266 active not recruiting. 266 Phase 1, 126 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 266 | Active not recruiting 266 |
| Phase 2 | 126 | Active not recruiting 126 |
Follow Nervous System Diseases: new trials by email Literature Review of Nervous System Diseases trials Research Report on Nervous System Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Anisodine Hydrobromide for Patients With Acute Ischemic Stroke Undergoing Endovascular Therapy (HEAL) Anisodine Hydrobromide - Acute Ischemic Stroke | Phase 1 | Active not recruiting | Capital Medical University | 92 | 2026-04-28 | 2026-08-24 |
| Safety and Efficacy of Intrathecal NTF001 Injection in ALS NTF001 Injection - ALS - Amyotrophic Lateral Sclerosis, ALS (Amyotrophic Lateral Sclerosis) | Phase 1 | Active not recruiting | Ruijin Hospital | 12 | 2026-04-01 | 2026-06-01 |
| Morning-Evening Specific Longevity Food Supplement Morning- and evening-specific compound food supplement, Control - Aging | Phase 1 | Active not recruiting | University of Primorska | 60 | 2026-03-07 | 2026-03-11 |
| A Trial to Learn How Safe AZD9750 is and How Well it Works in People With Metastatic Prostate Cancer When Given With or Without Other Anticancer Drugs AZD9750, AZD5305 - Prostate Cancer | Phase 1 / Phase 2 | Active not recruiting | AstraZeneca | 6 | 2026-01-27 | 2026-10-02 |
| A Study to Investigate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RO7812653 in Participants With Early Symptomatic Alzheimer's Disease (eAD) RO7812653, Placebo - Alzheimer's Disease | Phase 1 | Active not recruiting | Hoffmann-La Roche | 6 | 2026-01-27 | 2026-09-09 |
| A Phase 1b Study of BHV-7000 in Participants With Inherited Erythromelalgia BHV-7000, Placebo - Familial Erythromelalgia | Phase 1 | Active not recruiting | Biohaven Therapeutics Ltd. | 5 | 2026-01-15 | 2026-10-29 |
| Extracellular Vesicles for the Treatment of Syringomyelia Exosomes group - Syringomyelia | Phase 1 | Active not recruiting | Xuanwu Hospital, Beijing | 18 | 2025-12-23 | 2026-06-30 |
| A Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of RG6496 in Huntington's Disease RG6496, Placebo - Huntington's Disease | Phase 1 | Active not recruiting | Hoffmann-La Roche | 3 | 2025-11-19 | 2026-09-02 |
| Personalized Antisense Oligonucleotide for A Single Participant (nL62541) With ATN1 Gene Mutation nL-ATN1-001 - Dentatorubral-Pallidoluysian Atrophy | Phase 1 / Phase 2 | Active not recruiting | n-Lorem Foundation | 1 | 2025-11-06 | 2026-04-07 |
| A Study to Evaluate the Safety, Tolerability, Cellular Kinetics, and Pharmacodynamics of P-CD19CD20-ALLO1 in Participants With Multiple Sclerosis P-CD19CD20-ALLO1 Cells, Cyclophosphamide, Fludarabine - Multiple Sclerosis | Phase 1 | Active not recruiting | Genentech, Inc. | 60 | 2025-10-15 | 2026-10-13 |
| EFFECTS OF A FULL SPECTRUM CANNABIS EXTRACT WITH DIFFERENT DOSES OF CBD AND THC ON THE MODULATION OF FIBROMYALGIA: A PILOT, MULTICENTER, OPEN LABEL CLINICAL TRIAL (FRIDINHA) Cannabis - Fibromyalgia | Phase 1 / Phase 2 | Active not recruiting | Federal University of Latin American Integration | 36 | 2025-09-15 | 2026-03-27 |
| Evaluation of BH4 Responsiveness in Our PKU Patients Sapropterin Dihydrochloride (BH4, tetrahydrobiopterin) - Phenylketonuria (PKU) | Phase 1 | Active not recruiting | Sohag University | 20 | 2025-09-01 | 2025-12-01 |
| Door-Through-Door Companion Rideshare Technology for Individuals With Alzheimer's Disease and Related Dementias (AD/ADRD) Door-through-door companion rideshare, Curb-to-curb rideshare services - Alzheimer Disease or Associated Disorder, Dementia | Phase 1 | Active not recruiting | Onward Health, Inc | 120 | 2025-08-29 | 2026-07-21 |
| Dexamethasone-Enhanced TAP Block in Lapchole Dexamethasone enhanced TAP Block, Marcaine- 0.25% - Laparoscopic Cholecystectomy | Phase 1 | Active not recruiting | Makassed General Hospital | 100 | 2025-08-19 | 2025-09-19 |
| The Safety,Tolerability, Efficacy of XS411 Cell Injection for the Treatment of Primary Parkinson's Disease human allogeneic induced pluripotent stem cell (iPSC)-derived dopaminergic neural progenitor cell injection - Parkinson's Disease | Phase 1 / Phase 2 | Active not recruiting | XellSmart Therapeutics (Shanghai) Co., Ltd. | 39 | 2025-08-05 | 2026-09-30 |
