58 completed, 7 unknown, 3 terminated, 3 withdrawn. 21 Phase 1, 19 Not applicable, 2 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 21 | Completed 21 |
| Not applicable | 19 | Completed 12, Terminated 3, Unknown 2, Not yet recruiting 1, Suspended 1 |
| Phase 2 | 2 | Completed 2 |
| Phase 3 | 1 | Completed 1 |
Follow Zika Virus Infection: new trials by email Literature Review of Zika Virus Infection trials Research Report on Zika Virus Infection
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Using Digital Technology for the Prevention of Aedes-Borne Diseases in Colombian Communities Full intervention, Partial intervention - Dengue, Zika | Not applicable | Completed | University of Freiburg | 900 | 2026-03-26 | 2026-04-08 |
| Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective Dengue, Chikungunya | Recruiting | Institut Pasteur du Cambodge | 10000 | 2025-12-18 | 2026-01-22 | |
| Xpert® Tropical Fever Test on GeneXpert® Edge X System Xpert Tropical Fever test - Malaria Fever, Zika | Enrolling by invitation | Cepheid | 2500 | 2025-08-18 | 2026-04-09 | |
| Serological Measurement of Montpellier Professionals' Contacts with Infectious Agents Responsible for Animal-borne Diseases Peripheral venous blood sample - Leishmaniasis, Leptospirosis | Not applicable | Not yet recruiting | University Hospital, Montpellier | 183 | 2025-03-03 | 2025-03-05 |
| Evaluation of the Protective Efficacy of TV003 or Previous Zika Infection Against Infection With ZIKV-SJRP Challenge Compared to DENV and ZIKV-naïve Controls Against Infection With ZIKV-SJRP Challenge TetraVax-DV-TV003 (TV003), Plasmalyte, Challenge virus ZIKV-SJRP/2016-184 - Zika Virus | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 27 | 2024-09-24 | 2026-03-09 |
| Testing Combined IIT-SIT to Control Mosquito-Borne Diseases At Scale Wolbachia induced incompatible mating, Standard traditional chemical mosquito control - Dengue, Zika | Not applicable | Terminated | Michigan State University | 15243 | 2024-05-28 | 2026-03-19 |
| Phase 1 Trial to Assess the Safety and Immunogenicity of an Inactivated, Adjuvanted Whole Zika Virus Vaccine Candidate (VLA1601) in Healthy Adults VLA1601, CpG 1018®, 3M-052-AF - Zika, Zika Virus Infection | Phase 1 | Completed | Valneva Austria GmbH | 150 | 2024-03-25 | 2026-03-09 |
| Evaluation of Viral Replication by Tonate Virus (TONV) and Zika Virus (ZIKV), Within an ex Vivo Trophoblast and Placental Model Cell line and virus, Infection of human placental culture explants, Determination of viral load in tissues by qRT-PCR - Zika Virus Infection | Withdrawn | Assistance Publique - Hôpitaux de Paris | 2023-11-01 | 2026-08-12 | ||
| Spatial Repellents for Aedes-borne Virus Control in Sri Lanka Transfluthrin, Placebo - Arbovirus Infections | Not applicable | Completed | University of Notre Dame | 6949 | 2023-03-02 | 2025-09-15 |
| Population Immunity AgaiNst mosquitO-borne Diseases in Vanuatu Blood collection - Arbovirus Disease, Zika | Not applicable | Completed | Institut Pasteur | 1122 | 2022-10-17 | 2024-05-23 |
| Evaluation of Two Zika Viruses for Use in Controlled Human Infection Models (CHIM) ZIKV-SJRP/2016-184 Strain, Experimental: ZIKV-Nicaragua/2016 Strain, Placebo - Zika Virus | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 56 | 2022-02-16 | 2025-04-11 |
| Baromètre Santé Adulte 2021-2022 Blood sample - Diabetes, Hypercholesterolemia | Not applicable | Suspended | Agence Sanitaire et Sociale de Nouvelle Calédonie | 5471 | 2021-07-26 | 2022-02-01 |
| Adherence to Care for Children With Congenital Zika Virus Infection in Puerto Rico Community Health Worker - Zika Virus Infection, Adherence, Patient | Not applicable | Completed | Massachusetts General Hospital | 50 | 2021-07-06 | 2023-12-15 |
| A Study of Zika Vaccine mRNA-1893 in Adult Participants Living in Endemic and Non-Endemic Flavivirus Areas mRNA-1893, Placebo - Zika Virus | Phase 2 | Completed | ModernaTX, Inc. | 808 | 2021-06-07 | 2025-09-25 |
| Virological and Immunological Determinants of Arbovirus Infection in New Caledonia Blood sample collection - Arbovirus Infections, Zika | Not applicable | Unknown | Institut Pasteur | 250 | 2021-02-15 | 2024-05-23 |
