29 completed, 10 terminated, 10 unknown, 7 recruiting. 62 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 62 | Completed 29, Terminated 10, Unknown 10, Recruiting 7, Not yet recruiting 3, Withdrawn 3 |
Follow Neoplasm Metastasis: new trials by email Literature Review of Neoplasm Metastasis trials Research Report on Neoplasm Metastasis
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Evaluating Treatment Outcomes Using Darolutamide and Androgen Deprivation Therapy in Patients With Metastatic Hormone-Sensitive Prostate Cancer. Darolutamide, Physician choice Androgen Deprivation (Hormone) Therapy - Prostate Cancer | Phase 4 | Not yet recruiting | University of Chicago | 80 | 2026-11-01 | 2026-01-08 |
| Efficacy and Safety of Ensartinib Combined With Anlotinib in Lorlatinib-Resistant ALK-Positive NSCLC Combined group of ensatinib and arotinib - ALK-positive, Locally Advanced or Metastatic (TNM Stage IIIB-IV) Non-small Cell Lung Cancer That Has Developed Resistance to Prior Treatment With Lorlatinib | Phase 4 | Not yet recruiting | Qiming Wang | 80 | 2026-07-01 | 2026-06-26 |
| Morning Versus Afternoon Administration of Immunotherapy for the Treatment of Advanced or Metastatic Solid Tumors, The Knight SHIFT Study Biospecimen Collection, Immune Checkpoint Inhibitor - Advanced Biliary Tract Carcinoma, Advanced Head and Neck Squamous Cell Carcinoma | Phase 4 | Recruiting | OHSU Knight Cancer Institute | 160 | 2026-04-24 | 2026-10-13 |
| FOLFOX Chemotherapy Combined With Fruquintinib and Serplulimab as First-Line Conversion Therapy for Initially Unresectable pMMR/MSS Colorectal Cancer Serplulimab, Fruquintinib, mFOLFOX6 (oxaliplatin, calcium folinate, and 5-FU) - Colorectal Cancer (Locally Advanced or Metastatic), Colorectal Cancer Microsatellite Stable (MSS) | Phase 4 | Not yet recruiting | Ye Xu | 42 | 2026-03-01 | 2026-03-03 |
| Evaluating Dose Timing (Morning vs Evening) of Endocrine-based Therapies in Metastatic Breast and Prostate Cancers Morning administration of CDK4/6 inhibitor, Evening administration of CDK4/6 inhibitor, Morning administration of ARPI - Metastatic Breast Cancer, Metastatic Prostate Cancer | Phase 4 | Recruiting | Ottawa Hospital Research Institute | 50 | 2026-02-02 | 2026-07-17 |
| Digital Monitoring of Self-reported Symptoms by Patients Treated With Cabozantinib Plus Nivolumab for Advanced Clear-cell Renal Carcinoma cabozantinib and nivolumab - Renal Cell Carcinoma (Kidney Cancer), Metastatic Renal Cell Carcinoma | Phase 4 | Recruiting | Centre Francois Baclesse | 83 | 2025-10-01 | 2026-07-14 |
| Post-operative Adjuvant Therapy w/wo GammaTile + Systemic Therapy Gamma Tile-Surgically Targeted Radiation Therapy (STaRT), Stereotactic Radiation Therapy - Glioblastoma | Phase 4 | Withdrawn | GT Medical Technologies, Inc. | 2025-05-01 | 2025-04-10 | |
| DDR Genes Alteration and Response to Platinum-based Chemotherapy in Advanced Urothelial Cancer. Platinum + Gemcitabine, Avelumab first-line maintenance, NGS test for DDR alterations - Bladder (Urothelial, Transitional Cell) Cancer Metastatic or Unresectable, Upper Tract Urothelial Cancer | Phase 4 | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 135 | 2025-01-07 | 2025-02-11 |
| Prevention of Recurrence and Metastasis of Colorectal Cancer by Comparing Huaier With Capecitabine Monotherapy Huaier granule, Capecitabine - Colorectal Cancer | Phase 4 | Recruiting | Fudan University | 756 | 2024-10-18 | 2025-05-07 |
| Anesthesia and Non-small Cell Lung Cancer Recurrence Propofol, Inhaled anesthetics - Non-small Cell Lung Cancer, Surgery | Phase 4 | Recruiting | Samsung Medical Center | 5384 | 2024-08-05 | 2026-04-20 |
| Clinical Study on the Effect of Selenium Yeast Capsule on Prognosis of Differentiated Thyroid Carcinoma Selenium Yeast, Placebo - Selenium Deficiency, Thyroid Cancer TNM Staging | Phase 4 | Unknown | Qianfoshan Hospital | 5000 | 2022-05-30 | 2022-03-14 |
| A Study of Abemaciclib in Indian Women With Advanced Breast Cancer Abemaciclib, Nonsteroidal Aromatase Inhibitor (NSAI), Fulvestrant - Breast Neoplasms, Neoplasm Metastasis | Phase 4 | Completed | Eli Lilly and Company | 200 | 2021-02-22 | 2023-11-24 |
| Propofol vs Sevo for Paediatric Tumor Surgery propofol, sevoflurane - Solid Tumor, Carcinoma | Phase 4 | Recruiting | Hong Kong Children's Hospital | 100 | 2021-01-11 | 2022-03-16 |
