10 recruiting, 8 not yet recruiting, 4 completed, 2 active not recruiting. 12 Not applicable, 4 Phase 4, 3 Phase 2, 2 Phase 1, 1 Phase 3.
Follow Venous Leg Ulcer (VLU): new trials by email Literature Review of Venous Leg Ulcer (VLU) trials Research Report on Venous Leg Ulcer (VLU)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Lower Extremity Ulcers PRFM - Lower Extremity, Chronic Ulcers | Phase 1 / Phase 2 | Not yet recruiting | Tiger Biosciences, LLC. | 30 | 2026-09-01 | 2026-10-07 |
| Effect of Photobiomodulation on Healing of Venous Leg Ulcers Photobiomodulation Therapy, Sham Photobiomodulation, Compression Therapy - Venous Leg Ulcer (VLU), Venous Hypertension Ulcers | Not applicable | Recruiting | University of Nove de Julho | 102 | 2026-08-03 | 2026-09-09 |
| An Open Label, Single Treatment, Single Arm, Multiple Dose Phase-2 Study to Evaluate the Pharmacokinetics, Safety, and Clinical Performance of EscharEx (EX-03) in Participants With Venous Leg Ulcers EX-03 - Venous Leg Ulcer (VLU) | Phase 2 | Not yet recruiting | MediWound Ltd | 20 | 2026-08-01 | 2026-07-09 |
| OCM™ Treatment With Routine Care in Venous Leg Ulcers Compared to Routine Care Treatment Alone. Omeza OCM™ Wound Matrix, Routine Care - Venous Leg Ulcer (VLU) | Not applicable | Not yet recruiting | Omeza, LLC | 254 | 2026-08-01 | 2026-08-10 |
| Smart Bandage With Telemonitoring vs Standard Care for Venous Leg Ulcer: Randomized Trial Smart Bandage with Telemonitoring, Conventional Bandage - Venous Leg Ulcer (VLU), Chronic Wound | Not applicable | Not yet recruiting | Asmat Burhan | 110 | 2026-07-26 | 2026-06-04 |
| A Randomized Non-Inferiority Study of Mepi™ Press 2 vs UrgoK2® for Compression Therapy in Venous Leg Ulcers Compression bandage system (Mepi™ Press 2), Compression bandage system (UrgoK2®), Wound Dressing Material - Venous Leg Ulcer (VLU), Compression Bandages | Not applicable | Not yet recruiting | Molnlycke Health Care AB | 386 | 2026-05-01 | 2026-05-20 |
| Evaluation of the Safety and Efficacy of Dehydrated Human Placenta Tissue (dHPT) for Wound Healing dHPT, AIC - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Active not recruiting | Cellution Biologics | 300 | 2026-03-12 | 2026-08-27 | |
| EVALUATION OF THE EFFICACY AND TOLERANCE OF VASHE SOLUTION VERSUS SALINE SOLUTION IN THE TREATMENT OF VENOUS OR MIXED LEG ULCERS PRESENTING INFLAMMATORY SIGNS SUGGESTING HEAVY BACTERIAL LOAD Saline solution, Vashe solution - Venous Leg Ulcer (VLU) | Not applicable | Not yet recruiting | Laboratoires URGO | 102 | 2026-03-01 | 2026-03-04 |
| Nonhealing Venous Leg Ulcers Treated With a Standard of Care (SoC) Alone or Standard of Care and Dehydrated Human Placenta Tissue (dHPT) With Crossover Amnion-Intermediate-Chorion, Standard of Care (SOC) - Venous Leg Ulcer (VLU) | Phase 4 | Enrolling by invitation | Cellution Biologics | 70 | 2026-02-04 | 2026-08-06 |
| Assessing Sensor-Guided Compression Therapy for Venous Leg Ulcers Healing Outcomes A connected-health, pressure-sensing system for monitoring sub-bandage pressure during compression therapy - Venous Leg Ulcer (VLU) | Not applicable | Not yet recruiting | Feeltect Limited | 40 | 2026-01-15 | 2025-12-05 |
| ConvaVAC™ Ag+ Negative Pressure Wound Therapy System in Chronic Wounds ConvaVAC™ Ag+ Negative Pressure Wound Therapy System - Venous Leg Ulcer (VLU) | Not applicable | Recruiting | ConvaTec Inc. | 87 | 2026-01-12 | 2026-07-09 |
| Efficacy of Human Placental Membrane Products and Standard of Care in the Management of Nonhealing Diabetic Foot Ulcers and Venous Leg Ulcers Tri-Membrane Wrap™ DFU, Membrane Wrap™ DFU, Membrane Wrap-Lite™ DFU - Diabetic Foot Ulcer, Foot Ulcer Chronic | Not applicable | Recruiting | BioLab Holdings | 50 | 2026-01-02 | 2026-10-01 |