| Determining the Biodistribution of an Imaging Tracer (68Ga-FAPi-46) in Patients With Solid Tumors or Hematologic Cancers Computed Tomography, Fludeoxyglucose F-18, Gallium Ga 68 FAPi-46 - Anal Carcinoma, Bladder Carcinoma | Phase 1 | Active not recruiting | Jonsson Comprehensive Cancer Center | 30 | 2025-08-01 | 2026-10-20 |
| A Study to Investigate the Safety and Biodistribution of a Single Intrathecal (IT) Injection of INS1201 in Ambulatory Males With Duchenne Muscular Dystrophy (DMD) INS1201 - Duchenne Muscular Dystrophy | Phase 1 | Active not recruiting | Insmed Gene Therapy LLC | 12 | 2025-07-22 | 2026-10-28 |
| A Study to Assess THN391 in Subjects With Alzheimer's Disease THN391, Placebo - Alzheimer Disease, Early Onset | Phase 1 | Active not recruiting | Therini Bio, Inc. | 19 | 2025-07-17 | 2026-07-08 |
| A Study on Bioequivalence of Cabergoline Tablets in Human Body Cabergoline tablets test formulation, Cabergoline tablets reference formulation - Hyperprolactinemia | Phase 1 | Active not recruiting | Changchun GeneScience Pharmaceutical Co., Ltd. | 72 | 2025-06-30 | 2025-11-17 |
| Safety Of Nrtis for Alzheimer's Therapeutic Advancement in Singapore Study Emtricitabine (FTC), Descovy® (TAF/FTC), Placebo to Match Emtricitabine 200mg/Tenofovir Alafenamide 25 mg. - Mild Cognitive Impairment (MCI), Alzheimer Dementia (AD) | Phase 1 | Active not recruiting | National University Hospital, Singapore | 48 | 2025-06-30 | 2026-08-10 |
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Brain Neoplasms (42) · Glioma (18) · Alzheimer Disease (16) · Glioblastoma (16) · Central Nervous System Neoplasms (14) · Parkinson Disease (13) · Multiple Sclerosis (12) · Amyotrophic Lateral Sclerosis (11) · Carcinoma, Non-Small-Cell Lung (11) · Medulloblastoma (10) · Meningeal Carcinomatosis (10) · Breast Neoplasms (9) · Diffuse Intrinsic Pontine Glioma (9) · Ependymoma (8) · Melanoma (8)
Central Nervous System Diseases (155) · Brain Diseases (136) · Neurodegenerative Diseases (88) · Neoplasms (86) · Nervous System Neoplasms (80) · Neoplasms by Site (77) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (76) · Genetic Diseases, Inborn (71) · Neoplasms by Histologic Type (60) · Central Nervous System Neoplasms (55) · Neuromuscular Diseases (54) · Neoplasms, Nerve Tissue (52) · Nutritional and Metabolic Diseases (48) · Pathological Conditions, Signs and Symptoms (48)
Cyclophosphamide (9) · Magnetic Resonance Spectroscopy (6) · Radiosurgery (6) · Temozolomide (6) · fludarabine (6) · pembrolizumab (6) · AZD 6244 (5) · Nivolumab (5) · Radiotherapy (5) · Specimen Handling (5) · Carboplatin (3) · Cisplatin (3) · Mental Status and Dementia Tests (3) · Methylprednisolone (3) · Pemetrexed (3)
National Cancer Institute (NCI) (12) · Hoffmann-La Roche (8) · AstraZeneca (5) · n-Lorem Foundation (5) · Eli Lilly and Company (4) · M.D. Anderson Cancer Center (4) · Memorial Sloan Kettering Cancer Center (4) · Novartis Pharmaceuticals (4) · Prevail Therapeutics (4) · Seattle Children's Hospital (4) · University of Florida (4) · Guangzhou Medical University (3) · Jonsson Comprehensive Cancer Center (3) · UniQure Biopharma B.V. (3) · University of California, Los Angeles (3)
United States (186) · United Kingdom (45) · Spain (38) · Canada (36) · Australia (35) · France (30) · Germany (26) · Italy (26) · China (24) · Netherlands (15) · South Korea (14) · Japan (13) · Belgium (12) · Brazil (11) · Israel (9)
Ashley Ghiaseddin, MD (3) · Craig van Horne, MD, PhD (2) · Jeremie Calais (2) · Pranshu Mohindra (2) · Rebecca Ronsley, MD (2) · Aaron Tward, MD, PhD (1) · Abi Vainstein-Haras, MD (1)
PMID 36463457, PMID 37624739, PMID 38489195, PMID 10870744, PMID 11165371, PMID 11786502, PMID 12473512, PMID 14621285, PMID 15647484, PMID 15800228, PMID 15911704, PMID 16466122, PMID 16508405, PMID 17123731, PMID 17237664, PMID 17433624, PMID 17635557, PMID 17853395, PMID 18294378, PMID 18362258, PMID 18378801, PMID 18419722, PMID 18619874, PMID 18774343, PMID 19198615, PMID 19409861, PMID 19687359, PMID 19789074, PMID 20031953, PMID 20086062, PMID 21029787, PMID 21148579, PMID 21249671, PMID 21358740, PMID 21412914, PMID 21765969, PMID 22336864, PMID 22494121, PMID 22898544, PMID 24002370, PMID 24068826, PMID 24227635, PMID 24495468, PMID 24606242, PMID 24661411, PMID 24721800, PMID 24867013, PMID 25221944, PMID 25418676, PMID 25872113
2023 (21), 2019 (7), UM1CA081457 (4), 2025 (2), UM1CA186686 (2), UM1CA186691 (2), UM1CA186712 (2), 2014 (1), 2017 (1), 2018 (1), DP2HD101400 (1), K08CA245181 (1), K12CA120780 (1), K23HD111623 (1), P30CA016058 (1)