42 terminated. 42 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 42 | Terminated 42 |
Follow Respiratory Hypersensitivity: new trials by email Literature Review of Respiratory Hypersensitivity trials Research Report on Respiratory Hypersensitivity
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Step-up to Medium Strength Triple Therapy vs High Strength ICS/LABA in Adult Asthmatics Uncontrolled on Medium Strength ICS/LABA Administration via pressurized metered dose inhaler (pMDI) - Asthma | Phase 4 | Terminated | Chiesi Farmaceutici S.p.A. | 320 | 2022-02-25 | 2024-11-15 |
| The Effect of NAC on Lung Function and CT Mucus Score n-acetylcystine + albuterol, 0.9% saline + albuterol - Asthma | Phase 4 | Terminated | University of California, San Francisco | 4 | 2019-02-20 | 2026-06-11 |
| Comparison of Dexamethasone Oral Preparations to Assess Taste and Acceptance in Children With Asthma and Croup Dexamethasone IV for PO, Dexamethasone crushed tablets - Asthma, Croup | Phase 4 | Terminated | Vanderbilt University Medical Center | 40 | 2018-10-23 | 2021-11-08 |
| Reducing Exercise-induced Bronchoconstriction in Children With Asthma and Obesity Albuterol Sulfate, Interval Warm-up exercise - Asthma in Children, Obesity, Childhood | Phase 4 | Terminated | University of Nevada, Las Vegas | 34 | 2018-09-18 | 2021-07-22 |
| Comparison of Albuterol for Status Asthmaticus preservative free albuterol - Status Asthmaticus | Phase 4 | Terminated | Norton Healthcare | 8 | 2018-09-10 | 2021-05-20 |
| Inpatient Clinical Trial of NAC N-acetylcysteine - Asthma | Phase 4 | Terminated | University of California, San Francisco | 1 | 2018-07-06 | 2021-10-26 |
| Targeted AntiBiotics for Chronic Pulmonary Diseases Piperacillin/tazobactam, Ciprofloxacin - COPD, Respiratory Tract Infections | Phase 4 | Terminated | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | 51 | 2018-01-10 | 2023-05-25 |
| PRISTINE - Personalised Approach to Improve aSThma prescrIbing iN childrEn Montelukast or Salmeterol or Theophylline or Steroid - Asthma | Phase 4 | Terminated | Brighton and Sussex University Hospitals NHS Trust | 2 | 2017-07-01 | 2019-12-18 |
| An Imaging Study Using PET/CT to Characterize the Effect of Intravenous Reslizumab on Airway Inflammation Reslizumab, Fludeoxyglucose F 18 (FDG), Placebo - Asthma | Phase 4 | Terminated | Teva Branded Pharmaceutical Products R&D, Inc. | 5 | 2017-05-08 | 2021-11-09 |
| Steroids in Children Hospitalized With Asthma Dexamethasone, Prednisone - Asthma, Status Asthmaticus | Phase 4 | Terminated | University of Florida | 6 | 2017-03-20 | 2019-06-21 |
| Effects of Intranasal Fluticasone Plus Azelastine on Airway Inflammation in Patients With Asthma & Allergic Rhinitis Azelastine-Fluticasone Nasal, Placebos - Asthma, Allergic, Rhinitis,Allergic | Phase 4 | Terminated | University of Dundee | 7 | 2017-01-20 | 2019-04-08 |
| C1-inhibitor in Allergic ASThma Patients C1-inhibitor, Saline, Antibiotics - Asthma | Phase 4 | Terminated | T. van der Poll | 37 | 2016-11-16 | 2020-06-24 |
| Clinical Trial of NAC in Asthma n-acetylcystine, 0.9% saline - Asthma | Phase 4 | Terminated | University of California, San Francisco | 1 | 2016-03-01 | 2019-08-20 |
| Sputum-derived Cellular Targets After Xolair (Omalizumab) Omalizumab, Placebo - Asthma | Phase 4 | Terminated | NYU Langone Health | 3 | 2016-01-01 | 2019-09-30 |
| Small Airway Function of Fluticasone/Formoterol (Flutiform®) and Fluticasone/Salmeterol Fluticasone/Formoterol, Fluticasone/Salmeterol - Asthma | Phase 4 | Terminated | Mundipharma Korea Ltd | 15 | 2015-08-31 | 2018-05-16 |
