10 completed, 9 unknown, 3 terminated. 22 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 22 | Completed 10, Unknown 9, Terminated 3 |
| Phase 1 | 4 | Unknown 2, Completed 1, Terminated 1 |
Follow Malignant Pleural Effusion: new trials by email Literature Review of Malignant Pleural Effusion trials Research Report on Malignant Pleural Effusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion bevacizumab and camrelizumab - Malignant Pleural Effusion | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital of Zhengzhou University | 55 | 2022-08-01 | 2022-04-15 |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| A Study of Nivolumab and Intrapleural Talimogene Laherparepvec for Malignant Pleural Effusion Talimogene laherparepvec (TVEC), Nivolumab - Malignant Pleural Effusion, Stage IV Metastatic Cancer | Phase 1 / Phase 2 | Terminated | UNC Lineberger Comprehensive Cancer Center | 1 | 2019-03-06 | 2021-04-20 |
| A Study of Syngenon (BSG-001) for Inhalation in Subjects With Malignant Pleural Effusion and/or Malignant Ascites BSG-001 - Malignant Pleural Effusion, Malignant Ascites | Phase 1 / Phase 2 | Unknown | BioSyngen Pte Ltd | 58 | 2019-01-01 | 2018-11-08 |
| A Randomized Study of Primary Tumor Radiotherapy for Patients With MPE Stage IV NSCLC Radiation, Chemotherapy - Malignant Pleural Effusion, Nonsmall Cell Lung Cancer, Stage IV | Phase 2 | Unknown | Guizhou Medical University | 68 | 2018-09-01 | 2019-06-14 |
| Bevacizumab in the Treatment of Malignant Pleural Effusions of Non-squamous Non-small Cell Lung Cancer Bevacizumab - Malignant Pleural Effusion | Phase 2 | Unknown | Peking University Cancer Hospital & Institute | 87 | 2016-10-01 | 2018-11-07 |
| Clinical Trial of Tumor Cell-derived Microparticles Packaging Chemotherapeutic Drugs to Treat Malignant Pleural Effusion tumor derived microparticles, cisplatin - Malignant Pleural Effusion | Phase 2 | Unknown | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | 90 | 2016-01-01 | 2019-02-26 |
| Recombinant Adenoviral Human p53 Gene in Treatment of Malignant Pleural Effusion rAdp53, Cisplatin, rAdp53 plus cisplatin - Malignant Pleural Effusion | Phase 2 | Unknown | Shenzhen SiBiono GeneTech Co.,Ltd | 90 | 2015-06-01 | 2015-04-29 |
| Metformin and Chemotherapy in Treating Patients With Stage III-IV Ovarian, Fallopian Tube, or Primary Peritoneal Cancer metformin hydrochloride, placebo, Chemotherapy - Brenner Tumor, Malignant Ascites | Phase 2 | Completed | University of Chicago | 111 | 2015-02-25 | 2026-03-27 |
| Intrapleural Bevacizumab Injection for Malignant Effusion in Lung Cancer Bevacizumab - Non-small Cell Lung Cancer, Malignant Pleural Effusion | Phase 2 | Completed | Haihong Yang, MD, Pricipal investigator | 22 | 2014-01-01 | 2019-03-29 |
| Efficacy and Safety of Bevacizumab Versus Pulvis Talci in Malignant Pleural Effusion Bevacizumab, Pulvis talci - Malignant Pleural Effusion | Phase 2 | Unknown | Tang-Du Hospital | 183 | 2012-01-01 | 2014-02-04 |
| Effectiveness of Doxycycline for Treating Pleural Effusions Related to Cancer in an Outpatient Population Doxycycline, normal saline - Malignant Pleural Effusion | Phase 2 | Unknown | Ottawa Hospital Research Institute | 40 | 2011-06-01 | 2020-09-25 |
| Endostar and/or Cisplatin for Treatment of Malignant Pleural Effusion or Ascites Endostar, Cisplatin - Malignant Pleural Effusion, Malignant Ascites | Phase 2 | Completed | Jiangsu Simcere Pharmaceutical Co., Ltd. | 336 | 2011-03-01 | 2014-08-01 |
| Cediranib as Palliative Treatment in Patients With Symptomatic Malignant Ascites or Pleural Effusion immediate cediranib, Start cediranib after 28 days Best Supportive Care - Malignant Ascites, Malignant Pleural Effusion | Phase 2 | Terminated | Radboud University Medical Center | 12 | 2010-04-01 | 2013-07-15 |
| Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer zoledronic acid - Malignant Pleural Effusion, Non Small Cell Lung Cancer | Phase 2 | Terminated | Peter Bushunow MD | 3 | 2009-11-01 | 2012-12-04 |
| Safety and Effectiveness Study for Pleurodesis With Silver Nitrate in Malignant Pleural Effusion Silver Nitrate - Malignant Pleural Effusion | Phase 2 | Unknown | University of Sao Paulo General Hospital | 60 | 2009-08-01 | 2010-05-18 |
| Tunneled Pleural Catheter in Partially Entrapped Lung VATS, Talc-Pleurodesis, tunneled pleural drainage, VATS, Talc-pleurodesis - Malignant Pleural Effusion | Phase 2 | Completed | Heidelberg University | 50 | 2008-07-01 | 2022-09-02 |
| AZD0530 in Treating Patients With Extensive Stage Small Cell Lung Cancer saracatinib - Extensive Stage Small Cell Lung Cancer, Lung Metastases | Phase 2 | Completed | National Cancer Institute (NCI) | 23 | 2007-11-01 | 2017-12-07 |
| FDG-Labeled PET Scan in Planning Chemotherapy in Treating Patients With Stage IIIB or IV Non-Small Cell Lung Cancer carboplatin, docetaxel, gemcitabine hydrochloride - Malignant Pleural Effusion, Stage IIIB Non-small Cell Lung Cancer | Phase 2 | Completed | University of Washington | 55 | 2007-10-01 | 2017-02-10 |
| Imatinib Mesylate and Paclitaxel in Treating Older Patients With Stage IIIB or Stage IV Non-Small Cell Lung Cancer imatinib mesylate, paclitaxel - Malignant Pleural Effusion, Recurrent Non-small Cell Lung Cancer | Phase 2 | Completed | University of Washington | 34 | 2006-02-01 | 2017-04-25 |
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Pleural Effusion, Malignant (22) · Carcinoma, Non-Small-Cell Lung (6) · Adenocarcinoma of Lung (2) · Adenocarcinoma, Bronchiolo-Alveolar (1) · Brenner Tumor (1) · Carcinoma, Ovarian Epithelial (1) · Fallopian Tube Neoplasms (1) · Lung Neoplasms (1) · Mesothelioma (1) · Mesothelioma, Malignant (1) · Neoplasm Metastasis (1) · Pain (1) · Pericardial Effusion (1) · Small Cell Lung Carcinoma (1)
Neoplasms (22) · Neoplasms by Site (22) · Pleural Diseases (22) · Pleural Effusion (22) · Pleural Neoplasms (22) · Respiratory Tract Diseases (22) · Respiratory Tract Neoplasms (22) · Thoracic Neoplasms (22) · Lung Diseases (9) · Lung Neoplasms (9) · Bronchial Neoplasms (7) · Carcinoma, Bronchogenic (7) · Neoplasms by Histologic Type (4) · Neoplasms, Glandular and Epithelial (4) · Carcinoma (3)
Bevacizumab (4) · Cisplatin (3) · Paclitaxel (3) · Taxes (3) · Carboplatin (2) · Docetaxel (2) · Drug Therapy (2) · 2-phenyl-6-(2'-(4'-(ethoxycarbonyl)thiazolyl))thiazolo(3,2-b)(1,2,4)triazole (1) · Bortezomib (1) · Cetuximab (1) · Doxycycline (1) · Erlotinib Hydrochloride (1) · Fluorodeoxyglucose F18 (1) · Gemcitabine (1) · Imatinib Mesylate (1)
National Cancer Institute (NCI) (3) · University of Washington (2) · BioSyngen Pte Ltd (1) · Guizhou Medical University (1) · Haihong Yang, MD, Pricipal investigator (1) · Heidelberg University (1) · Jiangsu Simcere Pharmaceutical Co., Ltd. (1) · Ottawa Hospital Research Institute (1) · Peking University Cancer Hospital & Institute (1) · Peter Bushunow MD (1) · RS Oncology LLC (1) · Radboud University Medical Center (1) · Shenzhen SiBiono GeneTech Co.,Ltd (1) · Tang-Du Hospital (1) · The First Affiliated Hospital of Zhengzhou University (1)
United States (8) · China (7) · Australia (1) · Brazil (1) · Canada (1) · Germany (1) · Netherlands (1) · United Kingdom (1)
Feng Wang (1) · Haihong Yang, MD (1) · Hans Hoffmann, MD, PhD (1) · James Spicer, MD (1) · Jared Weiss, MD (1) · Jian Fang (1) · Julian Molina (1) · K. Amjadi, MD, FRCPC (1) · Keith Eaton (1) · Kevin Lightner, M.D. (1) · Lietao Li, MD (1) · Pasi A Janne (1) · Peter Bushunow, M.D. (1) · Renato Martins (1)
PMID 16107633, PMID 16111068, PMID 16790519, PMID 16797681, PMID 16940982, PMID 18561992, PMID 18710781, PMID 21267391, PMID 22083202, PMID 23178954, PMID 23925664, PMID 25798278, PMID 27007334, PMID 35080187, PMID 42448681
U10CA031946 (2), R21CA123866 (1), U10CA025224 (1), U10CA180821 (1)