27 completed, 2 not yet recruiting, 2 recruiting, 1 unknown. 10 Phase 3, 8 Phase 4, 7 Not applicable, 3 Phase 2, 2 Phase 1.
Follow Vivax Malaria: new trials by email Literature Review of Vivax Malaria trials Research Report on Vivax Malaria
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Tafenoquine Drug Levels in Small Children Chloroquine, Tafenoquine - Plasmodium Vivax Malaria, Vivax Malaria | Phase 2 | Not yet recruiting | University of Oxford | 20 | 2026-09-01 | 2026-09-22 |
| Tafenoquine and ACTs (TADORE- Plus) Tafenoquine plus DHA-Piperaquine, Tafenoquine plus Artesunate-pyronaridine - Vivax Malaria | Phase 4 | Not yet recruiting | Menzies School of Health Research | 507 | 2026-06-01 | 2026-03-18 |
| Primaquine for Vivax Malaria in G6PD Intermediate and Deficient Cases. Patients with G6PD enzyme activities between 30 and <70% of the AMM will be treated with schizontocidal treatment plus high dose primaquine 1mg/kg/day for 7 days, Patients with G6PD enzyme activities <30% of the AMM will be treated with schizontocidal treatment plus 8 weekly primaquine (0.75mg/kg dose). - Vivax Malaria, G6PD Deficiency | Phase 4 | Recruiting | Menzies School of Health Research | 100 | 2024-05-17 | 2026-03-12 |
| A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria Tafenoquine, Primaquine - Vivax Malaria | Phase 3 | Recruiting | Menzies School of Health Research | 1090 | 2024-05-10 | 2025-07-18 |
| Short Course Primaquine for the Radical Cure of P. Vivax Malaria - Indonesia Revised case management package - Vivax Malaria, G6PD Deficiency | Not applicable | Completed | Menzies School of Health Research | 2999 | 2023-08-07 | 2026-01-15 |
| Short Course Primaquine for the Radical Cure of P. Vivax - Papua New Guinea Revised case management package - Vivax Malaria, G6PD Deficiency | Not applicable | Completed | Macfarlane Burnet Institute for Medical Research and Public Health Ltd | 794 | 2023-08-07 | 2026-09-02 |
| Therapeutic Efficacy of Chloroquine Plus Primaquine in the Treatment of Uncomplicated Plasmodium Vivax Chloroquine, Primaquine - Efficacy, Malaria | Phase 4 | Completed | Dinka Dugassa | 100 | 2022-12-19 | 2023-09-22 |
| Effectiveness of Novel Approaches to Radical Cure With Tafenoquine and Primaquine Tafenoquine, Primaquine - Vivax Malaria, Plasmodium Vivax | Phase 3 | Completed | Menzies School of Health Research | 960 | 2021-04-25 | 2024-10-08 |
| Rigorous Assessment of P. Vivax Relapses and Primaquine Efficacy for Radical Cure Primaquine, Artesunate - Vivax Malaria | Phase 4 | Completed | University of Maryland, Baltimore | 160 | 2021-04-15 | 2026-06-03 |
| Biomarkers of P. Vivax Relapse Primaquine - Malaria, Vivax Malaria | Not applicable | Unknown | Armed Forces Research Institute of Medical Sciences, Thailand | 100 | 2019-11-19 | 2020-01-14 |
| Reducing the Risk of P. Vivax After Falciparum Infections in Co-endemic Areas primaquine - Malaria, Vivax Malaria | Phase 4 | Completed | Menzies School of Health Research | 500 | 2019-08-18 | 2023-11-21 |
| Safety and Efficacy of Different Regimens of Primaquine on Vivax Malaria Treatment in G6PD Deficient Patients Chloroquine, Primaquine - Vivax Malaria, G6PD Deficiency | Phase 2 | Completed | Fundação de Medicina Tropical Dr. Heitor Vieira Dourado | 106 | 2018-07-20 | 2025-02-20 |
| G6PD Assessment Before Primaquine for Radical Treatment of Vivax Malaria Chloroquine, Primaquine 0.25 mg/kg/day, Primaquine 0.75 mg/kg weekly - Vivax Malaria | Phase 4 | Completed | University of Oxford | 1000 | 2016-09-01 | 2020-10-14 |
| Methylene Blue Against Vivax Malaria in Ethiopia Artemeter-Lumefantrine and MB (combination therapy), Artemeter-Lumefantrine (combination therapy), Artemeter-Lumefantrine and Primaquine (combination therapy) - Vivax Malaria | Phase 2 | Withdrawn | Heidelberg University | 2016-04-01 | 2020-03-25 | |
