24 completed, 4 terminated, 3 unknown, 2 active not recruiting. 11 Phase 4, 8 Not applicable, 8 Phase 2, 6 Phase 3, 5 Phase 1.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Computational Assessment of GABA Receptor Modulation in PTSD Lorazepam 1 mg tablet, Placebo tablet - Stress Disorders, Post-Traumatic | Phase 4 | Recruiting | VA Office of Research and Development | 150 | 2025-07-01 | 2026-06-16 |
| Intranasal Dexmedetomidine vs. Standard of Care for Emergency Department (ED) Procedural Sedation in the Older Adult Dexmedetomidine, Lorazepam, Haloperidol - Altered Mental Status | Phase 3 | Unknown | State University of New York - Upstate Medical University | 60 | 2024-06-01 | 2024-04-22 |
| Processes and Circuitry Underlying Threat Sensitivity as a Treatment Target for Co-morbid Anxiety and Depression Lorazepam, Placebo - Depression, Anxiety, Fear | Phase 4 | Recruiting | Laureate Institute for Brain Research, Inc. | 165 | 2023-11-08 | 2025-10-31 |
| Evaluating Sublingual Dexmedetomidine For Moderate To Severe Agitation In Inpatients With Schizophrenia Or Bipolar Disorder Dexmedetomidine, Lorazepam 2 MG/ML - Schizophrenia Agitation, Schizo Affective Disorder | Phase 4 | Unknown | Temple University | 32 | 2023-07-01 | 2023-10-23 |
| Therapies for Down Syndrome Regression Disorder Lorazepam, Intravenous immunoglobulin (IVIG), Tofacitinib - Down Syndrome, Regression | Phase 2 | Completed | University of Colorado, Denver | 66 | 2023-06-29 | 2026-09-03 |
| Pharmacological Mechanisms of Low-intensity Focused Ultrasound for Motor Cortex Neuroplasticity Carbamazepine, Lorazepam, Dextromethorphan - Low Intensity Focussed Ultrasound | Early Phase 1 | Active not recruiting | University Health Network, Toronto | 20 | 2021-05-25 | 2025-08-03 |
| Multimodal Analgesia Effect on Post Surgical Patient Neurontin, Dilaudid Injectable Product, Marcaine Injectable Product - Obesity, Morbid, Surgery | Phase 4 | Completed | University of California, Davis | 60 | 2021-01-20 | 2026-09-14 |
| Phenobarbital vs Ativan for Alcohol Withdrawal in the Intensive Care Unit Phenobarbital, Lorazepam - Alcohol Withdrawal, Alcohol Withdrawal Delirium | Phase 4 | Unknown | OSF Healthcare System | 142 | 2020-07-06 | 2020-10-08 |
| Multi-modal Assessment of Gamma-aminobutyric Acid (GABA) Function in Psychosis Placebo and fMRI, Lorazepam and fMRI - Schizophrenia, Bipolar Disorder | Phase 4 | Completed | University of Michigan | 143 | 2020-01-16 | 2026-06-17 |
| Haloperidol and Lorazepam in Controlling Symptoms of Persistent Agitated Delirium in Patients With Advanced Cancer Undergoing Palliative Care Haloperidol, Lorazepam, Placebo - Delirium, Locally Advanced Malignant Neoplasm | Phase 2 / Phase 3 | Active not recruiting | M.D. Anderson Cancer Center | 110 | 2019-07-17 | 2026-06-15 |
| Alcohol Withdrawal Syndrome Treated With Adjunctive Phenobarbital or Ketamine Ketamine, Phenobarbital, Lorazepam - Alcohol Withdrawal Syndrome | Phase 4 | Withdrawn | Santa Barbara Cottage Hospital | 2019-04-12 | 2019-09-19 | |
| Benzodiazepines for the Reduction of Distress and Pain During and After Emergency Department Care Placebos, Lorazepam - Acute Pain | Phase 2 | Terminated | Maria Pacella | 1 | 2019-01-25 | 2020-03-09 |
| Oral Sedation During Cervical Dilator Placement Oxycodone and Lorazepam (Active Comparator), Placebo Comparator - Oral Sedation and Cervical Dilator Pain | Phase 4 | Completed | Johns Hopkins University | 27 | 2017-06-28 | 2020-03-30 |
