51 completed, 20 recruiting, 18 unknown, 12 terminated. 62 Phase 2, 22 Not applicable, 21 Phase 1, 6 Phase 3, 2 Phase 4.
Follow Thymoma: new trials by email Literature Review of Thymoma trials Research Report on Thymoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase II, Investigator-Initiated Exploratory Study of Sacituzumab Tirumotecan for Previously Treated Unresectable Thymic Carcinomas Sacituzumab Tirumotecan (Sac-TMT) - Unresectable Thymic Carcinoma | Phase 2 | Not yet recruiting | National Cancer Center, Japan | 35 | 2027-02-01 | 2026-08-06 |
| STAR0602 With Nivolumab in Non Small Cell Lung Cancer and in Metastatic Castrate-Resistant Prostate Cancer, and STAR0602 Alone in Thymic Carcinoma STAR0602, Nivolumab - NSCLC, Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | Not yet recruiting | National Cancer Institute (NCI) | 67 | 2026-11-04 | 2026-10-30 |
| Phase II Trial of Hypofractionated Radiotherapy Guided by Optical Surface Imaging and Fan-beam CT for Thymoma With Pleural Metastasis hypofractionated radiotherapy guided by optical surface imaging and FBCT, hypofractionated radiotherapy guided by CBCT - Thymoma and Thymic Carcinoma, Pleural Metastasis | Phase 2 | Not yet recruiting | Sun Yat-sen University | 234 | 2026-10-12 | 2026-10-16 |
| Incidence and Predictors of Early Clinical Relapse Within Six Months After Thymectomy in Patients With Myasthenia Gravis Myasthenia Gravis, Thymoma | Not yet recruiting | Assiut University | 30 | 2026-10-01 | 2026-10-01 | |
| Thymic Disease, Autoimmunity, and Neuromuscular Junction Integrity in Myasthenia Gravis Myasthenia Gravis (MG), Myasthenia Gravis Associated With Thymoma | Not yet recruiting | IRCCS San Raffaele | 40 | 2026-09-15 | 2026-05-06 | |
| Hypofractionated Adjuvant Radiotherapy for Thymic Epithelial Tumors Hypofractionated Adjuvant Proton Therapy, Hypofractionated Adjuvant Photon Radiation Therapy - Thymus Neoplasms, Thymic Epithelial Tumor | Not applicable | Not yet recruiting | National Taiwan University Hospital | 69 | 2026-08-01 | 2026-07-16 |
| Neoadjuvant Adebrelimab Plus CRT for Locally Advanced Thymic Carcinoma adebrelimab plus chemoradiation - Thymic Carcinoma | Phase 2 | Not yet recruiting | Shanghai Chest Hospital | 31 | 2026-04-01 | 2026-03-18 |
| Sacituzumab Tirumotecan in Participants With Locally Advanced or Metastatic Thymic Carcinoma Sacituzumab tirumotecan - Thymic Carcinoma | Phase 2 | Recruiting | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | 30 | 2026-03-13 | 2026-08-12 |
| Target-Selected CAR-NK Cells (CD30, CD5, or Mesothelin) for Relapsed/Refractory B2 Thymoma or Thymic Carcinoma Cyclophosphamide, Fludarabine, EB-CAR30-NK - B2 Thymoma, Thymic Carcinoma | Phase 1 / Phase 2 | Recruiting | Beijing Biotech | 36 | 2026-03-02 | 2026-05-20 |
| 6 vs 3 Cycles of Neoadjuvant Chemotherapy for Potentially Resectable Locally Advanced Thymic Epithelial Tumors Cyclophosphamide, Doxorubicin, and Cisplatin (CAP), nab-Paclitaxel and Carboplatin - Thymoma and Thymic Carcinoma | Phase 2 / Phase 3 | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 116 | 2026-03-01 | 2026-03-11 |