| A Non-Randomized Open Label Clinical Trial Evaluating DermaBind TL DermaBind TL - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Phase 4 | Recruiting | HealthTech Wound Care | 150 | 2025-12-10 | 2025-12-23 |
| Safety and Preliminary Efficacy of TrophiPatch, an Adipose-Derived Stromal Cell Patch for Chronic Leg Ulcers TrophiPatch: allogeneic adipose-derived stromal cell patch - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Phase 1 / Phase 2 | Recruiting | Nicolò Brembilla | 18 | 2025-07-01 | 2025-07-02 |
| Reducing Skin Tone Inequities in Chronic Venous Insufficiency Chronic Venous Insufficiency, CVI, Chronic Venous Insufficiency C2 or Higher | Recruiting | King's College London | 51 | 2025-06-01 | 2025-09-16 | |
| A Double Blind Study Performed to Evaluate the Efficacy and the Safety of EscharEx in Debridement of VLU (VALUE) EscharEx (EX-03), Placebo (Gel vehicle) - Venous Leg Ulcer (VLU) | Phase 3 | Recruiting | MediWound Ltd | 216 | 2025-06-01 | 2026-10-09 |
| Evaluation of Cold Plasma in Chronic Wound Healing Cold Atmospheric Plasma treatment - Chronic Wounds, Venous Leg Ulcer (VLU) | Not applicable | Not yet recruiting | Plasana Medical | 66 | 2025-06-01 | 2025-05-09 |
| A Real World Data Collection of Human Amniotic Membrane(s) on Diabetic Foot Ulcers, Venous Leg Ulcers, Pressure Ulcers and Post Operative Wounds Tri-Membrane Wrap™, Membrane Wrap™, Membrane Wrap-Hydro™ - Venous Leg Ulcer (VLU), Diabetic Foot Ulcer (DFU) | Completed | BioLab Holdings | 500 | 2025-04-23 | 2026-10-01 | |
| Trial to Evaluate Cyclical Topical Wound Oxygen Therapy in the Treatment of Chronic Venous Leg Ulcers Topical Wound Oxygen Therapy, Sham Control Topical Wound Oxygen - Venous Leg Ulcer (VLU) | Phase 4 | Recruiting | AOTI Ltd. | 212 | 2025-01-15 | 2025-11-19 |
| Evaluating the Durability of Closure for Venous Leg Ulcers Venous Leg, Venous Leg Ulcer (VLU) | Recruiting | Kerecis Ltd. | 150 | 2025-01-01 | 2025-01-24 |
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Varicose Ulcer (25) · Diabetic Foot (7) · Pressure Ulcer (5) · Ulcer (2) · Blindness, Cortical (1) · Foot Ulcer (1) · Leg Ulcer (1) · Varicose Veins (1) · Wounds and Injuries (1)
Cardiovascular Diseases (25) · Skin Diseases (25) · Skin Ulcer (25) · Skin and Connective Tissue Diseases (25) · Vascular Diseases (25) · Leg Ulcer (24) · Varicose Veins (24) · Diabetes Complications (7) · Diabetes Mellitus (7) · Diabetic Angiopathies (7) · Diabetic Neuropathies (7) · Endocrine System Diseases (7) · Foot Ulcer (6) · Pathological Conditions, Signs and Symptoms (3) · Pathologic Processes (2)
Standard of Care (4) · Gels (2) · Low-Level Light Therapy (2) · Abortion, Induced (1) · Aminoimidazole Carboxamide (1) · Bandages (1) · COVID-19 Serotherapy (1)
BioLab Holdings (2) · Cellution Biologics (2) · Kerecis Ltd. (2) · MediWound Ltd (2) · Molnlycke Health Care AB (2) · AOTI Ltd. (1) · Asmat Burhan (1) · ConvaTec Inc. (1) · Feeltect Limited (1) · HARTMANN GROUP (1) · HealthTech Wound Care (1) · Healthpoint (1) · King's College London (1) · Laboratoires URGO (1) · Nicolò Brembilla (1)
United States (11) · Poland (3) · Czechia (2) · Germany (2) · United Kingdom (2) · Austria (1) · Belgium (1) · Brazil (1) · Canada (1) · Chile (1) · France (1) · Hungary (1) · Indonesia (1) · Ireland (1) · Israel (1)
Alisha Oropallo, MD (1) · Anil Hingorani, MD (1) · Dured Dardari, MD, PhD (1) · Marshall Medley (1) · Mike Griffiths, DProf, DMS, CRT, FCMI (1) · Septian Mixrova Sebayang, MSN (1) · Stan Andrews, MS (1) · Victoria J Clemett, PhD, BNurs (1) · Wael Tawfick, MB.BCH, MRCSI. (1) · Wolfgang Vanscheidt, MD (1)