-09-30 | 2026-09-01 |
| PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis Rosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression | Phase 3 | Recruiting | Duke University | 1500 | 2026-07-21 | 2026-10-07 |
| Colchicine for the Prevention of Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting: A Single-Center, Strategy-Stratified, Randomized, Double-Blind, Placebo-Controlled Trial Colchicine 0.5 MG oral tablet twice daily, Placebo Oral Tablet - Post-Operative Atrial Fibrillation After Coronary Artery Bypass Grafting (CABG) | Phase 2 / Phase 3 | Enrolling by invitation | National Taiwan University Hospital | 400 | 2026-07-06 | 2026-07-10 |
| Colchicine for Autoimmune and Subacute Thyroiditis colchicine, Prednisolone, NSAID - Hashimoto Thyroiditis, Subacute Thyroiditis | Phase 2 / Phase 3 | Recruiting | Mansoura University | 300 | 2026-06-15 | 2026-07-29 |
| Colchicine in Chronic Limb-Threatening Ischemia Colchicine 0.5 MG Oral Tablet Once Daily, Placebo - Chronic Limb-Threatening Ischemia | Phase 3 | Recruiting | Shin Kong Wu Ho-Su Memorial Hospital | 200 | 2026-06-02 | 2026-07-14 |
| Design and Rationale of the COLT Study Colchicine 0.5 MG Oral Tablet, Placebo - Venous Thrombosis Deep (Limbs), Post-thrombotic Syndrome | Phase 3 | Not yet recruiting | Azienda Sanitaria Locale ASL 6, Livorno | 940 | 2026-06-01 | 2026-02-25 |
| Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial) Colchicine 0.5 mg po, Placebo 0.5 mg po - Venous Thromboembolism | Phase 3 | Recruiting | Ottawa Hospital Research Institute | 150 | 2025-07-07 | 2026-07-23 |
| Colchicine for Secondary Prevention After Ischemic Stroke (CHANCE-3 EX) Colchicine 0.5 mg, Placebo colchicine - Stroke | Phase 3 | Not yet recruiting | Beijing Tiantan Hospital | 7500 | 2025-07-04 | 2025-06-27 |
| Polypill and Colchicine for Risk Reduction in Atherosclerotic Cardiovascular Disease Cardiovascular Polypill (Valsartan, Atorvastatin, Aspirin), Colchicine 0.5 mg, Usual Care Group - Atherothrombotic Diseases, Atherosclerotic Cardiovascular Disease (ASCVD) | Phase 3 | Recruiting | Hospital do Coracao | 7713 | 2025-06-12 | 2026-01-22 |
| Colchicine in Patients at Cardiac Risk Undergoing Major Non-Cardiac Surgery Colchicine, Placebo - Cardiovascular Diseases, Cardiovascular Complication | Phase 3 | Recruiting | Cantonal Hospital of St. Gallen | 880 | 2025-04-20 | 2025-04-24 |
| The Fifth INTEnsive pReventing Secondary Injury in Acute Cerebral Haemorrhage Trial Within ACT-GLOBAL Colchicine 0.5 mg, Deferoxamine Mesylate, Control (Standard treatment) - Intracerebral Hemorrhage, Spontaneous Intracerebral Hemorrhage | Phase 3 | Recruiting | The George Institute | 2000 | 2025-02-27 | 2026-07-08 |
| RECLAIM Adaptive Platform Trial for PCC Treatments Metformin, colchicine - Post COVID Condition | Phase 3 | Enrolling by invitation | Janneke van de Wijgert | 1250 | 2025-02-17 | 2025-12-12 |
| The Effect of ColcHicine on the Incidence of Knee or Hip Replacements Colchicine, Placebo - Osteoarthritis, Knee, Osteoarthritis, Hip | Phase 3 | Recruiting | Sint Maartenskliniek | 1410 | 2025-01-01 | 2025-02-20 |
| ACT-GLOBAL Adaptive Platform Trial for Stroke Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase - Stroke | Phase 3 | Recruiting | The George Institute | 20000 | 2024-09-26 | 2026-07-08 |
| Colchicine Versus Placebo in Acute Myocarditis Patients Colchicine Pill, Placebo - Acute Myocarditis | Phase 3 | Recruiting | Assistance Publique - Hôpitaux de Paris | 300 | 2024-07-16 | 2026-02-25 |
