17 completed, 3 terminated, 2 not yet recruiting, 1 recruiting. 24 Phase 1, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 24 | Completed 17, Terminated 3, Not yet recruiting 2, Recruiting 1, Unknown 1 |
| Phase 2 | 12 | Completed 7, Terminated 2, Not yet recruiting 1, Recruiting 1, Unknown 1 |
Follow Varicose Ulcer: new trials by email Literature Review of Varicose Ulcer trials Research Report on Varicose Ulcer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| LUT017 Gel for Venous Leg Ulcers and Chronic Non-Healing Skin Wounds in Adults LUT017 gel - Venous Leg Ulcer, Chronic Non-Healing Cutaneous Wounds | Phase 1 | Not yet recruiting | Antoni Ribas | 18 | 2026-10-02 | 2026-05-29 |
| Evaluating Autologous Platelet-Rich Fibrin Plasma for Chronic Lower Extremity Ulcers PRFM - Lower Extremity, Chronic Ulcers | Phase 1 / Phase 2 | Not yet recruiting | Tiger Biosciences, LLC. | 30 | 2026-09-01 | 2026-10-07 |
| Safety and Preliminary Efficacy of TrophiPatch, an Adipose-Derived Stromal Cell Patch for Chronic Leg Ulcers TrophiPatch: allogeneic adipose-derived stromal cell patch - Diabetic Foot Ulcer (DFU), Venous Leg Ulcer (VLU) | Phase 1 / Phase 2 | Recruiting | Nicolò Brembilla | 18 | 2025-07-01 | 2025-07-02 |
| Clinical Trial With Adipose Tissue Stem Cells on Biological Matrix for the Treatment of Venous Ulcer of the Lower Limbs Bioengineered Artificial Mesenchimal Sheet (BAMS), Standard treatment (Control) - Venous Ulcer | Phase 1 / Phase 2 | Unknown | Andalusian Network for Design and Translation of Advanced Therapies | 20 | 2023-07-12 | 2023-07-27 |
| A Study of XSTEM-VLU in Patients With Difficult-to-heal Venous Leg Ulcers XSTEM-VLU, Vehicle - Venous Leg Ulcer | Phase 1 / Phase 2 | Completed | Xintela AB | 6 | 2022-10-26 | 2026-06-26 |
| Treatment Outcome of Autologous PRP Versus Conventional Therapy Among Patients With Chronic Venous Leg Ulcers PRP, Conventional therapy - Venous Leg Ulcer | Phase 1 | Completed | Jinnah Postgraduate Medical Centre | 48 | 2022-09-01 | 2023-08-03 |
| Safety and Tolerability of Single and Multiple Doses of SoftOx Biofilm Eradicator (SBE) in Chronic Leg Wounds SoftOx Biofilm Eradicator (Groups 1 to 7), Sterile isotonic saline (Groups 1 to 4) - Chronic Leg Ulcer, Venous Leg Ulcer | Phase 1 | Completed | SoftOx Solutions AS | 28 | 2021-10-19 | 2023-02-02 |
| Allogeneic ABCB5-positive Stem Cells for Treatment of CVU allo-APZ2-CVU - Skin Ulcer Venous Stasis Chronic | Phase 1 / Phase 2 | Completed | RHEACELL GmbH & Co. KG | 31 | 2017-11-16 | 2020-09-10 |
| Clinical Trial to Investigate Efficacy and Safety of the IMP in Patients With Non Healing Wounds Originating From Ulcers APZ2 application - Skin Ulcer Venous Stasis Chronic | Phase 1 / Phase 2 | Terminated | RHEACELL GmbH & Co. KG | 13 | 2016-08-01 | 2020-07-07 |
| Safety Study to Examine the Systemic Exposure of Granexin® Gel After Topical Application to Venous Leg Ulcers Granexin - Venous Leg Ulcer | Phase 1 | Completed | Xequel Bio, Inc. | 10 | 2015-09-01 | 2018-08-01 |
| The Effect of the Cosmetic Cream NMBM on Leg Ulcers - a Pilot Study NMBM, Compression garments - Ulcer, Venous Ulcer | Phase 1 / Phase 2 | Completed | M.D. Lederman Consulting Ltd | 30 | 2013-02-01 | 2017-01-11 |
| Autologous Skin Substitute for Chronic Leg/Foot Ulcers. Tiscover, AS210 - Varicose Ulcer | Phase 1 / Phase 2 | Terminated | Chantal Blok | 8 | 2012-08-01 | 2016-01-07 |
| Cooling Lower Leg Skin to Prevent Venous Leg Ulcers in Patients With Poor Vein Circulation Cryotherapy: Cooling gel wrap, Usual care - Venous Disease, Venous Vascular Diseases and Syndromes | Phase 1 / Phase 2 | Completed | Medical University of South Carolina | 197 | 2011-08-01 | 2016-04-05 |
