3 active not recruiting, 2 not yet recruiting, 2 recruiting, 1 completed. 6 Phase 2, 2 Phase 1, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 6 | Active not recruiting 3, Not yet recruiting 2, Recruiting 1 |
| Phase 1 | 2 | Completed 1, Recruiting 1 |
| Phase 4 | 1 | Terminated 1 |
Follow WHO Grade 3 Glioma: new trials by email Literature Review of WHO Grade 3 Glioma trials Research Report on WHO Grade 3 Glioma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of Relatlimab and Nivolumab (Opdualag) in Replication Repair Deficient HGG and DIPG Opdualag - High Grade Glioma, Diffuse Intrinsic Pontine Glioma | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 12 | 2027-03-01 | 2026-09-09 |
| Study of Tovorafenib in High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG) Tovorafenib - High Grade Glioma (HGG) of the Brain With BRAF Aberration, High Grade Glioma (III or IV) | Phase 2 | Not yet recruiting | Nationwide Children's Hospital | 79 | 2027-02-01 | 2026-10-20 |
| An Investigational Scan (Ga-68 PSMA-11 PET/CT) for Detection of Disease Recurrence or Progression in Patients With Glioma Computed Tomography, Electronic Health Record Review, Ga 68 PSMA-11 - WHO Grade 3 Glioma, WHO Grade 4 Glioma | Phase 2 | Recruiting | Mayo Clinic | 25 | 2026-01-12 | 2026-06-22 |
| Anti-GARP Chimeric Antigen Receptor T Cell Therapy for the Treatment of Recurrent Grade III or IV Gliomas Anti-GARP Chimeric Antigen Receptor-T Cells, Biospecimen Collection, Chest Radiography - Recurrent Malignant Glioma, Recurrent WHO Grade 3 Glioma | Phase 1 | Recruiting | Ohio State University Comprehensive Cancer Center | 30 | 2025-05-21 | 2026-05-08 |
| Perampanel for the Reduction of Seizure Frequency in Patients With High-grade Glioma and Focal Epilepsy Anticonvulsant Agent, Perampanel, Quality-of-Life Assessment - Intractable Epilepsy, Malignant Glioma | Phase 4 | Terminated | Mayo Clinic | 4 | 2020-12-04 | 2023-06-22 |
| Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma Biospecimen Collection, Dabrafenib Mesylate, Lumbar Puncture - Anaplastic Astrocytoma, Anaplastic Astrocytoma, Not Otherwise Specified | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 58 | 2020-02-20 | 2026-07-10 |
| Olaparib in Treating Patients With Advanced Glioma, Cholangiocarcinoma, or Solid Tumors With IDH1 or IDH2 Mutations Biopsy Procedure, Biospecimen Collection, Computed Tomography - Advanced Malignant Solid Neoplasm, Glioblastoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 89 | 2019-01-30 | 2026-09-09 |
| Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma Biospecimen Collection, Intensity-Modulated Radiation Therapy, Laboratory Biomarker Analysis - Anaplastic Astrocytoma, Anaplastic Oligoastrocytoma | Phase 2 | Active not recruiting | NRG Oncology | 120 | 2018-01-23 | 2026-07-28 |
| Selinexor in Treating Younger Patients With Recurrent or Refractory Solid Tumors or High-Grade Gliomas Pharmacological Study, Selinexor - Malignant Glioma, Recurrent Brain Neoplasm | Phase 1 | Completed | Children's Oncology Group | 59 | 2015-10-30 | 2025-01-14 |
Glioma (8) · Astrocytoma (3) · Brain Neoplasms (2) · Diffuse Intrinsic Pontine Glioma (2) · Glioblastoma (2) · Central Nervous System Neoplasms (1) · Cholangiocarcinoma (1) · Drug Resistant Epilepsy (1) · Epilepsy (1) · Lymphoma (1) · Oligodendroglioma (1)
Neoplasms (8) · Neoplasms by Histologic Type (8) · Neoplasms, Germ Cell and Embryonal (8) · Neoplasms, Glandular and Epithelial (8) · Neoplasms, Nerve Tissue (8) · Neoplasms, Neuroepithelial (8) · Neuroectodermal Tumors (8) · Brain Diseases (4) · Central Nervous System Diseases (4) · Nervous System Diseases (4) · Neoplasms by Site (3) · Nervous System Neoplasms (3) · Brain Stem Neoplasms (2) · Central Nervous System Neoplasms (2) · Infratentorial Neoplasms (2)
Magnetic Resonance Spectroscopy (5) · Specimen Handling (4) · 68Ga-DKFZ-PSMA-11 (1) · Anticonvulsants (1) · Biopsy (1) · Blood Component Removal (1) · Opdualag (1) · Proton Therapy (1) · Protons (1) · Radiation (1) · Radiotherapy (1) · Radiotherapy, Intensity-Modulated (1) · Spinal Puncture (1) · Surgical Procedures, Operative (1) · Temozolomide (1)
Mayo Clinic (2) · National Cancer Institute (NCI) (2) · Nationwide Children's Hospital (2) · Children's Oncology Group (1) · NRG Oncology (1) · Ohio State University Comprehensive Cancer Center (1)
United States (7) · Puerto Rico (1)
Brian J. Burkett, MD, MPH (1) · David R Grosshans (1) · James B Elder, MD (1) · Julia Glade-Bender (1) · Patricia M LoRusso (1) · Rishi R Lulla (1) · William Tatum (1)
PMID 34331515, PMID 39998852, PMID 40873341
U10CA180868 (1), U10CA180886 (1), UM1CA097452 (1), UM1CA186689 (1)