10 completed, 6 unknown, 1 enrolling by invitation, 1 not yet recruiting. 20 Phase 1, 12 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 20 | Completed 10, Unknown 6, Enrolling by invitation 1, Not yet recruiting 1, Recruiting 1, Terminated 1 |
| Phase 2 | 12 | Completed 7, Unknown 3, Recruiting 1, Terminated 1 |
Follow Periodontal Atrophy: new trials by email Literature Review of Periodontal Atrophy trials Research Report on Periodontal Atrophy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Autogenous Mesenchymal Stem Cell Culture-Derived Signalling Molecules as Enhancers of Bone Formation in Bone Grafting Maxillary sinus floor elevation grafting with synthetic bone substitute. - Bone Loss, Osteoclastic, Bone Loss, Alveolar | Phase 1 | Not yet recruiting | Pontificia Universidade Católica do Rio Grande do Sul | 20 | 2027-12-15 | 2026-09-21 |
| Evaluation of Stem Cell Exosomes Versus Platelet-Rich Fibrin in Tooth Extraction Socket Healing MSC-Derived Exosomes, Platelet-rich fibrin (PRF) - Alveolar Bone Loss, Tooth Extraction | Phase 1 / Phase 2 | Recruiting | Al Salam University | 40 | 2026-01-15 | 2026-04-02 |
| PRF vs. Graftless Sinus Lift With Implant Placement Graftless Transcrestal Sinus Floor Elevation with Immediate Implant Placement, Platelet-Rich Fibrin (PRF)-Assisted Transcrestal Sinus Floor Elevation with Immediate Implant Placement - Maxillary Sinus Floor Augmentation, Alveolar Bone Loss | Phase 1 | Enrolling by invitation | Dar Al Uloom University | 8 | 2025-02-01 | 2025-07-29 |
| Effects of the Adjunctive Use of Hyaluronic Acid-based Gel With Coranally Advanced Flap in the Gingival Recession Hyaluronic acid, Steril saline solution - Gingival Recession | Phase 1 / Phase 2 | Completed | Ordu University | 20 | 2024-09-01 | 2026-02-27 |
| Diode Laser Photo Activation for Pocket Reduction Decontamination A Clinical Study Diode laser and 3% hydrogen peroxide - Pocket, Periodontal, Periodontal Inflammation | Phase 1 | Completed | Krishnadevaraya College of Dental Sciences & Hospital | 10 | 2023-05-28 | 2024-05-08 |
| RhEGF Incorporated in An Absorbable Collagen Membrane for The Management Of Gingival Recession Defects RhEGF, Plain Collagen - Periodontitis | Phase 1 | Unknown | SVS Institute of Dental Sciences | 30 | 2019-10-01 | 2020-05-05 |
| MEBO Ointment and Hyaluronic Acid Gel in the Management of Pain After Free Gingival Graft Harvesting MEBO ointment, Hyaluronic Acid gel - Graft Pain, Gingival Recession | Phase 1 / Phase 2 | Unknown | Cairo University | 30 | 2019-02-01 | 2018-11-02 |
| Treatment of Gingival Recession Using Mesenchymal Stem Cells mesenchymal stem cells, standard treatment - Gingival Recession | Phase 1 / Phase 2 | Completed | Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus | 27 | 2018-01-01 | 2020-06-17 |
| Using Platelet Rich Plasma in Reducing Alveolar Bone Resorption During Rapid Maxillary Expansion Platelet Rich Plasma, No Platelet Rich Plasma - Bone Resorption | Phase 1 | Completed | Damascus University | 16 | 2016-07-01 | 2018-07-30 |
| Effect of Buccal Fat Pad Derived Stem Cells in Maxillary Sinus Augmentation BFPSCs+ DFDBA+ PRF, DFDBA + PRF - Alveolar Bone Loss | Phase 1 | Unknown | Shahid Beheshti University of Medical Sciences | 20 | 2016-01-01 | 2016-10-17 |
| Buccal Fat Pad Derived Stem Cells With Cortical Tenting in Posterior Mandible Reconstruction BFPSC+FDBA+PRF, FDBA+PRF - Alveolar Bone Loss, Atrophy | Phase 1 | Unknown | Shahid Beheshti University of Medical Sciences | 20 | 2016-01-01 | 2016-10-17 |
| Description of Pain in Pediatric Patients With Cleft Lip and Palate Undergoing Alveolar Grafting Using Two Surgical Strategies: Stem Cells and Autogenous Iliac Crest Bone (Pain Evaluation in Children Undergoing Alveolar Grafting: Stem Cells vs. Iliac Crest Bone) Autogenous Iliac Crest Bone Grafting, Bioengineered Alveolar Grafting (SHED + Scaffold) - Clift Lip, Cleft Palate | Phase 1 / Phase 2 | Completed | Hospital Sirio-Libanes | 20 | 2015-03-01 | 2026-07-29 |
| Effectiveness and Safety of Method of Maxilla Alveolar Process Reconstruction Using Synthetic Tricalcium Phosphate and Autologous MMSCs Oral mucosa biopsy, Sinus lift with implantation of tissue engineered construction, Dental implant - Partially Edentulous Maxilla, Alveolar Bone Atrophy | Phase 1 / Phase 2 | Unknown | Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation | 12 | 2014-09-01 | 2016-11-30 |
