15 not yet recruiting, 12 completed, 6 recruiting, 2 enrolling by invitation. 22 Not applicable, 5 Phase 4, 3 Phase 3.
Follow Surgical Site Infection (SSI): new trials by email Literature Review of Surgical Site Infection (SSI) trials Research Report on Surgical Site Infection (SSI)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Investigation of the PREVENTIA® Irrigation Solution for Reducing Bacteria in Spinal Surgery With Implants - A Comparative Study Preventia Surgical Solution, 0.9 % NaCl - Surgical Site Infection (SSI), Spine Surgery | Phase 4 | Not yet recruiting | Universität Luzern | 114 | 2027-01-01 | 2026-06-29 |
| Efficacy of Integrating Next Generation Sequencing for Treatment of Surgical Site Infection After Fracture Fixation: NGS diagnostic findings - Next Generation Sequencing (NGS), Surgical Site Infection (SSI) | Phase 3 | Not yet recruiting | Johns Hopkins Bloomberg School of Public Health | 250 | 2026-11-01 | 2026-10-08 |
| Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin Cefazolin 2 g Infusion, Placebo infusion of .9 normal saline - Breast Cancer, Breast Surgery | Phase 3 | Not yet recruiting | University Hospital, Clermont-Ferrand | 1600 | 2026-11-01 | 2026-10-27 |
| DRONE-WOUND Study: Severe Infection After Drone-Related Combat Trauma Combat Related Symptoms, Combat Trauma | Not yet recruiting | Ukrainian Society of Regional Anesthesia and Pain Therapy | 500 | 2026-10-23 | 2026-07-16 | |
| Gene Expression Analysis of Biofilm Formation and Antimicrobial Resistance in Clinical Methicillin-Resistant Staphylococcus Aureus swab from lesion, Biochemical reactions, Antibiotic sensitivity - Staphylococcal Aureus Infection, Surgical Site Infection (SSI) | Not yet recruiting | Sohag University | 100 | 2026-09-20 | 2026-09-01 | |
| Infection Prevention for "Bellwether" Surgery in Ethiopia Surgical Site Infection Prevention and Control (IPC) Bundle - Ceserean Section, Lower Limb Fractures | Not yet recruiting | Karolinska Institutet | 1000 | 2026-09-01 | 2026-06-15 | |
| Rationale of Subcutaneous Levofloxacin Infiltration as an Adjunct for Surgical Site Infection Prevention in Emergency Laparotomy Levofloxacin - Surgical Site Infection (SSI) | Not applicable | Not yet recruiting | Sylhet M.A.G.Osmani Medical College | 90 | 2026-08-01 | 2026-07-13 |
| Prophylactic Subcutaneous Drainage After Gynecologic Oncology Midline Laparotomy Prophylactic subcutaneous closed-suction drainage, Standard closure without subcutaneous drainage - Wound Complication, Surgical Site Infection (SSI) | Not applicable | Recruiting | Mahmut Yassa | 334 | 2026-07-20 | 2026-07-30 |
| Closed Incision NPWT to Prevent Wound Complications Post-ECMO Prophylactic Closed-Incision Negative Pressure Wound Therapy, Standard Wound Dressing - ExtraCorporeal Membrane Oxygenation (ECMO), Wound Complications | Not applicable | Not yet recruiting | St. Antonius Hospital | 144 | 2026-07-13 | 2026-07-16 |
| Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During Orthopedic Surgeries in Egyptian Patients. Cefazolin 2 g Infusion, Cefazolin 2 GM Injection - Surgical Site Infection (SSI) | Phase 4 | Not yet recruiting | Helwan University | 100 | 2026-07-01 | 2026-06-24 |
| Prophylactic Use of ciNPWT in Gynecologic Laparotomy closed incision negative pressure wound therapy (ciNPWT) - Surgical Site Infection (SSI), Wound Healing Complication | Not applicable | Not yet recruiting | University Hospital Hradec Kralove | 30 | 2026-07-01 | 2026-06-12 |
| Continuous Infusion Versus Intermittent IV Bolus of Cefazolin: Prevention of Surgical Site Infection During CABG Surgeries in Egyptian Patients. Cefazolin 2 g Infusion, Cefazolin 2 GM Injection - Surgical Site Infection (SSI) | Phase 4 | Not yet recruiting | Helwan University | 100 | 2026-07-01 | 2026-06-24 |
| Effect of Early vs Late Water Exposure After Cutaneous Surgery Care as usual - Surgical Site Infection (SSI) | Not applicable | Not yet recruiting | Pak Emirates Military Hospital | 82 | 2026-06-01 | 2026-05-12 |
| Efficacy and Cost-Effectiveness of Topical Vancomycin Powder in Preventing Pediatric Ventriculoperitoneal Shunt Infections Across Different Etiologies Topical Vancomycin Powder, Standard Perioperative Care - Hydrocephalus, Ventriculoperitoneal Shunt Infection | Phase 4 | Not yet recruiting | Assiut University | 164 | 2026-05-01 | 2026-04-23 |
