16 completed, 13 recruiting, 9 terminated, 6 active not recruiting. 27 Phase 1, 24 Phase 2, 4 Phase 3, 3 Not applicable, 2 Early Phase 1.
Follow Synovial Sarcoma: new trials by email Literature Review of Synovial Sarcoma trials Research Report on Synovial Sarcoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| N-803 in Patients With Progressive Synovial Sarcoma and Myxoid/Round Cell Liposarcoma Previously Treated With Adoptive Cellular Therapy Biospecimen Collection, Computed Tomography, Leukapheresis - Myxoid Liposarcoma, Round Cell Liposarcoma | Early Phase 1 | Recruiting | Seth Pollack | 8 | 2026-04-13 | 2026-08-27 |
| Alpha/Beta T and B Cell Depletion With Zoledronic Acid for Solid Tumors Miltenyi CliniMACS Prodigy ® system, Zoledronic acid - Neuroblastoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University of Florida | 27 | 2026-02-11 | 2026-06-30 |
| ACTengine® IMA203 Combined With mRNA-4203 IMA203, mRNA-4203 - Cutaneous Melanoma, Synovial Sarcoma | Phase 1 | Recruiting | Immatics US, Inc. | 15 | 2025-07-25 | 2026-01-08 |
| EPITOME-1015-I: a Study to Investigate the Safety and Tolerability of MDG1015 in Patients with Epithelial Ovarian Cancer, Gastroesophageal Adenocarcinoma, Round Cell Liposarcoma And/or Synovial Sarcoma Lymphodepletion, TCR-T cells (MDG1015) - Epithelial Ovarian Cancer, Gastro-esophageal Junction Cancer | Phase 1 | Not yet recruiting | Medigene AG | 55 | 2025-07-01 | 2024-12-27 |
| Evaluation of Chest CT Versus Chest X-Ray for Lung Surveillance After Curative-Intent Resection of High-Risk Truncal-Extremity Soft Tissue Sarcoma Biopsy, Chest Computed Tomography, Chest Radiography - Adult Pleomorphic Rhabdomyosarcoma, AJCC Grade 2 Sarcoma | Not applicable | Not yet recruiting | ECOG-ACRIN Cancer Research Group | 1582 | 2025-01-28 | 2024-07-30 |
| Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor Signifor - Desmoplastic Small Round Cell Tumor, Synovial Sarcoma | Phase 2 | Recruiting | University Hospital Heidelberg | 28 | 2024-12-19 | 2025-01-13 |
| NRSTS2021, A Risk Adapted Study Evaluating Maintenance Pazopanib, Limited Margin, Dose-Escalated Radiation Therapy and Selinexor in Non-Rhabdomyosarcoma Soft Tissue Sarcoma (NRSTS) Surgical resection, Proton beam radiation therapy, Pazopanib - Adipocytic Neoplasm, Liposarcoma | Phase 1 / Phase 2 | Recruiting | St. Jude Children's Research Hospital | 139 | 2024-03-27 | 2026-08-03 |
| Phase I/Ib Study of NK Expressing an Affinity-enhanced T-cell Receptor (TCR) Against the NY-ESO-1 Fludarabine phosphate, NY-ESO-1 TCR/IL-15 NK, Cyclophosphamide - Synovial Sarcoma, Myxoid/Round Cell Liposarcoma | Phase 1 | Recruiting | M.D. Anderson Cancer Center | 44 | 2024-03-27 | 2026-07-29 |
| MASCT-I Combined With Doxorubicin and Ifosfamide for First-line Treatment of Advanced Soft Tissue Sarcoma MASCT-I, Doxorubicin, Ifosfamide - Leiomyosarcoma, Liposarcoma | Phase 2 | Recruiting | HRYZ Biotech Co. | 148 | 2024-02-21 | 2025-07-24 |
| Personalized Vaccination in Fusion+ Sarcoma Patients (PerVision) Peptide vaccine IPX - Ewing Sarcoma, Rhabdomyosarcoma | Phase 1 / Phase 2 | Recruiting | University Hospital Tuebingen | 30 | 2023-09-19 | 2026-05-04 |
| SPEARHEAD-3 Pediatric Study Afamitresgene autoleucel - Synovial Sarcoma, Malignant Peripheral Nerve Sheath Tumor (MPNST) | Phase 1 / Phase 2 | Recruiting | USWM CT, LLC | 20 | 2023-09-01 | 2026-08-11 |
| Synovial Sarcoma Registry / Biospecimen Repository Synovial Sarcoma | Recruiting | Children's Hospital of Philadelphia | 1000 | 2023-06-12 | 2026-06-09 | |
| START: Safety and Anti-Tumor Activity of PeptiCRAd-1 in Treatment of Cancer PeptiCRAd-1, Cyclophosphamide, Pembrolizumab - Melanoma (Skin), Triple-Negative Breast Cancer | Phase 1 | Recruiting | Valo Therapeutics Oy | 15 | 2023-02-02 | 2026-05-12 |
| A Study to Assess the Safety and Tolerability of CFT8634 in Locally Advanced or Metastatic SMARCB1-Perturbed Cancers, Including Synovial Sarcoma and SMARCB1-Null Tumors CFT8634 - Synovial Sarcoma, Soft Tissue Sarcoma | Phase 1 | Terminated | C4 Therapeutics, Inc. | 49 | 2022-03-25 | 2024-12-17 |
| Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma Gemcitabine, 9-ING-41, Docetaxel - Soft Tissue Sarcoma, Undifferentiated Pleomorphic Sarcoma | Phase 2 | Withdrawn | Brown University | 2022-03-01 | 2021-12-07 | |
