29 terminated. 29 Phase 3, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 29 | Terminated 29 |
| Phase 2 | 4 | Terminated 4 |
Follow Nervous System Neoplasms: new trials by email Literature Review of Nervous System Neoplasms trials Research Report on Nervous System Neoplasms
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3 Study to Assess the Efficacy and Safety of Batoclimab as Induction and Maintenance Therapy in Adult Participants With Generalized Myasthenia Gravis Batoclimab 680 mg SC weekly, Batoclimab 340 mg SC weekly, Matching Placebo SC - Generalized Myasthenia Gravis | Phase 3 | Terminated | Immunovant Sciences GmbH | 233 | 2022-06-27 | 2026-09-14 |
| Efficacy and Safety of Tolebrutinib (SAR442168) Tablets in Adult Participants With Generalized Myasthenia Gravis Tolebrutininb, Placebo - Myasthenia Gravis | Phase 3 | Terminated | Sanofi | 6 | 2021-12-03 | 2025-09-09 |
| A Study To Evaluate Efficacy, Safety, Pharmacokinetics, And Pharmacodynamics Of Satralizumab In Patients With Generalized Myasthenia Gravis Satralizumab, Placebo - Generalized Myasthenia Gravis | Phase 3 | Terminated | Hoffmann-La Roche | 188 | 2021-10-19 | 2025-02-28 |
| Pre- Versus Post-operative SRS for Resectable Brain Metastases Brain Surgery, Stereotactic Radiosurgery - Brain Metastases | Phase 3 | Terminated | AHS Cancer Control Alberta | 8 | 2021-09-27 | 2025-07-18 |
| Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma | Phase 3 | Terminated | NRG Oncology | 19 | 2021-08-05 | 2026-05-20 |
| GM1 Prophylaxis for WBRT Related Cognitive Dysfunction Monosialotetrahexosyl ganglioside (GM1), Control - Brain Metastases, Radiotherapy Side Effect | Phase 3 | Terminated | Sun Yat-sen University | 51 | 2020-05-15 | 2024-08-01 |
| A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder Eculizumab - Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder | Phase 2 / Phase 3 | Terminated | Alexion Pharmaceuticals, Inc. | 5 | 2020-01-14 | 2024-09-25 |
| 131I-omburtamab Radioimmunotherapy for Neuroblastoma Central Nervous System/Leptomeningeal Metastases 131I-omburtamab - Neuroblastoma, CNS Metastases | Phase 2 / Phase 3 | Terminated | Y-mAbs Therapeutics | 52 | 2018-12-11 | 2024-02-13 |
| Long Term Safety Study of Amifampridine Phosphate in MuSK-MG (Muscle Specific Tyrosine Kinase Myasthenia Gravis) Amifampridine Phosphate - Myasthenia Gravis, MuSK, AChR Myasthenia Gravis | Phase 3 | Terminated | Catalyst Pharmaceuticals, Inc. | 63 | 2018-06-11 | 2024-05-07 |
| VAL-083 Phase 3 Study in Temozolomide-Avastin (Bevacizumab) Recurrent GBM VAL-083, Dianhydrogalactitol, Physician's Choice of Salvage Therapy - temozolomide, Physician's Choice of Salvage Therapy - lomustine - Glioblastoma Multiforme, Glioblastoma | Phase 3 | Terminated | DelMar Pharmaceuticals, Inc. | 2 | 2017-10-27 | 2025-09-04 |
| A Multicentre randomiSed Controlled TRial of IntraVEnous Immunoglobulin Versus Standard Therapy for Transverse Myelitis Intravenous Methylprednisolone, Intravenous Immunoglobulin - Myelitis, Transverse, Neuromyelitis Optica | Phase 3 | Terminated | Guy's and St Thomas' NHS Foundation Trust | 2 | 2015-03-01 | 2016-07-20 |
| Ga-68-DOTATOC -PET in the Management of Pituitary Tumours Gallium-68 DOTATOC PET - Pituitary Tumours | Phase 3 | Terminated | Göteborg University | 22 | 2015-01-01 | 2022-03-31 |
| A Randomized Controlled Trial of Eculizumab in AQP4 Antibody-positive Participants With NMO (PREVENT Study) Eculizumab, Placebo - Neuromyelitis Optica, Neuromyelitis Optica Spectrum Disorder | Phase 3 | Terminated | Alexion Pharmaceuticals, Inc. | 143 | 2014-04-11 | 2019-06-26 |
| Study of Fixed vs. Flexible Filgrastim to Accelerate Bone Marrow Recovery After Chemotherapy in Children With Cancer filgrastim - Childhood Choroid Plexus Tumor, Childhood Medulloblastoma | Phase 3 | Terminated | Barbara Ann Karmanos Cancer Institute | 23 | 2013-08-01 | 2020-10-29 |
