14 unknown, 6 recruiting, 4 completed, 3 active not recruiting. 14 Not applicable, 5 Phase 2, 3 Phase 1, 3 Phase 3.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stereotactic Body RadioTherapy With Continuous Tracking for Primary and Secondary Renal Cancer Stereotactic body radiotherapy (SBRT) - Renal Cancer, Renal Secondary Cancer | Not applicable | Recruiting | IRCCS San Raffaele | 60 | 2026-09-14 | 2026-10-27 |
| Functional Lung Avoidance Planning Guided by Lung Perfusion PET/CT Versus Anatomical Planning for Lung Stereotactic Body Radiotherapy Conventional anatomical planning radiotherapy, Functional Lung avoidance planning - Stereotactic Body Radiotherapy, 68Ga-MAA | Phase 3 | Recruiting | University Hospital, Brest | 418 | 2026-09-04 | 2026-10-15 |
| Neoadjuvant SF-SBRT Plus Toripalimab and Chemotherapy in Resectable Stage II-III NSCLC. Stereotactic body radiotherapy (SBRT), neoadjuvant immunotherapy, Neoadjuvant Chemotherapy - Non Small Cell Lung Cancer, Stereotactic Body Radiotherapy | Phase 3 | Not yet recruiting | Shanghai Pulmonary Hospital, Shanghai, China | 201 | 2026-05-01 | 2026-05-29 |
| Is Adaptive SBRT for Prostate vs Image-guided Radiotherapy a True Evolution (ASPIRE) SBRT - Localized Prostate Cancer, Stereotactic Body Radiotherapy | Phase 3 | Recruiting | University Health Network, Toronto | 320 | 2025-02-04 | 2026-06-02 |
| Early Magnetic Resonance Imaging Response of the Dominant Intraprostatic Lesion After Online Adaptive Stereotactic Body Radiotherapy for Localized Prostate Cancer and Correlation With Prostate Specific Antigen Response Prostate Carcinoma, Localized Prostate Adenocarcinoma | Active not recruiting | University of Zurich | 28 | 2024-08-20 | 2025-12-23 | |
| Atezolizumab and BEvacizumab With STereotactic Body Radiotherapy for Advanced Hepatocellular Carcinoma Stereotactic body radiotherapy - Advanced Hepatocellular Carcinoma, Chemotherapy | Not applicable | Recruiting | Yonsei University | 33 | 2024-05-28 | 2024-11-01 |
| Elimination of PTV Margins Based on Online Adaptive Stereotactic Radiotherapy for Early-stage Non-small Cell Lung Cancer or Pulmonary Oligometastases Online adaptive SBRT, Conventional SBRT - Adaptive Radiotherapy, Stereotactic Body Radiotherapy | Phase 2 | Recruiting | Sun Yat-sen University | 130 | 2024-05-22 | 2025-11-17 |
| Safety and Efficacy of Stereotactic Body Radiotherapy in the Treatment of Hypertrophic Obstructive Cardiomyopathy Stereotactic Body Radiotherapy (SBRT) Treatment, Sham Procedure - Hypertrophic Obstructive Cardiomyopathy, Stereotactic Body Radiotherapy | Not applicable | Unknown | Second Xiangya Hospital of Central South University | 36 | 2023-12-15 | 2023-12-19 |
| Stereotactic Body Radiotherapy Combined With Cadonilimab for Advanced Refractory Malignant Solid Tumors Cadonilimab, Stereotactic body radiotherapy - Advanced Solid Tumor, Stereotactic Body Radiotherapy | Phase 1 / Phase 2 | Unknown | Peking University Third Hospital | 60 | 2023-06-21 | 2023-06-23 |
| Single Ultra-high Dose Stereotactic Body Radiation Therapy for Early Lung Cancer SBRT - Early Lung Cancer, Stereotactic Body Radiotherapy | Not applicable | Not yet recruiting | Peking University Third Hospital | 100 | 2023-06-01 | 2023-06-22 |
| Safety and Efficacy of Preoperative SBRT and Radical Surgery for Soft Tissue Sarcoma of Extremities stereotactic body raiotherapy - Soft Tissue Sarcoma, Stereotactic Body Radiotherapy | Not applicable | Recruiting | Second Affiliated Hospital, Zhejiang University, School of Medicine | 20 | 2023-03-23 | 2025-01-06 |
| Phase Ib/II Trial of Combining Pembrolizumab and Lenvatinib With SBRT for HCC Patients With Portal Vein Thrombosis. Lenvatinib/Pembrolizumab plus SBRT combinations - Unresectable Hepatocellular Carcinoma, Pembrolizumab | Phase 1 / Phase 2 | Unknown | National Taiwan University Hospital | 27 | 2023-03-01 | 2023-03-02 |
| Preoperative Stereotactic Body Radiotherapy (SBRT) Followed by Hepatectomy for Centrally Located Hepatocellular Carcinoma: a Prospective, Single-center, Phase I Study Neoadjuvant stereotactic body radiation therapy (Multiple ascending dose) followed by hepatectomy for centrally located hepatocellular carcinoma. - Centrally Located Hepatocellular Carcinoma, Stereotactic Body Radiotherapy | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 15 | 2022-11-01 | 2023-02-06 |