| Effect of Vitamin D as add-on Therapy for Vitamin D Insufficient Patients With Severe Asthma Vitamin D3, Placebo - Asthma | Phase 4 | Terminated | Johannes Gutenberg University Mainz | 54 | 2015-06-26 | 2017-05-01 |
| Azithromycin for Children Hospitalized With Asthma Azithromycin, Placebo - Asthma | Phase 4 | Terminated | Montefiore Medical Center | 159 | 2013-10-01 | 2020-08-13 |
| Comparison of Nebulizers in ED in Pediatric Asthma Patients Hudson RCI® nebulizer, NebuTech® HDN® nebulizer, Albuterol - Asthma | Phase 4 | Terminated | Seton Healthcare Family | 40 | 2013-09-01 | 2021-04-08 |
| Study of Safety of Foradil in Patients With Persistent Asthma Formoterol 12 mcg, Fluticasone propionate 100 mcg, Fluticasone propionate 250 mcg - Persistent Asthma | Phase 4 | Terminated | Novartis Pharmaceuticals | 827 | 2013-05-01 | 2017-03-21 |
| Inhaled Fluticasone Effects on Upper Airway Patency in Obstructive Lung Disease Inhaled Fluticasone Propionate - Asthma, Chronic Obstructive Pulmonary Disease | Phase 4 | Terminated | VA Office of Research and Development | 25 | 2013-03-12 | 2020-02-05 |
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Asthma (35) · Asthma, Exercise-Induced (2) · Pulmonary Disease, Chronic Obstructive (2) · Rhinitis, Allergic, Perennial (2) · Rhinitis, Allergic, Seasonal (2) · Status Asthmaticus (2) · Angioedemas, Hereditary (1) · Aspergillosis, Allergic Bronchopulmonary (1) · Bronchiectasis (1) · Croup (1) · Cystic Fibrosis (1) · Dermatitis (1) · Dermatitis, Atopic (1) · Dyspnea (1) · Hypersensitivity (1)
Hypersensitivity, Immediate (42) · Immune System Diseases (42) · Hypersensitivity (41) · Respiratory Tract Diseases (41) · Bronchial Diseases (37) · Lung Diseases (35) · Lung Diseases, Obstructive (35) · Otorhinolaryngologic Diseases (6) · Pathological Conditions, Signs and Symptoms (6) · Nose Diseases (5) · Rhinitis (4) · Rhinitis, Allergic (4) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (3) · Genetic Diseases, Inborn (3)
Fluticasone (5) · Mometasone Furoate (5) · Albuterol (4) · Fluticasone-Salmeterol Drug Combination (4) · montelukast (4) · Acetylcysteine (3) · Budesonide (3) · Sodium Chloride (3) · Adrenal Cortex Hormones (2) · Azithromycin (2) · Calcium Dobesilate (2) · Ciprofloxacin (2) · Dexamethasone (2) · N-monoacetylcystine (2) · Omalizumab (2)
Novartis Pharmaceuticals (3) · University of California, San Francisco (3) · GlaxoSmithKline (2) · Organon and Co (2) · Teva Branded Pharmaceutical Products R&D, Inc. (2) · University of Alberta (2) · University of Chicago (2) · Apieron (1) · Boehringer Ingelheim (1) · Boston Children's Hospital (1) · Brighton and Sussex University Hospitals NHS Trust (1) · Chiesi Farmaceutici S.p.A. (1) · Chronic Obstructive Pulmonary Disease Trial Network, Denmark (1) · Critical Therapeutics (1) · Duke University (1)
United States (25) · United Kingdom (4) · Canada (3) · Netherlands (3) · Germany (2) · Belgium (1) · Denmark (1) · Hungary (1) · Italy (1)
Irvin Mayers, MD, FRCPC (2) · John Fahy, M.D, M.Sc. (2) · Alyssa H Silver, MD (1) · Brian Lipworth, MD (1) · Chrsitopher Compton (1) · Cornelis Wortel, MD, PhD (1) · Dharini M Bhammar, Ph.D. (1) · Diana S. Lee, MD (1) · Donald Arnold, MD, MPH (1) · Edmund Volkerts, PhD (1) · Eric C Kleerup, MD (1) · Fernando D. Martinez, MD (1) · Jayant M Pinto, MD (1) · Jeffrey C Winer, MD (1)
PMID 18951618, PMID 20674827, PMID 20819468, PMID 24267370, PMID 26302738, PMID 26598458, PMID 27560168, PMID 31238116, PMID 34303860, PMID 35124256, PMID 36596609, PMID 38844921
2014 (1), 2015 (1), P01HL128191 (1), U10HL064287 (1), U10HL064288 (1), U10HL064295 (1), U10HL064305 (1), U10HL064307 (1), U10HL064313 (1)