21 completed, 7 not yet recruiting, 7 recruiting, 2 unknown. 16 Phase 2, 7 Phase 4, 6 Phase 3, 5 Phase 1, 2 Not applicable.
Follow tafenoquine: new trials by email Literature Review of tafenoquine trials Research Report on tafenoquine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| This is a Clinical Study to Assess Whether the Combination of SJ733 and Tafenoquine Will be a Safe and Rapidly Acting Anti-malarial for the Radical Cure of P. Vivax Malaria SJ733/TQ placebo, CQ/TQ Placebo, CQ/TQ - Malaria, Malaria Vivax | Phase 2 | Not yet recruiting | R. Kiplin Guy | 104 | 2026-12-01 | 2026-10-21 |
| Tafenoquine Drug Levels in Small Children Chloroquine, Tafenoquine - Plasmodium Vivax Malaria, Vivax Malaria | Phase 2 | Not yet recruiting | University of Oxford | 20 | 2026-09-01 | 2026-09-22 |
| Tafenoquine and ACTs (TADORE- Plus) Tafenoquine plus DHA-Piperaquine, Tafenoquine plus Artesunate-pyronaridine - Vivax Malaria | Phase 4 | Not yet recruiting | Menzies School of Health Research | 507 | 2026-06-01 | 2026-03-18 |
| Tafenoquine Combinations for Improved Radical Cure Efficacy of Plasmodium Vivax Tafenoquine (TQ), Chloroquine (CQ), Dihydroartemisinin-piperaquine (DHA-PPQ) - Uncomplicated P. Vivax Mono-infection | Not applicable | Not yet recruiting | Walter Reed Army Institute of Research (WRAIR) | 300 | 2026-05-01 | 2026-04-16 |
| Pharmacokinetic (PK) Study of Tafenoquine in Healthy Adults Tafenoquine Oral Tablet - Pharmacokinetic in Normal Population | Early Phase 1 | Not yet recruiting | State University of New York - Upstate Medical University | 20 | 2026-05-01 | 2026-03-20 |
| Postpartum 8-aminoquinoline Breast Milk Study Daily primaquine (0.5 mg/kg per day) for 14 days given with food food and water, Daily primaquine 1 mg/kg per day for 7 days given with food and water, Single-dose tafenoquine given with food and water to prevent gastrointestinal discomfort - Drug Pharmacokinetics in Healthy Volunteers | Phase 2 / Phase 3 | Not yet recruiting | Curtin University | 60 | 2026-04-01 | 2026-03-18 |
| Investigating the Pharmacology of Tafenoquine in Papua New Guinean Children With Uncomplicated Malaria Single dose tafenoquine (10 mg/kg), Dihydroartemisinin-piperaquine (DHA-PPQ), Artemether + Lumefantrine - Uncomplicated Malaria | Phase 4 | Not yet recruiting | Curtin University | 60 | 2026-04-01 | 2026-02-12 |
| B-FREE Chronic Babesiosis Study Tafenoquine 100mg - Chronic Babesiosis | Phase 2 | Recruiting | 60 Degrees Pharmaceuticals LLC | 40 | 2025-11-18 | 2025-11-21 |
| Investigating the Pharmacokinetics of Tafenoquine in Healthy Papua New Guinean Children Single dose tafenoquine (10 mg/kg) given with water, Single dose tafenoquine (10 mg/kg) given with fat - Pharmacokinetics of Tafenoquine | Phase 4 | Recruiting | Curtin University | 30 | 2025-10-20 | 2026-03-18 |
| Vivax Elimination With Tafenoquine (VET) Study Tafenoquine - Malaria, Malaria, Vivax | Phase 4 | Completed | Shoklo Malaria Research Unit | 1242 | 2025-02-19 | 2026-01-06 |
| An Interventional Study to Compare the Efficacy and Safety of Tafenoquine (TQ) and Primaquine (PQ) When Either Are Taken Together With Chloroquine (CQ) for the Treatment of P. Vivax Malaria in Indian Participants Aged 2 Years and Older Tafenoquine, Primaquine, Chloroquine - Malaria, Vivax | Phase 3 | Recruiting | GlaxoSmithKline | 324 | 2024-11-13 | 2026-10-01 |
| Southeast Asia Dose Optimization of Tafenoquine Tafenoquine, Chloroquine, Artemether 20 mg-Lumefantrine 120 mg - Plasmodium Vivax Malaria | Phase 4 | Recruiting | University of Oxford | 820 | 2024-07-22 | 2026-10-09 |
