8 not yet recruiting, 7 completed, 7 recruiting, 2 unknown. 18 Not applicable, 1 Early Phase 1, 1 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 18 | Completed 6, Not yet recruiting 5, Recruiting 4, Unknown 2, Withdrawn 1 |
| Early Phase 1 | 1 | Not yet recruiting 1 |
| Phase 2 | 1 | Recruiting 1 |
| Phase 3 | 1 | Recruiting 1 |
Follow Olfactory Dysfunction: new trials by email Literature Review of Olfactory Dysfunction trials Research Report on Olfactory Dysfunction
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Neural Dissimilarity in Patients With Chronic Rhinosinusitis With Nasal Polyps Treated With Biologics Olfactory Dysfunction, Chronic Rhinosinusitis With Nasal Polyps (CRSwNP) | Not yet recruiting | Copenhagen University Hospital, Rigshospitalet | 40 | 2027-06-01 | 2026-09-14 | |
| Olfactory Dysfunction in Aging Adults Clinical and Biomarker Assessments - Olfactory Dysfunction | Not yet recruiting | Medical University of South Carolina | 500 | 2027-04-01 | 2026-06-22 | |
| In Vivo Imaging of the Olfactory Epithelium Using Confocal Laser Endomicroscopy CONVIVO system, Fluorescein injection, USP 10% - Endonasal Surgery, Endoscopic Sinus Surgery | Early Phase 1 | Not yet recruiting | Dartmouth-Hitchcock Medical Center | 36 | 2026-11-03 | 2026-10-20 |
| Position-Directed Budesonide Nasal Drops for CRS-associated Olfactory Dysfunction Nasal Drops, Nasal Spray - Chronic Rhinosinusitis (CRS), Olfactory Dysfunction | Not applicable | Not yet recruiting | Peking University Third Hospital | 78 | 2026-09-25 | 2026-09-16 |
| Acupuncture for Post-traumatic Olfactory Dysfunction: A Randomized Controlled Trial Acupuncture, Corticosteroid therapy, sham acupuncture - Post-traumatic Olfactory Dysfunction, Traumatic Brain Injury | Not applicable | Not yet recruiting | Beijing Tiantan Hospital | 84 | 2026-09-15 | 2026-09-22 |
| Impact of Smell Testing on Health Outcomes Patient-centered information and education - Olfactory Dysfunction, Wellbeing | Phase 2 | Recruiting | Monell Chemical Senses Center | 1000 | 2026-05-29 | 2026-10-06 |
| Slow-SPEED UK: A Double-Blind Randomised Feasibility Trial Slow-SPEED app - Hyposmia, Olfactory Dysfunction | Not applicable | Recruiting | Queen Mary University of London | 110 | 2026-05-27 | 2026-06-29 |
| PANDORA: Evaluation of Platelet-rich Plasma in Non-tumoural Odour Disorders: a Descriptive Pilot Study. Autologous Platelet-Rich Plasma (PRP) Injection - Olfactory Dysfunction, Post-traumatic Olfactory Dysfunction | Not applicable | Not yet recruiting | Hospices Civils de Lyon | 30 | 2026-05-01 | 2026-03-20 |
| rTMS and Olfactory Training for Parkinson's Disease Repetitive Transcranial Magnetic Stimulation (rTMS), Structured Olfactory Training, Sham rTMS - Parkinson Disease (PD), Olfactory Dysfunction | Not applicable | Completed | Mustafa Baran | 120 | 2026-01-02 | 2026-06-26 |
| Olfactory Function and Oral Malodor in Periodontitis Before and After Periodontal Therapy Scaling and Root Planing (SRP) - Periodontitis, Olfactory Dysfunction | Not applicable | Completed | Batman University | 101 | 2025-12-03 | 2026-10-20 |
| Topical Versus Injection PRP for Olfactory Dysfunction Intranasal Injection of Autologous PRP, Carrier-Assisted Topical Application of Autologous PRP, platelet-rich plasma - Olfactory Dysfunction, Anosmia | Phase 3 | Recruiting | Taipei Veterans General Hospital, Taiwan | 60 | 2025-09-11 | 2026-10-05 |
| Scents of Progress: Leveraging a Novel Device for Olfactory Training in Older Adults Sudoku Puzzles, ScentCare (Olfactory Training Device) - Olfactory Dysfunction, Smell Loss | Not applicable | Recruiting | Johns Hopkins University | 60 | 2025-04-15 | 2026-04-13 |
| The Efficacy of Modified Olfactory Training for MCI High-Risk Individuals Modified olfactory training device, Conventional olfactory training device - Subjective Cognitive Decline (SCD), Olfactory Dysfunction | Not applicable | Not yet recruiting | Peking University Third Hospital | 114 | 2025-03-22 | 2025-02-12 |
| The Efficacy of Modified Olfactory Training Method for Patients With Post-viral Olfactory Dysfunction Conventional olfactory training device, Modified olfactory training device, Conventional olfactory training device with placebo - Olfactory Dysfunction, Post Viral Olfactory Dysfunction (PVOD) | Not applicable | Recruiting | Peking University Third Hospital | 150 | 2025-03-22 | 2025-02-17 |