| Use of Indocyanine Green During Pelvic Lymph Node Dissection in Prostate Cancer. Indocyanine green - Prostate Cancer, Lymph Node Metastases | Phase 4 | Unknown | TC Erciyes University | 50 | 2019-11-08 | 2021-05-12 |
| Influence of Opioid Analgesia on Circulating Tumor Cells in Laparoscopic Colorectal Cancer Surgery Morphine, Piritramid - Colorectal Cancer, Circulating Tumor Cell | Phase 4 | Completed | The Institute of Molecular and Translational Medicine, Czech Republic | 71 | 2019-01-07 | 2023-12-07 |
| Influence of Opioid Analgesia on Circulating Tumor Cells in Open Colorectal Cancer Surgery Morphine, Piritramid, Epidural - Colorectal Cancer, Circulating Tumor Cell | Phase 4 | Completed | The Institute of Molecular and Translational Medicine, Czech Republic | 125 | 2019-01-07 | 2023-12-07 |
| Dual Time Point FDG PET/MRI Scan in Improving the Imaging Cancer Patients With Brain Metastases Fludeoxyglucose F-18, Magnetic Resonance Imaging, Positron Emission Tomography - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 4 | Completed | M.D. Anderson Cancer Center | 12 | 2018-08-03 | 2024-05-01 |
| Obstetrical Gel Use to Shorten Labor and Prevent Lower Genital Tract Trauma Natalis - Labor Stage, Second | Phase 4 | Completed | American University of Beirut Medical Center | 160 | 2018-04-03 | 2020-09-03 |
| Study to Explore the Mechanism of Acquired Immune Escape In Participants With Metastatic Cancer Progressing on CPI Therapy Biopsy - Neoplasms | Phase 4 | Completed | Hoffmann-La Roche | 15 | 2018-02-16 | 2022-08-12 |
| Impact of eHealth-support on Quality of Life in Metastatic Breast Cancer Patients Treated With Palbociclib and Endocrine Therapy Palbociclib, Fulvestrant, Anastrozole - Breast Neoplasm | Phase 4 | Terminated | Palleos Healthcare GmbH | 532 | 2017-07-24 | 2022-01-06 |
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Breast Neoplasms (12) · Colorectal Neoplasms (9) · Prostatic Neoplasms (7) · Neoplastic Cells, Circulating (6) · Melanoma (5) · Neoplasms (5) · Recurrence (5) · Carcinoma, Hepatocellular (4) · Pain (4) · Brain Neoplasms (3) · Carcinoma, Renal Cell (3) · Lung Neoplasms (3) · Bone Neoplasms (2) · Burns (2)
Neoplastic Processes (62) · Pathologic Processes (62) · Pathological Conditions, Signs and Symptoms (62) · Neoplasms (57) · Neoplasms by Site (43) · Digestive System Diseases (17) · Digestive System Neoplasms (17) · Skin Diseases (16) · Skin and Connective Tissue Diseases (16) · Neoplasms by Histologic Type (14) · Breast Diseases (12) · Gastrointestinal Diseases (12) · Urogenital Diseases (12) · Male Urogenital Diseases (11) · Neoplasms, Glandular and Epithelial (11)
Zoledronic Acid (5) · Bevacizumab (3) · Capecitabine (2) · Cetuximab (2) · Desflurane (2) · Fluorouracil (2) · Fulvestrant (2) · Ibandronic Acid (2) · Letrozole (2) · Magnetic Resonance Spectroscopy (2) · Misoprostol (2) · Morphine (2) · Oxaliplatin (2) · Pamidronate (2) · Pirinitramide (2)
Novartis Pharmaceuticals (4) · Hoffmann-La Roche (3) · Bayer (2) · Centre Francois Baclesse (2) · Fudan University (2) · Ottawa Hospital Research Institute (2) · Spanish Breast Cancer Research Group (2) · The Institute of Molecular and Translational Medicine, Czech Republic (2) · Xu jianmin (2) · Ain Shams Maternity Hospital (1) · American University of Beirut Medical Center (1) · Astellas Pharma Global Development, Inc. (1) · Ataturk University (1) · Bispebjerg Hospital (1) · Centre hospitalier de l'Université de Montréal (CHUM) (1)
United States (14) · China (9) · Germany (9) · Spain (7) · South Korea (6) · France (5) · Canada (4) · Czechia (4) · Italy (4) · Netherlands (3) · Poland (3) · United Kingdom (3) · Hong Kong (2) · Hungary (2) · India (2)
Marian Hajduch, MD PhD (2) · Abebe Haregewoin, MD, PhD (1) · Aihua Zhang (1) · Aili Jiang (1) · Alaa Elfeky, Professor (1) · Ana-Alicia Beltran-Bless, MD (1) · Axel Hauschild, MD (1) · Beatrice Beck Schimmer, Prof. MD (1)
PMID 11981766, PMID 12049862, PMID 12091661, PMID 12540794, PMID 15249979, PMID 18650514, PMID 18708295, PMID 19095497, PMID 19927040, PMID 20361253, PMID 20375851, PMID 21605146, PMID 22704310, PMID 23569301, PMID 24652690, PMID 26465781, PMID 28494643, PMID 28497402, PMID 29802174, PMID 31410598, PMID 32220944, PMID 34068083, PMID 36855089, PMID 37147645, PMID 37201751, PMID 38412408, PMID 39039548
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