55 completed, 16 terminated, 4 withdrawn. 35 Phase 1, 33 Phase 2, 7 Not applicable, 5 Phase 3, 1 Early Phase 1.
Follow Recurrent Colon Cancer: new trials by email Literature Review of Recurrent Colon Cancer trials Research Report on Recurrent Colon Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of A166 in Patients With Relapsed/Refractory Cancers Expressing HER2 Antigen or Having Amplified HER2 Gene A166 - HER2-positive Breast Cancer, HER2 Gene Mutation | Phase 1 / Phase 2 | Completed | Klus Pharma Inc. | 49 | 2018-07-16 | 2023-08-03 |
| Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal Cancer That Has Spread to the Liver irinotecan-eluting beads, hepatic artery embolization - Liver Metastases, Mucinous Adenocarcinoma of the Colon | Phase 1 | Terminated | Fox Chase Cancer Center | 2 | 2016-01-29 | 2018-02-26 |
| Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in Treating Patients With Stage IV Colorectal Cancer ziv-aflibercept, leucovorin calcium, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Withdrawn | University of Southern California | 2015-03-01 | 2015-05-06 | |
| CPI-613 and Fluorouracil in Treating Patients With Metastatic Colorectal Cancer That Cannot Be Removed by Surgery 6,8-bis(benzylthio)octanoic acid, fluorouracil, pharmacological study - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | Wake Forest University Health Sciences | 19 | 2015-01-06 | 2023-08-07 |
| MEK Inhibitor MEK162 in Combination With Leucovorin Calcium, Fluorouracil, and Oxaliplatin in Treating Patients With Advanced Metastatic Colorectal Cancer MEK inhibitor MEK162, leucovorin calcium, fluorouracil - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | City of Hope Medical Center | 26 | 2014-07-16 | 2026-10-19 |
| Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer Receiving Combination Chemotherapy ziv-aflibercept, leucovorin calcium, irinotecan hydrochloride - Recurrent Colon Cancer, Recurrent Rectal Cancer | Not applicable | Withdrawn | City of Hope Medical Center | 2014-01-01 | 2014-07-21 | |
| Family Caregiver Palliative Care Intervention in Supporting Caregivers of Patients With Stage II-IV Gastrointestinal, Gynecologic, Urologic and Lung Cancers educational intervention, telephone-based intervention, quality-of-life assessment - Healthy Subject, Localized Transitional Cell Cancer of the Renal Pelvis and Ureter | Not applicable | Completed | City of Hope Medical Center | 200 | 2013-10-29 | 2026-10-01 |
| Comprehensive Gene Sequencing in Guiding Treatment Recommendations Patients With Metastatic or Recurrent Solid Tumors cytology specimen collection procedure, laboratory biomarker analysis - Recurrent Breast Cancer, Recurrent Colon Cancer | Completed | Ohio State University Comprehensive Cancer Center | 150 | 2013-09-03 | 2021-10-28 | |
| Irinotecan and Alisertib in Treating Patients With Advanced Solid Tumors or Colorectal Cancer irinotecan hydrochloride, alisertib - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 1 | Completed | University of California, Davis | 17 | 2013-08-01 | 2019-01-04 |
| PET-MRI in Diagnosing Patients With Colon or Rectal Cancer positron emission tomography, computed tomography, magnetic resonance imaging - Recurrent Colon Cancer, Recurrent Rectal Cancer | Not applicable | Completed | Case Comprehensive Cancer Center | 15 | 2013-04-01 | 2021-05-18 |
| 18F-FPPRGD2 PET/CT or PET/MRI in Predicting Early Response in Patients With Cancer Receiving Anti-Angiogenesis Therapy 18F-fludeoxyglucose (18F-FDG), 18F-FPPRGD2 - Adult Giant Cell Glioblastoma, Adult Glioblastoma | Phase 1 / Phase 2 | Completed | Sanjiv Sam Gambhir | 25 | 2013-03-04 | 2019-10-03 |
| Ipilimumab and Local Radiation for Selected Solid Tumors Ipilimumab, Radiation therapy - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Terminated | Stanford University | 3 | 2013-02-01 | 2024-01-24 |
| Panitumumab and Chemotherapy in Patients With Advanced Colorectal Cancer After Prior Therapy With Bevacizumab panitumumab, irinotecan hydrochloride, fluorouracil - Mucinous Adenocarcinoma of the Colon, Mucinous Adenocarcinoma of the Rectum | Phase 2 | Completed | John Hays | 16 | 2013-02-01 | 2025-02-05 |
| Selumetinib and Cetuximab in Treating Patients With Refractory Solid Tumors selumetinib, cetuximab, laboratory biomarker analysis - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | National Cancer Institute (NCI) | 33 | 2012-10-01 | 2014-05-29 |
