7 completed, 4 unknown, 1 not yet recruiting, 1 recruiting. 14 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 14 | Completed 7, Unknown 4, Not yet recruiting 1, Recruiting 1, Withdrawn 1 |
Follow Polypoidal Choroidal Vasculopathy: new trials by email Literature Review of Polypoidal Choroidal Vasculopathy trials Research Report on Polypoidal Choroidal Vasculopathy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Prospective, Multicenter, Open-label, Randomized Clinical Trial to Evaluate the Efficacy, Durability, and Safety of Aflibercept 8mg in Different Treatment Regimens in Chinese Patients With Polypoidal Choroidal Vasculopathy (PCV) Aflibercept Intravitreous Injection - Polypoidal Choroidal Vasculopathy (PCV), Neovascular Age Related Macular Degeneration (AMD) | Phase 4 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 174 | 2026-01-01 | 2026-01-26 |
| Study to Investigate the Efficacy, Safety and Durability of Faricimab in Caucasian Patients With Polypoidal Choroidal Vasculopathy (MONDEGO) Faricimab Injection [Vabysmo] - Polypoidal Choroidal Vasculopathy | Phase 4 | Recruiting | Association for Innovation and Biomedical Research on Light and Image | 120 | 2025-08-06 | 2026-02-06 |
| Efficacy and Safety of Two Regimens of Anti-VEGF Therapy in Chinese Patients With Polypoidal Choroidal Vasculopathy OCTA plus OCT guided 3+PRN regimen, OCT guided 3+PRN regimen, Anti-VEGF drug - Polypoidal Choroidal Vasculopathy | Phase 4 | Unknown | Xiaodong Sun | 102 | 2020-06-01 | 2020-05-08 |
| An Open Label-study to Compare the Efficacy of Aflibercept Monotherapy for Polypoidal Choroidal Vasculopathy Treat and Extend with Aflibercept 2mg, Fixed Dosing with Aflibercept 2mg - Age Related Macular Degeneration, Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Singapore National Eye Centre | 54 | 2017-12-01 | 2021-08-18 |
| Intravitreal Ranibizumab and TA Combination Therapy vs. Ranibizumab Monotherapy in Polypoidal Choroidal Vasculopathy Triamcinolone Acetonide, Ranibizumab - Wet Macular Degeneration | Phase 4 | Unknown | Aier School of Ophthalmology, Central South University | 120 | 2017-01-01 | 2018-11-30 |
| Initial Versus Delayed PDT Combination With Conbercept in PCV conbercept, Initial PDT, Delayed PDT - Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | The Eye Hospital of Wenzhou Medical University | 80 | 2017-01-01 | 2019-07-19 |
| Intraocular Cytokine in Recurrence of Polypoidal Choroidal Vasculopathy ranibizumab - Exudative Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy | Phase 4 | Unknown | Pusan National University Hospital | 28 | 2016-11-22 | 2019-10-10 |
| Randomized, Double-masked, Sham-controlled Phase 4 Study, Efficacy, Safety, and Tolerability of Intravitreal Aflibercept Monotherapy Compared to Aflibercept With Adjunctive Photodynamic Therapy in Patients With Polypoidal Choroidal Vasculopathy Intravitreal Aflibercept - Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Association for Innovation and Biomedical Research on Light and Image | 50 | 2015-11-23 | 2020-01-10 |
| The Efficacy Assessment of Intravitreal Injection of Conbercept in Patients With Polypoidal Choroidal Vasculopathy (PCV) Conbercept - Polypoidal Choroidal Vasculopathy (PCV) | Phase 4 | Unknown | Chengdu Kanghong Biotech Co., Ltd. | 300 | 2015-10-01 | 2017-07-19 |
| Effect of Intravitreal VEGF-Trap Eye on Polypoidal Choroidal Vasculopathy aflibercept - Exudative Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Pusan National University Hospital | 48 | 2013-09-01 | 2016-04-29 |
| Visual Outcome in Patients With Symptomatic Macular Polypoidal Choroidal Vasculopathy (PCV) Treated With Either Ranibizumab as Monotherapy or Combined With Verteporfin Photodynamic Therapy (vPDT) Ranibizumab, Verteporfin PDT, Sham PDT - Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Novartis Pharmaceuticals | 321 | 2013-08-07 | 2019-06-07 |
| Intravitreal Aflibercept Injection for Polypoidal Choroidal Vasculopathy With Hemorrhage or Exudation Intravitreal aflibercept injection 2.0mg - Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Gregg T. Kokame, MD | 25 | 2013-05-01 | 2016-11-23 |
| Triple Treatment for Detachment of Retinal Pigment Epithelium Secondary to Polypoidal Choroidal Vasculopathy Triple Therapy - Choroidal Neovascularization, Retinal Pigment Epithelial Detachment | Phase 4 | Withdrawn | Federal University of São Paulo | 2012-09-01 | 2015-08-13 | |
| Efficacy and Safety of Verteporfin Added to Ranibizumab in the Treatment of Symptomatic Macular Polypoidal Choroidal Vasculopathy Verteporfin Photodynamic Therapy, Ranibizumab - Polypoidal Choroidal Vasculopathy | Phase 4 | Completed | Novartis | 61 | 2008-04-01 | 2011-04-19 |
Macular Degeneration (4) · Choroidal Neovascularization (1) · Polyps (1) · Retinal Detachment (1) · Wet Macular Degeneration (1)
Choroid Diseases (14) · Eye Diseases (14) · Metaplasia (14) · Neovascularization, Pathologic (14) · Pathologic Processes (14) · Pathological Conditions, Signs and Symptoms (14) · Uveal Diseases (14) · Choroidal Neovascularization (13) · Retinal Degeneration (5) · Retinal Diseases (5) · Macular Degeneration (1) · Pathological Conditions, Anatomical (1)
Ranibizumab (5) · Verteporfin (3) · aflibercept (3) · KH902 fusion protein (2) · Coal Tar (1) · Triamcinolone (1) · Triamcinolone Acetonide (1) · faricimab (1)
Association for Innovation and Biomedical Research on Light and Image (2) · Pusan National University Hospital (2) · Aier School of Ophthalmology, Central South University (1) · Chengdu Kanghong Biotech Co., Ltd. (1) · Federal University of São Paulo (1) · Gregg T. Kokame, MD (1) · Novartis (1) · Novartis Pharmaceuticals (1) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (1) · Singapore National Eye Centre (1) · The Eye Hospital of Wenzhou Medical University (1) · Xiaodong Sun (1)
China (5) · South Korea (4) · Singapore (3) · Hong Kong (2) · Portugal (2) · Spain (2) · Taiwan (2) · Thailand (2) · Brazil (1) · Italy (1) · Japan (1) · Malaysia (1) · United Kingdom (1) · United States (1)
Gemmy Cheung (1) · Gregg T. Kokame, MD, MMS (1) · Jae Pil Shin, MD, PhD (1) · Ji Eun Lee, MD, PhD (1) · Pedro Paulo O Bonomo, phD (1) · Rufino Silva, PhD (1) · Shibo Tang (1) · Xiaodong Sun (1) · Xiaoling Liu, Professor (1)
PMID 22426346, PMID 25758601, PMID 27465105, PMID 28851779, PMID 28983556, PMID 32672800, PMID 33574033, PMID 34348351, PMID 35223882, PMID 38308746, PMID 40504425, PMID 42054086