25 completed, 14 unknown, 4 recruiting, 3 terminated. 14 Phase 4, 9 Phase 2, 8 Not applicable, 7 Phase 1, 5 Phase 3.
Follow Polypoidal Choroidal Vasculopathy: new trials by email Literature Review of Polypoidal Choroidal Vasculopathy trials Research Report on Polypoidal Choroidal Vasculopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Trial of the Efficacy and Safety of a Personalized Regimen of High-dose Aflibercept 8mg on Treatment-naive Polypoidal Choroidal Vasculopathy: the PALLAS Trial aflibercept 8 mg - Polypoidal Choroidal Vasculopathy, Polypoidal Choroidal Vasculopathy (PCV) | Phase 3 | Recruiting | Yeungnam University College of Medicine | 50 | 2026-12-24 | 2026-02-05 |
| Speculum-Free Intravitreal Injection Using Cotton-Tipped Applicator Retraction: Pain, Procedure Time, Patient Satisfaction, and Safety Eyelid Speculum Retraction, Cotton-Tipped Applicator Retraction - Neovascular Age-Related Macular Degeneration (nAMD), Diabetic Macular Edema | Not applicable | Active not recruiting | Jakkrit Juhong | 129 | 2026-09-09 | 2026-09-25 |
| Efficacy and Durability of a Personalized Treat-and-extend Regimen of Faricimab for Treatment-naive Polypoidal Choroidal Vasculopathy Faricimab Injection [Vabysmo] - Polypoidal Choroidal Vasculopathy (PCV), Age Related Macular Degeneration | Phase 3 | Recruiting | Yeungnam University College of Medicine | 50 | 2026-03-01 | 2026-03-10 |
| A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV) Aflibercept Intravitreous Injection - Polypoidal Choroidal Vasculopathy (PCV), Neovascular Age Related Macular Degeneration (AMD) | Phase 4 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 174 | 2026-01-01 | 2026-01-26 |
| Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO) Faricimab Injection [Vabysmo] - Polypoidal Choroidal Vasculopathy | Phase 4 | Recruiting | Association for Innovation and Biomedical Research on Light and Image | 120 | 2025-08-06 | 2026-02-06 |
| Study Assessing the Efficacy and Safety of a Personalized Monotherapy Regimen of Brolucizumab in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy Brolucizumab 6mg - Macular Polypoidal Choroidal Vasculopathy (PCV) | Phase 3 | Completed | Novartis Pharmaceuticals | 148 | 2023-02-06 | 2025-12-15 |
| Outcomes of Tolerating Subretinal Fluid in Type 1 MNV and PCV Intravitreal aflibercept injection - Polypoidal Choroidal Vasculopathy, Choroidal Neovascularization | Completed | Kim's Eye Hospital | 135 | 2022-12-05 | 2023-12-14 | |
| Comparing Intravitreal Aflibercept Monotherapy vs Aflibercept Combined With Reduced Fluence PDT in PCV Treatment Aflibercept + reduced fluence photodynamic therapy (RF-PDT), Aflibercept + sham reduced fluence photodynamic therapy (RF-PDT) - Polypoidal Choroidal Vasculopathy | Not applicable | Completed | Singapore National Eye Centre | 60 | 2021-02-01 | 2025-11-18 |
| Clinical Implication of Aflibercept in PCV Treatment in China non-interventional - Polypoidal Choroidal Vasculopathy | Unknown | Peking Union Medical College Hospital | 1000 | 2021-01-01 | 2022-12-06 | |
| Interval of Disease Inactivity After Complete Polypoidal Regression in PCV Receiving Aflibercept Aflibercept Injection (2 mg/0.05 ml), Defer treatment - Polypoidal Choroidal Vasculopathy | Not applicable | Unknown | Chiang Mai University | 80 | 2020-11-01 | 2021-01-15 |
| Efficacy and Safety of Two Regimens of Anti-VEGF Therapy in Chinese Patients With Polypoidal Choroidal Vasculopathy OCTA plus OCT guided 3+PRN regimen, OCT guided 3+PRN regimen, Anti-VEGF drug - Polypoidal Choroidal Vasculopathy | Phase 4 | Unknown | Xiaodong Sun | 102 | 2020-06-01 | 2020-05-08 |
| Biomarkers of Common Eye Diseases Collection of blood samples - Uveitis, Diabetic Retinopathy | Unknown | Sun Yat-sen University | 220 | 2019-09-26 | 2019-09-27 | |
| Eyes That Do Not Meet the Eligibility Criteria of Clinical Trials on Age-Related Macular Degeneration: Proportion of the Real-World Patient Population and Reasons for Exclusion Intravitreal anti-vascular endothelial growth factor injection - Age-related Macular Degeneration | Completed | Kim's Eye Hospital | 512 | 2019-08-26 | 2021-04-08 | |
