130 completed, 20 unknown, 14 terminated, 12 recruiting. 203 Phase 2, 31 Phase 3, 29 Phase 1.
Follow Acetaminophen: new trials by email Literature Review of Acetaminophen trials Research Report on Acetaminophen
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Clinical Trial of MK-6916 in Participants With Pain After Bunion Removal Surgery (MK-6916-007) MK-6916, Hydrocodone/acetaminophen (HB/APAP), MK-6916 Placebo - Pain Management | Phase 2 | Not yet recruiting | Merck Sharp & Dohme LLC | 380 | 2026-11-23 | 2026-11-06 |
| Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy Celecoxib, Acetaminophen, Dexamethasone - Adenotonsillectomy, Postoperative Pain | Phase 1 / Phase 2 | Not yet recruiting | NYU Langone Health | 500 | 2026-11-01 | 2026-10-13 |
| A Clinical Trial of MK-1045 in People With B-cell Cancer (MK-1045-006) MK-1045, Acetaminophen (or similar antipyretic), Diphenhydramine (or similar antihistamine) - Chronic Lymphocytic Leukaemia, Small Lymphocytic Lymphoma | Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 60 | 2026-10-14 | 2026-11-04 |
| A Clinical Trial of MK-2010 With Sacituzumab Tirumotecan (Sac-TMT) in Participants With Solid Tumors (MK-2010) MK-2010, Sacituzumab tirumotecan, Histamine H1 Receptor Antagonist - Advanced Solid Tumors, Malignant Neoplasm | Phase 2 | Recruiting | Merck Sharp & Dohme LLC | 200 | 2026-10-07 | 2026-10-15 |
| Pain After Strabismus Surgery Tylenol - Strabismus | Phase 2 | Suspended | Ann & Robert H Lurie Children's Hospital of Chicago | 80 | 2026-10-01 | 2026-07-30 |
| A Clinical Trial of GRT7040 in Adults With Acute Pain Following Bunionectomy GRT7040, Hydrocodone bitartrate/ acetaminophen (HB/APAP), Placebo (matched to HB/APAP) - Acute Pain, Bunionectomy | Phase 2 | Not yet recruiting | Grünenthal GmbH | 400 | 2026-09-01 | 2026-09-15 |
| A Clinical Trial of MK-1045 in People With B-cell Acute Lymphoblastic Leukemia (MK-1045-005) MK-1045, Blinatumomab, Acetaminophen - B-cell Acute Lymphoblastic Leukemia | Phase 2 / Phase 3 | Recruiting | Merck Sharp & Dohme LLC | 340 | 2026-05-18 | 2026-10-30 |
| Maxigesic for Postoperative Pain Control After Laparoscopic or Robotic Gastrectomy Acetaminophen and Ibuprofen, Acetaminophen - Stomach Neoplasms | Phase 2 | Active not recruiting | Seoul National University Bundang Hospital | 90 | 2025-11-21 | 2026-08-17 |
| KinesioTaping for Thoracic Drain Support Kinesiotaping, paracetamol tramadol - Primary Condition: Pain, Postoperative, Associated Conditions: Cardiac Surgical Procedures, Thoracic Surgery | Phase 2 / Phase 3 | Completed | Kastamonu University | 100 | 2025-08-15 | 2026-06-09 |
| Intravenous Acetaminophen for Postoperative Delirium in Older Patients Recovering From Major Noncardiac Surgery Acetaminophen, Saline - Delirium in Old Age | Phase 2 / Phase 3 | Not yet recruiting | RenJi Hospital | 1930 | 2025-06-01 | 2025-04-04 |
| Pembrolizumab (MK-3475) Plus Investigational Agents in Resectable Non-small Cell Lung Cancer (NSCLC) (MK-3475-01E/KEYMAKER-U01) Pembrolizumab (neoadjuvant), Cisplatin, Gemcitabine - Lung Neoplasm Malignant | Phase 2 | Active not recruiting | Merck Sharp & Dohme LLC | 60 | 2025-03-20 | 2026-10-13 |
| A Study to Investigate Subcutaneous Isatuximab in Combination With Weekly Carfilzomib and Dexamethasone in Adult Participants With Relapsed and/or Refractory Multiple Myeloma Isatuximab SC-OBDS, Montelukast, Dexamethasone - Plasma Cell Myeloma Refractory | Phase 2 | Active not recruiting | Sanofi | 64 | 2025-03-17 | 2026-10-26 |
| Celecoxib for ENT Pain Management Celecoxib, Tylenol, Oxycodone - Parotidectomy | Phase 2 | Recruiting | University of Wisconsin, Madison | 84 | 2025-02-28 | 2026-07-29 |
| Single-Site Study of Naltrexone/Acetaminophen for the Acute Treatment of Migraine: A Phase 2 Randomized Trial Stage 1: Naltrexone/Acetaminophen, Stage 1: Naltrexone, Stage 1: Acetaminophen - Migraine | Phase 2 | Withdrawn | Allodynic Therapeutics, Inc | 2025-01-31 | 2025-12-08 | |
