8 active not recruiting. 8 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Active not recruiting 8 |
| Phase 2 | 4 | Active not recruiting 4 |
Follow Peripheral Nervous System Neoplasms: new trials by email Literature Review of Peripheral Nervous System Neoplasms trials Research Report on Peripheral Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study to Evaluate the Safety, Tolerability, PK Characteristics and Anti-tumor Activity of FCN-159 in Adult and Pediatric Participants With Neurofibromatosis Type 1 FCN-159 - Neurofibromatosis 1, Plexiform Neurofibroma | Phase 1 / Phase 2 | Active not recruiting | Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. | 160 | 2021-03-26 | 2024-11-12 |
| A Study of Selumetinib in Chinese Paediatric and Adult Subjects With Neurofibromatosis Type 1 (NF1) and Inoperable Plexiform Neurofibromas (PN) Selumetinib - Neurofibromatosis 1, Neurofibroma Plexiform | Phase 1 | Active not recruiting | AstraZeneca | 32 | 2020-12-16 | 2026-08-18 |
| Nivolumab and BO-112 Before Surgery for the Treatment of Resectable Soft Tissue Sarcoma Definitive Surgical Resection, Nanoplexed Poly I:C BO-112, Nivolumab - Leiomyosarcoma, Malignant Peripheral Nerve Sheath Tumor | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 14 | 2020-10-14 | 2026-03-10 |
| B7H3 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ B7H3-EGFRt-DHFR, second generation 4-1BBζ B7H3-EGFRt-DHFR(selected) and a second generation 4-1BBζ CD19-Her2tG, Pembrolizumab - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 68 | 2020-07-13 | 2026-04-28 |
| EGFR806 CAR T Cell Immunotherapy for Recurrent/Refractory Solid Tumors in Children and Young Adults second generation 4-1BBζ EGFR806-EGFRt, second generation 4-1BBζ EGFR806-EGFRt and a second generation 4 1BBζ CD19-Her2tG - Pediatric Solid Tumor, Germ Cell Tumor | Phase 1 | Active not recruiting | Seattle Children's Hospital | 44 | 2019-06-18 | 2026-10-08 |
| A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors Phase 1b: APG-115+pembrolizumab - Unresectable or Metastatic Melanoma or Advanced Solid Tumors, Melanoma | Phase 1 / Phase 2 | Active not recruiting | Ascentage Pharma Group Inc. | 230 | 2018-08-29 | 2025-08-07 |
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Mebendazole, Vincristine, Carboplatin - Pilomyxoid Astrocytoma, Pilocytic Astrocytoma | Phase 1 / Phase 2 | Active not recruiting | Julie Krystal | 10 | 2013-10-22 | 2026-08-06 |
| AZD6244 Hydrogen Sulfate for Children With Nervous System Tumors AZD6244 - Neurofibromatosis 1, Neurofibromatosis Type 1 | Phase 1 / Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 99 | 2011-09-21 | 2026-10-27 |
Neurofibrosarcoma (4) · Neurofibroma, Plexiform (3) · Neurofibromatosis 1 (3) · Sarcoma (3) · Sarcoma, Synovial (3) · Carcinoma (2) · Desmoplastic Small Round Cell Tumor (2) · Hepatoblastoma (2) · Melanoma (2) · Neoplasms, Germ Cell and Embryonal (2) · Neuroblastoma (2) · Osteosarcoma (2) · Retinoblastoma (2) · Rhabdoid Tumor (2) · Rhabdomyosarcoma (2)
Neoplasms (8) · Neoplasms by Histologic Type (8) · Neoplasms, Nerve Tissue (8) · Nervous System Diseases (8) · Nervous System Neoplasms (8) · Nerve Sheath Neoplasms (7) · Neurofibroma (7) · Neuromuscular Diseases (7) · Peripheral Nervous System Diseases (7) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (5) · Genetic Diseases, Inborn (5) · Neoplastic Syndromes, Hereditary (5) · Eye Diseases (4) · Fibrosarcoma (4)
AZD 6244 (2) · pembrolizumab (2) · BO-112 (1) · Bevacizumab (1) · Carboplatin (1) · Irinotecan (1) · Mebendazole (1) · Nivolumab (1) · Radiation (1) · Radiotherapy (1) · Temozolomide (1) · Vincristine (1)
Seattle Children's Hospital (2) · Ascentage Pharma Group Inc. (1) · AstraZeneca (1) · Jonsson Comprehensive Cancer Center (1) · Julie Krystal (1) · National Cancer Institute (NCI) (1) · Shanghai Fosun Pharmaceutical Industrial Development Co. Ltd. (1)
United States (7) · China (2) · Australia (1) · Spain (1)
Brigitte C Widemann, M.D. (1) · Catherine Albert, MD (1) · Julie Krystal, MD (1) · Katie Albert, MD (1) · Qingfeng Li (1) · Vishruth Reddy, MD, PhD (1) · Yifan Zhai, MD, PhD (1)
PMID 28029918, PMID 31401903, PMID 32187457, PMID 35467749, PMID 37115514, PMID 37400844, PMID 38869947, PMID 39255444, PMID 40709016, PMID 41139346, PMID 42394972, PMID 42540436
K08CA245181 (1)