7 recruiting, 6 completed, 4 terminated, 2 active not recruiting. 10 Phase 2, 7 Phase 1, 3 Not applicable, 2 Phase 3, 1 Early Phase 1.
Follow Metastatic Malignant Neoplasm in the Liver: new trials by email Literature Review of Metastatic Malignant Neoplasm in the Liver trials Research Report on Metastatic Malignant Neoplasm in the Liver
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CCR5 Targeting Leronlimab in Combination With Hepatic Arterial Infusion Floxuridine and Systemic Therapy for the Treatment of Colorectal Cancer Liver Metastases, CHAMP Trial Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 1 | Not yet recruiting | City of Hope Medical Center | 36 | 2027-05-06 | 2026-09-25 |
| HRX215, A First Generation MKK4 Inhibitor Drug, for the Treatment of Patients With Colorectal Liver Metastasis After Undergoing a Portal Vein Embolization Biopsy Procedure, Biospecimen Collection, Computed Tomography - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Not yet recruiting | Mayo Clinic | 80 | 2026-12-01 | 2026-10-05 |
| Local Liver Treatment for Multi-organ Colorectal Cancer Metastases Radical local Surgery, Systemic therapy, Interventional therapy - Metastatic Colorectal Carcinoma, Multi-organ Metastatic Colorectal Cancer | Not applicable | Recruiting | Anhui Provincial Hospital | 130 | 2024-07-01 | 2024-06-10 |
| Surgical Debulking Prior to Peptide Receptor Radionuclide Therapy in Well Differentiated Gastroenteropancreatic Neuroendocrine Tumors Tumor Debulking, Lutetium Lu 177 Dotatate, Computed Tomography - Digestive System Neuroendocrine Tumor G1, Digestive System Neuroendocrine Tumor G2 | Phase 4 | Recruiting | Vanderbilt-Ingram Cancer Center | 6 | 2024-05-31 | 2026-06-24 |
| Testing Pump Chemotherapy in Addition to Standard of Care Chemotherapy Versus Standard of Care Chemotherapy Alone for Patients With Unresectable Colorectal Liver Metastases: The PUMP Trial Bevacizumab, Capecitabine, Cetuximab - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 3 | Recruiting | ECOG-ACRIN Cancer Research Group | 408 | 2024-04-10 | 2026-09-24 |
| Phase I/II Randomized Study of NBTXR3 Activated by Abscopal or RadScopal Radiation in Combination With Immunotherapy (Anti-PD-1/L-1) for Patients With Advanced Solid Malignancies Hafnium Oxide-containing Nanoparticles NBTXR3, Radiation Therapy - Advanced Malignant Solid Neoplasm, Metastatic Malignant Neoplasm in the Liver | Phase 1 / Phase 2 | Recruiting | M.D. Anderson Cancer Center | 40 | 2023-05-08 | 2026-07-30 |
| AU409 for the Treatment of Advanced Primary Liver Cancers or Solid Tumor With Liver Metastatic Disease Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Advanced Cholangiocarcinoma, Advanced Hepatocellular Carcinoma | Phase 1 | Suspended | University of Southern California | 36 | 2023-03-29 | 2026-08-17 |
| Testing the Use of Chemotherapy After Surgery for High-Risk Pancreatic Neuroendocrine Tumors Capecitabine, Temozolomide - Metastatic Malignant Neoplasm in the Liver, Pancreatic Neuroendocrine Tumor | Phase 2 | Recruiting | SWOG Cancer Research Network | 141 | 2022-05-05 | 2025-12-15 |
| Short Stitch Versus Traditional Suture for the Prevention of Incisional Hernia After Open Hepatectomy Quality-of-Life Assessment, Surgical Procedure - Liver and Intrahepatic Bile Duct Neoplasm, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Recruiting | M.D. Anderson Cancer Center | 140 | 2022-01-04 | 2026-05-26 |
| Transarterial Chemoembolization for the Treatment of Uveal Melanoma With Liver Metastases Carmustine, Ethiodized Oil, Transarterial Chemoembolization - Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma | Phase 2 | Active not recruiting | Thomas Jefferson University | 28 | 2021-09-27 | 2026-05-06 |