| Prophylactic IV Paracetamol in Extremely Premature Infants Paracetamol (drug) - Patent Ductus Arteriosus in Preterm Infants, Patent Ductus Arteriosus After Premature Birth | Phase 2 / Phase 3 | Completed | Al-Quds University | 40 | 2025-01-01 | 2026-04-07 |
| Oral Acetaminophen for Post-Op Pain Management in Bariatric Surgery Patients Acetaminophen - Post Operative Analgesia, Bariatric Surgery | Phase 2 | Completed | Rutgers, The State University of New Jersey | 65 | 2024-11-13 | 2026-08-24 |
| Safety and Immunogenicity of an Investigational Pentavalent Meningococcal ABCYW Vaccine Against Meningococcal Disease in Children, Toddlers, and Infants Pentavalent Meningococcal ABCYW vaccine, MenACYW conjugate vaccine, Meningococcal group B vaccine - Meningococcal Immunization, Healthy Volunteers | Phase 1 / Phase 2 | Active not recruiting | Sanofi Pasteur, a Sanofi Company | 750 | 2024-11-05 | 2026-01-20 |
| Fascia Transversalis Versus Transversus Abdominis Plane Block for Children Undergoing Inguinal Hernia Surgery Ultrasound- guided Fascia Transversalis plane block, Ultrasound-guided Transversus abdominus plane block, Fentanyl - Fascia Transversalis Plane Block | Phase 2 | Completed | Kasr El Aini Hospital | 50 | 2024-04-01 | 2026-06-16 |
| Assessment of Therapeutic Effect of Rectal Vs. Intravenous Paracetamol in The Treatment of Patent Ductus Arteriosus (PDA) in Neonates Paracetamol - Patent Ductus Arteriosus | Phase 1 / Phase 2 | Unknown | Soha mahmoud Hussien mahdy | 100 | 2024-03-01 | 2024-02-13 |
| Combined Pericapsular Nerve Group Block and Lateral Femoral Cutaneous Nerve Block for Pediatric Hip Surgeries Caudal epidural analgesia, Ultrasound-guided Combined Pericapsular Nerve Group Block, Ultrasound-guided Lateral Femoral Cutaneous Nerve Block - Pericapsular Nerve Group Block | Phase 2 | Completed | Kasr El Aini Hospital | 68 | 2024-03-01 | 2026-06-16 |
Showing 20 of 203. Sign in to see all of them.
Pain (28) · Pain, Postoperative (23) · Agnosia (18) · Ductus Arteriosus, Patent (14) · Fever (7) · Multiple Myeloma (7) · Toothache (7) · Acute Pain (4) · Leukemia (4) · Lymphoma, Non-Hodgkin (4) · Migraine Disorders (4) · Neoplasms (4) · Osteoarthritis (4) · Premature Birth (4) · COVID-19 (3)
National Cancer Institute (NCI) (9) · Merck Sharp & Dohme LLC (8) · National Institute of Allergy and Infectious Diseases (NIAID) (7) · Stanford University (5) · Sanofi (4) · Allodynic Therapeutics, Inc (3) · Concentric Analgesics (3) · Henry Ford Health System (3) · Kasr El Aini Hospital (3) · Montefiore Medical Center (3) · University of Miami (3) · Wake Forest University Health Sciences (3) · Abbott (2) · Antonios Likourezos (2) · Assiut University (2)
United States (110) · Canada (10) · Egypt (10) · Italy (9) · Spain (8) · France (7) · United Kingdom (7) · Brazil (6) · China (6) · Israel (6) · Finland (5) · Greece (5) · Denmark (4) · Hungary (4) · Poland (4)
Toufic R Jildeh, MD (3) · Adam J Singer, MD (2) · Annette C Toledano, M.D. (2) · Arlyne Thung, MD (2) · Benjamin Friedman, MD (2) · Cathy Hammerman, MD (2) · David H Chi, MD (2) · James L Gulley, M.D. (2) · Nancy Wu (2) · Rita Jain, MD (2) · Sergey Motov, MD (2) · Todd Bertoch, MD (2)
PMID 11112243, PMID 16135345, PMID 17175134, PMID 18662331, PMID 19453963, PMID 20548058, PMID 22520687, PMID 25744676, PMID 26603732, PMID 28322750, PMID 29310498, PMID 36519620, PMID 10352050, PMID 10506634, PMID 10613619, PMID 11387363, PMID 12148679, PMID 12917995, PMID 14701781, PMID 15230906, PMID 15310785, PMID 15507941, PMID 16051965, PMID 17196714, PMID 17397460, PMID 17437870, PMID 18498882, PMID 19217726, PMID 20039413, PMID 21457238, PMID 21765198, PMID 22213489, PMID 22563089, PMID 23170854, PMID 23440827, PMID 23545428, PMID 23611363, PMID 24144215, PMID 24247230, PMID 24399578, PMID 24756302, PMID 24756514, PMID 24781936, PMID 24806873, PMID 25370510, PMID 25370513, PMID 25794212, PMID 26024112, PMID 26201306, PMID 26335066
2023 (6), 2019 (4), 2025 (2), 2008 (1), 2014 (1), 2016 (1), 2017 (1), 2018 (1), KL2RR025754-04 (1), P01CA049605 (1), P30CA012197 (1), P30CA023074 (1), R01NS102176 (1), U01AI063594 (1), U10EY017281 (1)