| The Spotlight Study: Early Identification of Post-Surgical Infections Using Bedside Ultrasound. Point-of-Care Ultrasound (POCUS), Microbiological Wound Swab, ASEPSIS Wound Assessment - Surgical Site Infection (SSI), Emergency Laparotomies | Not applicable | Recruiting | Slagelse Hospital | 100 | 2026-04-10 | 2026-04-24 |
| Effects of Intensive Glycemic Control in the Postoperative Period of Neurosurgical Patients on the Incidence of Surgical Site Infection Intensive glycemic control, Hypokalemia Prevention Protocol During IV Insulin Therapy, Glucose-Supported Intravenous Insulin Infusion Protocol - Surgical Site Infection (SSI) | Not applicable | Not yet recruiting | University of Sao Paulo | 572 | 2026-04-05 | 2026-04-23 |
| Comparing Polyglactin vs Polypropylene Sutures for Rectus Sheath Closure Polyglactin 910 (Vicryl) Suture, Polypropylene (Prolene) Suture - Chronic Pain, Wound Dehiscence | Not applicable | Not yet recruiting | Lady Reading Hospital, Pakistan | 156 | 2026-04-01 | 2025-12-15 |
| Subcutaneous Suture Versus no Subcutaneous Suture for Abdominal Wound Closure subcutaneous suture - Surgical Site Infection (SSI), Wound Healing Complication | Not applicable | Recruiting | University Hospital Augsburg | 655 | 2026-03-23 | 2026-05-29 |
| Preoperative Clindamycin Vaginal Cream Versus Vaginal Cleansing With Povidone-iodine on Postoperative Infections After Cesarean Section Clindamycin vaginal cream, Vaginal preparation with povidone- iodide solution 10 % - Infection Control / Methods, Surgical Site Infection (SSI) | Phase 4 | Recruiting | Beni-Suef University | 150 | 2025-09-20 | 2026-03-16 |
| Prophylaxis Against Surgical Site Infections Using Local as Well as Systemic Antibiotic Cefazolin plus Gentamicin, Cefazolin - Surgical Site Infection (SSI) | Not applicable | Completed | Lahore General Hospital | 284 | 2025-07-01 | 2026-03-18 |
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Surgical Wound Infection (36) · Postoperative Complications (6) · Femoral Fractures (2) · Hematoma (2) · Incisional Hernia (2) · Bacterial Infections and Mycoses (1) · Breast Neoplasms (1) · Central Nervous System Neoplasms (1) · Chronic Pain (1) · Hip Fractures (1) · Hydrocephalus (1) · Infections (1) · Intestinal Obstruction (1) · Intestinal Perforation (1) · Mediastinitis (1)
Pathologic Processes (36) · Pathological Conditions, Signs and Symptoms (36) · Infections (35) · Wound Infection (35) · Postoperative Complications (30) · Wounds and Injuries (3) · Fractures, Bone (2) · Hemorrhage (2) · Hernia (2) · Leg Injuries (2) · Neoplasms (2) · Neoplasms by Site (2) · Nervous System Diseases (2) · Pathological Conditions, Anatomical (2) · Bone Diseases (1)
Cefazolin (4) · Gentamicins (2) · Vancomycin (2) · Drug Collateral Sensitivity (1) · Enhanced Recovery After Surgery (1) · Levofloxacin (1) · Polyglactin 910 (1) · Polypropylenes (1) · Saline Solution (1) · Sutures (1) · bone wax (1) · octyl 2-cyanoacrylate (1)
Ain Shams University (2) · Helwan University (2) · Assiut University (1) · Beni-Suef University (1) · Central Hospital, Nancy, France (1) · Doron Kabiri (1) · Hamad Medical Corporation (1) · Hayat Abad Medical Complex, Peshawar (1) · Istanbul University (1) · Johns Hopkins Bloomberg School of Public Health (1) · Karolinska Institutet (1) · Kathmandu University School of Medical Sciences (1) · Lady Reading Hospital, Pakistan (1) · Lahore General Hospital (1) · Mahmut Yassa (1)
Pakistan (6) · Egypt (5) · France (2) · Turkey (Türkiye) (2) · Bangladesh (1) · China (1) · Denmark (1) · Ethiopia (1) · Germany (1) · Israel (1) · Nepal (1) · Qatar (1) · South Korea (1) · Switzerland (1) · Thailand (1)
Erik Scholten, MD (1) · Faria Javed (1) · Jakob Burcharth, MD, Ph.D (1) · Johannes Lauscher, Prof. Dr. med. (1) · Khuzaima Tariq (1) · Mahmoud H Ragab, MD (1) · Mahmoud M. Ghaleb (1) · Marc Garnier, MD, PhD (1) · Mohammad A. Alzeiny (1) · Muhammad I Seerat, FCPS (1) · Pranto Chakroborty, MBBS (1) · Roman M Natoli, MD (1)
PMID 25212963, PMID 26114986, PMID 29149428, PMID 35512376, PMID 37978002, PMID 40354101, PMID 41580707
2025 (1)