| An Investigational Scan (Intravoxel Incoherent Motion Diffusion Weighted Imaging) for the Evaluation of Colorectal Cancer Liver Metastases Treatment Response Diffusion Weighted Imaging - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Not applicable | Recruiting | M.D. Anderson Cancer Center | 70 | 2020-08-12 | 2026-07-20 |
| Combination Chemotherapy and Bevacizumab With the NovoTTF-100L(P) System in Treating Participants With Advanced, Recurrent, or Refractory Hepatic Metastatic Cancer Bevacizumab, Fluorouracil, Leucovorin - Advanced Malignant Neoplasm, Colorectal Carcinoma Metastatic in the Liver | Phase 1 | Terminated | M.D. Anderson Cancer Center | 38 | 2020-06-23 | 2026-07-27 |
| Preoperative Immunotherapy (Pembrolizumab) for Patients With Colorectal Cancer and Resectable Hepatic Metastases Hepatectomy, Pembrolizumab, Vactosertib - Metastatic Malignant Neoplasm in the Liver, Stage IV Colorectal Cancer AJCC v8 | Phase 2 | Terminated | Chloe Atreya, MD, PhD | 6 | 2019-07-22 | 2025-12-31 |
| Pembrolizumab With Liver-Directed or Peptide Receptor Radionuclide Therapy for Neuroendocrine Tumors and Liver Metastases Arterial Embolization, Pembrolizumab, Peptide Receptor Radionuclide Therapy (PRRT) using 177Lu-DOTA0-Tyr3-Octreotate - Metastatic Malignant Neoplasm in the Liver, Neuroendocrine Neoplasm | Phase 2 | Completed | Nicholas Fidelman, MD | 32 | 2018-08-27 | 2026-08-28 |
| Ipilimumab and Nivolumab With Immunoembolization in Treating Participants With Metastatic Uveal Melanoma in the Liver Ipilimumab, Nivolumab, Embolization Therapy - Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma | Phase 2 | Completed | Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University | 14 | 2018-05-02 | 2026-07-07 |
| Autologous CD8+ SLC45A2-Specific T Lymphocytes With Cyclophosphamide, Aldesleukin, and Ipilimumab in Treating Patients With Metastatic Uveal Melanoma Aldesleukin, Autologous CD8+ SLC45A2-specific T Lymphocytes, Cyclophosphamide - Metastatic Malignant Neoplasm in the Liver, Metastatic Uveal Melanoma | Phase 1 | Unknown | M.D. Anderson Cancer Center | 34 | 2017-09-08 | 2024-01-25 |
| Liver Surgery and Chemotherapy in Treating Patients With Colorectal Cancer With Liver Metastases That Can Be Removed by Surgery and Lung Metastases That Cannot Be Removed by Surgery Chemotherapy, Laboratory Biomarker Analysis, Metastasectomy - Metastatic Colorectal Carcinoma, Metastatic Malignant Neoplasm in the Liver | Phase 2 | Terminated | M.D. Anderson Cancer Center | 29 | 2016-09-23 | 2026-02-17 |
| Radiation Therapy in Treating Patients With Hepatocellular Carcinoma, Cholangiocarcinoma, or Liver Metastasis Who Have Impaired Liver Function Laboratory Biomarker Analysis, Magnetic Resonance Imaging, Radiation Therapy - Cholangiocarcinoma, Cirrhosis | Phase 1 | Terminated | M.D. Anderson Cancer Center | 36 | 2016-02-15 | 2026-06-17 |
| MRI-Guided Stereotactic Body Radiation Therapy in Treating Patients With Liver Metastases or Liver Cancer Image-Guided Adaptive Radiation Therapy, Stereotactic Body Radiation Therapy - Adult Hepatocellular Carcinoma, Metastatic Malignant Neoplasm in the Liver | Early Phase 1 | Completed | Jonsson Comprehensive Cancer Center | 21 | 2015-06-03 | 2023-02-21 |
| Testing Whether Treating Breast Cancer Metastases With Surgery or High-Dose Radiation Improves Survival Stereotactic Body Radiotherapy, Surgery - Anatomic Stage IV Breast Cancer American Joint Committee on Cancer (AJCC) v8, Metastatic Breast Carcinoma | Phase 2 / Phase 3 | Completed | NRG Oncology | 129 | 2014-12-24 | 2026-07-10 |
Showing 20 of 23. Sign in to see all of them.