| Electrocautery Resection Combined With HITHOC for Thymic Epithelial Tumors With Pleural Metastasis Patients with thymic epithelial tumors with pleural metastasis or recurrence who undergo extended thymectomy with electrocautery resection of pleural metastases followed by two cycles of hyperthermic, Hyperthermic Intrathoracic Chemotherapy (HITHOC) - Thymic Epithelial Tumor, Thymoma | Not yet recruiting | Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine | 70 | 2026-02-01 | 2026-02-05 | |
| HEARTS Trial for Thoracic Cancers MRgART, LINAC - Non-Small Cell Lung Cancer (Stage III), Esophageal Cancer Stage I-III | Phase 2 | Suspended | University of Wisconsin, Madison | 60 | 2025-10-08 | 2026-10-30 |
| IMMUNORARE5: A National Platform of 5 Academic Phase II Trials Coordinated by Lyon University Hospital to Assess the Safety and the Efficacy of the IMMUNOtherapy With Domvanalimab + Zimberelimab Combination in Patients With Advanced RARE Cancers DOMVANALIMAB + ZIMBERELIMAB, DOMVANALIMAB + ZIMBERELIMAB + FOLFOX-4 - Peritoneal Mesothelioma, Gestational Trophoblastic Tumor | Phase 2 | Active not recruiting | Hospices Civils de Lyon | 27 | 2025-10-01 | 2026-06-25 |
| CD70-Targeted CAR-T Therapy in CD70-Positive Advanced Solid Tumors CD70-targeted CAR-T cells - Renal Cell Carcinoma (RCC), Lung Cancer | Phase 1 | Suspended | Chongqing Precision Biotech Co., Ltd | 90 | 2025-09-12 | 2026-09-11 |
| Anti-Mesothelin TNaive/SCM hYP218 (TNhYP218) CAR T Cells in Participants With Mesothelin-Expressing Solid Tumors Including Mesothelioma cyclophosphamide, fludarabine, TNhYP218 CAR T Cells - Mesothelioma, Neoplasms | Phase 1 | Recruiting | National Cancer Institute (NCI) | 120 | 2025-07-08 | 2026-10-16 |
| Tislelizumab Combined With Anlotinib as Second-line Therapy in Thymoma and Thymic Carcinoma Experimental: tislelizumab+anlotinib - Thymic Carcinoma, Thymoma | Phase 2 | Recruiting | The First Affiliated Hospital with Nanjing Medical University | 20 | 2025-03-31 | 2025-12-01 |
| Serratus Posterior Superior Intercostal Plane Block in Robotic-Assisted Thymectomy Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block performed with 0.25% bupivacaine, Ultrasound-guided Serratus Posterior Superior Intercostal Plane Block performed with a placebo solution (0.9% NaCl) - RATS Surgery, Thymectomy | Not applicable | Recruiting | Fondazione Policlinico Universitario Agostino Gemelli IRCCS | 28 | 2025-03-01 | 2025-03-25 |
| Glucocorticoids Combined With Concurrent Chemoradiotherapy for Unresectable Thymoma Radiotherapy, Concurrent chemotherapy, Methylprednisolone - Thymoma | Phase 2 | Recruiting | Sun Yat-sen University | 45 | 2024-11-20 | 2024-12-12 |
| Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs Stage III Breast Cancer, Stage IV Breast Cancer | Withdrawn | Travera Inc | 2024-11-01 | 2024-11-25 | ||
| Hypofractionated Radiotherapy for Thymic Epithelial Tumors Hypofractionated Radiation Therapy - Thymoma and Thymic Carcinoma, Thymoma | Not applicable | Recruiting | Rongrong Zhou | 100 | 2024-10-01 | 2024-11-18 |