| A Phase II Clinical Study of Stereotactic Radiation Therapy in Patients With High-risk Prostate Cancer stereotactic body radiotherapy - Prostate Cancer, Stereotactic Body Radiotherapy | Not applicable | Unknown | West China Hospital | 60 | 2022-06-30 | 2022-06-24 |
| Stereotactic Body Radiotherapy for Lung Lesions With Markerless Tracking (MLT) on the VERO® SBRT System Standard radiotherapy treatment - Lung Cancer, Stereotactic Body Radiotherapy | Withdrawn | Universitair Ziekenhuis Brussel | 2022-01-01 | 2024-12-09 | ||
| Safety and Tolerability of Low Dose Radiotherapy Concurrent SBRT and PD-1 Inhibitors in Advanced NSCLC. Low Dose Radiotherapy, stereotactic body radiation therapy, PD-1 Inhibitors - NSCLC, Low Dose Radiotherapy | Phase 1 | Active not recruiting | Sichuan University | 9 | 2021-12-15 | 2026-05-11 |
| Sintilimab Combined With Chemotherapy and SBRT in Limited Metastatic Head and Neck Squamous Cell Carcinoma (LM-HNSCC) Sintilimab, SBRT, Platinum based chemotherapy - Head and Neck Squamous Cell Carcinoma, Metastases | Phase 2 | Unknown | Jun-Lin Yi, MD | 50 | 2021-12-01 | 2021-11-29 |
| Stereotactic Body Radiotherapy Combined With PD-1 Blockers for Locally Advanced or Locally Recurrent Pancreatic Cancer Stereotactic body radiotherapy (SBRT), PD-1 blocking antibody - Stereotactic Body Radiotherapy, PD-1 Inhibitors | Completed | Peking University Third Hospital | 19 | 2020-12-01 | 2024-01-08 | |
| LIVELUNG - Impact of CGA in Patients Diagnosed With Localized NSCLC Treated With SBRT Comprehensive Geriatric Assessment - Non-small Cell Lung Cancer, Stereotactic Body Radiotherapy | Unknown | Odense University Hospital | 130 | 2020-09-29 | 2023-06-26 | |
| Post SBRT Pulmonary Metastasectomy (PSPM) Trial Surgical resection and stereotactic body radiation therapy (SBRT) - Surgical Resection, Stereotactic Body Radiotherapy | Not applicable | Unknown | McMaster University | 39 | 2020-07-14 | 2021-02-25 |
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Lung Neoplasms (5) · Carcinoma, Hepatocellular (4) · Carcinoma, Non-Small-Cell Lung (4) · Neoplasm Metastasis (2) · Pancreatic Neoplasms (2) · Prostatic Neoplasms (2) · Breast Neoplasms (1) · Cardiomyopathy, Hypertrophic (1) · Cauda Equina Syndrome (1) · Cholangiocarcinoma (1) · Diabetes Mellitus, Insulin-Dependent, 12 (1) · Disease (1) · Kidney Neoplasms (1) · Liver Neoplasms (1) · Lung Diseases (1)
Neoplasms (20) · Neoplasms by Site (19) · Respiratory Tract Diseases (8) · Respiratory Tract Neoplasms (8) · Thoracic Neoplasms (8) · Lung Diseases (7) · Digestive System Diseases (6) · Digestive System Neoplasms (6) · Neoplasms by Histologic Type (6) · Carcinoma (5) · Neoplasms, Glandular and Epithelial (5) · Adenocarcinoma (4) · Bronchial Neoplasms (4) · Carcinoma, Bronchogenic (4) · Liver Diseases (4)
Radiosurgery (13) · Drug Therapy (2) · Geriatric Assessment (1) · Immune Checkpoint Inhibitors (1) · Neoadjuvant Therapy (1) · Platinum Compounds (1) · Radiofrequency Ablation (1) · Radiotherapy (1) · Radiotherapy, Conformal (1) · Surgical Procedures, Operative (1) · Therapeutics (1) · lenvatinib (1) · pembrolizumab (1) · sintilimab (1)
Second Affiliated Hospital, Zhejiang University, School of Medicine (5) · Peking University Third Hospital (4) · Gangnam Severance Hospital (1) · Gitte Fredberg Persson MD PhD (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · IRCCS San Raffaele (1) · Jun-Lin Yi, MD (1) · Juravinski Cancer Center (1) · McMaster University (1) · National Taiwan University Hospital (1) · Odense University Hospital (1) · Second Xiangya Hospital of Central South University (1) · Shanghai Pulmonary Hospital, Shanghai, China (1) · Sichuan University (1) · Sun Yat-sen University (1)
China (14) · Canada (3) · Denmark (3) · Italy (2) · South Korea (2) · Belgium (1) · France (1) · Hong Kong (1) · Norway (1) · Switzerland (1) · Taiwan (1)
Hongqing Zhuang, M.D. (3) · Qichun Wei, MD/PhD (2) · Alessio G Morganti, MD (1) · Chia-Hsien Cheng (1) · Christine Collen, MD (1) · Gitte Persson (1) · Hui Liu, Professor (1) · John Agzarian, MD, MPH (1) · Joon Jeong, Ph.D. (1) · Junjie Wang, M.D. (1) · Junlin Yi, MD (1) · Kristian K Bentsen, Dr. med (1) · Mark De Ridder, MD, PhD (1) · Matthias Guckenberger, Prof. Dr. med. (1)
PMID 29266183, PMID 30243799, PMID 30352550, PMID 32456993, PMID 33208170, PMID 35571641, PMID 35843777, PMID 36383304, PMID 36400098, PMID 38181809, PMID 38423047, PMID 39123406, PMID 39920013, PMID 40693391, PMID 40714134, PMID 42727887