14 completed, 7 withdrawn, 6 unknown, 5 terminated. 11 Not applicable, 9 Phase 2, 6 Phase 4, 4 Phase 1, 4 Phase 3.
Follow Status Asthmaticus: new trials by email Literature Review of Status Asthmaticus trials Research Report on Status Asthmaticus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pediatric Asthma Trial of Corticosteroid Heterogeneity (PATCH): Trial of Dexamethasone Versus Methylprednisolone for Pediatric Critical Asthma Dexamethasone (0.6mg/kg; Max 16mg) Once Daily, Dexamethasone (0.25 mg/kg/dose, Max dose 16mg) every 6-hours, Methylprednisolone - Asthma (Diagnosis) | Phase 2 | Recruiting | Johns Hopkins All Children's Hospital | 159 | 2026-08-01 | 2026-08-12 |
| IV DEXAMETHASONE VS. METHYLPREDNISOLONE IN CHILDREN WITH SEVERE ASTHMA EXACERBATION Intravenous Dexamethasone, Intravenous Methylprednisolone - Status Asthmaticus, Asthma (Diagnosis) | Phase 4 | Completed | Istanbul Medeniyet University | 129 | 2025-09-01 | 2026-07-28 |
| Treating Exacerbations of Asthma With Oral Montelukast in Children Montelukast Oral Granules, Albuterol, Corticosteroid - Status Asthmaticus | Phase 2 | Completed | Vanderbilt University Medical Center | 90 | 2023-10-20 | 2026-07-02 |
| Different Doses of Nebulized Magnesium Sulphate in Status Asthmaticus Magnesium Sulfate 500 mg/ml+ ventolin, Ventolin - Status Asthmaticus | Phase 1 | Completed | Ziauddin University | 126 | 2022-01-01 | 2023-04-05 |
| BPAP in Pediatric Asthma Pilot Study Philips Respironics V60 Non-invasive ventilator, BPAP, Standard Therapy - Asthma in Children, Status Asthmaticus | Not applicable | Withdrawn | Columbia University | 2021-01-15 | 2023-02-14 | |
| The Role of Ketamine as an Adjuvant Therapy for Children With Acute Status Asthmaticus Ketamine - Status Asthmaticus | Phase 3 | Withdrawn | Augusta University | 2020-01-01 | 2024-02-06 | |
| Pilot Simulation RCT of Telemedical Support for Paramedics Telemedicine - Respiratory Failure, Status Epilepticus | Not applicable | Completed | Boston Medical Center | 72 | 2018-12-18 | 2022-07-28 |
| Comparison of Albuterol for Status Asthmaticus preservative free albuterol - Status Asthmaticus | Phase 4 | Terminated | Norton Healthcare | 8 | 2018-09-10 | 2021-05-20 |
| High Flow Nasal Cannula in Children With Status Asthmaticus HFNC, Standard Oxygen Treatment - Status Asthmaticus | Not applicable | Completed | Hospices Civils de Lyon | 272 | 2018-08-08 | 2023-09-26 |
| NiPPV in the Treatment of Acute Asthma Exacerbations Standard of Care therapies, NiPPV Therapy, Routine Respiratory Care - Bronchial Asthma, Status Asthmaticus | Not applicable | Withdrawn | Arkansas Children's Hospital Research Institute | 2017-06-01 | 2023-02-22 | |
| Steroids in Children Hospitalized With Asthma Dexamethasone, Prednisone - Asthma, Status Asthmaticus | Phase 4 | Terminated | University of Florida | 6 | 2017-03-20 | 2019-06-21 |
| Optimizing Vitamin D Status in Children With Wheeze / Asthma (OPTIVIT) Fultium-D3 drops (Internis) - Asthmatic Crisis, Wheezing | Not applicable | Completed | Queen Mary University of London | 40 | 2016-12-01 | 2019-04-08 |
| Phase I, Placebo-Controlled, Blinded Pilot Study of Ipratropium in Children Admitted to the ICU With Status Asthmaticus Ipratropium, 0.9% Sodium Chloride, Albuterol - Status Asthmaticus | Phase 1 | Completed | University Hospitals Cleveland Medical Center | 30 | 2016-09-05 | 2019-04-18 |
| A Prospective Trial of BiPAP Administration vs. Non-positive Pressure Therapy for Pediatric Status Asthmaticus BiPAP treatment - Status Asthmaticus | Not applicable | Withdrawn | Northwell Health | 2016-04-01 | 2016-04-27 | |
