28 completed, 23 unknown, 8 recruiting, 6 terminated. 22 Phase 2, 16 Not applicable, 15 Phase 1, 4 Phase 3, 2 Phase 4.
Follow Malignant Pleural Effusion: new trials by email Literature Review of Malignant Pleural Effusion trials Research Report on Malignant Pleural Effusion
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Cancer Ratio and Cancer Ratio Plus in Malignant and Tuberculous Pleural Effusions Cancer Ratio and Cancer Ratio Plus - Malignant Pleural Effusion, Tuberculous Pleural Effusion | Not yet recruiting | Sohag University | 120 | 2026-09-01 | 2026-08-17 | |
| Fast TILs to Treat Metastatic Cancer Patients With Pleural Disease locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | David Bartlett, MD | 10 | 2026-06-03 | 2026-08-04 |
| Fast TILs to Treat Metastatic Pleural Effusions From Epithelial or Mesothelial Primary Tumors locally manufactured adoptive cellular therapy (ACT) product, Interleukin-2 (IL-2) - Malignant Pleural Effusion, Malignant Mesothelioma | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 10 | 2026-05-01 | 2026-04-07 |
| Effectiveness of Intercostal Tube Drainage Vs Pigtail Catheter Drainage Vs Ultrasound-Guided Aspiration in Management of Massive Malignant Pleural Effusion intercostal tube drainage, big tail catheter drainage, ultrasound-guided aspiration - Malignant Pleural Effusion | Not applicable | Not yet recruiting | Assiut University | 66 | 2025-06-01 | 2025-05-09 |
| Impact of Patient Position on Chemical Pleurodesis by Chest Ultrasound side to side and front to back rotation 30 minutes each - Effect of Patient Rotation on Pleurodesis Success and Patient Comfort, Malignant Pleural Effusion | Not applicable | Recruiting | Ain Shams University | 30 | 2025-05-01 | 2025-08-29 |
| Pleural Bleomycin vs Mechanical Abrasion in Malignant Pleural Effusion Group 1 (mechanical pleurodesis), Group 2 chemical pleurodesis by bleomycin) - Malignant Pleural Effusion | Not applicable | Not yet recruiting | Assiut University | 70 | 2024-12-10 | 2024-11-15 |
| Defining the Clinical Potential of Mass Response As a Biomarker for Patient Tumor Sensitivity to Drugs Stage III Breast Cancer, Stage IV Breast Cancer | Withdrawn | Travera Inc | 2024-11-01 | 2024-11-25 | ||
| Cytological Examination of Malignant Pleural Effusion in Breast Cancer Thoracentesis - Malignant Pleural Effusion | Completed | Mansoura University Hospital | 50 | 2024-10-19 | 2025-05-29 | |
| A Study of MT027 in Patients with Pleural Malignant Tumors MT027 cells suspension - Advanced Malignant Solid Tumor, Malignant Pleural Effusion | Phase 1 | Recruiting | Suzhou Maximum Bio-tech Co., Ltd. | 18 | 2024-05-15 | 2024-12-10 |
| Tocilizumab Delivered Via Pleural and Peritoneal Catheters in Patients With Advanced Metastatic Cancer Tocilizumab - Malignant Pleural Effusion, Malignant Ascites | Phase 1 | Recruiting | Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) | 12 | 2024-01-30 | 2025-05-22 |
| Feasibility of Ambulatory Talc. Pleurodesis ambulatory chest drain and talc pleurodesis - Malignant Pleural Effusion, Malignancy | Not applicable | Recruiting | David Rollins | 15 | 2024-01-10 | 2024-11-12 |
| OPC5: Pressurized IntraThoracic Aerosol Chemotherapy (PITAC) in Patients With Malignant Pleural Effusion. PITAC - Malignant Pleural Effusion, Pleural Neoplasms | Phase 1 | Unknown | Odense University Hospital | 20 | 2023-09-15 | 2024-05-20 |
| A Phase I Study of JMKX000197 Injection in the Treatment of Malignant Pleural Effusion JMKX000197 - Malignant Pleural Effusion | Phase 1 | Unknown | Jemincare | 78 | 2023-05-22 | 2023-06-28 |
| Video Assisted Thoracoscopic Surgery (VATS) - Surgical Pleurodesis vs Tube Drainage in Management of Malignant Pleural Effusion (MPE) VATS-Surgical pleurodesis, Tube Drainage - Malignant Pleural Effusion, Thoracic Cancer | Not applicable | Unknown | Assiut University | 60 | 2023-04-01 | 2023-05-24 |
| A Prospective Observational Study on the Role of Transthoracic Ultrasound in Differentiating Tuberculous From Malignant Pleural Effusion Pleural Effusion, Tuberculosis, Pleural | Unknown | Sarawak General Hospital | 100 | 2023-04-01 | 2023-07-07 | |
| A Study of Intrapleural Administration of Bevacizumab and Camrelizumab for Malignant Pleural Effusion bevacizumab and camrelizumab - Malignant Pleural Effusion | Phase 1 / Phase 2 | Unknown | The First Affiliated Hospital of Zhengzhou University | 55 | 2022-08-01 | 2022-04-15 |
| Malignant Pleural Effusions: Evaluating the psYchosocial Impact of Indwelling Pleural Catheters on Patients Semi-structure interviews - Malignant Pleural Effusion, Indwelling Pleural Catheter | Completed | Guy's and St Thomas' NHS Foundation Trust | 18 | 2022-05-09 | 2023-06-09 | |
| Study of RSO-021 in Patients With Malignant Pleural Effusion Due to Advanced/Metastatic Solid Tumors Including Mesothelioma RSO-021 - Malignant Pleural Effusion, Malignant Pleural Mesothelioma | Phase 1 / Phase 2 | Completed | RS Oncology LLC | 50 | 2022-03-31 | 2026-07-24 |
| A Phase Ⅲ Clinical Study of Combined Cisplatin Versus Placebo Combined With Intracavitary Cisplatin Injection in the Treatment of Malignant Pleural Effusions ENDOSTAR，cisplatin, Placebo , cisplatin - Malignant Pleural Effusion | Phase 3 | Active not recruiting | Jiangsu Simcere Pharmaceutical Co., Ltd. | 290 | 2021-07-28 | 2026-01-02 |
| A Multicenter Survey Study Into Patient Experience With Mobile Apps eMPowEr App - Malignant Pleural Effusion | Unknown | National University of Ireland, Galway, Ireland | 20 | 2021-07-01 | 2021-11-23 |
Showing 20 of 71. Sign in to see all of them.