| Cell Therapy for Venous Leg Ulcers Pilot Study Autologous BMDC implantation at the venous ulcer - Venous Ulcer | Phase 1 | Completed | Hospital de Clínicas Dr. Manuel Quintela | 4 | 2011-05-01 | 2017-03-06 |
| Study of Individualized Wound Prevention Instruction to Prevent Venous Ulcer Development Aftercare summary - Varicose Ulcer | Phase 1 | Terminated | US Department of Veterans Affairs | 72 | 2008-07-01 | 2015-06-26 |
| Feasibility Study to Evaluate the Safety of Topically Applied Revera in Subjects With Venous Leg Ulcers Revera Wound Care, Normal Saline - Venous Stasis Ulcers | Phase 1 | Completed | Revalesio Corporation | 13 | 2008-03-01 | 2012-06-26 |
| Assessment of the Safety and Efficacy of DERMASTREAM™ - ENZYSTREAM™ System for the Treatment of Chronic Venous Ulcers Papain - Lower Extremity Chronic Venous Ulcers | Phase 1 / Phase 2 | Completed | EnzySurge | 48 | 2007-07-01 | 2010-05-25 |
| Evaluation of Safety and Activity of Celaderm in Healing Venous Leg Ulcers Celaderm (Frozen Cultured Epidermal Allograft), Control (compression bandaging) - Leg Ulcer, Varicose Ulcer | Phase 1 / Phase 2 | Completed | Shire | 40 | 2007-01-31 | 2021-06-11 |
| Wound Healing Effects of HO/03/03 In Patients With Diabetic Neuropathic Plantar and Venous Ulcers, Pilot Study. HO/03/03 - Diabetic Foot Ulcer, Venous Ulcer | Phase 1 | Completed | HealOr | 22 | 2006-06-01 | 2007-08-17 |
| FGF-1 for Topical Administration for the Treatment of Diabetic or Venous Stasis Ulcers FGF-1 - Chronic Wounds, Diabetes | Phase 1 | Completed | Venturis Therapeutics, Inc. | 8 | 2005-09-02 | 2026-08-19 |
Showing 20 of 24. Sign in to see all of them.
Leg Ulcer (3) · Skin Ulcer (3) · Diabetic Foot (2) · Ulcer (2) · Bronchiolitis Obliterans Syndrome (1) · Diabetes Mellitus (1) · Pressure Ulcer (1) · Recurrence (1) · Syndrome (1) · Venous Insufficiency (1) · Wounds and Injuries (1)
Cardiovascular Diseases (24) · Skin Diseases (24) · Skin and Connective Tissue Diseases (24) · Varicose Veins (24) · Vascular Diseases (24) · Leg Ulcer (21) · Skin Ulcer (21) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Endocrine System Diseases (3) · Diabetes Complications (2) · Diabetes Mellitus (2) · Diabetic Angiopathies (2) · Diabetic Neuropathies (2) · Foot Ulcer (2)
Compression Bandages (1) · Fibroblast Growth Factor 1 (1) · Papain (1) · Standard of Care (1)
RHEACELL GmbH & Co. KG (2) · University of Pennsylvania (2) · Andalusian Network for Design and Translation of Advanced Therapies (1) · Antoni Ribas (1) · CHU de Quebec-Universite Laval (1) · Chantal Blok (1) · EnzySurge (1) · HealOr (1) · Hospital de Clínicas Dr. Manuel Quintela (1) · Jinnah Postgraduate Medical Centre (1) · M.D. Lederman Consulting Ltd (1) · Medical University of South Carolina (1) · Nicolò Brembilla (1) · Revalesio Corporation (1) · Roger Williams Medical Center (1)
United States (9) · Israel (3) · Germany (2) · Canada (1) · Denmark (1) · Netherlands (1) · Pakistan (1) · Spain (1) · Sweden (1) · Switzerland (1) · Uruguay (1)
Aksone Nouvong, MD (1) · Andreas Kerstan, Dr. (1) · Andreas Kerstan, PD Dr.med. (1) · Antoni Ribas, M.D., PhD (1) · Arie Bass, Prof. (1) · David J. Margolis, MD (1) · David J. Margolis, MD, PhD (1) · David Peick Sonne, MD; PhD (1) · Francois A Auger, MD (1) · Gabriela Otero, MD (1) · Gayle E. Reiber, MPH PhD (1) · Glenn Gundersen, PhD (1)
PMID 25703058, PMID 26719678, PMID 26888961, PMID 29489633, PMID 33011075, PMID 40373055
N01AR092238 (1), R01AR046557 (1), R01NR012237 (1)