6 completed, 2 terminated, 2 withdrawn, 1 not yet recruiting. 5 Not applicable, 5 Phase 1, 3 Phase 2, 2 Phase 3.
Follow Stage II Rectal Cancer: new trials by email Literature Review of Stage II Rectal Cancer trials Research Report on Stage II Rectal Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Quicksilver II Pilot Study Direct-to-surgery (i.e., no neoadjuvant chemotherapy), Control Group - Stage II Rectal Cancer, Stage III Rectal Cancer | Not applicable | Not yet recruiting | Mount Sinai Hospital, Canada | 18 | 2026-09-01 | 2026-07-07 |
| Dasatinib for the Prevention of Oxaliplatin-Induced Neuropathy in Patients With Metastatic Gastrointestinal Cancer Receiving FOLFOX Chemotherapy With or Without Bevacizumab Bevacizumab, Dasatinib, Fluorouracil - Advanced Colorectal Carcinoma, Metastatic Colorectal Carcinoma | Phase 1 | Completed | Anne Noonan | 9 | 2020-09-02 | 2024-12-27 |
| Health Care Coach Support in Reducing Acute Care Use and Cost in Patients With Cancer Best Practice, Laboratory Biomarker Analysis, Supportive Care - Acute Myeloid Leukemia, Brain Glioblastoma | Not applicable | Completed | Stanford University | 128 | 2017-08-08 | 2025-01-24 |
| Randomizing Two Radiotherapy Boost Options to Avoid Rectal Cancer Surgery Complete responders and Non-complete responders, Chemoradiation + EBRT Boost, Chemoradiation + HDRBT Boost - Stage II Rectal Cancer, Organ Preservation | Phase 2 / Phase 3 | Recruiting | Sir Mortimer B. Davis - Jewish General Hospital | 131 | 2017-04-25 | 2026-06-30 |
| Low Glycemic Load Diet in Patients With Stage I-III Colon Cancer questionnaire administration, laboratory biomarker analysis, Standard Dietary Intervention - Stage I Colon Cancer, Stage II Colon Cancer | Not applicable | Completed | Case Comprehensive Cancer Center | 18 | 2015-02-16 | 2018-07-20 |
| Laparoscopic Surgery or Robotic-Assisted Laparoscopic Surgery in Treating Patients With Rectal Cancer That Can Be Removed By Surgery conventional laparoscopic surgery, robotic-assisted laparoscopic surgery, quality-of-life assessment - Recurrent Rectal Cancer, Stage I Rectal Cancer | Not applicable | Withdrawn | City of Hope Medical Center | 2011-12-01 | 2012-04-17 | |
| Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or III Rectal Adenocarcinoma Capecitabine, 5-FU, Leucovorin - Stage II Rectal Cancer, Stage III Rectal Cancer | Phase 1 / Phase 2 | Withdrawn | University of Texas Southwestern Medical Center | 2011-03-01 | 2020-08-20 | |
| Resveratrol in Treating Patients With Colorectal Cancer That Can Be Removed By Surgery resveratrol, pharmacological study, laboratory biomarker analysis - Adenocarcinoma of the Colon, Adenocarcinoma of the Rectum | Phase 1 | Completed | National Cancer Institute (NCI) | 20 | 2006-12-01 | 2014-09-15 |
| Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III Rectal Cancer oxaliplatin, fluorouracil, leucovorin calcium - Adenocarcinoma of the Rectum, Stage II Rectal Cancer | Phase 3 | Terminated | ECOG-ACRIN Cancer Research Group | 355 | 2006-05-11 | 2023-07-06 |
| EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or Non-Small Cell Lung Cancer EF5, motexafin lutetium, pharmacological study - Advanced Adult Primary Liver Cancer, Carcinoma of the Appendix | Not applicable | Terminated | National Cancer Institute (NCI) | 30 | 2004-05-01 | 2013-01-16 |
| Bevacizumab, Fluorouracil, and External-Beam Radiation Therapy in Treating Patients With Stage II or Stage III Rectal Cancer bevacizumab, fluorouracil, external beam radiation therapy - Adenocarcinoma of the Rectum, Stage II Rectal Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 32 | 2002-08-01 | 2013-06-05 |
| Oxaliplatin, Fluorouracil, and External-Beam Radiation Therapy Followed by Surgery in Treating Patients With Locally Advanced Cancer of the Rectum oxaliplatin, fluorouracil, external beam radiation therapy - Adenocarcinoma of the Rectum, Stage II Rectal Cancer | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 24 | 2000-07-01 | 2013-01-16 |
Rectal Neoplasms (12) · Colonic Neoplasms (5) · Pancreatic Neoplasms (3) · Stomach Neoplasms (3) · Bile Duct Neoplasms (2) · Carcinoma, Non-Small-Cell Lung (2) · Esophageal Neoplasms (2) · Gallbladder Neoplasms (2) · Sarcoma (2) · Appendiceal Neoplasms (1) · Bone Neoplasms (1) · Breast Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Ovarian Epithelial (1) · Carcinoma, Renal Cell (1)
Digestive System Diseases (12) · Digestive System Neoplasms (12) · Gastrointestinal Diseases (12) · Gastrointestinal Neoplasms (12) · Intestinal Diseases (12) · Intestinal Neoplasms (12) · Neoplasms (12) · Neoplasms by Site (12) · Rectal Diseases (12) · Colorectal Neoplasms (11) · Colonic Diseases (5) · Endocrine Gland Neoplasms (3) · Endocrine System Diseases (3) · Pancreatic Diseases (3) · Stomach Diseases (3)
Fluorouracil (5) · Oxaliplatin (4) · Bevacizumab (3) · Leucovorin (3) · Capecitabine (1) · Chemoradiotherapy (1) · Control Groups (1) · Dasatinib (1) · Disulfides (1) · Immunoglobulin G (1) · Laparoscopy (1) · Palliative Care (1) · Practice Guidelines as Topic (1) · Radiation (1) · Resveratrol (1)
National Cancer Institute (NCI) (4) · Anne Noonan (1) · Case Comprehensive Cancer Center (1) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · Mount Sinai Hospital, Canada (1) · Sir Mortimer B. Davis - Jewish General Hospital (1) · Stanford University (1) · University of Texas Southwestern Medical Center (1)
United States (10) · Canada (2) · Peru (1) · Puerto Rico (1)
Al Benson (1) · Alessio Pigazzi (1) · Anne M Noonan, MBBChBAO, MSc (1) · Christopher Willett (1) · David Ryan (1) · Dean Brenner (1) · Manali Patel (1) · Michelle Treasure, MD (1) · Stephen Michael Hahn (1) · Te Vuong, MD (1)
PMID 33142018, PMID 34749008, PMID 35771552
P01CA087971 (1), P30CA043703 (1), P30CA046592 (1), U01CA062490 (1), U01CA099118 (1), U10CA021115 (1), U10CA031946 (1)