7 completed, 5 unknown, 3 recruiting, 3 terminated. 10 Phase 4, 3 Not applicable, 3 Phase 3, 1 Phase 1, 1 Phase 2.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Short-Term Effects of Antihypertensive Drugs on Postural Balance and Fall Risk Beta Blocker, ACE inhibitor, Calcium channel blocker - Hypertension, Fall Risk | Not applicable | Recruiting | Abant Izzet Baysal University | 186 | 2025-08-01 | 2026-02-12 |
| Single and Twice-daily Dosing of Ramipril on Renal Function in Chronic Kidney Disease Patients With Reduced Ejection Fraction Heart Failure Ramipril - Chronic Kidney Disease, Heart Failure With Reduced Ejection Fraction (HFrEF) | Phase 4 | Recruiting | Evi Liliek Wulandari | 80 | 2025-06-30 | 2025-12-10 |
| STunning in Acute Myocardial Infarction - BAS Bisoprolol Oral Tablet, Ramipril Oral Product, Dapagliflozin Oral Product - Myocardial Infarct | Phase 4 | Recruiting | Vastra Gotaland Region | 120 | 2025-01-06 | 2026-10-13 |
| Efficacy of Dapagliflozin in Early Diabetic Nephropathy in Type 1 Diabetes dapagliflozin, ACE inhibitor - Diabetic Kidney Disease, Type 1 Diabetes | Phase 4 | Unknown | The First Affiliated Hospital with Nanjing Medical University | 54 | 2024-07-01 | 2024-08-01 |
| Replication of the PARADIGM-HF Heart Failure Trial in Healthcare Claims Data. ACE inhibitor, Sacubitril/Valsartan - Heart Failure | Completed | Brigham and Women's Hospital | 6066 | 2020-09-22 | 2023-08-01 | |
| Coronavirus (COVID-19) ACEi/ARB Investigation Thiazide or Thiazide-like diuretics, Calcium Channel Blockers, ACE inhibitor - Hypertension, COVID-19 | Phase 4 | Suspended | National University of Ireland, Galway, Ireland | 2414 | 2020-04-30 | 2020-06-30 |
| Endothelial Function Evaluation in Patients With PAOD Treated With Sulodexide + Conventional Treatment (CT) Vs CT Alone Sulodexide, Statin, Antiplatelet Agents - Peripheral Arterial Obstructive Disease | Phase 3 | Unknown | Alfa Wassermann Tunisia | 156 | 2019-01-31 | 2019-12-02 |
| Randomized Evaluation of Beta Blocker and ACEI/ARB Treatment in MINOCA Patients - MINOCA-BAT Beta blocker, ACEI, ARB - Myocardial Infarction With Non-obstructive Coronary Arteries | Phase 4 | Terminated | Uppsala University | 198 | 2018-12-16 | 2023-11-27 |
| Effect of Sodium Glucose co Transporter 2 Inhibitor ( SGLT2) on Proteinuria in Diabetic Patients SGLT2 inhibitor, ACE inhibitor - Diabetic Nephropathies | Phase 4 | Unknown | Nahla H Tohami | 60 | 2018-06-20 | 2020-04-21 |
| Efficacy and Safety of a Combination of Mycophenolate Mofetil and Corticosteroid in Advanced IgA Nephropathy Mycophenolate Mofetil, ACE inhibitor, Corticosteroid - IgA Nephropathy | Phase 4 | Unknown | Yonsei University | 100 | 2016-06-01 | 2016-12-05 |
| A Study for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients Nutrition, Exercise, Smoking cessation - Prostate Cancer, Cardiovascular Disease | Not applicable | Active not recruiting | McMaster University | 5000 | 2015-10-21 | 2026-07-02 |
| Sequential Nephron Blockade vs. Dual Blockade Renin-angiotensin System + Bisoprolol in Resistant Arterial Hypertension Spironolactone, Furosemide,, Amiloride - Hypertension Resistant to Conventional Therapy | Phase 4 | Completed | Sao Jose do Rio Preto Medical School | 72 | 2015-09-01 | 2019-04-05 |
| Risk Factor Control Before Orthopedic Surgery Metoprolol, Lisinopril, Atorvastatin - Osteoarthritis, Cardiovascular Disease | Phase 4 | Terminated | NYU Langone Health | 198 | 2014-02-01 | 2020-07-27 |