| Sylvatic Transmission of Zika, Dengue, and Chikungunya Viruses in Thailand and Cambodia Dengue Fever, Zika | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 300 | 2021-02-08 | 2024-04-26 | |
| Infection Tracking in Travellers. The Project Aims to Identify Profiles of Travel-associated Illness and to Follow up on Long-term Sequelae of Arboviral Infections and Malaria Observational study - Travel-Related Illness, Malaria | Unknown | Patricia Schlagenhauf | 10000 | 2021-01-30 | 2020-12-17 | |
| Neurodevelopmental Outcomes in ZIKV-Exposed Children Neurodevelopmental assessments - Zika Virus, Congenital Zika Syndrome | Enrolling by invitation | Children's National Research Institute | 204 | 2020-11-23 | 2025-07-03 | |
| Quantifying the Epidemiological Impact of Targeted Indoor Residual Spraying on Aedes-borne Diseases Targeted Indoor Residual Spraying (TIRS) - Aedes-borne Diseases, Dengue | Not applicable | Completed | Emory University | 4461 | 2020-11-03 | 2025-09-18 |
| Research Study to Assess New Chikungunya and Zika Vaccines in Healthy Adults in Mexico. CHIK low dose, CHIK mid dose, CHIK high dose - Chikungunya, Zika | Phase 1 | Completed | University of Oxford | 120 | 2020-10-23 | 2022-03-23 |
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Chikungunya Fever (27) · Dengue (25) · Arbovirus Infections (6) · Microcephaly (6) · Malaria (5) · Vector Borne Diseases (4) · Leishmaniasis (3) · Leptospirosis (3) · Virus Diseases (3) · Brucellosis (2) · Communicable Diseases (2) · Encephalitis, Tick-Borne (2) · Fever (2) · Flavivirus Infections (2)
Infections (77) · Flaviviridae Infections (76) · RNA Virus Infections (76) · Flavivirus Infections (75) · Mosquito-Borne Diseases (75) · Virus Diseases (74) · Vector Borne Diseases (73) · Arbovirus Infections (71) · Alphavirus Infections (27) · Togaviridae Infections (27) · Hemorrhagic Fevers, Viral (25) · Nervous System Diseases (11) · Pathological Conditions, Signs and Symptoms (9) · Congenital, Hereditary, and Neonatal Diseases and Abnormalities (7) · Musculoskeletal Diseases (7)
GLS-5700 vaccine (3) · Blood Specimen Collection (2) · 1018 oligonucleotide (1) · COVID-19 Nucleic Acid Testing (1) · Community Health Workers (1) · Control Groups (1) · Erythrocyte Count (1) · Hydrotherapy (1) · Immersion (1) · Observation (1) · Physical Therapy Modalities (1) · Plasmalyte A (1) · Pregnancy Trimester, First (1) · Pregnancy Trimester, Second (1) · Saline Solution (1)
National Institute of Allergy and Infectious Diseases (NIAID) (12) · Institut Pasteur (3) · ModernaTX, Inc. (3) · University of Heidelberg Medical Center (3) · GeneOne Life Science, Inc. (2) · Oswaldo Cruz Foundation (2) · RTI International (2) · Themis Bioscience GmbH (2) · Universidade Federal de Pernambuco (2) · University Hospital Center of Martinique (2) · University of Notre Dame (2) · University of Oxford (2) · Valneva Austria GmbH (2) · Westat (2) · Agence Sanitaire et Sociale de Nouvelle Calédonie (1)
United States (23) · Brazil (15) · Colombia (12) · Puerto Rico (12) · Mexico (8) · Guadeloupe (5) · Peru (5) · France (4) · Cambodia (3) · Martinique (3) · Austria (2) · Bolivia (2) · Canada (2) · Cuba (2) · French Guiana (2)
Myrielle Dupont-Rouzeyrol, PhD (3) · Anna Durbin, MD (2) · Matthew J Memoli, M.D. (2) · Adi Utarini, MD, PhD (1) · Adrian V Hill, DPhill FRCP (1) · Albert Ko, MD (1) · Ana Garces, MD (1) · Andre Cabie, MD (1) · Angel Balmaseda (1) · Anna Durbin, M.D. (1)
PMID 29217375, PMID 31878895, PMID 33422034, PMID 36682364, PMID 37254133, PMID 27694629, PMID 27705091, PMID 28715527, PMID 28877754, PMID 29855331, PMID 30476967, PMID 30572920, PMID 31002058, PMID 31053842, PMID 31391005, PMID 31672665, PMID 31904798, PMID 32163420, PMID 32274991, PMID 32450914, PMID 32618279, PMID 33400705, PMID 33472606, PMID 33503145, PMID 33686914, PMID 33828518, PMID 33872214, PMID 34019802, PMID 34107180, PMID 34454432, PMID 34525286, PMID 34529649, PMID 34610572, PMID 34718636, PMID 34900237, PMID 34962177, PMID 35144270, PMID 35236394, PMID 35255097, PMID 35255839, PMID 35259172, PMID 36384430, PMID 36446920, PMID 36484441, PMID 37068115, PMID 37390836, PMID 38032857, PMID 38244996, PMID 38392908, PMID 38438554
2016 (1), 2019 (1), R01HD102445 (1), R21AI139777 (1), R21HD095420 (1), R21HD096369 (1), U01AI148069 (1)