| HER2 Chimeric Antigen Receptor (CAR) T Cells in Combination With Checkpoint Blockade in Patients With Advanced Sarcoma T cells or CAR T cells, Pembrolizumab Injectable Product, Nivolumab Injectable Product - Sarcoma, HER-2 Protein Overexpression | Phase 1 | Recruiting | Baylor College of Medicine | 25 | 2021-12-07 | 2026-01-22 |
| A Phase 2 Study of 9-ING-41Combined With Chemotherapy in Adolescents and Adults With Advanced Sarcomas Gemcitabine, Docetaxel, 9-ING-41 - Sarcoma, Soft Tissue Sarcoma | Phase 2 | Withdrawn | Brown University | 2021-09-01 | 2021-07-28 | |
| The Registry of Oncology Outcomes Associated With Testing and Treatment Biomarker Testing (L), Systemic Treatment (T), Patient Reported Outcomes (P) - Adenocarcinoma, Adenocystic Carcinoma | Completed | Taproot Health | 167 | 2021-05-05 | 2024-12-18 | |
| Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma Definitive Surgical Resection, Nanoplexed Poly I:C BO-112, Nivolumab - Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 14 | 2020-10-14 | 2026-03-10 |
| B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ B7H3-EGFRt-DHFR, second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG, Pembrolizumab - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 68 | 2020-07-13 | 2026-04-28 |
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Sarcoma, Synovial (56) · Sarcoma (37) · Leiomyosarcoma (16) · Liposarcoma (15) · Liposarcoma, Myxoid (13) · Neurofibrosarcoma (13) · Osteosarcoma (11) · Rhabdomyosarcoma (11) · Histiocytoma, Malignant Fibrous (10) · Sarcoma, Ewing (10) · Melanoma (9) · Dermatofibrosarcoma (8) · Fibrosarcoma (8) · Sarcoma, Clear Cell (7) · Desmoplastic Small Round Cell Tumor (6)
Neoplasms by Histologic Type (56) · Neoplasms, Connective Tissue (56) · Neoplasms, Connective and Soft Tissue (56) · Neoplasms (51) · Neoplasms, Muscle Tissue (24) · Neoplasms, Nerve Tissue (24) · Neoplasms, Adipose Tissue (23) · Sarcoma (19) · Neoplasms, Fibrous Tissue (17) · Neoplasms by Site (16) · Neoplasms, Bone Tissue (15) · Nervous System Diseases (15) · Nervous System Neoplasms (15) · Neoplasms, Glandular and Epithelial (14) · Neuroectodermal Tumors (14)
Cyclophosphamide (6) · tazemetostat (5) · Doxorubicin (4) · fludarabine (4) · Docetaxel (3) · Gemcitabine (3) · Ifosfamide (3) · Radiation (3) · Radiotherapy (3) · 3-(5-fluorobenzofuran-3-yl)-4-(5-methyl-5H-(1,3)dioxolo(4,5-f)indol-7-yl)-pyrrole-2,5-dione (2) · Dacarbazine (2) · Immunotherapy, Adoptive (2) · Radiation Dose Hypofractionation (2) · X-Rays (2) · pazopanib (2)
Epizyme, Inc. (5) · USWM CT, LLC (4) · Brown University (2) · Eli Lilly and Company (2) · Immune Design, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) (2) · Maria Sklodowska-Curie National Research Institute of Oncology (2) · Memorial Sloan Kettering Cancer Center (2) · National Cancer Institute (NCI) (2) · Seattle Children's Hospital (2) · St. Jude Children's Research Hospital (2) · Washington University School of Medicine (2) · AC Camargo Cancer Center (1) · Advenchen Laboratories, LLC (1) · Baylor College of Medicine (1) · C4 Therapeutics, Inc. (1)
United States (41) · Canada (7) · France (7) · Germany (7) · Italy (6) · United Kingdom (6) · Spain (5) · Australia (4) · Belgium (4) · China (4) · Poland (4) · Netherlands (3) · Japan (2) · Brazil (1) · Denmark (1)
Brian A Van Tine, M.D., Ph.D. (2) · Aaron R Weiss (1) · Angela M. Corr, PT, DPT (1) · Bradley D DeNardo, MD (1) · Bradley DeNardo, MD (1) · Catherine Albert, MD (1) · Crystal L Mackall, M.D. (1) · David Dr. Zhen, MD (1) · David Hong, MD (1) · Dejka Araujo, MD (1) · Don S Dizon, MD (1) · Edward Stadtmauer, MD (1)
PMID 32002290, PMID 32827353, PMID 20932656, PMID 22682017, PMID 23554566, PMID 25258541, PMID 29149611, PMID 31215818, PMID 31401903, PMID 32029687, PMID 32269142, PMID 32702309, PMID 33035459, PMID 34260265, PMID 34515544, PMID 36624315, PMID 37523624, PMID 37794590, PMID 39255444, PMID 40934647, PMID 42194972
2015 (3), 2018 (1), 2023 (1), K08CA245181 (1), K12CA076930 (1), K23CA175167 (1), P30CA015704 (1), P30CA060553 (1), R01CA276684 (1), R21CA117128 (1), U10CA098543 (1), U10CA180830 (1), U10CA180886 (1), UG1CA189828 (1)