13 recruiting, 9 unknown, 8 not yet recruiting, 6 completed. 16 Phase 2, 11 Not applicable, 8 Phase 1, 3 Phase 4, 2 Early Phase 1.
Follow Pancreatic Cancer Non-resectable: new trials by email Literature Review of Pancreatic Cancer Non-resectable trials Research Report on Pancreatic Cancer Non-resectable
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study on the Construction and Application of a Large Model Corpus for Pancreatic Cancer Based on Real Clinical Cases Pancreatic Cancer, Pancreatic Cancer Metastatic | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 3000 | 2026-08-01 | 2026-07-21 | |
| EUS Procedures Using RIVOS™ EUS Access Device EUS-guided intervention using the RIVOS™ EUS access device - Pancreatic Fluid Collections, Biliary Obstruction | Recruiting | Orlando Health, Inc. | 30 | 2026-07-13 | 2026-10-20 | |
| Safety and Performance of a Novel Infusion Catheter System for Peri/Intratumoral Gemcitabine Delivery in Patients With Pancreatic Cancer Gemcitabine, Extroducer Infusion Catheter System - Pancreatic Cancer Non-resectable | Phase 1 / Phase 2 | Recruiting | Smartwise Sweden AB | 9 | 2026-04-29 | 2026-06-12 |
| CREO - Microwave Ablation Feasibility Study EUS-Guided MWA Device - Pancreatic Cancer, Liver Cancer (Locally Advanced or Metastatic) | Not applicable | Recruiting | Banner Health | 75 | 2026-02-19 | 2026-11-06 |
| Tunlametinib + AG + Cetuximab β as First-Line Therapy for Advanced Pancreatic Cancer Experimental: Tunlametinib+gemcitabine+albumin paclitaxel + cetuximab β - Pancreatic Cancer Non-resectable | Phase 4 | Not yet recruiting | Tianjin Medical University Cancer Institute and Hospital | 28 | 2026-01-20 | 2025-12-24 |
| Nimotuzumab Combined With Chemoradiotherapy in the Treatment of Unresectable Locally Advanced or Oligometastatic Pancreatic Cancer Nimotuzumab combined with chemoradiotherapy - Pancreatic Cancer Non-resectable | Phase 2 | Enrolling by invitation | Peking University First Hospital | 30 | 2025-12-09 | 2026-02-04 |
| Construction of a Predictive Model for the Efficacy of Chemoprevention Combined With Targeted Therapy in Pancreatic Cancer Sample Collection - Pancreatic Cancer Resectable, Pancreatic Cancer Non-resectable | Active not recruiting | Zhejiang Cancer Hospital | 70 | 2025-12-08 | 2026-01-08 | |
| Efficacy of Stereotactic Body Radiotherapy (SBRT) Combined With Maintenance Therapy Compared to Maintenance Therapy Alone in Advanced Pancreatic Cancer Stereotactic Body Radiotherapy (SBRT) with maintenance therapy, Maintenance therapy - Pancreatic Cancer Non-resectable | Phase 2 | Recruiting | Shandong Cancer Hospital and Institute | 24 | 2025-08-14 | 2026-05-20 |
| Outcomes of Ablation of Unresectable Pancreatic Cancer Using the NanoKnife Irreversible Electroporation System- NanoKnife - Pancreatic Cancer Non-resectable | Recruiting | Englewood Hospital and Medical Center | 25 | 2025-05-13 | 2025-06-17 | |
| Mesothelin and Claudin 18.2 Dual-Target CAR-T Therapy in Advanced Pancreatic Cancer Mesothelin and Claudin 18.2 CAR-T cells - Pancreatic Cancer, Pancreatic Carcinoma | Phase 1 / Phase 2 | Recruiting | Essen Biotech | 60 | 2025-04-29 | 2025-07-15 |
| Adebrelimab Combined With AG Regimen in Patients With Unresectable Locally Advanced or Metastatic Pancreatic Cancer Adebrelimab, AG - Pancreatic Cancer Non-resectable, Pancreatic Cancer Metastatic | Phase 2 | Not yet recruiting | Jin Xu | 46 | 2025-04-15 | 2025-04-08 |
| Personalized Tumor Neoantigen MRNA Therapy for Advanced Pancreatic Cancer. individualized anti-tumor new antigen iNeo-Vac-R01 injection, mFOLFIRINOX Treatment Regimen, Sintilimab injection - Pancreatic Cancer Metastatic, Pancreatic Cancer Non-resectable | Phase 1 / Phase 2 | Not yet recruiting | Zhejiang University | 30 | 2025-04-01 | 2025-03-21 |
| Clinical Study of Carbon Ion Radiotherapy for Pancreatic Cancer. carbon ion radiotherapy (CIRT) - Pancreatic Cancer Metastatic, Pancreatic Cancer Non-resectable | Not applicable | Recruiting | Gansu Wuwei Tumor Hospital | 62 | 2025-03-01 | 2025-03-25 |
| A Phase I Study of Intra-Arterial Yttrium-90 Radioembolization for Unresectable Pancreatic Cancer Transarterial Radioembolization - Pancreatic Cancer Non-resectable | Phase 1 | Recruiting | National Medical Research Radiological Centre of the Ministry of Health of Russia | 12 | 2025-02-11 | 2026-10-27 |
