12 completed, 2 recruiting, 1 unknown. 10 Not applicable, 4 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 10 | Completed 10 |
| Phase 1 | 4 | Completed 2, Recruiting 1, Unknown 1 |
| Phase 2 | 2 | Recruiting 2 |
Follow Lysine: new trials by email Literature Review of Lysine trials Research Report on Lysine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| RYZ101 for the Treatment of Progressive or Recurrent Intracranial Meningioma Actinium Ac 225 DOTATATE RYZ101, Biospecimen Collection, Computed Tomography - Recurrent Meningioma | Phase 1 / Phase 2 | Recruiting | Joshua Palmer | 30 | 2025-11-12 | 2026-08-13 |
| Leucine in Midlife Depression L-leucine, L-lysine - Major Depression | Phase 2 | Recruiting | Emory University | 75 | 2025-02-01 | 2026-09-11 |
| Effect of Lysine and Phosphorus Fortification on Glycemic Index and Postprandial Glycemia in Double Fortified Bread Control Group - Standard White Bread, Lysine Group - Lysine-Fortified Bread, Phosphorus Group - Phosphorus-Fortified Bread - Hyperglycemia, Glucose Metabolism Disorders | Not applicable | Completed | University of Veterinary and Animal Sciences, Lahore - Pakistan | 16 | 2023-11-13 | 2024-11-12 |
| Determinants of Alpha-aminoadipic Acid (2-AAA) and Relationship to Diabetes: Study 3 L-Lysine, Normal Saline - Diabetes Mellitus, Type 2 | Phase 1 | Completed | Vanderbilt University Medical Center | 23 | 2022-03-09 | 2024-06-05 |
| Determinants of Alpha-aminoadipic Acid (2-AAA) and Relationship to Diabetes: Study 2 Lysine, Controlled Diet - Healthy | Not applicable | Completed | Vanderbilt University Medical Center | 67 | 2020-08-17 | 2023-12-21 |
| The Effect of Bread Fortification With Phosphorus and Lysine on Postprandial Glycaemia and Thermogenesis lysine and phosphorus - Postprandial Hyperglycemia, Energy Expenditure | Not applicable | Completed | American University of Beirut Medical Center | 16 | 2019-02-06 | 2025-10-06 |
| Treatment Using 177Lu-DOTA-EB-TATE in Patients With Advanced Neuroendocrine Tumors 177Lu-DOTA-EB-TATE 1, 177Lu-DOTA-TATE, 177Lu-DOTA-EB-TATE 2 - Neuroendocrine Tumors | Phase 1 | Unknown | Peking Union Medical College Hospital | 60 | 2017-04-30 | 2022-08-31 |
| The Effect of Acute Lysine Administration on α-aminoadipic Acid L-Lysine, Normal (0.9%) Saline - Healthy, Pre-diabetic | Phase 1 | Completed | Vanderbilt University | 13 | 2016-05-01 | 2017-02-07 |
| Randomized Controlled Trial in South Africa Comparing the Efficacy of Complementary Food Products on Child Growth Fortified fat-based paste with essential fatty acids, DHA, ARA, phytase, L-lysine, potassium, phosphorous, magnesium and manganese, Fortified fat-based paste with essential fatty acids - Malnutrition | Not applicable | Completed | North-West University, South Africa | 750 | 2013-09-01 | 2017-11-30 |
| The Effect of L-lysine on Human Gastrointestinal Secretion: A Dose-finding Study Applying Magnetic Resonance Imaging (MRI) L-lysine - Healthy | Not applicable | Completed | University of Zurich | 6 | 2012-04-01 | 2015-05-28 |
| Effects of L-lysine on Adrenal Secretion L-lysine, placebo - Male, Healthy Volunteers | Not applicable | Completed | University Hospital, Rouen | 20 | 2010-10-01 | 2026-04-16 |
| L-lysine in Treating Oral Mucositis in Patients Undergoing Radiation Therapy With or Without Chemotherapy For Head and Neck Cancer quality-of-life assessment, management of therapy complications, L-lysine - Mucositis, Oral Complications of Chemotherapy | Not applicable | Completed | University of Washington | 10 | 2010-09-01 | 2013-05-17 |
| Estrogen and Serotonin on Changing Brain Chemistry estrogen patch, Amino acids, Placebo Patch - Menopause | Not applicable | Completed | University of Colorado, Denver | 47 | 2010-03-04 | 2021-04-02 |
| Muscle Regrowth During Physical Rehabilitation and Amino Acid Supplementation Essential amino acids, Alanine - Osteoarthritis | Not applicable | Completed | University of Oregon | 60 | 2008-06-01 | 2014-12-04 |
| An Exploratory Open Label Study of Adjunctive L-lysine Treatment in Patients With Schizophrenia L-lysine - Schizophrenia | Not applicable | Completed | Göteborg University | 10 | 2007-09-01 | 2009-10-16 |
Hyperglycemia (2) · Depressive Disorder, Major (1) · Diabetes Mellitus, Type 2 (1) · Glucose Intolerance (1) · Glucose Metabolism Disorders (1) · Inflammation (1) · Malnutrition (1) · Memory Disorders (1) · Meningioma (1) · Metabolic Diseases (1) · Mucositis (1) · Neuroendocrine Tumors (1) · Osteoarthritis (1) · Salivary Gland Neoplasms (1) · Schizophrenia (1)
Vanderbilt University Medical Center (2) · American University of Beirut Medical Center (1) · Emory University (1) · Göteborg University (1) · Joshua Palmer (1) · North-West University, South Africa (1) · Peking Union Medical College Hospital (1) · University Hospital, Rouen (1) · University of Colorado, Denver (1) · University of Oregon (1) · University of Veterinary and Animal Sciences, Lahore - Pakistan (1) · University of Washington (1) · University of Zurich (1) · Vanderbilt University (1)
United States (7) · China (1) · France (1) · Lebanon (1) · Pakistan (1) · South Africa (1) · Sweden (1) · Switzerland (1)
Cornelius M Smuts, PhD (1) · Cynthia Neill Epperson, M.D. (1) · Ebrahim Haroon, MD (1) · Hans C Dreyer, PT, PhD (1) · Jane F Ferguson, PhD (1) · Jane Ferguson, PhD (1) · Joshua D Palmer, MD (1) · Mah Noor, MPhil (1) · Omar Obeid, PhD (1) · Upendra Parvathaneni (1) · Werner Schwizer, Prof. MD (1) · Zhaohui Zhu, M.D.,PhD (1)
PMID 19553295, PMID 21501494, PMID 22204954, PMID 24135139, PMID 25100072, PMID 26514124, PMID 27269925, PMID 28103616, PMID 30649163, PMID 30965074, PMID 31832728, PMID 36132073, PMID 37075254
K01HD057332 (1), P50MH099910 (1), R01DK117144 (1), R01MH132059 (1)