| Vaccine Therapy in Treating Patients With Colorectal, Stomach, or Pancreatic Cancer laboratory biomarker analysis, enzyme-linked immunosorbent assay, flow cytometry - Recurrent Colon Cancer, Recurrent Gastric Cancer | Phase 1 | Completed | City of Hope Medical Center | 12 | 2011-12-22 | 2026-10-19 |
| Radiolabeled Monoclonal Antibody Therapy, Combination Chemotherapy, and Bevacizumab in Treating Patients With Metastatic Colorectal Cancer irinotecan hydrochloride, leucovorin calcium, fluorouracil - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | City of Hope Medical Center | 3 | 2011-08-30 | 2026-10-16 |
| Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer linifanib - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 2 | Terminated | Vanderbilt-Ingram Cancer Center | 30 | 2011-06-01 | 2014-08-26 |
| Supportive Intervention Programs Study Yoga therapy, questionnaire administration, quality-of-life assessment - Fatigue, Nausea and Vomiting | Not applicable | Completed | Wake Forest University | 15 | 2011-06-01 | 2018-08-15 |
| Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal Antibody Therapy in Treating Liver Metastases in Patients With Metastatic Colorectal Cancer oxaliplatin, leucovorin calcium, fluorouracil - Liver Metastases, Recurrent Colon Cancer | Phase 2 | Terminated | City of Hope Medical Center | 1 | 2011-03-01 | 2016-07-19 |
| Study of AUY922 and Cetuximab in Patients With KRAS Wild-Type Metastatic Colorectal Cancer AUY922, Cetuximab - Recurrent Colon Cancer, Recurrent Rectal Cancer | Phase 1 | Completed | Swedish Medical Center | 20 | 2011-02-01 | 2015-06-08 |
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Colonic Neoplasms (75) · Rectal Neoplasms (69) · Pancreatic Neoplasms (13) · Breast Neoplasms (11) · Salivary Gland Neoplasms (10) · Stomach Neoplasms (10) · Carcinoma, Non-Small-Cell Lung (9) · Carcinoma, Ovarian Epithelial (8) · Breast Neoplasms, Male (7) · Carcinoma, Hepatocellular (7) · Carcinoma, Renal Cell (7) · Esthesioneuroblastoma, Olfactory (7) · Squamous Cell Carcinoma of Head and Neck (7) · Appendiceal Neoplasms (5) · Bile Duct Neoplasms (5)
Colonic Diseases (74) · Digestive System Diseases (74) · Digestive System Neoplasms (74) · Gastrointestinal Diseases (74) · Intestinal Diseases (74) · Intestinal Neoplasms (74) · Neoplasms by Site (74) · Gastrointestinal Neoplasms (72) · Neoplasms (72) · Colorectal Neoplasms (70) · Rectal Diseases (68) · Neoplasms by Histologic Type (22) · Neoplasms, Glandular and Epithelial (19) · Endocrine Gland Neoplasms (17) · Endocrine System Diseases (17)
Fluorouracil (20) · Leucovorin (18) · Oxaliplatin (15) · Irinotecan (14) · Bevacizumab (11) · Cetuximab (11) · Capecitabine (6) · Erlotinib Hydrochloride (6) · 2,2-dimethyl-N-(6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-N'-(2,2,3,3,3-pentafluoropropyl)malonamide (3) · Floxuridine (3) · Fluorodeoxyglucose F18 (3) · aflibercept (3) · Dasatinib (2) · Early Intervention, Educational (2) · Gene Expression Profiling (2)
National Cancer Institute (NCI) (44) · City of Hope Medical Center (7) · Fox Chase Cancer Center (3) · Ohio State University Comprehensive Cancer Center (3) · University of Southern California (2) · Wake Forest University Health Sciences (2) · Abramson Cancer Center at Penn Medicine (1) · Alliance for Clinical Trials in Oncology (1) · Burzynski Research Institute (1) · Case Comprehensive Cancer Center (1) · John Hays (1) · Klus Pharma Inc. (1) · National Institutes of Health Clinical Center (CC) (1) · Roswell Park Cancer Institute (1) · Sanjiv Sam Gambhir (1)
United States (73) · Canada (3)
Marwan Fakih (3) · Jeffrey Wong (2) · Wells Messersmith (2) · William Schelman (2) · Afsaneh Barzi (1) · Alain Mita (1) · Allyson Ocean (1) · Amit Oza (1) · Antonius Miller (1) · Axel Grothey, MD (1) · Barbara Burtness (1) · Betty Ferrell (1) · Bruce Giantonio (1) · Caio Rocha Lima, MD (1) · Cathy Eng (1)
PMID 17634125, PMID 20048179, PMID 21208843, PMID 24583822, PMID 24987057, PMID 25965900, PMID 26062933, PMID 26611425, PMID 30850872, PMID 32201506, PMID 32375690, PMID 32641862, PMID 32692450, PMID 33993383
P30CA014520 (3), U01CA062491 (3), U10CA025224 (3), N01CM17003 (2), N01CM62201 (2), N01CM62202 (2), P30CA068485 (2), U01CA069856 (2), U01CA070095 (2), U10CA021115 (2), U10CA032102 (2), N01CM00038 (1), N01CM00099 (1), N01CM17101 (1), N01CM17102 (1)