12 unknown, 11 recruiting, 7 completed, 5 terminated. 21 Not applicable, 14 Phase 2, 5 Phase 1, 2 Phase 3, 1 Early Phase 1.
Follow Heavy Ion Radiotherapy: new trials by email Literature Review of Heavy Ion Radiotherapy trials Research Report on Heavy Ion Radiotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Prospective Phase I/II Study Evaluating the Safety and Efficacy of Preoperative Carbon Ion Radiotherapy in Patients With Soft Tissue Sarcoma : The SARCOMA-01 Trial by the Severance sARCOma Multidisciplinary Team Carbon-Ion Radiotherapy (CIRT) - Soft Tissue Sarcoma | Not applicable | Not yet recruiting | Yonsei University | 60 | 2025-11-01 | 2025-11-26 |
| Carbon Ion Radiotherapy in Frail Patients With Pancreatic Cancer Carbon Ion Radiotherapy - Pancreatic Neoplasm | Phase 2 | Recruiting | Yonsei University | 33 | 2025-09-23 | 2025-12-02 |
| Clinical Study of Postoperative Carbon Ion Radiotherapy for Thymus Tumor With Residual Tumor Carbon ion radiotherapy, combined with platinum-based regimen - Thymic Epithelial Tumor, Radiotherapy Side Effect | Phase 2 | Recruiting | Jian Chen | 48 | 2025-07-01 | 2025-06-13 |
| Efficacy and Safety of Chemoimmunotherapy and Carbon Ion Radiotherapy in Unresectable Locally Advanced Non-small Cell Lung Cancer Carbon ion radiotherapy, Chemotherapy, Immunotherapy - Carbon Ion Radiotheray | Not yet recruiting | Ji Yongling | 34 | 2025-06-16 | 2025-06-25 | |
| Clinical Study of Carbon Ion Radiotherapy for Pancreatic Cancer. carbon ion radiotherapy (CIRT) - Pancreatic Cancer Metastatic, Pancreatic Cancer Non-resectable | Not applicable | Recruiting | Gansu Wuwei Tumor Hospital | 62 | 2025-03-01 | 2025-03-25 |
| A Single-arm Phase II Clinical Study Investigating the Safety and Efficacy of Carbon Ion Radiotherapy in Patients With Hepatocellular Carcinoma Previously Treated With Transarterial Radioembolization (TARE) Carbon Ion Radiotherapy - Carcinoma, Hepatocellular Carcinoma | Not applicable | Recruiting | Yonsei University | 48 | 2024-11-12 | 2025-11-26 |
| Carbon Ion Radiotherapy for Locally Advanced Lung Cancer in Elderly Patients carbon ion radiotherapy, targeted therapy, single regimen chemotherapy in sequence with radiotherapy - Non-small Cell Lung Cancer, Older People | Phase 2 | Recruiting | Jian Chen | 29 | 2024-08-08 | 2025-06-13 |
| Clinical Study of Carbon Ion Radiotherapy Combined With Chemotherapy for Thymic Epithelial Tumors carbon ion radiotherapy - Carbon Ion Radiotherapy, Thymoma, Thymic Carcinoma, Radiotherapy, Chemotherapy | Phase 2 | Recruiting | Jian Chen | 48 | 2024-01-26 | 2025-06-13 |
| A Dose Escalation Study of Proton and Carbon Ion Irradiation for HER2 Positive and Triple Negative Breast Cancer proton plus carbon ion radiotherapy - Triple Negative Breast Cancer, HER2-positive Breast Cancer | Phase 1 | Unknown | Shanghai Proton and Heavy Ion Center | 24 | 2023-01-10 | 2023-01-20 |
| Immunotherapy and Carbon Ion Radiotherapy In Solid Cancers With Stable Disease Carbon Ion Therapy, Immunotherapy (Pembrolizumab) - Non Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma | Phase 2 | Unknown | CNAO National Center of Oncological Hadrontherapy | 27 | 2022-07-26 | 2024-08-21 |
| Ablative Carbon Ion Radiotherapy With Pencil Beam Scanning for Locally Advanced Unresectable Pancreatic Cancer Carbon ion radiotherapy - Pancreatic Cancer Non-resectable | Not applicable | Recruiting | Shanghai Proton and Heavy Ion Center | 48 | 2022-07-01 | 2023-12-07 |
| Enhanced Systemic Combined With Local Treatment for Primary and Metastatic Lesions in Oligo-metastatic Prostate Cancer Leuprolide acetate, Goserelin acetate, Triptorelin acetate - Prostate Cancer | Phase 2 | Unknown | Fudan University | 160 | 2022-04-01 | 2022-03-16 |
