298 completed. 298 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 298 | Completed 298 |
Follow Pulmonary Disease, Chronic Obstructive: new trials by email Literature Review of Pulmonary Disease, Chronic Obstructive trials Research Report on Pulmonary Disease, Chronic Obstructive
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Comparative Effects of Triple Inhaled Therapy With Budesonide/Glycopyrronium/Formoterol Versus Fluticasone Furoate/Umeclidinium/Vilanterol on Small Airway Disease in COPD Patients: A Randomized Crossover Study Budesonide/Glycopyrronium/Formoterol (BGF), Fluticasone Furoate/Umeclidinium/Vilanterol (FUV) - COPD, Chronic Obstructive Pulmonary Disease (COPD) | Phase 4 | Completed | Thammasat University | 22 | 2025-04-01 | 2026-02-02 |
| A Randomized, Safety and Efficacy Study of Taneasy 600mg Granules and Fluimucil 600mg Granules in COPD Subjects Taneasy 600mg granules, Fluimucil 600mg granules - COPD (Chronic Obstructive Pulmonary Disease) | Phase 4 | Completed | Bun Yao Biotechnology Co., Ltd | 45 | 2025-02-20 | 2025-09-18 |
| The Safety and Effectiveness of Taneasy and Actein in COPD Patients Taneasy 600mg granules, Actein effervescent 600mg - COPD (Chronic Obstructive Pulmonary Disease) | Phase 4 | Completed | Bun Yao Biotechnology Co., Ltd | 42 | 2024-09-20 | 2025-02-05 |
| Effects of Oral Doxofylline and Procaterol on Chronic Obstructive Pulmonary Disease Doxofylline, Procaterol - COPD | Phase 4 | Completed | Thammasat University | 20 | 2024-03-01 | 2025-01-20 |
| Live Vaccines and Innate Immune Training in COPD. BCG vaccine (Danish strain 1331), MMR Vaccine, Placebo - Trained Innate Immunity, COPD | Phase 4 | Completed | Josefin Eklöf | 60 | 2024-02-28 | 2026-03-19 |
| A Study to Explore if Long-term Use of Mucinex Can Help With Symptoms in Patients With Stable Chronic Bronchitis. Guafenesin tablets - Chronic Bronchitis | Phase 4 | Completed | American Health Research | 82 | 2023-07-17 | 2026-03-20 |
| A Study to Evaluate the Safety and Efficacy of Fluticasone Furoate (FF)/Umeclidinium(UMEC)/Vilanterol (VI) in Participants With Chronic Obstructive Pulmonary Disease (COPD) FF/UMEC/VI, ELLIPTA - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | GlaxoSmithKline | 229 | 2023-06-06 | 2025-03-24 |
| To Evaluate Real-World Effectiveness of Fluticasone Furoate/Umeclidinium Bromide/Vilanterol (FF/UMEC/VI) in a Single Inhaler (Trelegy Ellipta) in Participants With Symptomatic COPD FF/UMEC/VI - Pulmonary Disease, Chronic Obstructive | Phase 4 | Completed | GlaxoSmithKline | 463 | 2022-10-14 | 2025-12-11 |
| A Study to Evaluate the Efficacy and Safety of Sitafloxacin in Adult Subjects With Acute Exacerbation of Chronic Obstructive Pulmonary Disease Sitafloxacin, Moxifloxacin Hydrochloride - COPD Exacerbation Acute | Phase 4 | Completed | Daiichi Sankyo | 140 | 2022-08-10 | 2025-01-09 |
| Outcomes of Once-Daily ICS/LABA/LAMA + PRN Respiratory Therapy Treatments in Hospitalized Patients With COPD Exacerbations TRELEGY ELLIPTA 100Mcg-62.5Mcg-25Mcg/Actuation Powder for Inhalation - Copd | Phase 4 | Completed | Baylor Research Institute | 80 | 2022-07-01 | 2025-11-21 |
| Phase 4 COPD and Suboptimal Inspiratory Flow Rate Revefenacin, Tiotropium, Revefenacin Placebo - Chronic Obstructive Pulmonary Disease | Phase 4 | Completed | Theravance Biopharma | 404 | 2022-01-07 | 2024-12-20 |
| CHF5993 and CHF1535 pMDI on Lung Hyperinflation and Exercise Endurance Time in Subjects With COPD CHF5993, CHF1535, Matched placebo - Chronic Obstructive Pulmonary Disease | Phase 4 | Completed | Chiesi Farmaceutici S.p.A. | 106 | 2021-10-28 | 2023-03-24 |
| Eosinophil-guided Reduction of Inhaled Corticosteroids Azithromycin, ICS - COPD, Inhaled Corticosteroid | Phase 4 | Completed | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | 444 | 2021-06-28 | 2026-01-28 |
| Effect of Dual Bronchodilation With Umeclidinium/Vilanterol on Patients With COPD, Hyperinflation and Heart Failure Umeclidinium/vilanterol, Placebo - Copd, Heart Failure | Phase 4 | Completed | Luis Puente Maestu | 60 | 2021-05-21 | 2026-09-21 |
| Comparison of Time to Extubation Using Sugammadex or Neostigmine neostigmine/glycopyrrolate, sugammadex - Neuromuscular Blockade, Chronic Obstructive Pulmonary Disease | Phase 4 | Completed | Temple University | 58 | 2021-04-08 | 2024-03-13 |