| Efficacy of Prednisone In the Treatment of Ocular Myasthenia Prednisone, Placebo - Ocular Myasthenia Gravis | Phase 3 | Terminated | Michael Benatar | 11 | 2011-12-01 | 2017-06-02 |
| Doxorubicin Hydrochloride or Trabectedin in Treating Patients With Previously Untreated Advanced or Metastatic Soft Tissue Sarcoma doxorubicin hydrochloride, trabectedin, laboratory biomarker analysis - Sarcoma | Phase 2 / Phase 3 | Terminated | European Organisation for Research and Treatment of Cancer - EORTC | 133 | 2011-05-01 | 2014-08-08 |
| Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer cyproheptadine hydrochloride, placebo - Cancer | Phase 3 | Terminated | University of South Florida | 22 | 2010-06-01 | 2015-07-02 |
| Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors Carboplatin, Cisplatin, Cyclophosphamide - Brain Cancer, Choroid Plexus Tumors | Phase 3 | Terminated | Tufts Medical Center | 27 | 2009-11-01 | 2019-08-20 |
| Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic Astrocytoma or Secondary Glioblastoma trabedersen, temozolomide, Drug delivery system for administration of AP 12009 - Anaplastic Astrocytoma, Glioblastoma | Phase 3 | Terminated | Isarna Therapeutics GmbH | 27 | 2008-12-01 | 2014-11-14 |
| Prophylactic Cranial Irradiation (PCI) Versus no PCI in Non Small Cell Lung Cancer After a Response to Chemotherapy Radiotherapy - Brain Metastases | Phase 3 | Terminated | Yi-Long Wu | 5 | 2008-04-01 | 2017-03-06 |
Showing 20 of 29. Sign in to see all of them.
Brain Neoplasms (13) · Myasthenia Gravis (5) · Choroid Plexus Neoplasms (4) · Glioblastoma (4) · Astrocytoma (3) · Breast Neoplasms (3) · Carcinoma, Non-Small-Cell Lung (3) · Glioma (3) · Myelitis, Transverse (3) · Neoplasm Metastasis (3) · Neuroblastoma (3) · Neuromyelitis Optica (3) · Recurrence (3) · Central Nervous System Neoplasms (2) · Demyelinating Diseases (2)
Nervous System Diseases (29) · Neoplasms (27) · Neoplasms by Site (27) · Central Nervous System Diseases (20) · Brain Diseases (17) · Central Nervous System Neoplasms (17) · Neoplasms by Histologic Type (10) · Neoplasms, Nerve Tissue (10) · Immune System Diseases (9) · Neurodegenerative Diseases (9) · Pathological Conditions, Signs and Symptoms (9) · Autoimmune Diseases (8) · Autoimmune Diseases of the Nervous System (8) · Neoplasms, Germ Cell and Embryonal (8)
Radiotherapy (7) · Radiosurgery (5) · Temozolomide (4) · Carboplatin (2) · Chemotherapy, Adjuvant (2) · Cyclophosphamide (2) · Doxorubicin (2) · Etoposide (2) · Methylphenidate (2) · Vincristine (2) · eculizumab (2) · Amifampridine (1) · Carmustine (1) · Cisplatin (1) · Cyproheptadine (1)
European Organisation for Research and Treatment of Cancer - EORTC (4) · Alexion Pharmaceuticals, Inc. (2) · M.D. Anderson Cancer Center (2) · AHS Cancer Control Alberta (1) · Barbara Ann Karmanos Cancer Institute (1) · Catalyst Pharmaceuticals, Inc. (1) · DelMar Pharmaceuticals, Inc. (1) · Guy's and St Thomas' NHS Foundation Trust (1) · Göteborg University (1) · Hoffmann-La Roche (1) · Immunovant Sciences GmbH (1) · Isarna Therapeutics GmbH (1) · Michael Benatar (1) · NRG Oncology (1) · National Cancer Institute (NCI) (1)
United States (20) · Germany (11) · Canada (9) · Spain (9) · Italy (8) · United Kingdom (8) · Japan (6) · France (5) · Hungary (5) · Poland (5) · South Korea (5) · Argentina (4) · China (4) · Denmark (4) · Netherlands (4)
Donald Sanders, MD (1) · Edward G. Shaw, MD (1) · Gil Wolfe, MD (1) · James E. Butrynski, MD (1) · Jeffrey P. Krischer, PhD (1) · Jeffrey S. Wefel, PhD (1) · Johannes Wolff, MD (1) · John G. Wolbers, MD, PhD (1) · John Roemer, MD (1) · Juergen C. Becker, MD, PhD (1) · Luis Souhami, MD (1) · Maxim Yankelevich (1)
PMID 19543851, PMID 21041710, PMID 21584645, PMID 23213105, PMID 26009577, PMID 28639937, PMID 28961826, PMID 30419088, PMID 31050279, PMID 33310418, PMID 33676197, PMID 34498507, PMID 34803867, PMID 36585629, PMID 38268752, PMID 38464207, PMID 39083105, PMID 39862880
2009 (1), 2014 (1), 2019 (1), P30CA022453 (1), U10CA021661 (1), U10CA081920 (1), U10CA180868 (1)