15 completed. 15 Phase 2, 2 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 15 | Completed 15 |
| Phase 1 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Olfaction Disorders: new trials by email Literature Review of Olfaction Disorders trials Research Report on Olfaction Disorders
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Stellate Ganglion Block for COVID-induced Parosmia Stellate Ganglion Block, Placebo Sham Injection - COVID-19-Induced Parosmia | Phase 2 | Completed | Washington University School of Medicine | 48 | 2023-10-25 | 2025-11-10 |
| Study of CYR-064 Versus Placebo in Patients. CYR-064 - Hyposmia | Phase 2 | Completed | Cyrano Therapeutics, Inc. | 151 | 2023-09-26 | 2026-08-31 |
| Directed Topical Drug Delivery for Treatment for PASC Hyposmia Beclomethasone, Placebo, Microsponge - Post Acute Sequelae Covid-19 Hyposmia | Phase 2 | Completed | Duke University | 16 | 2023-09-05 | 2026-03-19 |
| Smell in COVID-19 and Efficacy of Nasal Theophylline (SCENT 3) theophylline, Placebo - COVID-19 | Phase 2 | Completed | Washington University School of Medicine | 77 | 2022-11-22 | 2025-08-20 |
| Stellate Ganglion Block for COVID-19-Induced Olfactory Dysfunction Stellate Ganglion Block - Anosmia, Hyposmia | Phase 1 / Phase 2 | Completed | Washington University School of Medicine | 20 | 2022-09-01 | 2026-02-12 |
| Preparation and Characterization Intranasal Film Loaded With Steroid as a Local Treatment of Anosmia in Compare to Insulin Intranasal Film Prednisolone - Smell Loss | Phase 1 / Phase 2 | Completed | Deraya University | 200 | 2022-03-01 | 2023-06-01 |
| Efficacy of Gabapentin for Post-Covid-19 Olfactory Dysfunction Gabapentin gelatin capsules 300mg, Placebo - COVID-19, Olfactory Disorder | Phase 2 | Completed | Washington University School of Medicine | 68 | 2022-01-10 | 2025-03-04 |
| Smell in Covid-19 and Efficacy of Nasal Theophylline Theophylline Powder, Placebo Comparator - Covid19, Anosmia | Phase 2 | Completed | Washington University School of Medicine | 51 | 2021-03-15 | 2023-05-24 |
| Study of Hesperidin Therapy on COVID-19 Symptoms (HESPERIDIN) Hesperidin, Placebo - Covid19, Anosmia | Phase 2 | Completed | Montreal Heart Institute | 216 | 2021-02-18 | 2022-04-08 |
| Effectiveness and Safety of Platelet Rich Plasma (PRP) on Persistent Olfactory Dysfunction Related to COVID-19 Platelet rich plasma (PRP), olfactory training - Anosmia, COVID-19 | Phase 2 / Phase 3 | Completed | Centre Hospitalier Universitaire Saint Pierre | 56 | 2021-02-01 | 2022-02-25 |
| Clinical Assessment of Insulin Fast Dissolving Film in Treatment of Post Infection Anosmia Insulin film, Fast dissolving film - Anosmia | Phase 2 | Completed | Soad Ali | 40 | 2020-10-01 | 2021-10-26 |
| COVID-19 Anosmia Study Omega-3 Fatty Acid Supplement, Placebo/Control - Anosmia, Covid19 | Phase 2 | Completed | Icahn School of Medicine at Mount Sinai | 139 | 2020-07-15 | 2023-10-23 |
| Smell Changes & Efficacy of Nasal Theophylline Theophylline, Saline Nasal - Olfactory Disorder, Anosmia | Phase 2 | Completed | Washington University School of Medicine | 27 | 2019-05-15 | 2022-03-31 |
| Helping Olfaction and Nutrition On Renal Replacement Theophylline - End Stage Renal Disease, Olfactory Disorders | Phase 2 | Completed | Massachusetts General Hospital | 7 | 2015-10-01 | 2024-01-09 |
| Orexigenic Therapy With Delta-9-tetrahydrocannabinol in Advanced Cancer Patients With Chemosensory Abnormalities - a Pilot Study Marinol (Dronabinol), Placebo - Cancer, Anorexia | Phase 2 | Completed | Alberta Health services | 80 | 2006-08-01 | 2010-02-09 |
Anosmia (14) · COVID-19 (9) · Virus Diseases (2) · Abdominal Pain (1) · Ageusia (1) · Anorexia (1) · Arthralgia (1) · Chest Pain (1) · Confusion (1) · Coronaviridae Infections (1) · Coronavirus Infections (1) · Cough (1) · Dysgeusia (1) · Dyspnea (1)
Pathological Conditions, Signs and Symptoms (15) · Signs and Symptoms (15) · Nervous System Diseases (14) · Neurologic Manifestations (14) · Sensation Disorders (14) · Infections (9) · Coronaviridae Infections (8) · Coronavirus Infections (8) · Lung Diseases (8) · Nidovirales Infections (8) · Pneumonia (8) · Pneumonia, Viral (8) · RNA Virus Infections (8) · Respiratory Tract Diseases (8)
Theophylline (3) · Mepivacaine (2) · Beclomethasone (1) · Dronabinol (1) · Hesperidin (1) · Olfactory Training (1) · Prednisolone (1) · Saline Solution (1) · Sodium Chloride (1)
Washington University School of Medicine (6) · Alberta Health services (1) · Centre Hospitalier Universitaire Saint Pierre (1) · Cyrano Therapeutics, Inc. (1) · Deraya University (1) · Duke University (1) · Icahn School of Medicine at Mount Sinai (1) · Massachusetts General Hospital (1) · Montreal Heart Institute (1) · Soad Ali (1)
United States (10) · Canada (2) · Egypt (2) · Belgium (1)
Jay F Piccirillo, MD (2) · Alfred-Marc Iloreta, MD (1) · Bradley Goldstein, MD, PhD (1) · Ingrid H. de Kock, MD (1) · Jay F Piccirillo, M.D., FACS (1) · Jocelyn Dupuis, MD (1) · Mas Takashima, MD (1) · Mihaela Horoi, PhD (1) · Nyssa Farrell, MD (1) · Sagar U Nigwekar, MD, MMSc (1) · Soad Mohamed (1)
PMID 18377764, PMID 19359985, PMID 21191261, PMID 21343383, PMID 22377744, PMID 23165381, PMID 23731850, PMID 27923495, PMID 33225989, PMID 35797024, PMID 35904632, PMID 36062970, PMID 36063364, PMID 37733356, PMID 40504522