| Effect of Pioglitazone on Insulin Resistance, Atherosclerosis Progression and Clinical Course of Coronary Heart Disease Pioglitazone 15 mg Tablet, Isosorbide Dinitrate 10Mg Tablet, Acetylsalicylic Acid 75Mg Tablet - Adverse Effect, Atherosclerosis, Coronary | Phase 4 | Completed | Ukrainian Medical Stomatological Academy | 43 | 2012-11-01 | 2022-03-10 |
| Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril Lisinopril, Hydrochlorothiazide - Hypertension, Grade 1, Hypertension Treatment | Not applicable | Completed | Scripps Translational Science Institute | 2 | 2010-11-01 | 2015-05-20 |
| Paramedic Initiated Lisinopril For Acute Stroke Treatment Lisinopril, Placebo - Stroke | Phase 1 | Completed | Newcastle-upon-Tyne Hospitals NHS Trust | 14 | 2010-10-01 | 2017-03-30 |
| Adolescent Type 1 Diabetes Cardio-Renal Intervention Trial Statin, ACE inhibitor, Placebo - Type 1 Diabetes | Phase 3 | Completed | University of Cambridge | 443 | 2009-01-01 | 2018-06-28 |
| Effect of ACE-inhibitors on Aortic Stiffness in Elderly Patients With Chronic Kidney Disease angiotensin converting enzyme inhibitor, lisinopril - Cardiovascular Disease, Chronic Kidney Disease | Phase 2 | Completed | University of Wisconsin, Madison | 43 | 2009-01-01 | 2020-10-27 |
| PREVENTKD (Prevent Risks by Early interVEntion at Nighttime in Type 1 Diabetes for Kidney Disease) Ramipril, Placebo - Type 1 Diabetes | Phase 3 | Terminated | Northwestern University | 65 | 2008-07-01 | 2015-03-17 |
| The Use of Angiotensin Converting Enzyme Inhibitors and Incident Respiratory Infections, Are They Harmful or Protective? ACE inhibitor - Covid-19, Coronavirus, Angiotensin Converting Enzyme Inhibitors, Influenza, Electronic Health Records, Epidemiology, Comorbidity, Incidence, United Kingdom | Unknown | University College, London | 1302508 | 1998-01-01 | 2020-11-13 |
Cardiovascular Diseases (4) · Hypertension (4) · Diabetes Mellitus, Type 1 (3) · COVID-19 (2) · Coronary Artery Disease (2) · Coronavirus Infections (2) · Diabetes Mellitus (2) · Diabetic Nephropathies (2) · Myocardial Infarction (2) · Renal Insufficiency, Chronic (2) · Atherosclerosis (1) · Coronary Disease (1) · Glomerulonephritis, IGA (1) · Heart Failure (1) · Hypertension Resistant to Conventional Therapy (1)
Abant Izzet Baysal University (1) · Alfa Wassermann Tunisia (1) · Brigham and Women's Hospital (1) · Evi Liliek Wulandari (1) · McMaster University (1) · NYU Langone Health (1) · Nahla H Tohami (1) · National University of Ireland, Galway, Ireland (1) · Newcastle-upon-Tyne Hospitals NHS Trust (1) · Northwestern University (1) · Sao Jose do Rio Preto Medical School (1) · Scripps Translational Science Institute (1) · The First Affiliated Hospital with Nanjing Medical University (1) · Ukrainian Medical Stomatological Academy (1) · University College, London (1)
United States (6) · Australia (3) · Brazil (2) · Canada (2) · Sweden (2) · Turkey (Türkiye) (2) · China (1) · Colombia (1) · Egypt (1) · India (1) · Indonesia (1) · Ireland (1) · Israel (1) · New Zealand (1) · Norway (1)
Alp Ozel, PT, PhD (1) · Anand Dixit (1) · Ann Fox (1) · Arjang Djamali, MD (1) · Bertil Lindahl, Prof (1) · Bradley Patay, MD (1) · Christopher Price (1) · David B Dunger, Professor (1) · Dr. Darryl Leong, MBBs,MPH,PhD,FRACP,FESC (1) · Imed Frikha, MD (1) · Jeffrey Berger, MD (1) · John William McEvoy, MBBCh MHS (1) · Juan C Yugar-Toledo, MD, PhD (1)
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U01DK071733 (1)