8 completed, 1 active not recruiting, 1 recruiting, 1 terminated. 10 Not applicable, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 7, Active not recruiting 1, Recruiting 1, Unknown 1 |
| Phase 1 | 2 | Completed 1, Terminated 1 |
| Phase 3 | 1 | Withdrawn 1 |
Follow Pre-diabetic: new trials by email Literature Review of Pre-diabetic trials Research Report on Pre-diabetic
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| The GRoceries Aimed at Increasing Nutrition Study Marketing Nudges Only, Marketing Nudges + Dynamically Adapted Financial Incentives - Type 2 Diabetes, Type II Diabetes Mellitus | Not applicable | Active not recruiting | University of Pennsylvania | 219 | 2025-10-14 | 2026-10-20 |
| Targeted Precision Nutrition Strategy To Prevent Chronic Metabolic Diseases Optimal Metabotype-specific diet, Sub-optimal diet - Obesity and Overweight, Pre-diabetic | Not applicable | Recruiting | Maastricht University Medical Center | 240 | 2025-04-23 | 2026-01-20 |
| Effect of 1,25-dihydroxyvitamin D3, Treatment on Insulin Secretion and Muscle Strength in Pre-diabetic Persons Calcitriol capsules, Oral Placebo - Pre-Diabetic | Phase 1 | Terminated | Mayo Clinic | 17 | 2020-10-01 | 2022-04-18 |
| Personalized Glucose Optimization Through Nutritional Intervention Optimal diet, Suboptimal diet - Obesity, Pre-diabetic | Not applicable | Completed | Maastricht University Medical Center | 242 | 2018-06-04 | 2022-02-14 |
| Glucagon-like Peptide-1 Metabolism and Acute Neprilysin Inhibition Sacubitril/Valsartan 200mg (blinded), Valsartan 160mg (blinded) - Diabetes Mellitus, Type 2, Pre-diabetic | Phase 3 | Withdrawn | University of Pennsylvania | 2018-06-01 | 2026-09-21 | |
| The Effect of Insoluble Yeast Beta-glucan Intake on Pre-diabetic Patients Yeast Beta-glucan, Placebo - Pre-diabetic | Not applicable | Unknown | Huazhong University of Science and Technology | 52 | 2018-03-13 | 2018-04-12 |
| The Effect of Acute Lysine Administration on α-aminoadipic Acid L-Lysine, Normal (0.9%) Saline - Healthy, Pre-diabetic | Phase 1 | Completed | Vanderbilt University | 13 | 2016-05-01 | 2017-02-07 |
| Feasibility of an Interval Exercise and Nutrition Intervention to Reduce Cardiovascular Disease Risk Factors Exercise & Dietary Supplement - Pre-Diabetic, Overweight | Not applicable | Completed | University of North Carolina, Chapel Hill | 15 | 2015-05-01 | 2017-04-14 |
| The Effect of Oral Carnitine Supplementation on MRS-derived Mitochondrial Function Acute Exercise - Elderly, Pre-diabetic | Not applicable | Completed | Duke University | 14 | 2014-06-01 | 2015-06-17 |
| Investigation of the Ability of a Supplement to Increase Good Bacteria in the Human Intestine and Blood Sugar Levels Sugar Pill, XOS 2.8 - Pre-diabetic | Not applicable | Completed | University of California, Los Angeles | 18 | 2013-09-01 | 2017-03-01 |
| Evaluation of the Ottawa Model for Smoking Cessation in Diabetes Education Programs Ottawa Model for Smoking Cessation - Pre-diabetic, Diabetic Type II Mellitus | Not applicable | Completed | Ottawa Heart Institute Research Corporation | 313 | 2013-07-01 | 2022-04-20 |
| A Mobile Based Diabetes Prevention Program Mobile phone based physical activity with intervention, Pedometer Only - Sedentary Lifestyle, Physical Activity | Not applicable | Completed | University of California, San Francisco | 61 | 2012-05-01 | 2014-07-17 |
| Effects of a Wholegrain Diet on Body Composition and Energy Balance Whole grains - Overweight, Obesity | Not applicable | Completed | The Cleveland Clinic | 35 | 2010-06-01 | 2017-01-10 |
Glucose Intolerance (13) · Diabetes Mellitus, Type 2 (5) · Obesity (4) · Insulin Resistance (3) · Overweight (3) · Motor Activity (2) · Prediabetic State (2) · Chronic Disease (1) · Diabetes Mellitus (1) · Hypertension (1) · Sedentary Behavior (1)
Glucose Metabolism Disorders (13) · Hyperglycemia (13) · Metabolic Diseases (13) · Nutritional and Metabolic Diseases (13) · Endocrine System Diseases (6) · Diabetes Mellitus (5) · Pathological Conditions, Signs and Symptoms (5) · Body Weight (4) · Nutrition Disorders (4) · Overnutrition (4) · Signs and Symptoms (4) · Hyperinsulinism (3) · Behavior (2) · Cardiovascular Diseases (1) · Disease Attributes (1)
Exercise (2) · Body Composition (1) · Calcitriol (1) · Diet (1) · Dietary Supplements (1) · Lysine (1) · Methods (1) · Sodium Chloride (1) · Sugars (1) · Valsartan (1) · Whole Grains (1) · sacubitril (1) · sacubitril and valsartan sodium hydrate drug combination (1)
Maastricht University Medical Center (2) · University of Pennsylvania (2) · Duke University (1) · Huazhong University of Science and Technology (1) · Mayo Clinic (1) · Ottawa Heart Institute Research Corporation (1) · The Cleveland Clinic (1) · University of California, Los Angeles (1) · University of California, San Francisco (1) · University of North Carolina, Chapel Hill (1) · Vanderbilt University (1)
United States (8) · Netherlands (2) · Canada (1) · China (1)
Abbie Smith-Ryan, PhD (1) · Aiken Debbie, BScN (1) · Andrew Pipe, MD, FRCPC (1) · Anil Gupta, MD, FRCPC (1) · David Arbeau, BA, BTech, RT (1) · David Heber, MD, PhD (1) · Ellen E Blaak, Prof. (1) · Ellen E Blaak, Prof. Dr. Ir. (1) · Jane F Ferguson, PhD (1) · Jessica R Wilson, MD, MSCI (1) · John P. Kirwan, Ph.D. (1) · Kocourek Jana, MA (1) · Malcolm Janine, MD, FRCPC (1) · Mullen Kerri-Anne, MSc. (1) · Oh Paul, MD, FRCPC (1)
PMID 26300782, PMID 27798329, PMID 29269509, PMID 29305946, PMID 34277687, PMID 34337406, PMID 34805723, PMID 36599304, PMID 38594756, PMID 38851634, PMID 40336254, PMID 42097279, PMID 42191942
P30AG034546 (1)