| TES of Chloroquine for Pv in the Philippines in 2016 Chloroquine, Primaquine - Malaria, Vivax Malaria | Completed | Research Institute for Tropical Medicine, Philippines | 74 | 2016-01-04 | 2023-07-25 | |
| Assessment of Plasmodium Vivax Chloroquine Resistance in Cambodia: Chloroquine sulfate, DHA-PP - Vivax Malaria | Phase 4 | Completed | Institut Pasteur, Cambodia | 73 | 2014-05-01 | 2015-03-24 |
| TES of Artemether-lumefantrine for Pf and Chloroquine for Pv in the Philippines From 2013-2014 Arthemeter-lumefantrine, Chloroquine, Primaquine - Malaria, Falciparum Malaria | Completed | Research Institute for Tropical Medicine, Philippines | 159 | 2013-05-01 | 2023-07-21 | |
| Safety and Efficacy of Chloroquine and Primaquine for Vivax Malaria in Bhutan Chloroquine, Primaquine - Vivax Malaria | Completed | Menzies School of Health Research | 24 | 2013-01-01 | 2016-05-27 | |
| Primaquine Pharmacokinetics in Lactating Women and Their Infants Primaquine - Vivax Malaria | Phase 1 | Completed | University of Oxford | 20 | 2012-12-01 | 2016-02-15 |
| Comparison Between 7 and 14 Day Primaquine Combined With Dihydroartemisinin-piperaquine or 3 Day Chloroquine Radical Cure of P. Vivax (BPD) Dihydroartemisinin-Piperaquine, Chloroquine - Vivax Malaria | Phase 3 | Completed | University of Oxford | 680 | 2012-02-01 | 2016-04-28 |
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Malaria, Vivax (33) · Malaria (12) · Malaria, Falciparum (6) · Recurrence (5) · Glucosephosphate Dehydrogenase Deficiency (4)
Infections (33) · Mosquito-Borne Diseases (33) · Parasitic Diseases (33) · Protozoan Infections (33) · Vector Borne Diseases (33) · Malaria (21) · Disease Attributes (5) · Pathologic Processes (5) · Pathological Conditions, Signs and Symptoms (5) · Anemia (4) · Anemia, Hemolytic (4) · Anemia, Hemolytic, Congenital (4) · Carbohydrate Metabolism, Inborn Errors (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (4) · Genetic Diseases, Inborn (4)
Primaquine (20) · Chloroquine (15) · tafenoquine (4) · Artesunate (3) · artenimol (2) · fanasil, pyrimethamine drug combination (2) · piperaquine (2) · 2,6-diisopropylphenol docosahexaenoate (1) · 3,7-bis(diethylamino)phenothiazin-5-ium (1) · Amodiaquine (1) · Artemether (1) · Artemether, Lumefantrine Drug Combination (1) · Combined Modality Therapy (1) · Lumefantrine (1) · Pyrimethamine (1)
University of Oxford (11) · Menzies School of Health Research (9) · London School of Hygiene and Tropical Medicine (3) · Research Institute for Tropical Medicine, Philippines (2) · Armed Forces Research Institute of Medical Sciences, Thailand (1) · Dinka Dugassa (1) · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (1) · Heidelberg University (1) · Institut Pasteur, Cambodia (1) · Macfarlane Burnet Institute for Medical Research and Public Health Ltd (1) · University of Khartoum (1) · University of Maryland, Baltimore (1)
Thailand (8) · Indonesia (7) · Ethiopia (5) · Afghanistan (3) · Brazil (3) · Cambodia (3) · Pakistan (3) · Papua New Guinea (3) · Bangladesh (1) · Bhutan (1) · Sudan (1) · Vietnam (1)
Francois Nosten, MD (3) · Mark Rowland, PhD (2) · Rose McGready, MD (2) · Ayodhia Pitaloka Pasaribu, MD (1) · Bockretsion Gidey (1) · Christopher Whitty, FRCP (1) · Cindy Chu, MD (1) · Cindy Chu, MD, PhD (1) · Dysoley Lek, MD (1) · Emiliana Tjitra (1) · Emiliana Tjitre, PhD (1) · Ghulam R Awab, MD (1) · Ghulam Rahim Awab, MD (1)
PMID 36534705, PMID 40670924, PMID 17336652, PMID 17519409, PMID 18682739, PMID 20409302, PMID 22427705, PMID 23217037, PMID 23926329, PMID 24687509, PMID 26917051, PMID 28170391, PMID 29362233, PMID 29590311, PMID 29889239, PMID 30952158, PMID 33299558, PMID 33552517, PMID 34336132, PMID 34398667, PMID 35585641, PMID 37979594, PMID 38719803, PMID 39785834, PMID 39802788, PMID 40112852, PMID 41690325, PMID 42326839, PMID 42439801, PMID 42575554
R01AI103228 (1), U01AI195203 (1)