| Indenoisoquinoline LMP744 in Adults With Relapsed Solid Tumors and Lymphomas LMP744, Ondansetron, Olanzapine - Solid Tumors, Lymphoma | Phase 1 | Completed | National Cancer Institute (NCI) | 36 | 2017-02-27 | 2024-12-10 |
| A Multi-level Life-span Characterization of Adult-depression and Effects of Medication and Exercise Venlafaxine XR, Aerobic Exercise, Lorazepam - Depression, Depressive Disorder, Major | Phase 4 | Completed | Kirk Erickson, PhD | 31 | 2015-03-01 | 2018-05-23 |
| Clobazam Use in Epilepsia Partialis Continua - Pilot Study Clobazam, Clonazepam, Lorazepam - Epilepsia Partialis Continua, Kojewnikov's Epilepsy | Phase 3 | Terminated | The Cooper Health System | 7 | 2014-07-01 | 2018-05-09 |
| The Comparison of Stress Response to Rapid Opioid Detoxification Applying Different Methods of Opioid Antagonism Naltrexone, Clonidine, Lorazepam - Opiate Addiction | Not applicable | Completed | Vilnius University | 60 | 2014-05-01 | 2015-02-12 |
| Liver Fibrosis in Alpha-1 Antitrypsin Deficiency (Liver AATD) Abdominal ultrasound, History and physical, Intravenous catheter - Liver Fibrosis, Alpha-1 Antitrypsin Deficiency | Completed | University of Florida | 109 | 2013-10-01 | 2023-08-21 | |
| Characterizing and Predicting Drug Effects on Cognition Lorazepam, Placebo, Topiramate 100mg - Cognitive Deficits | Phase 4 | Completed | University of Minnesota | 60 | 2013-07-01 | 2019-12-17 |
| Catatonia in Nodding Syndrome and Lorazepam Treatment Lorazepam - Catatonia, Nodding Syndrome | Phase 1 | Completed | Makerere University | 16 | 2013-03-01 | 2015-06-03 |
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Bipolar Disorder (3) · Psychotic Disorders (3) · Alzheimer Disease (2) · Anxiety Disorders (2) · Catatonia (2) · Depression (2) · Schizophrenia (2) · Status Epilepticus (2) · Acute Pain (1) · Agnosia (1) · Alcohol Withdrawal Delirium (1) · Autoimmune Diseases (1) · Autoimmune Diseases of the Nervous System (1) · Cognition Disorders (1) · Critical Illness (1)
Virginia Commonwealth University (3) · Mayo Clinic (2) · National Cancer Institute (NCI) (2) · AstraZeneca (1) · Columbia University (1) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (1) · Johns Hopkins University (1) · Kirk Erickson, PhD (1) · Laureate Institute for Brain Research, Inc. (1) · M.D. Anderson Cancer Center (1) · Makerere University (1) · Maria Pacella (1) · Mclean Hospital (1) · OSF Healthcare System (1) · Orasi Medical, Inc. (1)
United States (30) · Canada (2) · Brazil (1) · Lithuania (1) · Netherlands (1)
Alice P Chen, M.D. (2) · Angela Christiano, PhD (1) · Angelina Kakooza-Mwesige, MMed (1) · Barbara Jachniewicz, MSN, CRNFA, (1) · Beth L Murphy, MD/PhD (1) · Bhagat Aulakh, MD (1) · Carolyn Sufrin (1) · Concetta Forchetti, MD, PhD (1) · Cynthia M Stonnington, M.D. (1) · Cynthia Stonnington, MD (1) · Daniel H Lowenstein, MD (1) · David Hui (1) · Devon Fletcher (1) · Dirk M Dhossche, MD, PhD (1) · Elise Sannar, MD (1)
PMID 16785215, PMID 19573495, PMID 21967361, PMID 22144928, PMID 22335736, PMID 22506949, PMID 22898443, PMID 22950484, PMID 24001080, PMID 24756515, PMID 26710961, PMID 27993298, PMID 28781452, PMID 30138687, PMID 30797651, PMID 32029262, PMID 32297992, PMID 33692709, PMID 33728561, PMID 34238838, PMID 34546899, PMID 34820831, PMID 35971024, PMID 35987977, PMID 36302173, PMID 36448276, PMID 40439882, PMID 40742738
K23AA000222 (1), K23DA014291 (1), R01MH118634 (1), R01MH132565 (1), U01NS056975 (1)