| Spanish Registry of Quality Indicators and Adverse Events of Endoscopic Retrograde Cholangiopancreatography Endoscopic retrograde cholangiopancreatography (ERCP) - Choledocholithiasis, Choledocholithiasis With Acute Cholangitis | Not yet recruiting | Germans Trias i Pujol Hospital | 3000 | 2024-11-01 | 2024-11-01 | |
| EUS-Gallbladder vs CDS as First Line in MBDO- Palliative (CARPEGIEM Trial) Endoscopic biliary drainage, Lumen-apposing metal stent (LAMS) and double-pigtail plastic stent (DPPS) - Malignant Biliary Obstruction, Biliary Tract Neoplasms | Not applicable | Suspended | Hospital Universitari de Bellvitge | 128 | 2024-10-18 | 2026-05-06 |
| Medical Cannabis in Patients With Advanced Pancreatic and Colorectal Cancer Medical Cannabis - Pancreatic Cancer Non-resectable, Pancreatic Cancer Metastatic | Phase 2 | Recruiting | HealthPartners Institute | 64 | 2024-09-16 | 2026-10-14 |
| Establishment of a Predictive Model for Immunotherapy Response in Pancreatic Cancer Sample Collection - Pancreatic Cancer Non-resectable | Active not recruiting | Zhejiang Cancer Hospital | 100 | 2024-09-01 | 2025-12-09 | |
| A Trail of Second-line Chemotherapy Sequential NKG2D CAR-NK Cell Therapy for Pancreatic Cancer chemotherapy sequential CAR-NK cell infusion - Pancreatic Cancer Non-resectable | Early Phase 1 | Unknown | Zhejiang University | 30 | 2024-07-09 | 2024-12-27 |
| Endoscopic Ultrasound (EUS) Intratumoral Injection of CAR-NK Cells in the Treatment of Advanced Pancreatic Cancer CAR-NK - Pancreatic Cancer Non-resectable | Early Phase 1 | Unknown | Zhejiang University | 20 | 2024-06-09 | 2024-12-27 |
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Pancreatic Neoplasms (18) · Neoplasm Metastasis (2) · Pancreatic cancer, adult (2) · Anophthalmia with pulmonary hypoplasia (1) · Bile Duct Neoplasms (1) · Biliary Fistula (1) · Biliary Tract Neoplasms (1) · Brain Neoplasms (1) · Cancer Pain (1) · Carcinoma, Papillary (1) · Cholangiocarcinoma (1) · Cholangitis, Sclerosing (1) · Choledocholithiasis (1) · Duodenal Neoplasms (1) · Head and Neck Neoplasms (1)
Neoplasms (23) · Digestive System Diseases (22) · Neoplasms by Site (21) · Digestive System Neoplasms (20) · Pancreatic Diseases (19) · Endocrine Gland Neoplasms (18) · Endocrine System Diseases (18) · Pathological Conditions, Signs and Symptoms (6) · Biliary Tract Diseases (3) · Pathologic Processes (3) · Signs and Symptoms (3) · Bile Duct Diseases (2) · Carcinoma (2) · Neoplasms by Histologic Type (2) · Neoplasms, Glandular and Epithelial (2)
Gemcitabine (6) · Fluorouracil (3) · Leucovorin (3) · Radiosurgery (3) · folfirinox (3) · 130-nm albumin-bound paclitaxel (2) · Heavy Ion Radiotherapy (2) · Irinotecan (2) · Oxaliplatin (2) · Specimen Handling (2) · Albumin-Bound Paclitaxel (1) · Capecitabine (1) · Chemoradiotherapy (1) · Cholangiopancreatography, Endoscopic Retrograde (1) · Dosage Forms (1)
Zhejiang University (3) · Zhejiang Cancer Hospital (2) · Amsterdam UMC, location VUmc (1) · Arbeitsgemeinschaft medikamentoese Tumortherapie (1) · Asan Medical Center (1) · Azienda Ospedaliero, Universitaria Pisana (1) · Baki Topal (1) · Banner Health (1) · CSPC Ouyi Pharmaceutical Co., Ltd. (1) · Chinese University of Hong Kong (1) · City of Hope Medical Center (1) · Englewood Hospital and Medical Center (1) · Essen Biotech (1) · Gansu Wuwei Tumor Hospital (1) · Germans Trias i Pujol Hospital (1)
China (14) · United States (10) · South Korea (4) · Germany (3) · Austria (2) · Belgium (2) · Israel (2) · Italy (2) · Spain (2) · Sweden (2) · United Kingdom (2) · Canada (1) · France (1) · Hong Kong (1) · Japan (1)
Ajay Goel, PhD (1) · Allen Bain, PhD (1) · Anna ME Bruynzeel, MD PhD (1) · Ashwin Somasundaram, MD (1) · Baki Topal, MD (1) · Carme Loras (1) · Changhoon Yoo, MD, PhD (1) · Edgar Castillo-Regalado, MD (1) · Eileen O'Reilly, MD (1) · Fei Xu (1) · Felix Keil, Prof.MD (1) · Heshui Wu (1) · Jacob R Izbicki, MD (1) · Jae Young Lee, MD (1) · Jing Sun (1)
PMID 25559415, PMID 28143873, PMID 29852194, PMID 31564556, PMID 34132691, PMID 35850192, PMID 36581914, PMID 37121331, PMID 37741968, PMID 42098550, PMID 42335570, PMID 42749887
2018 (1), 2025 (1), P50CA062924 (1)