| Long-term Outcomes, Recurrence Rates, and Treatment Needs in Polypoidal Choroidal Vasculopathy (PCV) Indocyanine Green Angiography - Polypoidal Choroidal Vasculopathy | Completed | Singapore National Eye Centre | 72 | 2019-07-05 | 2025-11-18 | |
| OCTA and Polypoidal Choroidal Vasculopathy Ranibizumab Injection - Polypoidal Choroidal Vasculopathy | Completed | Federico II University | 60 | 2019-01-15 | 2021-01-19 | |
| ZIMURA in Combination With Eylea in Patients With Idiopathic Polypoidal Choroidal Vasculopathy (IPCV) Zimura, Eylea - Idiopathic Polypoidal Choroidal Vasculopathy | Phase 2 | Withdrawn | Ophthotech Corporation | 2018-11-01 | 2024-02-21 | |
| Double-dose Ranibizumab for Polypoidal Choroidal Vasculopathy Lucentis® (Raibizumab) double-dose, Lucentis® (Raibizumab) regular-dose - Polypoidal Choroidal Vasculopathy | Phase 2 / Phase 3 | Terminated | Sun Yat-sen University | 5 | 2018-08-01 | 2019-09-19 |
| Conbercept for Polypoidal Choroidal Vasculopathy（START Study） Conbercept - Polypoidal Choroidal Vasculopathy, Conbercept | Completed | Peking Union Medical College Hospital | 500 | 2018-05-01 | 2022-02-08 | |
| An Open Label-study to Compare the Efficacy of Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy Treat and Extend with Aflibercept 2mg, Fixed Dosing with Aflibercept 2mg - Age Related Macular Degeneration, Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Singapore National Eye Centre | 54 | 2017-12-01 | 2021-08-18 |
| Treatment of Polypoidal Choroidal Vasculopathy in Pachychoroid Aflibercept Injection - Choroidal Neovascularization, Choroid Disease | Not applicable | Completed | Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo | 17 | 2017-09-18 | 2019-09-03 |
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Macular Degeneration (9) · Choroidal Neovascularization (8) · Central Serous Chorioretinopathy (2) · Myopia, Degenerative (2) · Retinal Detachment (2) · Vascular Diseases (2) · Behcet Syndrome (1) · Choroid Diseases (1) · Diabetic Retinopathy (1) · Eye Diseases (1) · Patient Satisfaction (1) · Polyps (1) · Pseudoxanthoma Elasticum (1) · Retinal Arterial Macroaneurysm (1)
Metaplasia (50) · Neovascularization, Pathologic (50) · Pathologic Processes (50) · Pathological Conditions, Signs and Symptoms (50) · Uveal Diseases (50) · Choroid Diseases (49) · Eye Diseases (49) · Choroidal Neovascularization (42) · Retinal Diseases (15) · Retinal Degeneration (11) · Cardiovascular Diseases (6) · Vascular Diseases (4) · Nervous System Diseases (3) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (2) · Genetic Diseases, Inborn (2)
Ranibizumab (15) · aflibercept (10) · Verteporfin (7) · KH902 fusion protein (3) · Bevacizumab (2) · faricimab (2) · Blood Specimen Collection (1) · Coal Tar (1) · Fluorescein Angiography (1) · Injections (1) · Sodium Chloride (1) · Tomography, Optical Coherence (1) · Triamcinolone (1) · Triamcinolone Acetonide (1) · brolucizumab (1)
Singapore National Eye Centre (4) · Sun Yat-sen University (3) · Yeungnam University College of Medicine (3) · Association for Innovation and Biomedical Research on Light and Image (2) · Fondation Ophtalmologique Adolphe de Rothschild (2) · Hawaii Pacific Health (2) · Kim's Eye Hospital (2) · Novartis Pharmaceuticals (2) · Ophthotech Corporation (2) · Peking Union Medical College Hospital (2) · Pusan National University Hospital (2) · Southeast Retina Center, Georgia (2) · Aier School of Ophthalmology, Central South University (1) · Asan Medical Center (1) · Azienda Ospedaliera Universitaria Policlinico Paolo Giaccone Palermo (1)
South Korea (14) · United States (12) · China (11) · Singapore (6) · Thailand (4) · Hong Kong (3) · Italy (3) · Taiwan (3) · France (2) · Japan (2) · Portugal (2) · Spain (2) · Brazil (1) · Malaysia (1) · United Kingdom (1)
Dennis M. Marcus, M.D. (2) · Gregg T Kokame, MD, MMM (2) · Jae Hui Kim, M.D. (2) · Youxin Chen, Professor (2) · Chenjin Jin, Ph.D. (1) · Chong-Lye Ang, FRCOphth (1) · Gemmy Cheung (1) · Gemmy Cheung Chui Ming (1) · Gilda Cennamo (1) · Glenn Stoller, MD (1) · Gregg T Kokame, MD (1) · Gregg T. Kokame, MD, MMS (1) · Hyewon Chung, MD (1) · Jae Pil Shin, MD, PhD (1)
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