3 terminated, 2 recruiting, 1 completed, 1 not yet recruiting. 8 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 8 | Terminated 3, Recruiting 2, Completed 1, Not yet recruiting 1, Unknown 1 |
| Phase 3 | 2 | Not yet recruiting 1, Terminated 1 |
Follow Mediastinal Diseases: new trials by email Literature Review of Mediastinal Diseases trials Research Report on Mediastinal Diseases
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Pharmacologic Therapies to Mitigate Radiation- Associated Heart Disease Atorvastatin and Lisinopril, Placebo - Chest Wall Tumor, Breast Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 60 | 2026-08-12 | 2026-09-17 |
| 6 vs 3 Cycles of Neoadjuvant Chemotherapy for Potentially Resectable Locally Advanced Thymic Epithelial Tumors Cyclophosphamide, Doxorubicin, and Cisplatin (CAP), nab-Paclitaxel and Carboplatin - Thymoma and Thymic Carcinoma | Phase 2 / Phase 3 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 116 | 2026-03-01 | 2026-03-11 |
| Phase II Trial of Lung Chemoemobolization Computed Tomography, Ethiodized Oil, Mitomycin - Lung Non-Small Cell Carcinoma, Mediastinal Neoplasm | Phase 2 | Recruiting | City of Hope Medical Center | 30 | 2023-05-12 | 2026-03-05 |
| MR-linac Guided Adaptive Radiotherapy for Inoperable Mediastinal Tumor Unity-based MR-Linac guided Radiotherapy - Mediastinal Tumor | Phase 2 | Unknown | Sun Yat-sen University | 59 | 2021-10-01 | 2021-12-20 |
| Pembrolizumab in Subjects With Incurable Platinum-Refractory Germ Cell Tumors Pembrolizumab - Germ Cell Neoplasms, Testicular Neoplasms | Phase 2 | Terminated | Nasser Hanna, M.D. | 12 | 2016-01-01 | 2022-07-11 |
| Belinostat (PXD101) to Treat Tumors of the Thymus at an Advanced Stage Belinostat (PDX101) - Thymoma, Thymic Carcinoma | Phase 2 | Completed | National Cancer Institute (NCI) | 41 | 2007-12-01 | 2015-09-30 |
| Efficacy, Immunogenicity, and Safety of a Single Dose of V710 in Adult Patients Scheduled for Cardiothoracic Surgery (V710-003 AM2) V710, Placebo - Staphylococcus Aureus, Bacteremia | Phase 2 / Phase 3 | Terminated | Merck Sharp & Dohme LLC | 8031 | 2007-12-01 | 2015-10-02 |
| Weekly Topotecan With Docetaxel in Recurrent Small Cell Lung Cancer Intravenous Topotecan, Intravenous Docetaxel - Mediastinal Neoplasms | Phase 2 | Terminated | Aultman Health Foundation | 7 | 2004-11-01 | 2018-08-20 |
Mediastinal Neoplasms (7) · Thymoma (2) · Bacteremia (1) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Cardiovascular Diseases (1) · Colonic Neoplasms (1) · Esophageal Neoplasms (1) · Genital Neoplasms, Female (1) · Genital Neoplasms, Male (1) · Lung Neoplasms (1) · Mediastinitis (1) · Neoplasms, Germ Cell and Embryonal (1) · Nonseminomatous germ cell tumor (1) · Ovarian Neoplasms (1)
Respiratory Tract Diseases (8) · Thoracic Diseases (8) · Neoplasms (7) · Neoplasms by Site (7) · Thoracic Neoplasms (6) · Neoplasms by Histologic Type (4) · Digestive System Diseases (2) · Digestive System Neoplasms (2) · Gastrointestinal Diseases (2) · Gastrointestinal Neoplasms (2) · Hemic and Lymphatic Diseases (2) · Lung Diseases (2) · Lymphatic Diseases (2) · Neoplasms, Complex and Mixed (2)
130-nm albumin-bound paclitaxel (1) · Atorvastatin (1) · Carboplatin (1) · Cisplatin (1) · Cyclophosphamide (1) · Docetaxel (1) · Doxorubicin (1) · Ethiodized Oil (1) · Iodized Oil (1) · Lisinopril (1) · Mitomycin (1) · Mitozytrex (1) · Topotecan (1) · V710 vaccine (1) · belinostat (1)
Aultman Health Foundation (1) · City of Hope Medical Center (1) · Merck Sharp & Dohme LLC (1) · Nasser Hanna, M.D. (1) · National Cancer Institute (NCI) (1) · Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine (1) · Sun Yat-sen University (1) · UNC Lineberger Comprehensive Cancer Center (1)
United States (5) · China (2)
Fan Jiang, MD, PhD (1) · Franz E Boas, MD (1) · Giuseppe Giaccone, M.D. (1) · Hui Liu (1) · Nasser Hanna, M.D. (1) · Raza Khan, MD (1) · Shivani Sud, MD (1)
PMID 21502553, PMID 23549582, PMID 29045540, PMID 37611799
P30CA033572 (1)