8 completed, 2 recruiting, 1 no longer available, 1 suspended. 5 Phase 2, 3 Not applicable, 1 Phase 1, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 5 |
| Not applicable | 3 | Completed 2, Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
| Phase 3 | 1 | Completed 1 |
Follow Narcolepsy Without Cataplexy: new trials by email Literature Review of Narcolepsy Without Cataplexy trials Research Report on Narcolepsy Without Cataplexy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Decreasing Nightmares in Adults With Narcolepsy Imagery Rehearsal Therapy (IRT) - Narcolepsy, Narcolepsy Type 1 | Not applicable | Recruiting | University of Utah | 80 | 2026-07-01 | 2026-07-15 |
| Narcolepsy Nightmare Study Imagery rehearsal therapy, Targeted dream control - Narcolepsy, Narcolepsy Type 1 | Not applicable | Completed | Northwestern University | 7 | 2023-02-22 | 2026-06-30 |
| An Open Label Study of NLS-2 (Mazindol Extended Release) in Subjects With Narcolepsy Mazindol - Narcolepsy With Cataplexy, Narcolepsy | Phase 2 | Completed | NLS Pharmaceutics | 52 | 2021-10-26 | 2023-03-13 |
| Awareness and Self-Compassion Enhancing Narcolepsy Treatment Brief MBI, Standard MBI, Extended MBI - Narcolepsy, Narcolepsy Without Cataplexy | Not applicable | Completed | Northwestern University | 60 | 2020-06-15 | 2024-08-20 |
| 'A Profile of Physical Performance Variables in an Out-patient Adult Population With Narcolepsy' Assessment of physical performance variables - Narcolepsy, Narcolepsy 1 | Suspended | University of Dublin, Trinity College | 70 | 2019-10-15 | 2020-06-05 | |
| Clarithromycin Mechanisms in Hypersomnia Syndromes Clarithromycin, Placebo - Narcolepsy Without Cataplexy, Idiopathic Hypersomnia | Phase 2 | Completed | Emory University | 83 | 2019-09-04 | 2026-08-07 |
| Modafinil Versus Amphetamines for the Treatment of Narcolepsy Type 2 and Idiopathic Hypersomnia Modafinil, Amphetamine-Dextroamphetamine - Idiopathic Hypersomnia, Narcolepsy Without Cataplexy | Phase 2 | Completed | Emory University | 44 | 2019-04-15 | 2024-05-23 |
| Efficacy and Safety of Pitolisant in Pediatric Narcoleptic Patients With or Without Cataplexy, Double-blind Study Followed by a Prolonged Open-label Period pitolisant, Placebo - Narcolepsy With Cataplexy, Narcolepsy Without Cataplexy | Phase 3 | Completed | Bioprojet | 110 | 2016-06-06 | 2025-06-26 |
| A Study of Safety and Efficacy of BTD-001 in Treatment of Patients With Idiopathic Hypersomnia (IH) or Narcolepsy Type 2 BTD-001, Placebo - Idiopathic Hypersomnia, Narcolepsy Without Cataplexy | Phase 2 | Completed | Balance Therapeutics | 120 | 2015-09-01 | 2019-01-16 |
| Flumazenil for the Treatment of Primary Hypersomnia Flumazenil - Hypersomnia, Primary Hypersomnia | Phase 1 / Phase 2 | Completed | Lynn Marie Trotti | 10 | 2010-09-01 | 2017-12-12 |
| Rare Disease Patient Registry & Natural History Study - Coordination of Rare Diseases at Sanford Rare Disorders, Undiagnosed Disorders | Recruiting | Sanford Health | 20000 | 2010-07-01 | 2026-10-28 | |
| Expanded Access Program to Provide Treatment With Pitolisant to Adult Patients in the U.S. With Excessive Daytime Sleepiness Associated With Narcolepsy With or Without Cataplexy Pitolisant - Narcolepsy Without Cataplexy, Narcolepsy With Cataplexy | No longer available | Harmony Biosciences Management, Inc. | 2019-08-28 |
Narcolepsy (9) · Idiopathic Hypersomnia (5) · Disorders of Excessive Somnolence (4) · 3-Methylglutaconic Aciduria, Type V (1) · Achalasia Addisonianism Alacrimia syndrome (1) · Acrodysostosis (1) · Activated PI3K-delta Syndrome (1) · Addison Disease (1) · Alagille Syndrome (1) · Alstrom Syndrome (1) · Amnesia, Transient Global (1) · Aniridia (1) · Aniridia and Absent Patella (1) · Aniridia, Partial, with Unilateral Renal Agenesis and Psychomotor Retardation (1) · Ataxia (1)
Dyssomnias (12) · Mental Disorders (12) · Nervous System Diseases (12) · Sleep Disorders, Intrinsic (12) · Sleep Wake Disorders (12) · Disorders of Excessive Somnolence (8) · Abnormalities, Multiple (1) · Adrenal Gland Diseases (1) · Adrenal Insufficiency (1) · Amino Acid Metabolism, Inborn Errors (1) · Amino Acid Transport Disorders, Inborn (1) · Amnesia (1) · Anemia (1) · Anemia, Hemolytic (1) · Aortic Stenosis, Supravalvular (1)
pitolisant (2) · Adderall (1) · Clarithromycin (1) · Cognitive Behavioral Therapy (1) · Flumazenil (1) · Mazindol (1) · Modafinil (1) · SLI381 (1)
Emory University (2) · Northwestern University (2) · Balance Therapeutics (1) · Bioprojet (1) · Harmony Biosciences Management, Inc. (1) · Lynn Marie Trotti (1) · NLS Pharmaceutics (1) · Sanford Health (1) · University of Dublin, Trinity College (1) · University of Utah (1)
United States (10) · Finland (1) · France (1) · Ireland (1) · Italy (1) · Netherlands (1) · Russia (1)
Jennifer Mundt, PhD (2) · Lynn Marie Trotti, MD, MSc (2) · Carlos Camozzi, MD (1) · Giuseppe Plazzi, MD (1) · Lyndon Lien, PhD (1) · Lynn Marie Trotti, MD (1) · Michael Thorpy, MD (1)
PMID 36931805, PMID 38895897, PMID 39306601
R01NS111280 (1), R34AT009551 (1)