Colorectal Neoplasms (8) · Carcinoma, Hepatocellular (5) · Uveal Melanoma (3) · Neoplasm Metastasis (2) · Adenoma, Islet Cell (1) · Breast Neoplasms (1) · Cholangiocarcinoma (1) · Digestive System Diseases (1) · Fibrosis (1) · Lung Neoplasms (1) · Lymphatic Metastasis (1) · Neoplasms (1) · Neuroendocrine Tumors (1)
Neoplasms (21) · Neoplasms by Site (18) · Digestive System Neoplasms (14) · Digestive System Diseases (13) · Neoplasms by Histologic Type (10) · Colonic Diseases (8) · Gastrointestinal Diseases (8) · Gastrointestinal Neoplasms (8) · Intestinal Diseases (8) · Intestinal Neoplasms (8) · Rectal Diseases (8) · Neoplasms, Glandular and Epithelial (6) · Adenocarcinoma (5) · Carcinoma (5) · Liver Diseases (5)
Magnetic Resonance Spectroscopy (6) · Specimen Handling (3) · Surgical Procedures, Operative (3) · 5-fluoro-2'-deoxyuridine (2) · Bevacizumab (2) · Biopsy (2) · CTLA-4 Antigen (2) · Capecitabine (2) · Disulfides (2) · Drug Therapy (2) · Embolization, Therapeutic (2) · Floxuridine (2) · Fluorouracil (2) · Hepatectomy (2) · Immunoglobulin G (2)
M.D. Anderson Cancer Center (9) · Anhui Provincial Hospital (1) · Chloe Atreya, MD, PhD (1) · City of Hope Medical Center (1) · ECOG-ACRIN Cancer Research Group (1) · Jonsson Comprehensive Cancer Center (1) · Mayo Clinic (1) · NRG Oncology (1) · National Cancer Institute (NCI) (1) · Nicholas Fidelman, MD (1) · SWOG Cancer Research Network (1) · Sidney Kimmel Comprehensive Cancer Center at Thomas Jefferson University (1) · Thomas Jefferson University (1) · University of Southern California (1) · Vanderbilt-Ingram Cancer Center (1)
United States (22) · Canada (2) · China (1) · Mexico (1) · Saudi Arabia (1) · South Korea (1) · Uruguay (1)
Ann Raldow, MD (1) · Anthony B El-Khoueiry, MD (1) · Carin Gonsalves, MD (1) · Chloe Atreya, MD, Ph.D. (1) · Eugene J Koay (1) · Heloisa P Soares (1) · Janio Szklaruk, MD, PHD (1) · Ji-Zhou Wang, MD PhD (1) · Kamran Idrees, MD (1) · Lillian L Siu (1) · Marlana Orloff, MD (1) · Michael Lidsky (1) · Nicholas Fidelman, MD (1) · Osama Mawlawi (1) · Pashtoon M Kasi (1)
PMID 35130943, PMID 35602670, PMID 38730548, PMID 40101049, PMID 41825097
P30CA016672 (3), N01CM00100 (1), P30CA014089 (1), P30CA033572 (1), R01DK140085 (1), U01CA062487 (1), U01CA062490 (1), U01CA132123 (1), U10CA180820 (1), U10CA180868 (1), U10CA180888 (1), UM1CA186644 (1), UM1CA186689 (1), UM1CA186690 (1), UM1CA186704 (1)