16 completed, 3 terminated, 1 active not recruiting, 1 recruiting. 21 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 21 | Completed 16, Terminated 3, Active not recruiting 1, Recruiting 1 |
| Phase 1 | 4 | Completed 2, Active not recruiting 1, Terminated 1 |
Follow Optic Nerve Neoplasms: new trials by email Literature Review of Optic Nerve Neoplasms trials Research Report on Optic Nerve Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Modified CV Regimen in Optic Pathway Glioma Carboplatin, Vincristine, Recombinant human endostatin - Optic Glioma, Pediatric Brain Tumor, Optic Nerve Glioma | Phase 2 | Recruiting | Beijing Sanbo Brain Hospital | 75 | 2022-04-13 | 2024-10-15 |
| Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours Selumetinib - Neurofibromatosis Type 1, Plexiform Neurofibroma | Phase 1 / Phase 2 | Completed | Great Ormond Street Hospital for Children NHS Foundation Trust | 14 | 2019-09-26 | 2024-04-04 |
| Selumetinib in Treating Patients With Neurofibromatosis Type 1 and Cutaneous Neurofibroma Laboratory Biomarker Analysis, Selumetinib Sulfate - Cutaneous Neurofibroma, Neurofibromatosis Type 1 | Phase 2 | Completed | National Cancer Institute (NCI) | 11 | 2017-08-26 | 2023-12-06 |
| Using MRI-Guided Laser Heat Ablation to Induce Disruption of the Peritumoral Blood Brain Barrier to Enhance Delivery and Efficacy of Treatment of Pediatric Brain Tumors MRI-guided laser ablation, Doxorubicin, Etoposide - Glioma, Pilocytic Astrocytoma | Phase 2 | Terminated | Washington University School of Medicine | 6 | 2015-08-14 | 2024-11-01 |
| Photodynamic Therapy (PDT) For Recurrent High Grade Gliomas Photofrin photodynamic therapy. - Brain Tumor, Recurrent | Phase 2 | Terminated | Harry T Whelan, MD | 1 | 2015-06-01 | 2019-08-20 |
| A Phase I Study of Mebendazole for the Treatment of Pediatric Gliomas Mebendazole, Vincristine, Carboplatin - Pilomyxoid Astrocytoma, Pilocytic Astrocytoma | Phase 1 / Phase 2 | Active not recruiting | Julie Krystal | 10 | 2013-10-22 | 2026-08-06 |
| Low-Dose or High-Dose Lenalidomide in Treating Younger Patients With Recurrent, Refractory, or Progressive Pilocytic Astrocytoma or Optic Pathway Glioma Lenalidomide, Pharmacological Study - Neurofibromatosis Type 1, Recurrent Childhood Pilocytic Astrocytoma | Phase 2 | Completed | National Cancer Institute (NCI) | 75 | 2012-07-05 | 2025-01-07 |
| Dasatinib, Ifosfamide, Carboplatin, and Etoposide in Treating Young Patients With Metastatic or Recurrent Malignant Solid Tumors carboplatin, dasatinib, etoposide phosphate - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 / Phase 2 | Terminated | City of Hope Medical Center | 7 | 2008-09-10 | 2026-11-04 |
| Cilengitide in Treating Younger Patients With Recurrent or Progressive High-Grade Glioma That Has Not Responded to Standard Therapy cilengitide, laboratory biomarker analysis, pharmacological study - Childhood High-grade Cerebellar Astrocytoma, Childhood High-grade Cerebral Astrocytoma | Phase 2 | Completed | National Cancer Institute (NCI) | 30 | 2008-06-01 | 2018-08-01 |
| Radiation Therapy in Treating Young Patients With Gliomas radiation therapy - Brain Tumor, Central Nervous System Tumor | Phase 2 | Completed | Children's Oncology Group | 92 | 2006-11-01 | 2019-08-07 |
| Iodine I 131 Monoclonal Antibody 3F8 in Treating Patients With Central Nervous System Cancer or Leptomeningeal Cancer DNA analysis, immunologic technique, pharmacological study - Brain and Central Nervous System Tumors, Intraocular Melanoma | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 78 | 2006-01-01 | 2024-04-04 |
| Oxaliplatin in Treating Young Patients With Recurrent Solid Tumors That Have Not Responded to Previous Treatment oxaliplatin - Childhood Central Nervous System Germ Cell Tumor, Childhood Extragonadal Germ Cell Tumor | Phase 2 | Completed | National Cancer Institute (NCI) | 180 | 2004-10-01 | 2013-06-05 |
| Tipifarnib in Treating Young Patients With Recurrent or Progressive High-Grade Glioma, Medulloblastoma, Primitive Neuroectodermal Tumor, or Brain Stem Glioma tipifarnib - Childhood High-grade Cerebral Astrocytoma, Childhood Oligodendroglioma | Phase 2 | Completed | National Cancer Institute (NCI) | 90 | 2003-11-01 | 2013-10-08 |