| Use of Hyaluronic Acid as a Therapeutic Strategy for Bone Repair in Human hyaluronic acid, Placebo - Alveolar Bone Loss | Phase 1 / Phase 2 | Completed | Federal University of Minas Gerais | 16 | 2012-07-01 | 2016-03-16 |
| A Clinical Investigation to Evaluate the Healing of Tooth Extraction Sites Filled With BioRestore™ Alveolar Bone Defect Regeneration Following Tooth Extraction - Alveolar Bone Loss | Phase 1 | Completed | University of Trieste | 14 | 2008-12-01 | 2010-04-16 |
| Treatment of Alveolar Bone Defects Using Aastrom Biosciences Autologous Tissue Repair Cell Therapy Tissue Repair Cells (TRC), Control - Alveolar Bone Loss | Phase 1 / Phase 2 | Completed | University of Michigan | 24 | 2008-06-01 | 2015-07-03 |
| A Pilot Study of CelTx(TM) (Apligraf®) in the Treatment of Gingival Recession Requiring Root Coverage CelTx, Autologous sub-epithelial connective tissue graft - Gingival Recession | Phase 1 / Phase 2 | Terminated | Organogenesis | 15 | 2008-05-01 | 2012-01-11 |
| Evaluation of OSSIX-Plus Resorbable Collagen Membranes for Alveolar Ridge Preservation Following Exodontia OSSIX-Plus - Alveolar Bone Loss, Loss of Teeth Due to Extraction | Phase 1 / Phase 2 | Completed | William Giannobile | 10 | 2008-03-01 | 2016-03-31 |
| Periapical Bone Healing After Apicectomy With and Without Retrograde Root Filling Mineral Trioxide Aggregate (MTA) - Stomatognathic Disease, Mouth Disease | Phase 1 / Phase 2 | Unknown | University of Aarhus | 54 | 2005-01-01 | 2008-12-04 |
| Regeneration of Human Intrabony Defects With rhFGF-2/HA a gel containing 4mg/ml rhFGF-2 in sodium hyaluronate, Periodontal flap surgery - Periodontitis | Phase 1 / Phase 2 | Completed | Universidade Federal Fluminense | 30 | 2002-12-01 | 2015-01-13 |
Alveolar Bone Loss (14) · Gingival Recession (5) · Periodontitis (3) · Atrophy (2) · Bone Resorption (2) · Periodontal Attachment Loss (2) · Cleft Lip (1) · Cleft Palate (1) · Mouth Diseases (1) · Pain (1) · Pain, Postoperative (1) · Periapical Diseases (1) · Periodontal Pocket (1) · Stomatognathic Diseases (1)
Periodontal Diseases (20) · Mouth Diseases (19) · Stomatognathic Diseases (19) · Bone Diseases (14) · Musculoskeletal Diseases (14) · Bone Resorption (12) · Gingival Diseases (5) · Pathological Conditions, Signs and Symptoms (4) · Jaw Diseases (2) · Neurologic Manifestations (2) · Pathological Conditions, Anatomical (2) · Signs and Symptoms (2) · Congenital Abnormalities (1) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (1)
Hyaluronic Acid (2) · Control Groups (1) · Dental Implants (1) · Gelatin Sponge, Absorbable (1) · Hydrogen Peroxide (1) · Lasers, Semiconductor (1) · Prolactin-Releasing Hormone (1) · gamma-sitosterol (1) · mineral trioxide aggregate (1)
Shahid Beheshti University of Medical Sciences (2) · Al Salam University (1) · Cairo University (1) · Central Clinical Hospital w/Outpatient Health Center of Business Administration for the President of Russian Federation (1) · Damascus University (1) · Dar Al Uloom University (1) · Federal University of Minas Gerais (1) · Hospital Sirio-Libanes (1) · Institute of Biophysics and Cell Engineering of National Academy of Sciences of Belarus (1) · Krishnadevaraya College of Dental Sciences & Hospital (1) · Ordu University (1) · Organogenesis (1) · Pontificia Universidade Católica do Rio Grande do Sul (1) · SVS Institute of Dental Sciences (1) · Universidade Federal Fluminense (1)
United States (3) · Brazil (2) · India (2) · Iran (2) · Belarus (1) · Denmark (1) · Egypt (1) · Russia (1) · Saudi Arabia (1) · Syria (1) · Turkey (Türkiye) (1)
Arash Khojasteh, DMD, OMFS (2) · William V Giannobile, DDS, DMedSc (2) · Anderson Ferreira, Professor (1) · Ann Wenzel, professor (1) · Darnell Kaigler, DDS, MS, PhD (1) · Denise C Machado, MSc., Ph.D. (1) · Eduardo R Teixeira, DDS, Ph.D. (1) · Grigory Volozhin A Volozhin, MD, PhD (1) · Igor D Volotovski, Prof (1) · Ilya I Eremin, MD, PhD (1) · Kinda Sultan, MSc, PhD (1) · Michael McGuire, DDS (1) · Omaima M Sakr, BDS, MSc, PhD (1) · Patricia Sesterheim, MSc, Ph.D. (1)
PMID 21845241, PMID 22691124, PMID 22776413, PMID 22848877, PMID 23671833, PMID 23763951, PMID 24910679, PMID 25005628, PMID 25171042, PMID 25478739, PMID 25490552, PMID 25722595, PMID 26124033, PMID 26367495, PMID 30920874, PMID 33410999