Pleural Effusion, Malignant (71) · Carcinoma, Non-Small-Cell Lung (12) · Pleural Effusion (7) · Breast Neoplasms (6) · Lung Neoplasms (6) · Neoplasms (5) · Mesothelioma, Malignant (4) · Mesothelioma (3) · Adenocarcinoma of Lung (2) · Anus Neoplasms (2) · Appendiceal Neoplasms (2) · Carcinoma, Hepatocellular (2) · Carcinoma, Ovarian Epithelial (2) · Carcinoma, Renal Cell (2) · Empyema (2)
Neoplasms by Site (71) · Respiratory Tract Diseases (71) · Respiratory Tract Neoplasms (71) · Thoracic Neoplasms (71) · Pleural Diseases (70) · Pleural Neoplasms (70) · Neoplasms (66) · Pleural Effusion (64) · Lung Diseases (23) · Lung Neoplasms (17) · Bronchial Neoplasms (13) · Carcinoma, Bronchogenic (13) · Neoplasms by Histologic Type (10) · Neoplasms, Glandular and Epithelial (10) · Pathological Conditions, Signs and Symptoms (8)
Bevacizumab (5) · Cisplatin (5) · Carboplatin (3) · Paclitaxel (3) · Povidone-Iodine (3) · Taxes (3) · Bortezomib (2) · Docetaxel (2) · Doxycycline (2) · Drug Therapy (2) · Gemcitabine (2) · High-Energy Shock Waves (2) · Interleukin-2 (2) · Pharmaceutical Preparations (2) · Pleurodesis (2)
National Cancer Institute (NCI) (5) · Assiut University (3) · Naestved Hospital (3) · Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) (2) · Jiangsu Simcere Pharmaceutical Co., Ltd. (2) · Ottawa Hospital Research Institute (2) · UNC Lineberger Comprehensive Cancer Center (2) · University of Washington (2) · Abnoba Korea (1) · Ain Shams University (1) · BioSyngen Pte Ltd (1) · C. R. Bard (1) · Candel Therapeutics, Inc. (1) · Chiang Mai University (1) · Chinese PLA General Hospital (1)
United States (21) · China (14) · United Kingdom (7) · Denmark (4) · Egypt (4) · Australia (2) · Canada (2) · Brazil (1) · France (1) · Germany (1) · Hong Kong (1) · India (1) · Ireland (1) · Malaysia (1) · Netherlands (1)
Patrick Wagner, MD (2) · Alexander Chen, M.D. (1) · Angela Davies (1) · Apichat Tantraworasin (1) · Charu Aggarwal, MD (1) · David Bartlett, MD (1) · David CL Lam, PhD, MD (1) · Donna Wakefield, MBBS (1) · Fei Ma, MD (1) · Feng Wang (1) · Friedemann Schad, MD (1) · Haihong Yang, MD (1) · Hans Hoffmann, MD, PhD (1) · Hossein Borghaei (1)
PMID 16107633, PMID 16111068, PMID 16460928, PMID 16790519, PMID 16797681, PMID 16940982, PMID 17573451, PMID 18561992, PMID 18678767, PMID 18710781, PMID 21267391, PMID 22083202, PMID 23178954, PMID 23925664, PMID 25798278, PMID 27007334, PMID 29550074, PMID 30243566, PMID 30272503, PMID 35080187, PMID 35363591, PMID 37428348, PMID 40628689, PMID 42448681, PMID 42669653
U10CA031946 (2), N01CM17101 (1), P30CA006927 (1), R21CA123866 (1), U01CA076576 (1), U10CA025224 (1), U10CA180821 (1)