5 completed, 1 not yet recruiting, 1 recruiting. 7 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 7 | Completed 5, Not yet recruiting 1, Recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
Follow Squamous Intraepithelial Lesions: new trials by email Literature Review of Squamous Intraepithelial Lesions trials Research Report on Squamous Intraepithelial Lesions
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Trial to Evaluate Nonavalent HPV Vaccine as a Secondary Prevention in Patients Treated for Human Papilloma Virus Related High-grade Squamous Intraepithelial Lesions HPV vaccine, Placebo vaccine - Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vulvar Site, Patients With Primary HPV High-grade Squamous Intra-epithelial Lesions (HSIL) at Vaginal Site | Phase 3 | Not yet recruiting | Gustave Roussy, Cancer Campus, Grand Paris | 984 | 2026-05-01 | 2026-02-27 |
| 5-Fluorouracil and Calcipotriene for Treatment of Low Grade Skin Cancer Combination cream of 5-fluorouracil and calcipotriene, 5-fluorouracil cream - Superficial Basal Cell Carcinoma, Squamous Cell Carcinoma in Situ | Phase 2 / Phase 3 | Recruiting | Boston University | 200 | 2022-10-15 | 2025-11-28 |
| REVEAL 2 Trial (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL) VGX-3100, Matched Placebo, CELLECTRA™-5PSP - Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion | Phase 3 | Completed | Inovio Pharmaceuticals | 203 | 2019-02-28 | 2024-10-17 |
| REVEAL 1 (Evaluation of VGX-3100 and Electroporation for the Treatment of Cervical HSIL) VGX-3100, Placebo, Electroporation (EP) - Cervical Dysplasia, Cervical High Grade Squamous Intraepithelial Lesion | Phase 3 | Completed | Inovio Pharmaceuticals | 201 | 2017-06-28 | 2023-07-27 |
| Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions imiquimod, fluorouracil, questionnaire administration - Anal Intraepithelial Neoplasia, High-grade Squamous Intraepithelial Lesion | Phase 3 | Completed | AIDS Malignancy Consortium | 91 | 2015-12-28 | 2025-07-23 |
| Treatment in Preventing Anal Cancer in Patients With HIV and Anal High-Grade Lesions imiquimod, fluorouracil, infrared photocoagulation therapy - Anal Cancer, High-grade Squamous Intraepithelial Lesion | Phase 3 | Completed | AIDS Malignancy Consortium | 4446 | 2014-09-24 | 2024-07-26 |
| Infrared Coagulator Ablation or Observation in Preventing Anal Cancer in HIV-Positive Patients With Anal Neoplasia clinical observation, infrared photocoagulation therapy - Anal Cancer, Neoplasm of Uncertain Malignant Potential | Phase 3 | Completed | AIDS Malignancy Consortium | 120 | 2011-04-01 | 2020-08-04 |
HIV Infections (3) · Anus Neoplasms (2) · Papillomavirus Infections (2) · Uterine Cervical Dysplasia (2) · Acquired Immunodeficiency Syndrome (1) · Precancerous Conditions (1)
Morphological and Microscopic Findings (7) · Pathological Conditions, Signs and Symptoms (7) · Genital Diseases (5) · Urogenital Diseases (5) · Neoplasms (4) · Blood-Borne Infections (3) · Communicable Diseases (3) · Immune System Diseases (3) · Immunologic Deficiency Syndromes (3) · Infections (3) · Lentivirus Infections (3) · RNA Virus Infections (3) · Retroviridae Infections (3) · Sexually Transmitted Diseases (3) · Sexually Transmitted Diseases, Viral (3)
Fluorouracil (2) · Imiquimod (2) · Light Coagulation (2) · VGX-3100 (2) · Watchful Waiting (2) · Electroporation (1) · Laser Therapy (1) · Observation (1) · Papillomavirus Vaccines (1) · calcipotriene (1)
AIDS Malignancy Consortium (3) · Inovio Pharmaceuticals (2) · Boston University (1) · Gustave Roussy, Cancer Campus, Grand Paris (1)
United States (6) · Puerto Rico (4) · Argentina (2) · Estonia (2) · Finland (2) · Lithuania (2) · Poland (2) · South Africa (2) · Spain (2) · Belgium (1) · Brazil (1) · Germany (1) · Italy (1) · Mexico (1) · Peru (1)
Jeffrey Skolnik, MD (2) · Bilal Fawaz, MD (1) · Joel Palefsky, MD (1) · Judith Michels, MD PhD (1) · Stephen E. Goldstone, MD (1) · Timothy Wilkin (1)
PMID 30060087, PMID 33594934, PMID 35416975, PMID 35704479, PMID 40801169
U01CA121947 (3), 2016 (1), 2018 (1), UM1CA121947 (1)