Hair Regrowth Following Partial Thickness Removal of SSCIS

NCT07809191 — Not applicable, Not yet recruiting, 15 participants, The Cooper Health System

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Hair Regrowth Following Partial Thickness Stages in Mohs Micrographic Surgery of Squamous Cell Carcinoma in Situ: A Prospective Pilot Study

Registry	NCT07809191
Status	Not yet recruiting
Phase	Not applicable
Study type	Interventional; na, single group, masking: none, prevention
Enrollment	15 (Estimated)
Sponsor	The Cooper Health System (Other)
Conditions	Squamous Cell Carcinoma (Skin), Squamous Cell Carcinoma in Situ, Alopecia
Interventions	Partial Thickness Excision (Procedure)
Dates	start 2026-09-01 (estimated), primary completion 2027-07-17 (estimated), completion 2028-07-17 (estimated), first posted 2026-09-09, last updated 2026-09-09

-Summary

Participants are being approached to participate in this study because they are undergoing surgery for a skin cancer known as squamous cell carcinoma in situ (SCCIS) on the scalp. Standard surgical techniques may remove deeper structures that contain hair follicles, which can result in permanent hair loss. This study evaluates whether a modified surgical technique, known as partial thickness excision, can preserve hair growth and improve cosmetic outcomes. Participation involves minimal risk beyond the standard risks of Mohs surgery. If patients choose to participate, their surgery will be performed using this technique, and photographs will be taken over time to evaluate hair regrowth and healing.

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+Arms and interventions

Arm	Type	Interventions	Description
Partial Thickness Excision	Experimental	Procedure: Partial Thickness Excision	Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.

Partial Thickness Excision (Procedure): Participants will receive excision of their squamous cell carcinoma in situ of the scalp via partial thickness excision (removal of epidermal and superficial dermal tissue) in an effort to preserve hair follicles and hair growth potential.

+Outcome measures

Primary outcomes

Hair Growth measured clinically by hair density percentage compared to baseline photo [3 and 6 months post-procedure.]: To evaluate hair growth following partial thickness excision of SCCIS at 3 and 6 months post-procedure.

Secondary outcomes

Clearance of SCCIS measured by Mohs surgeons' interpretation of margins on surgical slides. [Immediately following the final Mohs stage during the index procedure]: To assess clinical and histologic clearance of SCCIS treated with partial-thickness excision.
Patient Satisfaction measured via patient satisfaction questionnaire [3 and 6 months post-procedure]: To evaluate patient-reported satisfaction with hair density and cosmetic outcome. "Are you satisfied with amount of hair//appearance of skin/result of treatment?" etc. on scale of 1-10. 1 being not satisfied and 10 being very satisfied/.
Complications [2 weeks post-procedure, 3 months post-procedure, and 6 months post-procedure]: To document wound-healing, complications, and the need for additional treatment.

+Eligibility

Sex: All, ages: 18 Years to any

Inclusion Criteria:

* Adults ≥ 18 years old
* Histologically confirmed SCCIS
* Lesions located in the hair-bearing scalp
* Ability to provide informed consent

Exclusion Criteria:

* Invasive, poorly differentiated, or high-risk SCC features (e.g., perineural invasion)
* Recurrent SCC at the same site
* Prior radiation therapy to the scalp
* Scarring alopecia or active inflammatory scalp disease at the treatment site
* Immunosuppression that, in the investigator's judgement, increases oncologic risk
* Use of topical minoxidil, oral minoxidil, finasteride, spironolactone, or other hair-growth promoting agents