| The Impact of Endoscopic Endonasal Skull Base Surgery on Olfaction Endoscopic endonasal skull base surgery - Meningioma, Pituitary Disease | Recruiting | Universitaire Ziekenhuizen KU Leuven | 154 | 2025-03-18 | 2025-04-23 | |
| The Effect of Modified Olfactory Training on Postoperative Olfactory Dysfunction in Patients With CRS Conventional olfactory training device, Modified olfactory training device, Budesonide irrigation - Olfactory Dysfunction, Chronic Rhinosinusitis | Not applicable | Not yet recruiting | Peking University Third Hospital | 213 | 2025-03-14 | 2025-02-20 |
| Effect of Periodontal Treatment on Tongue Coating and Smell Function Non-Surgical Periodontal Treatment (Scaling and Root Planing - Periodontitis, Tongue Coating | Not applicable | Completed | Batman University | 108 | 2024-12-01 | 2026-01-08 |
| Characterisation of Functional and Cognitive Responses Following Olfactory Stimulation and/or Functional Training in Older Adults. Olfactory stimulation, Multicomponent physical training, Combined olfactory stimulation and multicomponent physical training - Healthy Aging, Frailty | Not applicable | Completed | Fundacion Miguel Servet | 120 | 2024-06-06 | 2026-06-03 |
| Dysfunction of Olfaction After COVID-19 Infection: Morphological and Histomolecular Investigation Biopsy and Cytobrush - Covid19, Olfactory Dysfunction | Not applicable | Recruiting | Universitaire Ziekenhuizen KU Leuven | 240 | 2024-01-24 | 2026-05-06 |
| Clinical Treatment Research of COVID-19-related Olfactory Dysfunction corticosteroids therapy, Olfactory training - Olfactory Dysfunction | Not applicable | Unknown | Eye & ENT Hospital of Fudan University | 124 | 2022-06-17 | 2022-06-22 |
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Anosmia (6) · COVID-19 (4) · Cognitive Dysfunction (2) · Periodontitis (2) · Brain Injuries, Traumatic (1) · Craniopharyngioma (1) · Frailty (1) · Halitosis (1) · Meningioma (1) · Motor Activity (1) · Olfaction Disorders (1) · Parkinson Disease (1) · Pituitary Diseases (1) · Pituitary Neoplasms (1) · Psychological Well-Being (1)
Nervous System Diseases (10) · Pathological Conditions, Signs and Symptoms (9) · Signs and Symptoms (8) · Neurologic Manifestations (7) · Sensation Disorders (7) · Olfaction Disorders (6) · Infections (5) · Respiratory Tract Diseases (5) · Respiratory Tract Infections (5) · Coronaviridae Infections (4) · Coronavirus Infections (4) · Lung Diseases (4) · Nidovirales Infections (4) · Pneumonia (4) · Pneumonia, Viral (4)
Olfactory Training (4) · Acupuncture Therapy (3) · Root Planing (2) · Tooth Exfoliation (2) · Biopsy (1) · Budesonide (1) · Educational Status (1) · Fluorescein (1) · Fluoresceins (1) · Injections (1) · Oils, Volatile (1) · Tobacco Use Cessation Devices (1) · Transcranial Magnetic Stimulation (1)
Peking University Third Hospital (4) · Batman University (2) · Universitaire Ziekenhuizen KU Leuven (2) · Beijing Tiantan Hospital (1) · Copenhagen University Hospital, Rigshospitalet (1) · Dartmouth-Hitchcock Medical Center (1) · Emory University (1) · Eye & ENT Hospital of Fudan University (1) · Fayoum University (1) · Fundacion Miguel Servet (1) · Hong Kong Baptist University (1) · Hospices Civils de Lyon (1) · Johns Hopkins University (1) · Mayo Clinic (1) · Medical University of South Carolina (1)
China (6) · United States (5) · Turkey (Türkiye) (3) · Belgium (2) · Germany (2) · Denmark (1) · Egypt (1) · France (1) · Hong Kong (1) · Netherlands (1) · Spain (1) · Switzerland (1) · Taiwan (1) · United Kingdom (1)
Alastair J Noyce, BMedSci, MBBS, MSc, MRCP, PhD (1) · Danielle Reed (1) · Hongmeng Yu, Dr (1) · Huanqin Li (1) · Janalee Stokken, MD (1) · Laura van Gerven (1) · Mustafa Baran, Asst. Prof. (1) · Nicholas Rowan, M.D. (1) · Nicolas Martinez-Velilla (1) · Pamela Dalton (1) · Thomas Edwards, MD (1) · Valentina Parma (1) · Xicai Sun, Dr (1)
PMID 28776718, PMID 28941136, PMID 29028274, PMID 29569385, PMID 29719139, PMID 29756211, PMID 30054977, PMID 30208208, PMID 31207172, PMID 31246360, PMID 31603563, PMID 31837149, PMID 32017433, PMID 32558260, PMID 33549569, PMID 34762776, PMID 35511170, PMID 35938699, PMID 37555485, PMID 38367249, PMID 39761371, PMID 40417805, PMID 40812823, PMID 40819876, PMID 41246125, PMID 41436263, PMID 42448717
R01DC019078 (1), R44DC022498 (1), UM1TR004772 (1)