23 active not recruiting, 22 completed, 16 recruiting, 11 terminated. 28 Phase 2, 23 Phase 1, 14 Not applicable, 12 Phase 3, 4 Early Phase 1.
Follow Metastatic Malignant Neoplasm in the Brain: new trials by email Literature Review of Metastatic Malignant Neoplasm in the Brain trials Research Report on Metastatic Malignant Neoplasm in the Brain
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CA-4948 in Combination With Pembrolizumab and Stereotactic Radiosurgery to Improve Treatment of Melanoma Brain Metastases Emavusertib, Pembrolizumab, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Melanoma | Phase 1 / Phase 2 | Suspended | Mayo Clinic | 23 | 2026-11-30 | 2026-10-20 |
| A PET Imaging Agent (64Cu-DOTA-Pembrolizumab) for Determining Treatment Response Among Patients With Stage IV Non-small Cell Lung Cancer Receiving Pembrolizumab Computed Tomography, Copper Cu 64-DOTA-pembrolizumab, Low Dose Radiation Therapy - Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Recruiting | City of Hope Medical Center | 6 | 2026-09-01 | 2026-10-19 |
| Advanced Magnetic Resonance Imaging for the Identification of Recurrent Brain Tumors and Radiation Necrosis Advanced Magnetic Resonance Imaging, Biospecimen Collection, Magnetic Resonance Imaging - Malignant Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain | Not applicable | Recruiting | Jonsson Comprehensive Cancer Center | 42 | 2025-08-28 | 2026-01-15 |
| Cemiplimab for the Treatment of Untreated Brain Metastases From PD-L1 >= 50% Non-Small Cell Lung Cancer Biospecimen Collection, Cemiplimab, Computed Tomography - Metastatic Lung Non-Small Cell Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Withdrawn | City of Hope Medical Center | 2025-04-15 | 2025-05-26 | |
| Testing Longer Duration Radiation Therapy Versus the Usual Radiation Therapy in Patients With Cancer That Has Spread to the Brain Computed Tomography, Fractionated Stereotactic Radiation Therapy, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 3 | Active not recruiting | NRG Oncology | 274 | 2024-12-12 | 2026-09-14 |
| Zr-89 Crefmirlimab Berdoxam and Immuno-Positron Emission Tomography for the Imaging of Patients With Resectable Brain Tumors Advanced Magnetic Resonance Imaging, Brain Surgery, Electronic Health Record Review - Glioma, Malignant Brain Neoplasm | Phase 1 | Recruiting | Jonsson Comprehensive Cancer Center | 20 | 2024-12-05 | 2026-02-05 |
| Arginine and Whole Brain Radiation Therapy for the Treatment of Patients With Brain Metastases Arginine, Biospecimen Collection, Computed Tomography - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Early Phase 1 | Recruiting | Emory University | 10 | 2024-09-05 | 2026-10-13 |
| Trotabresib in Combination With Vinorelbine and Radiation Therapy for the Treatment of HER2+ Breast Cancer With Central Nervous System or Leptomeningeal Metastasis Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Breast Carcinoma, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Withdrawn | Northwestern University | 2023-12-31 | 2024-04-01 | |
| An Interactive Time-Restricted Diet Intervention (txt4fasting) for Reducing Neurocognitive Decline and Improving Survival in Patients With Brain Metastases From Breast or Lung Cancer Behavioral Dietary Intervention, Text Message-Based Navigation Intervention, Internet-Based Intervention - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Not applicable | Terminated | Thomas Jefferson University | 1 | 2023-12-13 | 2026-03-03 |
| Natural Killer Cell Therapy (UD TGFbetai NK Cells) and Temozolomide for the Treatment of Stage IV Melanoma Metastatic to the Brain Natural Killer Cell Therapy, Temozolomide - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 1 / Phase 2 | Recruiting | Kari Kendra | 24 | 2023-03-01 | 2026-06-11 |
| An Investigational Scan (64Cu-DOTA-Trastuzumab PET/MRI) in Imaging Patients With HER2+ Breast Cancer With Brain Metastasis Copper Cu 64-DOTA-Trastuzumab, Magnetic Resonance Imaging, Positron Emission Tomography - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Breast Carcinoma | Phase 4 | Recruiting | City of Hope Medical Center | 10 | 2022-12-21 | 2026-07-01 |
| Dendritic Cell Vaccines Against Her2/Her3 and Pembrolizumab for the Treatment of Brain Metastasis From Triple Negative Breast Cancer or HER2+ Breast Cancer Anti-HER2/HER3 Dendritic Cell Vaccine, Pembrolizumab - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Recruiting | Roswell Park Cancer Institute | 23 | 2022-12-19 | 2026-07-21 |
| Comparing the Addition of Radiation Either Before or After Surgery for Patients With Brain Metastases Brain Surgery, Quality-of-Life Assessment, Questionnaire Administration - Metastatic Malignant Neoplasm in the Brain | Phase 3 | Active not recruiting | NRG Oncology | 237 | 2022-10-24 | 2026-09-10 |
