6 active not recruiting, 4 terminated, 3 completed, 3 withdrawn. 10 Phase 2, 8 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Active not recruiting 5, Withdrawn 2, Completed 1, Terminated 1, Unknown 1 |
| Phase 1 | 8 | Active not recruiting 4, Completed 2, Terminated 2 |
Follow Metastatic Rectal Adenocarcinoma: new trials by email Literature Review of Metastatic Rectal Adenocarcinoma trials Research Report on Metastatic Rectal Adenocarcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| xDRIVE in Metastatic Colorectal Cancer Functional precision medicine - Metastatic Colon Adenocarcinoma, Metastatic Colon Cancer | Withdrawn | First Ascent Biomedical Inc. | 2025-09-15 | 2026-09-02 | ||
| Botensilimab, Balstilimab and Regorafenib or Botensilimab and Balstilimab for the Treatment of Advanced or Metastatic Microsatellite Stable Colorectal Cancer Balstilimab, Biopsy, Biospecimen Collection - Advanced Colon Adenocarcinoma, Advanced Colorectal Adenocarcinoma | Phase 2 | Withdrawn | City of Hope Medical Center | 2024-11-01 | 2024-11-21 | |
| Tucatinib Combined with Trastuzumab and TAS-102 for the Treatment of HER2 Positive Metastatic Colorectal Cancer in Molecularly Selected Patients, 3T Study Trastuzumab, Trifluridine and Tipiracil Hydrochloride, Tucatinib - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 2 | Withdrawn | Academic and Community Cancer Research United | 2023-10-31 | 2024-09-19 | |
| FOLFOX and Bevacizumab in Combination With Botensilimab and Balstilimab (3B-FOLFOX) for the Treatment of Microsatellite Stable (MSS) Metastatic Colorectal Cancer Balstilimab, Bevacizumab, Biospecimen Collection - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 / Phase 2 | Active not recruiting | City of Hope Medical Center | 20 | 2023-05-03 | 2026-09-01 |
| Testing the Addition of Nivolumab to Standard Treatment for Patients With Metastatic or Unresectable Colorectal Cancer That Have a BRAF Mutation Cetuximab, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Rectal Adenocarcinoma | Phase 2 | Active not recruiting | National Cancer Institute (NCI) | 86 | 2022-07-19 | 2026-07-08 |
| A Vaccine (PolyPEPI1018 Vaccine) and TAS-102 for the Treatment of Metastatic Colorectal Cancer Colorectal Cancer Peptide Vaccine PolyPEPI1018, Trifluridine and Tipiracil Hydrochloride - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Completed | Mayo Clinic | 15 | 2022-01-10 | 2026-10-07 |
| BRIANSTORM - Early Identification of Patients With Brain Metastases Metastatic Rectal Adenocarcinoma, Brain Metastases | Unknown | Aarhus University Hospital | 50 | 2021-08-16 | 2023-02-03 | |
| LY3214996 and Cetuximab Alone or in Combination With Abemaciclib for the Treatment of Unresectable or Metastatic Colorectal Cancer Abemaciclib, Cetuximab, ERK1/2 Inhibitor LY3214996 - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Carcinoma | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 46 | 2020-12-02 | 2026-10-05 |
| SX-682 and Nivolumab for the Treatment of RAS-Mutated, MSS Unresectable or Metastatic Colorectal Cancer, the STOPTRAFFIC-1 Trial CXCR1/2 Inhibitor SX-682, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Carcinoma | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 51 | 2020-10-14 | 2026-07-20 |
| Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E Metastatic Colorectal Cancer Binimetinib, Encorafenib, Nivolumab - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Adenocarcinoma | Phase 1 | Terminated | University of California, San Francisco | 2 | 2020-08-31 | 2023-01-09 |
| Regorafenib, Ipilimumab and Nivolumab for the Treatment of Chemotherapy Resistant Microsatellite Stable Metastatic Colorectal Cancer Ipilimumab, Nivolumab, Regorafenib - Advanced Colon Adenocarcinoma, Metastatic Colon Adenocarcinoma | Phase 1 | Completed | City of Hope Medical Center | 39 | 2020-05-27 | 2026-01-28 |
| Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer Panitumumab, Quality-of-Life Assessment, Questionnaire Administration - Metastatic Colon Adenocarcinoma, Metastatic Colorectal Carcinoma | Phase 2 | Unknown | Academic and Community Cancer Research United | 12 | 2020-04-24 | 2024-05-21 |
| Genetic Testing in Screening Patients With Metastatic or Unresectable Colon or Rectal Cancer for a COLOMATE Trial Genetic Testing - Metastatic Colon Adenocarcinoma, Metastatic Rectal Adenocarcinoma | Terminated | Academic and Community Cancer Research United | 199 | 2020-04-20 | 2025-08-29 | |
| TAS-102, Irinotecan, and Bevacizumab for the Treatment of Pre-treated Metastatic or Unresectable Colorectal Cancer, the TABAsCO Study Irinotecan, Bevacizumab, Trifluridine and Tipiracil Hydrochloride - Advanced Colorectal Carcinoma, Metastatic Colon Adenocarcinoma | Phase 2 | Completed | Roswell Park Cancer Institute | 42 | 2019-12-27 | 2026-02-10 |
| Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer Savolitinib - Colorectal Carcinoma, Metastatic Colon Adenocarcinoma | Phase 2 | Terminated | National Cancer Institute (NCI) | 5 | 2019-07-25 | 2023-10-17 |
| Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer Cetuximab, Encorafenib, Nivolumab - BRAF NP_004324.2:p.V600E, Metastatic Colon Adenocarcinoma | Phase 1 / Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 38 | 2019-06-14 | 2026-06-11 |
| Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer Capecitabine, Fluorouracil, Leucovorin - Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma | Phase 1 | Terminated | National Cancer Institute (NCI) | 3 | 2019-05-14 | 2024-05-23 |
| Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer Biospecimen Collection - Locally Advanced Rectal Adenocarcinoma, Metastatic Rectal Adenocarcinoma | Active not recruiting | M.D. Anderson Cancer Center | 341 | 2013-09-05 | 2026-09-18 |
Rectal Neoplasms (18) · Colonic Neoplasms (15) · Colorectal Neoplasms (13) · Brain Neoplasms (1) · Disease Progression (1)
Digestive System Diseases (18) · Digestive System Neoplasms (18) · Gastrointestinal Diseases (18) · Gastrointestinal Neoplasms (18) · Intestinal Diseases (18) · Intestinal Neoplasms (18) · Neoplasms (18) · Neoplasms by Site (18) · Rectal Diseases (18) · Colonic Diseases (15) · Colorectal Neoplasms (5) · Brain Diseases (1) · Central Nervous System Diseases (1) · Central Nervous System Neoplasms (1) · Disease Attributes (1)
Nivolumab (5) · Trifluridine (4) · trifluridine tipiracil drug combination (4) · Cetuximab (3) · encorafenib (3) · regorafenib (3) · Bevacizumab (2) · Disulfides (2) · Fluorouracil (2) · Leucovorin (2) · Magnetic Resonance Spectroscopy (2) · Oxaliplatin (2) · Specimen Handling (2) · balstilimab (2) · dehydroftorafur (2)
M.D. Anderson Cancer Center (4) · Academic and Community Cancer Research United (3) · City of Hope Medical Center (3) · National Cancer Institute (NCI) (3) · Aarhus University Hospital (1) · First Ascent Biomedical Inc. (1) · Mayo Clinic (1) · Roswell Park Cancer Institute (1) · University of California, San Francisco (1)
United States (15) · Denmark (1) · Puerto Rico (1)
John H Strickler (4) · Marwan G Fakih (3) · Van K Morris (2) · Alisha Bent, MD (1) · Anders K Boysen, MD, PhD (1) · Chloe E Atreya, MD, PhD (1) · Christine M Parseghian, MD (1) · Christos Fountzilas, MD (1) · Diana J Azzam, PhD (1) · Hao Xie, MD PhD (1) · Lisa Boardman, MD (1) · Mojun Zhu, M.D. (1) · Nageshwara V Dasari (1) · Noah Berlow, PhD (1) · Yi-Qian N You (1)
PMID 36892833, PMID 39244627, PMID 39652198
P30CA015083 (3), P30CA033572 (2), R01CA187238 (1), U10CA180888 (1), UM1CA186688 (1), UM1CA186704 (1)