| Cyproheptadine and Megestrol in Preventing Weight Loss in Children With Cachexia Caused By Cancer or Cancer Treatment cyproheptadine hydrochloride, megestrol acetate - Brain Tumor, Central Nervous System Tumors | Phase 2 | Completed | University of South Florida | 70 | 2003-06-01 | 2014-02-03 |
| Temozolomide Plus Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Malignant Glioma or Recurrent CNS or Other Solid Tumors filgrastim, temozolomide, peripheral blood stem cell transplantation - Brain and Central Nervous System Tumors, Childhood Germ Cell Tumor | Phase 1 / Phase 2 | Completed | Duke University | 30 | 2000-08-01 | 2013-06-20 |
| Rebeccamycin Analogue in Treating Children With Solid Tumors or Non-Hodgkin's Lymphoma becatecarin - Brain and Central Nervous System Tumors, Lymphoma | Phase 2 | Completed | National Cancer Institute (NCI) | 200 | 2000-07-01 | 2013-02-05 |
| Irinotecan in Treating Children With Refractory Solid Tumors irinotecan hydrochloride - Childhood Central Nervous System Germ Cell Tumor, Childhood Choroid Plexus Tumor | Phase 2 | Completed | Children's Oncology Group | 181 | 1999-10-01 | 2013-06-14 |
| Lobradimil and Carboplatin in Treating Children With Brain Tumors carboplatin, lobradimil - Brain and Central Nervous System Tumors | Phase 2 | Completed | National Cancer Institute (NCI) | 1998-03-01 | 2013-08-16 | |
| Temozolomide in Treating Patients With Progressive Low-Grade Glioma temozolomide - Brain and Central Nervous System Tumors | Phase 2 | Completed | Duke University | 100 | 1998-03-01 | 2014-07-09 |
| Combination Chemotherapy and Tamoxifen in Treating Patients With Solid Tumors cisplatin, doxorubicin hydrochloride, tamoxifen citrate - Adrenocortical Carcinoma, Brain and Central Nervous System Tumors | Phase 2 | Completed | Ottawa Regional Cancer Centre | 30 | 1994-05-01 | 2013-07-10 |
Showing 20 of 21. Sign in to see all of them.
Optic Nerve Glioma (21) · Astrocytoma (18) · Oligodendroglioma (14) · Central Nervous System Neoplasms (10) · Familial ependymoma (9) · Medulloblastoma (9) · Brain Neoplasms (7) · Glioma (6) · Neuroblastoma (6) · Choroid Plexus Neoplasms (5) · Glioblastoma (5) · Neuroectodermal Tumors, Primitive, Peripheral (5) · Sarcoma (5) · Osteosarcoma (4) · Burkitt Lymphoma (3)
Cranial Nerve Diseases (21) · Cranial Nerve Neoplasms (21) · Eye Diseases (21) · Neoplasms (21) · Neoplasms by Histologic Type (21) · Neoplasms by Site (21) · Neoplasms, Glandular and Epithelial (21) · Neoplasms, Nerve Tissue (21) · Nervous System Diseases (21) · Nervous System Neoplasms (21) · Neuroectodermal Tumors (21) · Optic Nerve Diseases (21) · Peripheral Nervous System Neoplasms (21) · Neoplasms, Germ Cell and Embryonal (20)
Carboplatin (5) · Radiotherapy (3) · Temozolomide (3) · Doxorubicin (2) · Irinotecan (2) · Vincristine (2) · etoposide phosphate (2) · AZD 6244 (1) · Bevacizumab (1) · Blotting, Western (1) · Cilengitide (1) · Cisplatin (1) · Cyproheptadine (1) · Dasatinib (1) · Dynamic Contrast Enhanced Magnetic Resonance Imaging (1)
National Cancer Institute (NCI) (7) · Duke University (3) · Children's Oncology Group (2) · Beijing Sanbo Brain Hospital (1) · City of Hope Medical Center (1) · Great Ormond Street Hospital for Children NHS Foundation Trust (1) · Harry T Whelan, MD (1) · Julie Krystal (1) · Memorial Sloan Kettering Cancer Center (1) · Ottawa Regional Cancer Centre (1) · University of South Florida (1) · Washington University School of Medicine (1)
United States (18) · Canada (8) · Australia (4) · New Zealand (4) · Puerto Rico (4) · Switzerland (3) · Netherlands (2) · China (1) · United Kingdom (1)
Henry S. Friedman, MD (3) · Andrew Cluster, M.D. (1) · Anne-Marie Langevin, MD (1) · Bruce R Korf (1) · Darren Hargrave, MB Bch (1) · Edward G. Shaw, MD (1) · Harry T Whelan, MD (1) · Jennifer L. Mayer, MD (1) · Joel M. Cherlow, MD (1) · Judith K. Sato, MD (1) · Julie Krystal, MD (1) · Katherine E Warren (1) · Katherine Warren, MD (1) · Kim Kramer, MD (1) · Lisa Bomgaars (1)
PMID 16408203, PMID 17610262, PMID 18989154, PMID 20381270, PMID 37126770, PMID 38907342, PMID 40009403
U10CA098543 (5), P30CA013148 (1), P30CA033572 (1), U10CA081920 (1), U10CA180886 (1)