| E6201 and Dabrafenib for the Treatment of Central Nervous System Metastases From BRAF V600 Mutated Metastatic Melanoma Dabrafenib, MEK-1/MEKK-1 Inhibitor E6201, Biospecimen Collection - Clinical Stage IV Cutaneous Melanoma AJCC v8, Metastatic Malignant Neoplasm in the Brain | Phase 1 | Terminated | Mayo Clinic | 13 | 2022-10-20 | 2025-08-19 |
| Stereotactic Radiosurgery and Immune Checkpoint Inhibitors With NovoTTF-200M for the Treatment of Melanoma Brain Metastases Ipilimumab, Nivolumab, Pembrolizumab - Clinical Stage IV Cutaneous Melanoma AJCC v8, Melanoma of Unknown Primary | Phase 1 | Terminated | Emory University | 1 | 2022-10-13 | 2026-04-23 |
| Neuropsychological Care for Maintaining Quality of Life After Radiation Therapy in Patients With Brain Metastases Best Practice, Neuropsychological Assessment, Quality-of-Life Assessment - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 2 | Completed | Ohio State University Comprehensive Cancer Center | 110 | 2022-08-30 | 2026-10-21 |
| Low Dose Versus Standard Dose Dexamethasone for Reduction of Swelling in Patients with Primary or Metastatic Brain Tumors Dexamethasone - Malignant Brain Neoplasm, Metastatic Malignant Neoplasm in the Brain | Phase 2 | Unknown | City of Hope Medical Center | 26 | 2022-04-09 | 2024-09-19 |
| SRS Compared With FSRS for Treatment of Intact Metastatic Brain Disease, FRACTIONATE Trial Questionnaire Administration, Stereotactic Radiosurgery, Magnetic Resonance Imaging - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Phase 2 | Recruiting | Mayo Clinic | 90 | 2022-03-14 | 2026-10-01 |
| Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Anatomic Stage IV Breast Cancer AJCC v8, Metastatic Lung Non-Small Cell Carcinoma | Phase 3 | Terminated | NRG Oncology | 19 | 2021-08-05 | 2026-05-20 |
| Radiosurgery Before Surgery for the Treatment of Brain Metastases Dexamethasone, Resection, Stereotactic Radiosurgery - Metastatic Malignant Neoplasm in the Brain, Metastatic Malignant Solid Neoplasm | Early Phase 1 | Completed | Emory University | 26 | 2021-07-20 | 2026-05-14 |
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Brain Neoplasms (79) · Melanoma (18) · Carcinoma, Non-Small-Cell Lung (14) · Neoplasm Metastasis (14) · Breast Neoplasms (13) · Lung Neoplasms (12) · Glioma (7) · Small Cell Lung Carcinoma (5) · Glioblastoma (4) · Carcinoma, Renal Cell (3) · Central Nervous System Neoplasms (3) · Meningeal Carcinomatosis (3) · Neoplasms (3) · Triple Negative Breast Neoplasms (3) · Hematologic Neoplasms (2)
Brain Diseases (79) · Central Nervous System Diseases (79) · Neoplasms by Site (79) · Nervous System Diseases (79) · Nervous System Neoplasms (79) · Central Nervous System Neoplasms (76) · Neoplasms (76) · Skin Diseases (28) · Skin and Connective Tissue Diseases (28) · Neoplasms by Histologic Type (25) · Neoplasms, Germ Cell and Embryonal (23) · Neoplasms, Nerve Tissue (23) · Neuroectodermal Tumors (23) · Lung Diseases (18) · Neuroendocrine Tumors (18)
Magnetic Resonance Spectroscopy (24) · Radiosurgery (24) · Specimen Handling (12) · Mental Status and Dementia Tests (6) · pembrolizumab (6) · Nivolumab (5) · CTLA-4 Antigen (4) · Ipilimumab (4) · Ferrosoferric Oxide (3) · Gadolinium (3) · Immunoglobulin G (3) · Memantine (3) · Radiation (3) · Radiotherapy (3) · X-Rays (3)
M.D. Anderson Cancer Center (19) · National Cancer Institute (NCI) (12) · Emory University (6) · Mayo Clinic (6) · City of Hope Medical Center (5) · NRG Oncology (5) · OHSU Knight Cancer Institute (3) · SWOG Cancer Research Network (3) · University of Southern California (3) · Albert Einstein College of Medicine (2) · Alliance for Clinical Trials in Oncology (2) · Jonsson Comprehensive Cancer Center (2) · Kari Kendra (1) · Northwestern University (1) · Ohio State University Comprehensive Cancer Center (1)
United States (77) · Canada (8) · Hong Kong (2) · Puerto Rico (2) · South Korea (2) · Ireland (1) · Japan (1) · Saudi Arabia (1)
Jing Li (4) · Edward Neuwelt (2) · Hussein A Tawbi (2) · Paul D. Brown, MD (2) · Pranshu Mohindra (2) · Vinai Gondi (2) · Amy B Heimberger (1) · Andrew J Brenner (1) · Arya Amini (1) · Barbara J O'Brien, MD (1) · Bently Doonan, MD, MS (1) · Caroline Chung (1) · Dawid Schellingerhout (1) · Debra N Yeboa (1) · Debra NAna Yeboa (1)
PMID 28687375, PMID 32058845, PMID 32479604, PMID 33067126, PMID 35362047, PMID 35367525, PMID 35728046, PMID 36623515, PMID 37289451, PMID 37506981, PMID 37555284, PMID 37590001, PMID 37717787, PMID 38115038, PMID 38475765, PMID 39402027, PMID 40029972, PMID 40531511
P30CA138292 (6), P30CA033572 (4), U10CA180868 (4), P30CA014089 (3), U10CA180888 (3), UM1CA186691 (3), P30CA013330 (2), P30CA016042 (2), P30CA016058 (2), P30CA016672 (2), R01CA137488 (2), U01CA076576 (2), U10CA021661 (2), U10CA180821 (2), UG1CA189867 (2)