2 completed, 2 terminated. 4 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 2, Terminated 2 |
| Phase 2 | 2 | Terminated 2 |
Follow Microphthalmia, Isolated, with Coloboma 5: new trials by email Literature Review of Microphthalmia, Isolated, with Coloboma 5 trials Research Report on Microphthalmia, Isolated, with Coloboma 5
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluation of LY2606368 Therapy in Combination With Cyclophosphamide or Gemcitabine for Children and Adolescents With Refractory or Recurrent Group 3/Group 4 or SHH Medulloblastoma Brain Tumors Prexasertib, Cyclophosphamide, Gemcitabine - Brain Tumor, Brain Tumor, Recurrent | Phase 1 | Completed | St. Jude Children's Research Hospital | 21 | 2019-08-08 | 2025-02-07 |
| Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery CX 4945 - Medulloblastoma, Childhood, Medulloblastoma Recurrent | Phase 1 / Phase 2 | Terminated | Pediatric Brain Tumor Consortium | 21 | 2019-07-25 | 2026-10-19 |
| SJDAWN: St. Jude Children's Research Hospital Phase 1 Study Evaluating Molecularly-Driven Doublet Therapies for Children and Young Adults With Recurrent Brain Tumors Gemcitabine, ribociclib, sonidegib - Anaplastic Astrocytoma, Anaplastic Ependymoma | Phase 1 | Completed | St. Jude Children's Research Hospital | 68 | 2018-03-05 | 2024-05-31 |
| Study of Vismodegib in Combination With Temozolomide Versus Temozolomide Alone in Patients With Medulloblastomas With an Activation of the Sonic Hedgehog Pathway vismodegib, Temozolomide - Histologically Confirmed Medulloblastoma, Activation of the Sonic Hedgehog (SHH) Pathway | Phase 1 / Phase 2 | Terminated | Centre Leon Berard | 24 | 2012-06-01 | 2019-05-21 |
Medulloblastoma (4) · Brain Neoplasms (2) · Central Nervous System Neoplasms (2) · Astrocytoma (1) · Choroid Plexus Carcinoma (1) · Ependymoma (1) · Glioblastoma (1) · Glioma (1) · Lymphoma, Follicular (1) · Meningioma (1) · Neoplasms (1) · Neoplasms, Germ Cell and Embryonal (1) · Neoplasms, Neuroepithelial (1) · Neuroectodermal Tumors, Primitive (1)
Neoplasms by Histologic Type (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neuroectodermal Tumors (4) · Glioma (3) · Neoplasms (3) · Neoplasms, Germ Cell and Embryonal (3) · Neoplasms, Neuroepithelial (3) · Neuroectodermal Tumors, Primitive (3) · Brain Diseases (2) · Central Nervous System Diseases (2) · Neoplasms by Site (2) · Nervous System Diseases (2) · Nervous System Neoplasms (2) · Digestive System Diseases (1)
Filgrastim (2) · Gemcitabine (2) · Granulocyte Colony-Stimulating Factor (2) · Cyclophosphamide (1) · HhAntag691 (1) · Temozolomide (1) · pegfilgrastim (1) · prexasertib (1) · ribociclib (1) · silmitasertib (1) · sonidegib (1) · trametinib (1)
St. Jude Children's Research Hospital (2) · Centre Leon Berard (1) · Pediatric Brain Tumor Consortium (1)
United States (3) · France (1) · Italy (1) · Switzerland (1) · United Kingdom (1)
Giles W. Robinson, MD (2) · Ralph Salloum, MD (1)
UM1CA081457 (1)