| Efficacy and Safety of Colchicine After PCI Colchicine 0.5 mg, Colchicine 0.375 mg, Placebo - Coronary Heart Disease, Percutaneous Coronary Intervention | Phase 3 | Active not recruiting | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 8862 | 2024-07-09 | 2026-09-03 |
| Role of Colchicine as Anti-Inflammatory Therapy in HFpEF Colchicine Tablets - HFpEF - Heart Failure With Preserved Ejection Fraction | Phase 3 | Active not recruiting | Cairo University | 75 | 2024-07-01 | 2025-02-25 |
| ESCALATion of Medical Therapy Following Multimodality Plaque Evaluation in High-risk Chronic Coronary Syndromes Colchicine 0.5 MG - Coronary Artery Disease | Phase 3 | Unknown | King's College Hospital NHS Trust | 50 | 2024-06-24 | 2024-06-21 |
| Colchicine After Electrocardioversion for Atrial Fibrillation Colchicine, Placebo - Atrial Fibrillation, Cardiac Arrhythmia | Phase 3 | Recruiting | University Hospital, Basel, Switzerland | 416 | 2024-04-14 | 2025-05-28 |
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Atrial Fibrillation (12) · Inflammation (12) · COVID-19 (10) · Stroke (8) · Coronary Artery Disease (5) · Myocardial Infarction (5) · Heart Diseases (4) · Heart Failure (4) · Recurrence (4) · Acute Coronary Syndrome (3) · Arrhythmias, Cardiac (3) · Atherosclerosis (3) · Cardiovascular Diseases (3) · Cerebral Hemorrhage (3) · Coronavirus Infections (3)
Population Health Research Institute (7) · Montreal Heart Institute (4) · Assistance Publique - Hôpitaux de Paris (3) · Azienda Sanitaria Locale 3, Torino (3) · Beijing Tiantan Hospital (2) · Fundacion para la Formacion e Investigacion Sanitarias de la Region de Murcia (2) · Hamilton Health Sciences Corporation (2) · Insel Gruppe AG, University Hospital Bern (2) · Jordan Collaborating Cardiology Group (2) · Shahid Beheshti University of Medical Sciences (2) · Takeda (2) · The George Institute (2) · AZ Sint-Jan AV (1) · Affiliated Hospital of Nantong University (1) · Ain Shams University (1)
Canada (16) · United States (11) · France (8) · Italy (8) · Spain (8) · Egypt (7) · Netherlands (7) · Switzerland (7) · China (6) · Australia (5) · Belgium (5) · Brazil (5) · United Kingdom (4) · Colombia (3) · Denmark (3)
Hamid Ahmadieh, MD (2) · Jean-Claude Tardif, MD (2) · Abhijeet Singh, MD (1) · Adam Femerling Langhoff, M.D. (1) · Ahmed Kamal, MD in Cardiology (1) · Alexander Benz, MD (1) · Alexandra Lansky, MD (1) · Amr A. El Sehrawy, MD, PhD, FRCPE (1) · Andreas Orfanos, MD (1) · Andrew Demchuk, MD (1) · Aristeidis Katsanos, MD (1) · Ashkan Shoamanesh, MD (1) · Bijoy Menon, MD (1)
PMID 34658014, PMID 22090167, PMID 31733140, PMID 31986264, PMID 32020029, PMID 34269908, PMID 37489818, PMID 38505729, PMID 15308692, PMID 15320751, PMID 16134130, PMID 16439323, PMID 20131255, PMID 20336760, PMID 20373128, PMID 20805112, PMID 21435708, PMID 21873705, PMID 21884871, PMID 23208422, PMID 23816016, PMID 23992557, PMID 24773578, PMID 25172965, PMID 25925674, PMID 26304941, PMID 26576054, PMID 27344959, PMID 27378573, PMID 27502857, PMID 27585965, PMID 29426008, PMID 30073793, PMID 30349811, PMID 30976418, PMID 31978293, PMID 32073213, PMID 32074550, PMID 32083985, PMID 32109013, PMID 32150618, PMID 32171740, PMID 32176778, PMID 32187464, PMID 32192578, PMID 32205204, PMID 32227755, PMID 32295417, PMID 32302438, PMID 32302448
2023 (2), 2015 (1), 2018 (1), 2025 (1), R01HL146206 (1), U10HL051823 (1), U10HL051831 (1), U10HL051834 (1), U10HL051843 (1), U10HL051845 (1), U10HL056443 (1), U10HL074073 (1), U10HL074204 (1), U10HL074206 (1), U10HL074208 (1)