4 completed. 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 1 | Completed 1 |
Follow Pineoblastoma: new trials by email Literature Review of Pineoblastoma trials Research Report on Pineoblastoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors EGFR806-specific chimeric antigen receptor (CAR) T cell - Central Nervous System Tumor, Pediatric, Glioma | Phase 1 | Completed | Seattle Children's Hospital | 11 | 2019-03-19 | 2025-12-17 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Adavosertib, Irinotecan Hydrochloride - Central Nervous System Embryonal Tumor With Rhabdoid Features, Central Nervous System Embryonal Tumor, Not Otherwise Specified | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 76 | 2014-03-28 | 2023-09-26 |
| Vorinostat Combined With Isotretinoin and Chemotherapy in Treating Younger Patients With Embryonal Tumors of the Central Nervous System 3-Dimensional Conformal Radiation Therapy, Carboplatin, Cisplatin - Medulloblastoma, Pineoblastoma | Phase 1 | Completed | National Cancer Institute (NCI) | 33 | 2009-02-25 | 2022-01-13 |
Medulloblastoma (4) · Pinealoma (4) · Central Nervous System Neoplasms (3) · Neuroectodermal Tumors, Primitive (3) · Brain Neoplasms (2) · Choroid Plexus Carcinoma (2) · Ependymoma (2) · Glioma (2) · Neoplasms, Germ Cell and Embryonal (2) · Rhabdoid Tumor (2) · Astrocytoma (1) · Glioblastoma (1) · Lymphoma, Follicular (1) · Meningioma (1) · Microphthalmia, Isolated, with Coloboma 5 (1)
Brain Diseases (4) · Central Nervous System Diseases (4) · Neoplasms by Histologic Type (4) · Neoplasms by Site (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Nervous System Diseases (4) · Nervous System Neoplasms (4) · Neuroectodermal Tumors (4) · Neoplasms (3) · Neoplasms, Neuroepithelial (3) · Brain Neoplasms (2) · Glioma (2) · Neoplasms, Complex and Mixed (2) · Neoplasms, Germ Cell and Embryonal (2)
1,2-diaminocyclohexaneplatinum II citrate (1) · Automobiles (1) · Carboplatin (1) · Cisplatin (1) · Cyclophosphamide (1) · Filgrastim (1) · Gemcitabine (1) · Granulocyte Colony-Stimulating Factor (1) · Irinotecan (1) · Isotretinoin (1) · Peripheral Blood Stem Cell Transplantation (1) · Platinum (1) · Radiotherapy, Conformal (1) · Thiotepa (1) · Vincristine (1)
National Cancer Institute (NCI) (2) · Seattle Children's Hospital (1) · St. Jude Children's Research Hospital (1)
United States (4) · Canada (1)
Giles W. Robinson, MD (1) · Juliane Gust, MD, PhD (1) · Kristina A Cole (1) · Sarah E Leary (1)
U01CA081457 (1), UM1CA081457 (1), UM1CA097452 (1)