| Peak Inspiratory Flow and Dry Powder Inhaler Performance in COPD Trelegy Ellipta 100/62.5/25Mcg Inh 30D, Ventolin 90Mcg/Actuation Inhalation Aerosol - COPD | Phase 4 | Completed | Pulmonary Research Institute of Southeast Michigan | 30 | 2020-12-02 | 2023-05-08 |
| Bacillus Calmette-guérin Vaccination to Prevent COVID-19 BCG vaccine, Placebo - COVID-19, Virus Diseases | Phase 4 | Completed | Hellenic Institute for the Study of Sepsis | 301 | 2020-05-26 | 2021-05-11 |
| Association of Cathelicidin and Vitamin D Levels With the Category and Course of COPD Cholecalciferol Liquid - Chronic Obstructive Pulmonary Disease, Chronic Obstructive Pulmonary Disease Moderate | Phase 4 | Completed | Karaganda Medical University | 120 | 2020-02-18 | 2024-04-12 |
| Copd Exacerbation and Pulmonary Hypertension Trial Sildenafil - Acute Exacerbation of COPD | Phase 4 | Completed | Chronic Obstructive Pulmonary Disease Trial Network, Denmark | 250 | 2020-02-01 | 2025-03-13 |
| Effects of Spiolto® Respimat® (Tiotropium/Olodaterol) on Cardiac Function in Hyperinflated COPD Subjects Olodaterol-Tiotropium - Chronic Obstructive Pulmonary Disease | Phase 4 | Completed | Fraunhofer-Institute of Toxicology and Experimental Medicine | 32 | 2020-01-28 | 2023-04-26 |
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Emphysema (21) · Asthma (18) · Bronchitis, Chronic (16) · Dyspnea (14) · Motor Activity (14) · Bronchitis (11) · Lung Diseases (9) · Lung Diseases, Obstructive (7) · Inflammation (4) · Pneumonia (4) · Respiratory Aspiration (4) · Coronary Artery Disease (3) · Disease (3) · Heart Failure (3)
Chronic Disease (298) · Disease Attributes (298) · Pathologic Processes (298) · Pathological Conditions, Signs and Symptoms (298) · Respiratory Tract Diseases (295) · Lung Diseases, Obstructive (291) · Lung Diseases (289) · Bronchial Diseases (45) · Infections (35) · Respiratory Tract Infections (32) · Behavior (24) · Immune System Diseases (20) · Respiration Disorders (20) · Hypersensitivity (18) · Hypersensitivity, Immediate (18)
Tiotropium Bromide (57) · Salmeterol Xinafoate (28) · Fluticasone (27) · Formoterol Fumarate (26) · Albuterol (18) · Budesonide (18) · indacaterol (17) · Glycopyrrolate (13) · Ipratropium (11) · Budesonide, Formoterol Fumarate Drug Combination (9) · Fluticasone-Salmeterol Drug Combination (9) · Acetazolamide (8) · aclidinium bromide (8) · Roflumilast (7) · Acetylcysteine (6)
GlaxoSmithKline (35) · Boehringer Ingelheim (30) · Novartis Pharmaceuticals (21) · AstraZeneca (15) · University of Zurich (13) · University of Dundee (7) · University of Milan (7) · Queen's University (6) · Neutec Ar-Ge San ve Tic A.Ş (5) · Chronic Obstructive Pulmonary Disease Trial Network, Denmark (3) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (3) · Imperial College London (3) · Johns Hopkins University (3) · Laval University (3) · National Institute of Respiratory Diseases, Mexico (3)
United States (75) · Germany (45) · United Kingdom (40) · Canada (35) · Spain (31) · Netherlands (28) · Italy (27) · Belgium (20) · Denmark (20) · France (18) · Russia (14) · Sweden (14) · China (13) · Argentina (12) · Turkey (Türkiye) (12)
Konrad E Bloch, MD (11) · Talant M Sooronbaev, MD (10) · Denis E O'Donnell, MD (3) · Pierachille Santus, MD, PhD (3) · Silvia Ulrich, MD (3) · Tomas Andersson, MD (3) · Denis E O'Donnell, MD, FRCPC (2) · James Chalmers, MBChB, MRCP (2) · Narongkorn Saiphoklang, MD (2)
PMID 11019457, PMID 16322646, PMID 16799080, PMID 17310045, PMID 17951621, PMID 18625750, PMID 18804362, PMID 19897551, PMID 21428765, PMID 23613569, PMID 29763572, PMID 39756820, PMID 8810608, PMID 10430726, PMID 11401887, PMID 11491153, PMID 11549531, PMID 12114338, PMID 12204862, PMID 12570114, PMID 15229100, PMID 15591470, PMID 15764761, PMID 16055868, PMID 16055882, PMID 16113473, PMID 16135736, PMID 16144890, PMID 16157462, PMID 16203030, PMID 16235327, PMID 16310554, PMID 16396956, PMID 16844726, PMID 16914336, PMID 17088091, PMID 17532532, PMID 17605774, PMID 17646228, PMID 17678942, PMID 17765528, PMID 17951276, PMID 18162137, PMID 18403672, PMID 18479895, PMID 18550609, PMID 18584227, PMID 18836213, PMID 19208459, PMID 19229704
2017 (12), 2015 (5), 2014 (4), 2016 (4), 2018 (2), 2019 (2), 2008 (1), 2009 (1), P50HL084945 (1)