| Single Arm Study of Induction Chemoradiotherapy Combined With Surgery in the Treatment of Locally Advanced SNMM endoscopic surgery, intensity-modulated radiation therapy or volume of rotating intensity-modulated radiotherapy or Proton or heavy ion radiation therapy, Chemotherapy drug - Mucosal Melanoma, Sinonasal Melanoma | Early Phase 1 | Unknown | Eye & ENT Hospital of Fudan University | 28 | 2021-08-10 | 2021-08-17 |
| Longitudinal Registry Including Patients Treated With Heavy Particles Heavy-ion therapy (hadrontherapy) - Cancer, Oncology | Recruiting | CNAO National Center of Oncological Hadrontherapy | 3000 | 2021-06-04 | 2025-08-06 | |
| Carbon Ion Radiotherapy for Recurrent Pancreatic Cancer Post Surgery carbon ion radiotherapy - Pancreatic Carcinoma | Not applicable | Unknown | Shanghai Proton and Heavy Ion Center | 49 | 2021-06-01 | 2023-04-26 |
| Clinical Study on the Re-irradiation of Lateral Pelvic Recurrences of Gynecological Malignancies carbon ion radiation therapy - Tumor Recurrence, Malignant Epithelial Neoplasm of Vulva | Not applicable | Recruiting | CNAO National Center of Oncological Hadrontherapy | 55 | 2021-02-24 | 2025-08-06 |
| Carbon-Ion Radiotherapy Plus Camrelizumab for Locally Recurrent Nasopharyngeal Carcinoma Induction chemotherapy, Carbon-ion radiotherapy, Camrelizumab - Nasopharyngeal Carcinoma | Phase 2 | Unknown | Shanghai Proton and Heavy Ion Center | 146 | 2021-01-19 | 2022-04-29 |
| Carbon Ion Radiation Therapy in the Treatment of Mucous Melanomas of the Female Lower Genital Tract carbon ion radiation therapy CIRT - Malignant Melanoma, Gynecologic Cancer | Not applicable | Recruiting | CNAO National Center of Oncological Hadrontherapy | 9 | 2020-09-03 | 2024-08-21 |
| Comparison of Proton and Carbon Ion Radiotherapy With Advanced Photon Radiotherapy in Skull Base Meningiomas: The PINOCCHIO Trial. Carbon Ion Radiotherapy, Proton Therapy, Hypofractionated Photon Radiotherapy - Skull Base Meningioma | Not applicable | Withdrawn | University Hospital Heidelberg | 2020-05-01 | 2021-10-06 | |
| 12 Fractions Carbon Ion Radiotherapy for Localized Prostate Cancer carbon ion radiotherapy - Radiotherapy, Prostate Cancer | Not applicable | Unknown | Shanghai Proton and Heavy Ion Center | 30 | 2019-12-01 | 2021-11-19 |
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Pancreatic Neoplasms (6) · Carcinoma, Hepatocellular (4) · Nasopharyngeal Carcinoma (4) · Prostatic Neoplasms (4) · Carcinoma, Non-Small-Cell Lung (3) · Radiation Injuries (3) · Carcinoma (2) · Melanoma (2) · Sarcoma (2) · Adenocarcinoma (1) · Breast Neoplasms (1) · Carcinoma, Transitional Cell (1) · Chondrosarcoma (1) · Glioma (1) · Meningioma (1)
Shanghai Proton and Heavy Ion Center (15) · University Hospital Heidelberg (9) · CNAO National Center of Oncological Hadrontherapy (5) · Jian Chen (3) · Yonsei University (3) · Eye & ENT Hospital of Fudan University (1) · Fudan University (1) · Gansu Wuwei Tumor Hospital (1) · Heidelberg University (1) · Ji Yongling (1) · University of Texas Southwestern Medical Center (1)
China (21) · Germany (11) · Italy (5) · South Korea (3) · Japan (1) · United States (1)
Jiade J Lu, MD (4) · Amelia Barcellini, MD (2) · Jingfang Mao, PHD (2) · David Sher, MD (1) · Dingwei Ye, Doctoral (1) · Francesca Valvo, MD (1) · Guo-Liang Jiang, Dr. (1) · Guoliang Jiang, Dr. (1) · Hongmeng Yu, MD,PhD (1) · Jian Chen, M.D. (1) · Juergen Debus, Head of Dep. (1) · Juergen Debus, MD PhD (1) · Qing Zhang, Dr. (1) · Qing Zhang, MD (1)
PMID 20226028, PMID 20819220, PMID 20925951, PMID 21050498, PMID 21062428, PMID 21314962, PMID 22472035, PMID 23497349, PMID 24034562, PMID 25384705, PMID 31164172, PMID 31521134, PMID 32223048, PMID 33579340, PMID 36974574, PMID 38205914, PMID 38737600, PMID 39462835
2009 (3)