| Oral Tafenoquine Plus Standard of Care Versus Placebo Plus Standard of Care for Babesiosis Tafenoquine, Placebo - Babesiosis | Phase 2 | Recruiting | 60 Degrees Pharmaceuticals LLC | 33 | 2024-06-17 | 2025-11-21 |
| A Revised Tafenoquine Dose to Improve Radical Cure for Vivax Malaria Tafenoquine, Primaquine - Vivax Malaria | Phase 3 | Recruiting | Menzies School of Health Research | 1090 | 2024-05-10 | 2025-07-18 |
| Radical Cure (RC) With Tafenoquine or Primaquine After Semi-quantitative G6PD Testing: A Feasibility Study in Peru Tafenoquine (TQ) - Malaria, Vivax | Completed | Medicines for Malaria Venture | 187 | 2023-08-28 | 2026-03-20 | |
| A Clinical Evaluation of the Safety and Efficacy of Randomized Placebo Versus the 8-aminoquinoline Tafenoquine for Early Symptom Resolution in Patients With Mild to Moderate COVID 19 Disease and Low Risk of Disease Progression Tafenoquine Oral Tablet, Placebo - COVID 19 Disease, Mild to Moderate COVID 19 Disease | Phase 2 | Unknown | 60P Australia Pty Ltd | 148 | 2023-08-01 | 2023-07-17 |
| Tafenoquine and Primaquine in Colostrum and Breast Milk Primaquine, Tafenoquine - Healthy Lactating Women | Phase 4 | Withdrawn | University of Oxford | 2023-07-01 | 2024-04-04 | |
| ACT vs CQ With Tafenoquine for P. Vivax Mono-infection Dihydroartemisinin-piperaquine plus tafenoquine (450 mg adult dose), Chloroquine plus Tafenoquine (450 mg adult dose), Artemether-Lumefantrine plus Tafenoquine (450 mg adult dose) - Malaria, Malaria, Vivax | Phase 4 | Recruiting | Shoklo Malaria Research Unit | 606 | 2023-06-26 | 2025-05-16 |
| Radical CUREfor MAlaria Among Highly Mobile and Hard-to-reach Populations in the Guyanese Shield PART, Malakit, CROSS-SECTIONAL PRE- AND POST-INTERVENTION SURVEYS - Malaria, Vivax | Not applicable | Completed | Centre Hospitalier de Cayenne | 1991 | 2022-09-12 | 2025-07-24 |
| Operational Feasibility of Appropriate Plasmodium Vivax Radical Cure After G6PD Testing in Thailand Tafenoquine, Primaquine - Malaria, Vivax, G6PD Deficiency | Completed | Dr. Prayuth Sudathip | 187 | 2022-05-23 | 2023-10-26 |
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Malaria, Vivax (26) · Malaria (12) · Glucosephosphate Dehydrogenase Deficiency (3) · Communicable Diseases (2) · Malaria, Falciparum (2) · Recurrence (2) · Babesiosis (1) · Breast Feeding (1) · Hemolysis (1)
GlaxoSmithKline (10) · 60 Degrees Pharmaceuticals LLC (5) · U.S. Army Medical Research and Development Command (4) · Curtin University (3) · Menzies School of Health Research (3) · University of Oxford (3) · London School of Hygiene and Tropical Medicine (2) · Shoklo Malaria Research Unit (2) · 60P Australia Pty Ltd (1) · Centre Hospitalier de Cayenne (1) · Dr. Prayuth Sudathip (1) · Fundação de Medicina Tropical Dr. Heitor Vieira Dourado (1) · Medicines for Malaria Venture (1) · R. Kiplin Guy (1) · State University of New York - Upstate Medical University (1)
Thailand (11) · United States (9) · Brazil (5) · Ethiopia (4) · Indonesia (4) · Papua New Guinea (4) · Peru (4) · Vietnam (4) · Cambodia (3) · Colombia (2) · India (2) · Mali (2) · Australia (1) · Bangladesh (1) · Laos (1)
Brioni R Moore, PhD (2) · Cindy Chu, MD, PhD (2) · A.J Oloo (1) · Akila Chandrasekar, MD (1) · Alassane Dicko (1) · Alassane Dicko, PhD, MD (1) · Alejandro L Cuentas,, MD, PhD (1) · Braden Hale, MD (1) · Brian Vesely, PhD (1) · Brioni Moore, PhD (1) · Chalermpol Chalermpol, M.D. (1) · Chantana Padungtod, M.D., DrPH (1) · Dhelio Batista, MD, PhD (1) · Elmer Alejandro Llanos Cuentas, MD, PhD (1)
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U01AI195203 (1)