| Bilevel Positive Airway Pressure (BiPAP) for the Treatment of Moderate to Severe Acute Asthma Exacerbations Bilevel Positive Airway Pressure (BiPAP) (Trilogy BiPAP, Philips Respironics), Standard care - Asthma, Status Asthmaticus | Not applicable | Withdrawn | University of British Columbia | 2015-04-01 | 2017-09-21 | |
| Pleth Variability and Asthma Severity in Children Status Asthmaticus | Completed | Northwell Health | 37 | 2015-01-01 | 2016-07-26 | |
| Extra-fine Formoterol/Beclomethasone in Asthmatic Crisis Extra fine Formoterol/Beclomethasone - Asthma, Asthmatic Crisis | Phase 4 | Unknown | National Institute of Respiratory Diseases, Mexico | 120 | 2015-01-01 | 2015-04-03 |
| Compare Efficacy Nebulized and Intravenous Magnesium Sulphate in Thai Children isotonic magnesium sulphate, 50% magnesium sulphate - Acute Severe Asthma | Not applicable | Unknown | Queen Sirikit National Institute of Child Health | 40 | 2014-01-01 | 2014-11-18 |
| Intramuscular Epinephrine as an Adjunctive Treatment for Severe Pediatric Asthma Exacerbation IM epinephrine 1:1000, No intervention - Asthma | Phase 4 | Completed | University of Louisville | 49 | 2013-06-01 | 2021-07-06 |
| Evaluation Montelukast in the Treatment of Status Asthmaticus Montelukast, Placebo - Status Asthmaticus | Not applicable | Unknown | Corrie Fletcher | 100 | 2013-01-01 | 2013-02-25 |
Showing 20 of 33. Sign in to see all of them.
Asthma (16) · Respiratory Sounds (3) · Disease (2) · Bronchial Diseases (1) · Dyspnea (1) · Heart Arrest (1) · Respiratory Insufficiency (1) · Status Epilepticus (1)
Hypersensitivity (33) · Hypersensitivity, Immediate (33) · Immune System Diseases (33) · Respiratory Hypersensitivity (33) · Respiratory Tract Diseases (33) · Bronchial Diseases (32) · Asthma (17) · Lung Diseases (16) · Lung Diseases, Obstructive (16) · Pathological Conditions, Signs and Symptoms (6) · Signs and Symptoms (4) · Signs and Symptoms, Respiratory (3) · Pathologic Processes (2) · Respiration Disorders (2) · Cardiovascular Diseases (1)
montelukast (4) · Albuterol (3) · Dexamethasone (3) · Methylprednisolone (3) · Standard of Care (3) · Adrenal Cortex Hormones (2) · Magnesium Sulfate (2) · Prednisone (2) · Saline Solution (2) · Albuterol, Ipratropium Drug Combination (1) · Beclomethasone (1) · Blood Specimen Collection (1) · Budesonide (1) · Calcium Dobesilate (1) · Continuous Positive Airway Pressure (1)
Connecticut Children's Medical Center (2) · Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) (2) · Northwell Health (2) · Southern Illinois University (2) · Akron Children's Hospital (1) · Amphastar Pharmaceuticals, Inc. (1) · Arkansas Children's Hospital Research Institute (1) · Augusta University (1) · Boston Medical Center (1) · Children's Hospital Medical Center, Cincinnati (1) · Columbia University (1) · Corrie Fletcher (1) · Hill-Rom (1) · Hospices Civils de Lyon (1) · Istanbul Medeniyet University (1)
United States (22) · Canada (1) · France (1) · Mexico (1) · Pakistan (1) · Saudi Arabia (1) · Thailand (1) · Turkey (Türkiye) (1) · United Kingdom (1)
Christopher Carroll, MD (2) · Sangita Basnet, MD (2) · Abdullah A Alangari, MBBS (1) · Adrian Martineau (1) · Ariel Brandwein, MD (1) · Corrie Fletcher, DO (1) · Derek S Wheeler, M.D. (1) · Donald H Arnold, MD, MPH (1) · Jeffrey Blumer, MD (1) · Jeffrey C Winer, MD (1) · Jeffrey L. Blumer, M.D., Ph.D. (1) · Jim Shi, M.D., Ph.D. (1) · Jon Roberts, MD (1) · Jose Luis Miguel, MD, MsC (1) · Kerry Caperell, MD (1)
PMID 23949578, PMID 24144222, PMID 24384609, PMID 28639856, PMID 31056949, PMID 32150492, PMID 32960980, PMID 38827880, PMID 39356050
K23HL145126 (1)