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Carcinoma, Non-Small-Cell Lung (20) · Thymus Neoplasms (19) · Lung Neoplasms (16) · Esophageal Neoplasms (13) · Mesothelioma (13) · Ovarian Neoplasms (12) · Small Cell Lung Carcinoma (12) · Breast Neoplasms (10) · Carcinoma, Renal Cell (10) · Melanoma (10) · Myasthenia Gravis (10) · Neoplasms (10) · Pancreatic Neoplasms (10) · Thymic epithelial tumor (10)
Hemic and Lymphatic Diseases (128) · Lymphatic Diseases (128) · Neoplasms by Histologic Type (128) · Neoplasms by Site (128) · Neoplasms, Complex and Mixed (128) · Thoracic Neoplasms (128) · Neoplasms (118) · Thymus Neoplasms (109) · Respiratory Tract Diseases (35) · Lung Diseases (31) · Respiratory Tract Neoplasms (31) · Neoplasms, Glandular and Epithelial (25) · Adenoma (21) · Bronchial Neoplasms (21) · Carcinoma, Bronchogenic (21)
Cyclophosphamide (7) · Cisplatin (6) · Radiotherapy (6) · pembrolizumab (6) · Carboplatin (5) · Sunitinib (5) · Paclitaxel (4) · 130-nm albumin-bound paclitaxel (3) · Nivolumab (3) · Thymectomy (3) · Celecoxib (2) · Chemoradiotherapy (2) · Doxorubicin (2) · Drug Therapy (2) · Erlotinib Hydrochloride (2)
National Cancer Institute (NCI) (15) · Fudan University (4) · Georgetown University (3) · M.D. Anderson Cancer Center (3) · Novartis Pharmaceuticals (3) · Shanghai Pulmonary Hospital, Shanghai, China (3) · Sun Yat-sen University (3) · Assiut University (2) · Eastern Cooperative Oncology Group (2) · IRCCS San Raffaele (2) · Indiana University (2) · Intuitive Surgical (2) · Istituto Clinico Humanitas (2) · National Cancer Center, Japan (2) · Patrick Joseph Loehrer Sr. (2)
United States (58) · China (34) · Italy (13) · France (7) · Netherlands (6) · Spain (5) · Taiwan (5) · Canada (4) · Germany (4) · Japan (4) · South Korea (4) · Australia (3) · United Kingdom (3) · Belgium (2) · Singapore (2)
Arun Rajan, M.D. (8) · Armando Santoro, MD (3) · Anne S Tsao (2) · Arun Rajan, MD. (2) · Chul Kim, MD (2) · David S Schrump, M.D. (2) · Deping Zhao, MD,PhD (2) · Patrick Loehrer (2) · Patrick Loehrer, M.D. (2) · Raffit Hassan, M.D. (2) · Andreas Meisel, MD (1) · Barbara Jean Bambach, MD (1) · Barbara Ma, MD (1)
PMID 34393061, PMID 21502559, PMID 21502553, PMID 25403584, PMID 29395863, PMID 10555755, PMID 11123390, PMID 11282421, PMID 11383846, PMID 12712448, PMID 12778165, PMID 14722038, PMID 14963856, PMID 15201427, PMID 15725919, PMID 16332601, PMID 17410014, PMID 17570676, PMID 18222230, PMID 18268188, PMID 18567886, PMID 18596824, PMID 18675464, PMID 19220526, PMID 19451433, PMID 19461405, PMID 20068553, PMID 20117014, PMID 20421818, PMID 20859129, PMID 20930041, PMID 21847048, PMID 21847058, PMID 21953501, PMID 22047648, PMID 22480131, PMID 23229679, PMID 23278584, PMID 23444221, PMID 23761413, PMID 23860537, PMID 24099983, PMID 24139613, PMID 24439931, PMID 24974848, PMID 25146529, PMID 25189481, PMID 25202099, PMID 25260491, PMID 25275083
2009 (1), 2015 (1), 2016 (1), 2017 (1), 2019 (1), P30CA015083 (1), P30CA016056 (1), P30CA016672 (1), R01HL153720 (1), U01NS042685 (1), U10CA021115 (1), U10CA180888 (1)