11 completed, 2 recruiting, 1 unknown. 8 Not applicable, 3 Phase 2, 2 Phase 1, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 8 | Completed 7, Recruiting 1 |
| Phase 2 | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 1 | Unknown 1 |
Follow Xerosis Cutis: new trials by email Literature Review of Xerosis Cutis trials Research Report on Xerosis Cutis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The Effectiveness of Herbal Creams Compared to Urea in Dry Skin Treatment combination cream, control cream - Dry Skin, Xerosis Cutis | Phase 1 / Phase 2 | Completed | Universitas Syiah Kuala | 64 | 2025-06-01 | 2026-01-22 |
| A Clinical Evaluation of Marula-Derived Ceramide Cream on Skin Barrier Function Enhancement Apply a cream containing 0.05% marula oil-derived ceramide NPs - Atopic Dermatitis (AD), Psoriasis | Not applicable | Completed | Shanghai Chicmax Cosmetic Co., Ltd. | 32 | 2025-02-06 | 2025-07-15 |
| Effectiveness of CBD for Neuropathic Pain in Diabetic Foot Neuropathy Group 1. Complete formula, Group 2. Cannabidiol and Urea 10% formula., Group 3. Placebo formula. - Xerosis Cutis, Neuropathic Pain Associated With Diabetic Peripheral Neuropathy | Not applicable | Completed | Universidad Complutense de Madrid | 23 | 2024-11-01 | 2025-10-01 |
| Effectiveness and Safety of Topical Hyaluronic Acid of Different Molecular Weights in Xerotic Skin Treatment Low molecular weight hyaluronic acid, High molecular weight hyaluronic acid, Vehicle - Xerosis Cutis | Phase 3 | Completed | Universitas Indonesia | 36 | 2023-08-26 | 2024-04-30 |
| Study to Investigate the Efficacy, Safety, and Tolerability of Topical HT-001 for the Treatment of Skin Toxicities Associated With Epidermal Growth Factor Receptor Inhibitors HT-001 2% Topical Gel, HT-001 1% Topical Gel, HT-001 0.5% Topical Gel - Acneiform Eruption Due to Chemical, Xerosis Cutis | Phase 2 | Recruiting | Hoth Therapeutics, Inc. | 152 | 2023-07-19 | 2026-03-31 |
| Study on the Effectiveness of an Emollient Cream Containing Pre and Postbiotic and Niacinamide 4% in the Treatment of Skin Xerosis and Itching in Oncological Patients Treated with Anti-EGFR topical treatment with the pre- and postbiotic study preparation and niacinamide 4% and one with the 10% urea-based preparation. - Xerosis Cutis | Not applicable | Recruiting | Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse | 164 | 2022-07-29 | 2025-03-11 |
| Enhancing SKIN Health and Safety in Aged CARE Implementation of skin care algorithm - Xerosis Cutis, Dry Skin | Not applicable | Completed | PD Dr. Jan Kottner | 405 | 2018-10-01 | 2021-08-09 |
| Effect of Centella Asiatica on Xerotic Skin in Diabetes Mellitus Type 2 Centella Asiatica Extract, Topical CA, Petroleum jelly - Xerosis Cutis, Diabetes Mellitus, Type 2 | Phase 4 | Unknown | Universitas Indonesia | 159 | 2018-07-30 | 2019-01-24 |
| Comparison of 12% Ammonium Lactate and 10% Urea Cream in Geriatric With Xerosis Cutis Ammonium Lactate, Urea - Xerosis Cutis | Phase 3 | Completed | Universitas Indonesia | 40 | 2017-04-01 | 2019-10-15 |
| Skin Barrier Biophysical Properties and Clinical Appearance After Moisturizer in Dry Skin virgin coconut oil, virgin jojoba oil, virgin almond oil - Xerosis, Xerosis Cutis | Not applicable | Completed | University of Arizona | 37 | 2017-03-27 | 2018-10-11 |
| Effects of 2% IDL Lotion on Skin Hydration and Transepidermal Water Loss in Females With Dry Skin IDL lotion, Control lotion - Xerosis Cutis | Phase 1 / Phase 2 | Completed | Shyla Cantor | 16 | 2017-02-13 | 2020-02-05 |
| Comparison Dry Foot Skin Between Diabetic and Non-diabetic Subjects and the Effects of Two Cosmetic Foot Care Products 10% Urea foot lotion, 10% Urea foot ointment - Xerosis Cutis | Not applicable | Completed | Galderma R&D | 60 | 2016-09-01 | 2021-09-16 |
| Effectiveness of Using an Oil Bath Additive Balneum oil bath - Xerosis Cutis | Not applicable | Completed | Charite University, Berlin, Germany | 60 | 2014-11-01 | 2017-04-05 |
| Skin Health and Effectiveness of Standardized Skin Care Regimens in Nursing Home Residents Cetaphil® Restoraderm, Excipial - Xerosis Cutis | Not applicable | Completed | PD Dr. Jan Kottner | 133 | 2014-09-01 | 2018-04-13 |
Diabetes Mellitus, Type 2 (2) · Acne Vulgaris (1) · Dermatitis, Atopic (1) · Dermatitis, Contact (1) · Diabetes Mellitus (1) · Diabetic Foot (1) · Diabetic Neuropathies (1) · Eczema (1) · Ichthyosis (1) · Intertrigo (1) · Neuralgia (1) · Paronychia (1) · Pressure Ulcer (1) · Pruritus (1) · Psoriasis (1)
Skin Diseases (5) · Skin and Connective Tissue Diseases (5) · Dermatitis (3) · Endocrine System Diseases (3) · Glucose Metabolism Disorders (3) · Metabolic Diseases (3) · Nutritional and Metabolic Diseases (3) · Skin Diseases, Eczematous (3) · Diabetes Mellitus (2) · Pathological Conditions, Signs and Symptoms (2) · Signs and Symptoms (2) · Skin Ulcer (2) · Acneiform Eruptions (1) · Cardiovascular Diseases (1) · Congenital Abnormalities (1)
Urea (2) · Centella asiatica extract (1) · Food, Formulated (1) · Gels (1) · Lactic Acid (1) · Lidocaine, Prilocaine Drug Combination (1) · Niacinamide (1) · Petrolatum (1) · Therapeutics (1)
Universitas Indonesia (3) · PD Dr. Jan Kottner (2) · Charite University, Berlin, Germany (1) · Galderma R&D (1) · Hoth Therapeutics, Inc. (1) · Shanghai Chicmax Cosmetic Co., Ltd. (1) · Shyla Cantor (1) · Societa Italiana di Dermatologia Medica, Chirurgica, Estetica e di Malattie Sessualmente Trasmesse (1) · Universidad Complutense de Madrid (1) · Universitas Syiah Kuala (1) · University of Arizona (1)
Germany (4) · Indonesia (4) · United States (3) · Spain (2) · China (1) · Italy (1) · Poland (1)
Jan Kottner, Prof. Dr. (1) · Ketty MD Peris (1) · Mario Lacouture, MD (1) · Parikesit Muhammad, MD (1) · Shyla Cantor, PhD (1) · Suhendro Suhendro, Doctor (1) · Ulrike Blume-Peytavi, Prof Dr.med (1) · Ulrike Blume-Peytavi, Prof. Dr. (1) · Vivian Y Shi, MD (1)
PMID 22052267, PMID 25443420, PMID 27815985, PMID 28214613, PMID 28947467, PMID 29132305, PMID 30987588, PMID 31142364, PMID 36074117, PMID 36898269, PMID 37956524, PMID 38360494, PMID 38829483